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P10212

- TRM1_HHV11

UniProt

P10212 - TRM1_HHV11

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Protein

Tripartite terminase subunit UL28

Gene

UL28

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly.2 Publications

GO - Molecular functioni

  1. protein transporter activity Source: InterPro

GO - Biological processi

  1. protein processing Source: InterPro
  2. viral capsid assembly Source: InterPro
  3. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit UL28
Alternative name(s):
DNA-packaging protein UL28
Protein ICP18.5
Gene namesi
Name:UL28
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host nucleus 1 Publication
Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Tripartite terminase subunit UL28PRO_0000115874Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Associates with UL15 and UL33 to form the tripartite terminase complex. The interaction with UL15 directs UL15 to the host nucleus and allows the interaction between UL15 and UL33. Interacts with portal protein UL6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL15P042958EBI-7032948,EBI-7032965
UL33P102176EBI-7032948,EBI-7033000

Protein-protein interaction databases

BioGridi971470. 1 interaction.
IntActiP10212. 3 interactions.
MINTiMINT-6732646.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi465 – 4684Poly-Gly

Sequence similaritiesi

Belongs to the herpesviridae UL28 protein family.Curated

Family and domain databases

InterProiIPR000501. UL28/MDV041.
[Graphical view]
PfamiPF01366. PRTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10212 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPVSEPTV ARQKLLALLG QVQTYVFQIE LLRRCDPHIG RGKLPQLKLN
60 70 80 90 100
ALQVRALRRR LRPGLEAQAG AFLTPLSVTL ELLLEYAWRE GERLLGSLET
110 120 130 140 150
FATAGDVAAF FTETMGLARP CPYHQRVRLD TYGGTVHMEL CFLHDVENFL
160 170 180 190 200
KQLNYCHLIT PSRGATAALE RVREFMVGAV GSGLIVPPEL SDPSHPCAVC
210 220 230 240 250
FEELCVTANQ GATIARRLAD RICNHVTQQA QVRLDANELR RYLPHAAGLS
260 270 280 290 300
DADRARALSV LDHALARTAG GDGQPHPSPE NDSVRKEADA LLEAHDVFQA
310 320 330 340 350
TTPGLYAISE LRFWLASGDR AGQTTMDAFA SNLTALARRE LQQETAAVAV
360 370 380 390 400
ELALFGRRAE HFDRAFGSHL AALDMVDALI IGGQATSPDD QIEALIRACY
410 420 430 440 450
DHHLTTPLLR RLVSPEQCDE EALRRVLARM GAGGAADAPK GGAGPDDDGD
460 470 480 490 500
RVAVEEGARG LGAPGGGGED EDRRRGPGGQ GPETWGDIAT QAAADVRERR
510 520 530 540 550
RLYADRLTKR SLASLGRCVR EQRGELEKML RVSVHGEVLP ATFAAVANGF
560 570 580 590 600
AARARFCALT AGAGTVIDNR SAPGVFDAHR FMRASLLRHQ VDPALLPSIT
610 620 630 640 650
HRFFELVNGP LFDHSTHSFA QPPNTALYYS VENVGLLPHL KEELARFIMG
660 670 680 690 700
AGGSGADWAV SEFQRFYCFD GISGITPTQR AAWRYIRELI IATTLFASVY
710 720 730 740 750
RCGELELRRP DCSRPTSEGR YRYPPGVYLT YDSDCPLVAI VESAPDGCIG
760 770 780
PRSVVVYDRD VFSILYSVLQ HLAPRLPDGG HDGPP
Length:785
Mass (Da):85,578
Last modified:July 1, 1989 - v1
Checksum:iCFE8868BAA86F616
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32321.1.
PIRiA30085. WMBEW8.
RefSeqiNP_044630.1. NC_001806.1.

Genome annotation databases

GeneIDi2703457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32321.1 .
PIRi A30085. WMBEW8.
RefSeqi NP_044630.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 971470. 1 interaction.
IntActi P10212. 3 interactions.
MINTi MINT-6732646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703457.

Family and domain databases

InterProi IPR000501. UL28/MDV041.
[Graphical view ]
Pfami PF01366. PRTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Herpes simplex virus 1 DNA cleavage/packaging: the UL28 gene encodes a minor component of B capsids."
    Taus N.S., Baines J.D.
    Virology 252:443-449(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: F.
  3. "Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins."
    Koslowski K.M., Shaver P.R., Casey J.T. II, Wilson T., Yamanaka G., Sheaffer A.K., Tenney D.J., Pederson N.E.
    J. Virol. 73:1704-1707(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL15, SUBCELLULAR LOCATION.
    Strain: F.
  4. "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
    White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
    J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL6.
    Strain: F.
  5. "The putative terminase subunit of herpes simplex virus 1 encoded by UL28 is necessary and sufficient to mediate interaction between pUL15 and pUL33."
    Yang K., Baines J.D.
    J. Virol. 80:5733-5739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL33.
    Strain: F.
  6. "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
    Wills E., Scholtes L., Baines J.D.
    J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: F.

Entry informationi

Entry nameiTRM1_HHV11
AccessioniPrimary (citable) accession number: P10212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3