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P10216 (UL32_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Packaging protein UL32
Gene names
Name:UL32
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA. Ref.2 Ref.3

Subcellular location

Host cytoplasm. Host nucleus. Note: Mainly cytoplasmic in transfected cell culture. Ref.3

Sequence similarities

Belongs to the herpesviridae UL32 protein family.

Caution

Was originally thought to be an envelope glycoprotein.

Ontologies

Keywords
   Cellular componentHost cytoplasm
Host nucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral envelope

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Packaging protein UL32
PRO_0000116014

Sequences

Sequence LengthMass (Da)Tools
P10216 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 6E650D5EE9CB09B8

FASTA59663,950
        10         20         30         40         50         60 
MATSPPGVLA SVAVCEESPG SSWKAGAFER AYVAFDPSLL ALNEALCAEL LTASHVIGVP 

        70         80         90        100        110        120 
PVGTLDEDVA ADVVTAPSRA RGGAGDGGGS GGRGGPRNPP PDPCGEGLLD TGPFSAAAID 

       130        140        150        160        170        180 
TFALDRPCLV CRTIELYKQT YRLSPQWVAD YAFLCAKCLG APHCAASIFV AAFEFVYVMD 

       190        200        210        220        230        240 
RHFLRTKKAT LVGSFARFAL TINDIHRHFF LHCCFRTDGG VPGRHAQKQP KPSPSPGAAK 

       250        260        270        280        290        300 
VQYSNYSFLA QSATRALIGT LASGGEEGAG SAAGSGTQPS LTTALMNWKD CARLLDCTEG 

       310        320        330        340        350        360 
RRGGGDSCCT RAAARNGEFE TVAGDREPEE SPDTWAYADL VLLLLAGTPA VWESGPQLRA 

       370        380        390        400        410        420 
AAEARRATVR QSWEAHRGAR TRDVAPRFAQ FTEPDAQPDL DLGPLMATVL KHGRGRGRTG 

       430        440        450        460        470        480 
GECLLCNLLL VRAYWLALRR LRASVVRYSE NNTSLFDCIV PVVDQLEADP ETQPGDGGRF 

       490        500        510        520        530        540 
VSLLRAAGPE AIFKHMFCDP MCAITEMEVD PWVLFGHPPA THPDELLLHK AKLACGNEFE 

       550        560        570        580        590 
GRVCIALRAL IYTFKTYQVF VPKPTALATF VREAGALLRR HSISLLSLEH TLCTYV 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1."
Chang Y.E., Poon A.P., Roizman B.
J. Virol. 70:3938-3946(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments."
Lamberti C., Weller S.K.
J. Virol. 72:2463-2473(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32307.1.
PIRWMBEH2. E30085.
RefSeqNP_044634.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703352.

Phylogenomic databases

ProtClustDBPHA3232.

Family and domain databases

InterProIPR002597. Herpes_env.
[Graphical view]
PfamPF01673. Herpes_env. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUL32_HHV11
AccessionPrimary (citable) accession number: P10216
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families