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Protein

Packaging protein UL32

Gene

UL32

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Packaging protein UL32
Gene namesi
Name:UL32
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host cytoplasm 1 Publication. Host nucleus 1 Publication
Note: Mainly cytoplasmic in transfected cell culture.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral envelope Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Packaging protein UL32PRO_0000116014Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UL15F8RFH02EBI-9645871,EBI-9642200From a different organism.

Protein-protein interaction databases

IntActiP10216. 7 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL32 protein family.Curated

Family and domain databases

InterProiIPR002597. Herpes_env.
[Graphical view]
PfamiPF01673. Herpes_env. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSPPGVLA SVAVCEESPG SSWKAGAFER AYVAFDPSLL ALNEALCAEL
60 70 80 90 100
LTASHVIGVP PVGTLDEDVA ADVVTAPSRA RGGAGDGGGS GGRGGPRNPP
110 120 130 140 150
PDPCGEGLLD TGPFSAAAID TFALDRPCLV CRTIELYKQT YRLSPQWVAD
160 170 180 190 200
YAFLCAKCLG APHCAASIFV AAFEFVYVMD RHFLRTKKAT LVGSFARFAL
210 220 230 240 250
TINDIHRHFF LHCCFRTDGG VPGRHAQKQP KPSPSPGAAK VQYSNYSFLA
260 270 280 290 300
QSATRALIGT LASGGEEGAG SAAGSGTQPS LTTALMNWKD CARLLDCTEG
310 320 330 340 350
RRGGGDSCCT RAAARNGEFE TVAGDREPEE SPDTWAYADL VLLLLAGTPA
360 370 380 390 400
VWESGPQLRA AAEARRATVR QSWEAHRGAR TRDVAPRFAQ FTEPDAQPDL
410 420 430 440 450
DLGPLMATVL KHGRGRGRTG GECLLCNLLL VRAYWLALRR LRASVVRYSE
460 470 480 490 500
NNTSLFDCIV PVVDQLEADP ETQPGDGGRF VSLLRAAGPE AIFKHMFCDP
510 520 530 540 550
MCAITEMEVD PWVLFGHPPA THPDELLLHK AKLACGNEFE GRVCIALRAL
560 570 580 590
IYTFKTYQVF VPKPTALATF VREAGALLRR HSISLLSLEH TLCTYV
Length:596
Mass (Da):63,950
Last modified:July 1, 1989 - v1
Checksum:i6E650D5EE9CB09B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32307.1.
PIRiE30085. WMBEH2.
RefSeqiNP_044634.1. NC_001806.1.

Genome annotation databases

GeneIDi2703352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32307.1.
PIRiE30085. WMBEH2.
RefSeqiNP_044634.1. NC_001806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10216. 7 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703352.

Family and domain databases

InterProiIPR002597. Herpes_env.
[Graphical view]
PfamiPF01673. Herpes_env. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1."
    Chang Y.E., Poon A.P., Roizman B.
    J. Virol. 70:3938-3946(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments."
    Lamberti C., Weller S.K.
    J. Virol. 72:2463-2473(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUL32_HHV11
AccessioniPrimary (citable) accession number: P10216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be an envelope glycoprotein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.