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P10217 (TRM2_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite terminase subunit UL33
Gene names
Name:UL33
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly. Ref.3 Ref.5

Subunit structure

Associates with UL15 and UL28 to form the tripartite terminase complex. The interaction with UL15 directs UL33 to the host nucleus.

Subcellular location

Host nucleus. Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions. Ref.6

Sequence similarities

Belongs to the herpesviridae UL33 protein family.

Ontologies

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 130130Tripartite terminase subunit UL33
PRO_0000116023

Experimental info

Mutagenesis171I → D: Temperature-sensitive.

Sequences

Sequence LengthMass (Da)Tools
P10217 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: D04CFDA7A3C585D3

FASTA13014,437
        10         20         30         40         50         60 
MAGREGRTRQ RTLRDTIPDC ALRSQTLESL DARYVSRDGA HDAAVWFEDM TPAELEVVFP 

        70         80         90        100        110        120 
TTDAKLNYLS RTQRLASLLT YAGPIKAPDD AAAPQTPDTA CVHGELLAAK RERFAAVINR 

       130 
FLDLHQILRG 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The herpes simplex virus UL33 gene product is required for the assembly of full capsids."
Al-Kobaisi M.F., Rixon F.J., McDougall I., Preston V.G.
Virology 180:380-388(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA cleavage and packaging protein encoded by the UL33 gene of herpes simplex virus 1 associates with capsids."
Beard P.M., Baines J.D.
Virology 324:475-482(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
Yang K., Homa F., Baines J.D.
J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL15 AND UL28.
[5]"Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature."
Yang K., Poon A.P., Roizman B., Baines J.D.
J. Virol. 82:487-494(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres."
Higgs M.R., Preston V.G., Stow N.D.
J. Gen. Virol. 89:1709-1715(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32308.1.
M62932 Genomic DNA. Translation: AAA45829.1.
PIRWMBEH3. F30085.
RefSeqNP_044635.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP10217. 2 interactions.
MINTMINT-6732754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703353.

Family and domain databases

InterProIPR005208. Herpes_UL33.
[Graphical view]
PfamPF03581. Herpes_UL33. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRM2_HHV11
AccessionPrimary (citable) accession number: P10217
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families