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P10217

- TRM2_HHV11

UniProt

P10217 - TRM2_HHV11

Protein

Tripartite terminase subunit UL33

Gene

UL33

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. viral DNA genome packaging Source: InterPro
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Viral genome packaging, Virus exit from host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite terminase subunit UL33
    Gene namesi
    Name:UL33
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host nucleus 1 Publication
    Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi17 – 171I → D: Temperature-sensitive.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 130130Tripartite terminase subunit UL33PRO_0000116023Add
    BLAST

    Interactioni

    Subunit structurei

    Associates with UL15 and UL28 to form the tripartite terminase complex. The interaction with UL15 directs UL33 to the host nucleus.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UL15P042956EBI-7033000,EBI-7032965
    UL28P102126EBI-7033000,EBI-7032948

    Protein-protein interaction databases

    IntActiP10217. 2 interactions.
    MINTiMINT-6732754.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae UL33 protein family.Curated

    Family and domain databases

    InterProiIPR005208. Herpes_UL33.
    [Graphical view]
    PfamiPF03581. Herpes_UL33. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10217-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGREGRTRQ RTLRDTIPDC ALRSQTLESL DARYVSRDGA HDAAVWFEDM    50
    TPAELEVVFP TTDAKLNYLS RTQRLASLLT YAGPIKAPDD AAAPQTPDTA 100
    CVHGELLAAK RERFAAVINR FLDLHQILRG 130
    Length:130
    Mass (Da):14,437
    Last modified:July 1, 1989 - v1
    Checksum:iD04CFDA7A3C585D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32308.1.
    M62932 Genomic DNA. Translation: AAA45829.1.
    PIRiF30085. WMBEH3.
    RefSeqiNP_044635.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32308.1 .
    M62932 Genomic DNA. Translation: AAA45829.1 .
    PIRi F30085. WMBEH3.
    RefSeqi NP_044635.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10217. 2 interactions.
    MINTi MINT-6732754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703353.

    Family and domain databases

    InterProi IPR005208. Herpes_UL33.
    [Graphical view ]
    Pfami PF03581. Herpes_UL33. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The herpes simplex virus UL33 gene product is required for the assembly of full capsids."
      Al-Kobaisi M.F., Rixon F.J., McDougall I., Preston V.G.
      Virology 180:380-388(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA cleavage and packaging protein encoded by the UL33 gene of herpes simplex virus 1 associates with capsids."
      Beard P.M., Baines J.D.
      Virology 324:475-482(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
      Yang K., Homa F., Baines J.D.
      J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL15 AND UL28.
    5. "Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature."
      Yang K., Poon A.P., Roizman B., Baines J.D.
      J. Virol. 82:487-494(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres."
      Higgs M.R., Preston V.G., Stow N.D.
      J. Gen. Virol. 89:1709-1715(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTRM2_HHV11
    AccessioniPrimary (citable) accession number: P10217
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3