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Protein

Tripartite terminase subunit 2

Gene

TRM2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.UniRule annotation2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 2UniRule annotation
Gene namesi
Name:TRM2UniRule annotation
Ordered Locus Names:UL33
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation1 Publication

  • Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Tripartite terminase subunit 2PRO_0000116023Add
BLAST

Interactioni

Subunit structurei

Associates with TRM1 and TRM3 to form the tripartite terminase complex.UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRM1P102126EBI-7033000,EBI-7032948
TRM3P042956EBI-7033000,EBI-7032965

Protein-protein interaction databases

IntActiP10217. 2 interactions.
MINTiMINT-6732754.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRM2 protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04015. HSV_TRM2. 1 hit.
InterProiIPR005208. Herpes_TT2.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGREGRTRQ RTLRDTIPDC ALRSQTLESL DARYVSRDGA HDAAVWFEDM
60 70 80 90 100
TPAELEVVFP TTDAKLNYLS RTQRLASLLT YAGPIKAPDD AAAPQTPDTA
110 120 130
CVHGELLAAK RERFAAVINR FLDLHQILRG
Length:130
Mass (Da):14,437
Last modified:July 1, 1989 - v1
Checksum:iD04CFDA7A3C585D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32308.1.
M62932 Genomic DNA. Translation: AAA45829.1.
PIRiF30085. WMBEH3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32308.1.
M62932 Genomic DNA. Translation: AAA45829.1.
PIRiF30085. WMBEH3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10217. 2 interactions.
MINTiMINT-6732754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04015. HSV_TRM2. 1 hit.
InterProiIPR005208. Herpes_TT2.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM2_HHV11
AccessioniPrimary (citable) accession number: P10217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.