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P10216

- UL32_HHV11

UniProt

P10216 - UL32_HHV11

Protein

Packaging protein UL32

Gene

UL32

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.2 Publications

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Packaging protein UL32
    Gene namesi
    Name:UL32
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host cytoplasm 1 Publication. Host nucleus 1 Publication
    Note: Mainly cytoplasmic in transfected cell culture.

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. viral envelope Source: InterPro

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596Packaging protein UL32PRO_0000116014Add
    BLAST

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UL15F8RFH02EBI-9645871,EBI-9642200From a different organism.

    Protein-protein interaction databases

    IntActiP10216. 7 interactions.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae UL32 protein family.Curated

    Family and domain databases

    InterProiIPR002597. Herpes_env.
    [Graphical view]
    PfamiPF01673. Herpes_env. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSPPGVLA SVAVCEESPG SSWKAGAFER AYVAFDPSLL ALNEALCAEL    50
    LTASHVIGVP PVGTLDEDVA ADVVTAPSRA RGGAGDGGGS GGRGGPRNPP 100
    PDPCGEGLLD TGPFSAAAID TFALDRPCLV CRTIELYKQT YRLSPQWVAD 150
    YAFLCAKCLG APHCAASIFV AAFEFVYVMD RHFLRTKKAT LVGSFARFAL 200
    TINDIHRHFF LHCCFRTDGG VPGRHAQKQP KPSPSPGAAK VQYSNYSFLA 250
    QSATRALIGT LASGGEEGAG SAAGSGTQPS LTTALMNWKD CARLLDCTEG 300
    RRGGGDSCCT RAAARNGEFE TVAGDREPEE SPDTWAYADL VLLLLAGTPA 350
    VWESGPQLRA AAEARRATVR QSWEAHRGAR TRDVAPRFAQ FTEPDAQPDL 400
    DLGPLMATVL KHGRGRGRTG GECLLCNLLL VRAYWLALRR LRASVVRYSE 450
    NNTSLFDCIV PVVDQLEADP ETQPGDGGRF VSLLRAAGPE AIFKHMFCDP 500
    MCAITEMEVD PWVLFGHPPA THPDELLLHK AKLACGNEFE GRVCIALRAL 550
    IYTFKTYQVF VPKPTALATF VREAGALLRR HSISLLSLEH TLCTYV 596
    Length:596
    Mass (Da):63,950
    Last modified:July 1, 1989 - v1
    Checksum:i6E650D5EE9CB09B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32307.1.
    PIRiE30085. WMBEH2.
    RefSeqiNP_044634.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32307.1 .
    PIRi E30085. WMBEH2.
    RefSeqi NP_044634.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10216. 7 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703352.

    Family and domain databases

    InterProi IPR002597. Herpes_env.
    [Graphical view ]
    Pfami PF01673. Herpes_env. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1."
      Chang Y.E., Poon A.P., Roizman B.
      J. Virol. 70:3938-3946(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments."
      Lamberti C., Weller S.K.
      J. Virol. 72:2463-2473(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiUL32_HHV11
    AccessioniPrimary (citable) accession number: P10216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be an envelope glycoprotein.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3