P10216 (UL32_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Packaging protein UL32

Gene names

Name:

UL32

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA. Ref.2 Ref.3
Subcellular location	Host cytoplasm. Host nucleus. Note: Mainly cytoplasmic in transfected cell culture. Ref.3
Sequence similarities	Belongs to the herpesviridae UL32 protein family.
Caution	Was originally thought to be an envelope glycoprotein.

Ontologies

Keywords
Cellular component	Host cytoplasm Host nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral envelope Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Packaging protein UL32		PRO_0000116014

Sequences

	Sequence		Length	Mass (Da)
	P10216 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 6E650D5EE9CB09B8	FASTA	596	63,950
	10 20 30 40 50 60 MATSPPGVLA SVAVCEESPG SSWKAGAFER AYVAFDPSLL ALNEALCAEL LTASHVIGVP 70 80 90 100 110 120 PVGTLDEDVA ADVVTAPSRA RGGAGDGGGS GGRGGPRNPP PDPCGEGLLD TGPFSAAAID 130 140 150 160 170 180 TFALDRPCLV CRTIELYKQT YRLSPQWVAD YAFLCAKCLG APHCAASIFV AAFEFVYVMD 190 200 210 220 230 240 RHFLRTKKAT LVGSFARFAL TINDIHRHFF LHCCFRTDGG VPGRHAQKQP KPSPSPGAAK 250 260 270 280 290 300 VQYSNYSFLA QSATRALIGT LASGGEEGAG SAAGSGTQPS LTTALMNWKD CARLLDCTEG 310 320 330 340 350 360 RRGGGDSCCT RAAARNGEFE TVAGDREPEE SPDTWAYADL VLLLLAGTPA VWESGPQLRA 370 380 390 400 410 420 AAEARRATVR QSWEAHRGAR TRDVAPRFAQ FTEPDAQPDL DLGPLMATVL KHGRGRGRTG 430 440 450 460 470 480 GECLLCNLLL VRAYWLALRR LRASVVRYSE NNTSLFDCIV PVVDQLEADP ETQPGDGGRF 490 500 510 520 530 540 VSLLRAAGPE AIFKHMFCDP MCAITEMEVD PWVLFGHPPA THPDELLLHK AKLACGNEFE 550 560 570 580 590 GRVCIALRAL IYTFKTYQVF VPKPTALATF VREAGALLRR HSISLLSLEH TLCTYV

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1." Chang Y.E., Poon A.P., Roizman B. J. Virol. 70:3938-3946(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[3]	"The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments." Lamberti C., Weller S.K. J. Virol. 72:2463-2473(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32307.1.
PIR	WMBEH2. E30085.
RefSeq	NP_044634.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703352.
Phylogenomic databases
ProtClustDB	PHA3232.
Family and domain databases
InterPro	IPR002597. Herpes_env. [Graphical view]
Pfam	PF01673. Herpes_env. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL32_HHV11

Accession

Primary (citable) accession number: P10216

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program