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P10212 (TRM1_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite terminase subunit UL28
Alternative name(s):
DNA-packaging protein UL28
Protein ICP18.5
Gene names
Name:UL28
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the terminase, molecular motor that packages genomic DNA in empty capsid during assembly. Ref.2 Ref.6

Subunit structure

Associates with UL15 and UL33 to form the tripartite terminase complex. The interaction with UL15 directs UL15 to the host nucleus and allows the interaction between UL15 and UL33. Interacts with portal protein UL6. Ref.3 Ref.4 Ref.5

Subcellular location

Host nucleus. Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions. Ref.3

Sequence similarities

Belongs to the herpesviridae UL28 protein family.

Ontologies

Keywords
   Biological processViral genome packaging
Virus exit from host cell
   Cellular componentHost nucleus
   Developmental stageLate protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein processing

Inferred from electronic annotation. Source: InterPro

viral capsid assembly

Inferred from electronic annotation. Source: InterPro

viral release from host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 785785Tripartite terminase subunit UL28
PRO_0000115874

Regions

Compositional bias465 – 4684Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
P10212 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: CFE8868BAA86F616

FASTA78585,578
        10         20         30         40         50         60 
MAAPVSEPTV ARQKLLALLG QVQTYVFQIE LLRRCDPHIG RGKLPQLKLN ALQVRALRRR 

        70         80         90        100        110        120 
LRPGLEAQAG AFLTPLSVTL ELLLEYAWRE GERLLGSLET FATAGDVAAF FTETMGLARP 

       130        140        150        160        170        180 
CPYHQRVRLD TYGGTVHMEL CFLHDVENFL KQLNYCHLIT PSRGATAALE RVREFMVGAV 

       190        200        210        220        230        240 
GSGLIVPPEL SDPSHPCAVC FEELCVTANQ GATIARRLAD RICNHVTQQA QVRLDANELR 

       250        260        270        280        290        300 
RYLPHAAGLS DADRARALSV LDHALARTAG GDGQPHPSPE NDSVRKEADA LLEAHDVFQA 

       310        320        330        340        350        360 
TTPGLYAISE LRFWLASGDR AGQTTMDAFA SNLTALARRE LQQETAAVAV ELALFGRRAE 

       370        380        390        400        410        420 
HFDRAFGSHL AALDMVDALI IGGQATSPDD QIEALIRACY DHHLTTPLLR RLVSPEQCDE 

       430        440        450        460        470        480 
EALRRVLARM GAGGAADAPK GGAGPDDDGD RVAVEEGARG LGAPGGGGED EDRRRGPGGQ 

       490        500        510        520        530        540 
GPETWGDIAT QAAADVRERR RLYADRLTKR SLASLGRCVR EQRGELEKML RVSVHGEVLP 

       550        560        570        580        590        600 
ATFAAVANGF AARARFCALT AGAGTVIDNR SAPGVFDAHR FMRASLLRHQ VDPALLPSIT 

       610        620        630        640        650        660 
HRFFELVNGP LFDHSTHSFA QPPNTALYYS VENVGLLPHL KEELARFIMG AGGSGADWAV 

       670        680        690        700        710        720 
SEFQRFYCFD GISGITPTQR AAWRYIRELI IATTLFASVY RCGELELRRP DCSRPTSEGR 

       730        740        750        760        770        780 
YRYPPGVYLT YDSDCPLVAI VESAPDGCIG PRSVVVYDRD VFSILYSVLQ HLAPRLPDGG 


HDGPP 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Herpes simplex virus 1 DNA cleavage/packaging: the UL28 gene encodes a minor component of B capsids."
Taus N.S., Baines J.D.
Virology 252:443-449(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: F.
[3]"Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins."
Koslowski K.M., Shaver P.R., Casey J.T. II, Wilson T., Yamanaka G., Sheaffer A.K., Tenney D.J., Pederson N.E.
J. Virol. 73:1704-1707(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL15, SUBCELLULAR LOCATION.
Strain: F.
[4]"Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL6.
Strain: F.
[5]"The putative terminase subunit of herpes simplex virus 1 encoded by UL28 is necessary and sufficient to mediate interaction between pUL15 and pUL33."
Yang K., Baines J.D.
J. Virol. 80:5733-5739(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL33.
Strain: F.
[6]"Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
Wills E., Scholtes L., Baines J.D.
J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: F.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32321.1.
PIRWMBEW8. A30085.
RefSeqNP_044630.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid971470. 1 interaction.
IntActP10212. 3 interactions.
MINTMINT-6732646.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703457.

Phylogenomic databases

ProtClustDBCLSP2510213.

Family and domain databases

InterProIPR000501. Processing/transport_prot.
[Graphical view]
PfamPF01366. PRTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRM1_HHV11
AccessionPrimary (citable) accession number: P10212
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families