Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10212

- TRM1_HHV11

UniProt

P10212 - TRM1_HHV11

Protein

Tripartite terminase subunit UL28

Gene

UL28

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein transporter activity Source: InterPro

    GO - Biological processi

    1. protein processing Source: InterPro
    2. viral capsid assembly Source: InterPro
    3. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Viral genome packaging, Virus exit from host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite terminase subunit UL28
    Alternative name(s):
    DNA-packaging protein UL28
    Protein ICP18.5
    Gene namesi
    Name:UL28
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host nucleus 1 Publication
    Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 785785Tripartite terminase subunit UL28PRO_0000115874Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Associates with UL15 and UL33 to form the tripartite terminase complex. The interaction with UL15 directs UL15 to the host nucleus and allows the interaction between UL15 and UL33. Interacts with portal protein UL6.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UL15P042958EBI-7032948,EBI-7032965
    UL33P102176EBI-7032948,EBI-7033000

    Protein-protein interaction databases

    BioGridi971470. 1 interaction.
    IntActiP10212. 3 interactions.
    MINTiMINT-6732646.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi465 – 4684Poly-Gly

    Sequence similaritiesi

    Belongs to the herpesviridae UL28 protein family.Curated

    Family and domain databases

    InterProiIPR000501. Processing/transport_prot.
    [Graphical view]
    PfamiPF01366. PRTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPVSEPTV ARQKLLALLG QVQTYVFQIE LLRRCDPHIG RGKLPQLKLN    50
    ALQVRALRRR LRPGLEAQAG AFLTPLSVTL ELLLEYAWRE GERLLGSLET 100
    FATAGDVAAF FTETMGLARP CPYHQRVRLD TYGGTVHMEL CFLHDVENFL 150
    KQLNYCHLIT PSRGATAALE RVREFMVGAV GSGLIVPPEL SDPSHPCAVC 200
    FEELCVTANQ GATIARRLAD RICNHVTQQA QVRLDANELR RYLPHAAGLS 250
    DADRARALSV LDHALARTAG GDGQPHPSPE NDSVRKEADA LLEAHDVFQA 300
    TTPGLYAISE LRFWLASGDR AGQTTMDAFA SNLTALARRE LQQETAAVAV 350
    ELALFGRRAE HFDRAFGSHL AALDMVDALI IGGQATSPDD QIEALIRACY 400
    DHHLTTPLLR RLVSPEQCDE EALRRVLARM GAGGAADAPK GGAGPDDDGD 450
    RVAVEEGARG LGAPGGGGED EDRRRGPGGQ GPETWGDIAT QAAADVRERR 500
    RLYADRLTKR SLASLGRCVR EQRGELEKML RVSVHGEVLP ATFAAVANGF 550
    AARARFCALT AGAGTVIDNR SAPGVFDAHR FMRASLLRHQ VDPALLPSIT 600
    HRFFELVNGP LFDHSTHSFA QPPNTALYYS VENVGLLPHL KEELARFIMG 650
    AGGSGADWAV SEFQRFYCFD GISGITPTQR AAWRYIRELI IATTLFASVY 700
    RCGELELRRP DCSRPTSEGR YRYPPGVYLT YDSDCPLVAI VESAPDGCIG 750
    PRSVVVYDRD VFSILYSVLQ HLAPRLPDGG HDGPP 785
    Length:785
    Mass (Da):85,578
    Last modified:July 1, 1989 - v1
    Checksum:iCFE8868BAA86F616
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32321.1.
    PIRiA30085. WMBEW8.
    RefSeqiNP_044630.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32321.1 .
    PIRi A30085. WMBEW8.
    RefSeqi NP_044630.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 971470. 1 interaction.
    IntActi P10212. 3 interactions.
    MINTi MINT-6732646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703457.

    Family and domain databases

    InterProi IPR000501. Processing/transport_prot.
    [Graphical view ]
    Pfami PF01366. PRTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Herpes simplex virus 1 DNA cleavage/packaging: the UL28 gene encodes a minor component of B capsids."
      Taus N.S., Baines J.D.
      Virology 252:443-449(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: F.
    3. "Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins."
      Koslowski K.M., Shaver P.R., Casey J.T. II, Wilson T., Yamanaka G., Sheaffer A.K., Tenney D.J., Pederson N.E.
      J. Virol. 73:1704-1707(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL15, SUBCELLULAR LOCATION.
      Strain: F.
    4. "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
      White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
      J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL6.
      Strain: F.
    5. "The putative terminase subunit of herpes simplex virus 1 encoded by UL28 is necessary and sufficient to mediate interaction between pUL15 and pUL33."
      Yang K., Baines J.D.
      J. Virol. 80:5733-5739(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL33.
      Strain: F.
    6. "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
      Wills E., Scholtes L., Baines J.D.
      J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: F.

    Entry informationi

    Entry nameiTRM1_HHV11
    AccessioniPrimary (citable) accession number: P10212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3