P10212 (TRM1_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite terminase subunit UL28

Alternative name(s):
DNA-packaging protein UL28
Protein ICP18.5

Gene names

Name:

UL28

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly. Ref.2 Ref.6
Subunit structure	Associates with UL15 and UL33 to form the tripartite terminase complex. The interaction with UL15 directs UL15 to the host nucleus and allows the interaction between UL15 and UL33. Interacts with portal protein UL6. Ref.3 Ref.4 Ref.5
Subcellular location	Host nucleus. Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions. Ref.3
Sequence similarities	Belongs to the herpesviridae UL28 protein family.

Ontologies

Keywords
Biological process	Capsid maturation
Cellular component	Host nucleus
Developmental stage	Late protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein processing Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: GOC viral procapsid maturation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 785	785	Tripartite terminase subunit UL28		PRO_0000115874
Regions
	Compositional bias	465 – 468	4	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	P10212 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: CFE8868BAA86F616	FASTA	785	85,578
	10 20 30 40 50 60 MAAPVSEPTV ARQKLLALLG QVQTYVFQIE LLRRCDPHIG RGKLPQLKLN ALQVRALRRR 70 80 90 100 110 120 LRPGLEAQAG AFLTPLSVTL ELLLEYAWRE GERLLGSLET FATAGDVAAF FTETMGLARP 130 140 150 160 170 180 CPYHQRVRLD TYGGTVHMEL CFLHDVENFL KQLNYCHLIT PSRGATAALE RVREFMVGAV 190 200 210 220 230 240 GSGLIVPPEL SDPSHPCAVC FEELCVTANQ GATIARRLAD RICNHVTQQA QVRLDANELR 250 260 270 280 290 300 RYLPHAAGLS DADRARALSV LDHALARTAG GDGQPHPSPE NDSVRKEADA LLEAHDVFQA 310 320 330 340 350 360 TTPGLYAISE LRFWLASGDR AGQTTMDAFA SNLTALARRE LQQETAAVAV ELALFGRRAE 370 380 390 400 410 420 HFDRAFGSHL AALDMVDALI IGGQATSPDD QIEALIRACY DHHLTTPLLR RLVSPEQCDE 430 440 450 460 470 480 EALRRVLARM GAGGAADAPK GGAGPDDDGD RVAVEEGARG LGAPGGGGED EDRRRGPGGQ 490 500 510 520 530 540 GPETWGDIAT QAAADVRERR RLYADRLTKR SLASLGRCVR EQRGELEKML RVSVHGEVLP 550 560 570 580 590 600 ATFAAVANGF AARARFCALT AGAGTVIDNR SAPGVFDAHR FMRASLLRHQ VDPALLPSIT 610 620 630 640 650 660 HRFFELVNGP LFDHSTHSFA QPPNTALYYS VENVGLLPHL KEELARFIMG AGGSGADWAV 670 680 690 700 710 720 SEFQRFYCFD GISGITPTQR AAWRYIRELI IATTLFASVY RCGELELRRP DCSRPTSEGR 730 740 750 760 770 780 YRYPPGVYLT YDSDCPLVAI VESAPDGCIG PRSVVVYDRD VFSILYSVLQ HLAPRLPDGG HDGPP

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Herpes simplex virus 1 DNA cleavage/packaging: the UL28 gene encodes a minor component of B capsids." Taus N.S., Baines J.D. Virology 252:443-449(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: F.
[3]	"Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins." Koslowski K.M., Shaver P.R., Casey J.T. II, Wilson T., Yamanaka G., Sheaffer A.K., Tenney D.J., Pederson N.E. J. Virol. 73:1704-1707(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UL15, SUBCELLULAR LOCATION. Strain: F.
[4]	"Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28." White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G. J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UL6. Strain: F.
[5]	"The putative terminase subunit of herpes simplex virus 1 encoded by UL28 is necessary and sufficient to mediate interaction between pUL15 and pUL33." Yang K., Baines J.D. J. Virol. 80:5733-5739(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UL33. Strain: F.
[6]	"Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid." Wills E., Scholtes L., Baines J.D. J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: F.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32321.1.
PIR	WMBEW8. A30085.
RefSeq	NP_044630.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6732646.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703457.
Phylogenomic databases
ProtClustDB	CLSP2510213.
Family and domain databases
InterPro	IPR000501. Processing/transport_prot. [Graphical view]
Pfam	PF01366. PRTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRM1_HHV11

Accession

Primary (citable) accession number: P10212

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program