Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10218

- UL34_HHV11

UniProt

P10218 - UL34_HHV11

Protein

Virion egress protein UL34

Gene

UL34

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL31/UL34 complex induces capsids budding and envelopment into the perinuclear space. Then UL31/UL34 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network.3 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Virion egress protein UL34
    Alternative name(s):
    Primary envelopment factor UL34
    Gene namesi
    Name:UL34
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host nucleus inner membrane 2 Publications; Single-pass membrane protein 2 Publications
    Note: Localizes also at the transient membrane of perinuclear virions.

    GO - Cellular componenti

    1. host cell nuclear inner membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host membrane, Host nucleus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Virion egress protein UL34PRO_0000116026Add
    BLAST

    Post-translational modificationi

    Phosphorylated by viral kinase US3.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Forms a complex with UL31, which interacts with glycoprotein D. This interaction recruits glycoprotein D and glycoprotein M to the inner nuclear membrane.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LMNAP025452EBI-7183680,EBI-351935From a different organism.

    Protein-protein interaction databases

    IntActiP10218. 1 interaction.
    MINTiMINT-224104.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 251251Perinuclear spaceSequence AnalysisAdd
    BLAST
    Topological domaini273 – 2753NuclearSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 18145Interaction with UL31Add
    BLAST

    Sequence similaritiesi

    Belongs to the herpesviridae UL34 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR007626. Herpesvirus_viron_egress-type.
    [Graphical view]
    PfamiPF04541. Herpes_U34. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10218-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLGKPYTG HPGDAFEGLV QRIRLIVPST LRGGDGEAGP YSPSSLPSRC    50
    AFQFHGHDGS DESFPIEYVL RLMNDWAEVP CNPYLRIQNT GVSVLFQGFF 100
    HRPHNAPGGA ITPERTNVIL GSTETTGLSL GDLDTIKGRL GLDARPMMAS 150
    MWISCFVRMP RVQLAFRFMG PEDAGRTRRI LCRAAEQAIT RRRRTRRSRE 200
    AYGAEAGLGV AGTGFRARGD GFGPLPLLTQ GPSRPWHQAL RGLKHLRIGP 250
    PALVLAAGLV LGAAIWWVVG AGARL 275
    Length:275
    Mass (Da):29,790
    Last modified:July 1, 1989 - v1
    Checksum:iBA45B62F68838EC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32309.1.
    PIRiG30085. WMBEH4.
    RefSeqiNP_044636.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32309.1 .
    PIRi G30085. WMBEH4.
    RefSeqi NP_044636.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10218. 1 interaction.
    MINTi MINT-224104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703355.

    Family and domain databases

    InterProi IPR007626. Herpesvirus_viron_egress-type.
    [Graphical view ]
    Pfami PF04541. Herpes_U34. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "U(L)31 and U(L)34 proteins of herpes simplex virus type 1 form a complex that accumulates at the nuclear rim and is required for envelopment of nucleocapsids."
      Reynolds A.E., Ryckman B.J., Baines J.D., Zhou Y., Liang L., Roller R.J.
      J. Virol. 75:8803-8817(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL31.
    3. "Ultrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids."
      Reynolds A.E., Wills E.G., Roller R.J., Ryckman B.J., Baines J.D.
      J. Virol. 76:8939-8952(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    4. "Conformational changes in the nuclear lamina induced by herpes simplex virus type 1 require genes U(L)31 and U(L)34."
      Reynolds A.E., Liang L., Baines J.D.
      J. Virol. 78:5564-5575(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Effects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein."
      Bjerke S.L., Cowan J.M., Kerr J.K., Reynolds A.E., Baines J.D., Roller R.J.
      J. Virol. 77:7601-7610(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship."
      Ryckman B.J., Roller R.J.
      J. Virol. 78:399-412(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    7. "Herpes simplex virus 1 U(L)31 and U(L)34 gene products promote the late maturation of viral replication compartments to the nuclear periphery."
      Simpson-Holley M., Baines J., Roller R., Knipe D.M.
      J. Virol. 78:5591-5600(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Identification of an essential domain in the herpes simplex virus 1 UL34 protein that is necessary and sufficient to interact with UL31 protein."
      Liang L., Baines J.D.
      J. Virol. 79:3797-3806(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL31.
    9. "Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31."
      Kato A., Yamamoto M., Ohno T., Tanaka M., Sata T., Nishiyama Y., Kawaguchi Y.
      J. Virol. 80:1476-1486(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. "Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay."
      Schnee M., Ruzsics Z., Bubeck A., Koszinowski U.H.
      J. Virol. 80:11658-11666(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL31.
    11. "The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membranes of infected cells."
      Wills E., Mou F., Baines J.D.
      J. Virol. 83:4800-4809(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GLYCOPROTEIN D.

    Entry informationi

    Entry nameiUL34_HHV11
    AccessioniPrimary (citable) accession number: P10218
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3