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Protein

Tripartite terminase subunit 2

Gene

TRM2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.UniRule annotation2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 2UniRule annotation
Gene namesi
Name:TRM2UniRule annotation
Ordered Locus Names:UL33
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation1 Publication

  • Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Tripartite terminase subunit 2PRO_0000116023Add
BLAST

Interactioni

Subunit structurei

Associates with TRM1 and TRM3 to form the tripartite terminase complex.UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UL15P042956EBI-7033000,EBI-7032965
UL28P102126EBI-7033000,EBI-7032948

Protein-protein interaction databases

IntActiP10217. 2 interactions.
MINTiMINT-6732754.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRM2 protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04015. HSV_TRM2.
InterProiIPR005208. Herpes_UL33.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGREGRTRQ RTLRDTIPDC ALRSQTLESL DARYVSRDGA HDAAVWFEDM
60 70 80 90 100
TPAELEVVFP TTDAKLNYLS RTQRLASLLT YAGPIKAPDD AAAPQTPDTA
110 120 130
CVHGELLAAK RERFAAVINR FLDLHQILRG
Length:130
Mass (Da):14,437
Last modified:July 1, 1989 - v1
Checksum:iD04CFDA7A3C585D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32308.1.
M62932 Genomic DNA. Translation: AAA45829.1.
PIRiF30085. WMBEH3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32308.1.
M62932 Genomic DNA. Translation: AAA45829.1.
PIRiF30085. WMBEH3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10217. 2 interactions.
MINTiMINT-6732754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04015. HSV_TRM2.
InterProiIPR005208. Herpes_UL33.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The herpes simplex virus UL33 gene product is required for the assembly of full capsids."
    Al-Kobaisi M.F., Rixon F.J., McDougall I., Preston V.G.
    Virology 180:380-388(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA cleavage and packaging protein encoded by the UL33 gene of herpes simplex virus 1 associates with capsids."
    Beard P.M., Baines J.D.
    Virology 324:475-482(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
    Yang K., Homa F., Baines J.D.
    J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRM1 AND TRM3.
  5. "Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature."
    Yang K., Poon A.P., Roizman B., Baines J.D.
    J. Virol. 82:487-494(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres."
    Higgs M.R., Preston V.G., Stow N.D.
    J. Gen. Virol. 89:1709-1715(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTRM2_HHV11
AccessioniPrimary (citable) accession number: P10217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.