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P10217

- TRM2_HHV11

UniProt

P10217 - TRM2_HHV11

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Protein

Tripartite terminase subunit UL33

Gene

UL33

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly.2 Publications

GO - Biological processi

  1. viral DNA genome packaging Source: InterPro
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit UL33
Gene namesi
Name:UL33
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host nucleus 1 Publication
Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi17 – 171I → D: Temperature-sensitive.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Tripartite terminase subunit UL33PRO_0000116023Add
BLAST

Interactioni

Subunit structurei

Associates with UL15 and UL28 to form the tripartite terminase complex. The interaction with UL15 directs UL33 to the host nucleus.

Binary interactionsi

WithEntry#Exp.IntActNotes
UL15P042956EBI-7033000,EBI-7032965
UL28P102126EBI-7033000,EBI-7032948

Protein-protein interaction databases

IntActiP10217. 2 interactions.
MINTiMINT-6732754.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL33 protein family.Curated

Family and domain databases

InterProiIPR005208. Herpes_UL33.
[Graphical view]
PfamiPF03581. Herpes_UL33. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGREGRTRQ RTLRDTIPDC ALRSQTLESL DARYVSRDGA HDAAVWFEDM
60 70 80 90 100
TPAELEVVFP TTDAKLNYLS RTQRLASLLT YAGPIKAPDD AAAPQTPDTA
110 120 130
CVHGELLAAK RERFAAVINR FLDLHQILRG
Length:130
Mass (Da):14,437
Last modified:July 1, 1989 - v1
Checksum:iD04CFDA7A3C585D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32308.1.
M62932 Genomic DNA. Translation: AAA45829.1.
PIRiF30085. WMBEH3.
RefSeqiNP_044635.1. NC_001806.1.

Genome annotation databases

GeneIDi2703353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32308.1 .
M62932 Genomic DNA. Translation: AAA45829.1 .
PIRi F30085. WMBEH3.
RefSeqi NP_044635.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10217. 2 interactions.
MINTi MINT-6732754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703353.

Family and domain databases

InterProi IPR005208. Herpes_UL33.
[Graphical view ]
Pfami PF03581. Herpes_UL33. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The herpes simplex virus UL33 gene product is required for the assembly of full capsids."
    Al-Kobaisi M.F., Rixon F.J., McDougall I., Preston V.G.
    Virology 180:380-388(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA cleavage and packaging protein encoded by the UL33 gene of herpes simplex virus 1 associates with capsids."
    Beard P.M., Baines J.D.
    Virology 324:475-482(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
    Yang K., Homa F., Baines J.D.
    J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL15 AND UL28.
  5. "Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature."
    Yang K., Poon A.P., Roizman B., Baines J.D.
    J. Virol. 82:487-494(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres."
    Higgs M.R., Preston V.G., Stow N.D.
    J. Gen. Virol. 89:1709-1715(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTRM2_HHV11
AccessioniPrimary (citable) accession number: P10217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3