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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP. May mediate the capsid docking to the nuclear pore allowing entry of the viral genome into the host nucleus through binding to host nucleoporins NUP214.UniRule annotation2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Virus entry into host cell, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
Ordered Locus Names:UL25
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation1 Publication
  • Host nucleus UniRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159931 – 580Capsid vertex component 2Add BLAST580

Proteomic databases

PRIDEiP10209.

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP. Interacts with host NUP214; this interaction might be essential to the capsid docking to the host nuclear pore. Interacts with host C9orf69.UniRule annotation5 Publications

Protein-protein interaction databases

BioGridi971417. 1 interactor.
DIPiDIP-60387N.
IntActiP10209. 7 interactors.

Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi136 – 138Combined sources3
Beta strandi147 – 151Combined sources5
Helixi153 – 163Combined sources11
Helixi165 – 167Combined sources3
Beta strandi168 – 170Combined sources3
Helixi177 – 189Combined sources13
Helixi191 – 195Combined sources5
Helixi200 – 202Combined sources3
Helixi206 – 218Combined sources13
Helixi231 – 246Combined sources16
Helixi260 – 265Combined sources6
Helixi267 – 278Combined sources12
Helixi291 – 293Combined sources3
Turni308 – 313Combined sources6
Helixi315 – 322Combined sources8
Helixi351 – 360Combined sources10
Helixi368 – 370Combined sources3
Helixi372 – 392Combined sources21
Helixi401 – 403Combined sources3
Helixi408 – 411Combined sources4
Helixi438 – 446Combined sources9
Helixi448 – 454Combined sources7
Helixi460 – 463Combined sources4
Helixi465 – 474Combined sources10
Helixi491 – 494Combined sources4
Helixi496 – 508Combined sources13
Helixi517 – 540Combined sources24
Helixi547 – 549Combined sources3
Helixi550 – 554Combined sources5
Turni555 – 557Combined sources3
Helixi561 – 570Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F5UX-ray2.10A134-580[»]
ProteinModelPortaliP10209.
SMRiP10209.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10209.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Interaction with major capsid protein/MCPAdd BLAST50
Regioni1 – 49Interaction with major capsid protein/MCPUniRule annotationAdd BLAST49

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04025. HSV_CVC2. 1 hit.
InterProiIPR002493. Herpes_UL25.
[Graphical view]
PfamiPF01499. Herpes_UL25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPYCPFDAL DVWEHRRFIV ADSRNFITPE FPRDFWMSPV FNLPRETAAE
60 70 80 90 100
QVVVLQAQRT AAAAALENAA MQAAELPVDI ERRLRPIERN VHEIAGALEA
110 120 130 140 150
LETAAAAAEE ADAARGDEPA GGGDGGAPPG LAVAEMEVQI VRNDPPLRYD
160 170 180 190 200
TNLPVDLLHM VYAGRGATGS SGVVFGTWYR TIQDRTITDF PLTTRSADFR
210 220 230 240 250
DGRMSKTFMT ALVLSLQACG RLYVGQRHYS AFECAVLCLY LLYRNTHGAA
260 270 280 290 300
DDSDRAPVTF GDLLGRLPRY LACLAAVIGT EGGRPQYRYR DDKLPKTQFA
310 320 330 340 350
AGGGRYEHGA LASHIVIATL MHHGVLPAAP GDVPRDASTH VNPDGVAHHD
360 370 380 390 400
DINRAAAAFL SRGHNLFLWE DQTLLRATAN TITALGVIQR LLANGNVYAD
410 420 430 440 450
RLNNRLQLGM LIPGAVPSEA IARGASGSDS GAIKSGDNNL EALCANYVLP
460 470 480 490 500
LYRADPAVEL TQLFPGLAAL CLDAQAGRPV GSTRRVVDMS SGARQAALVR
510 520 530 540 550
LTALELINRT RTNPTPVGEV IHAHDALAIQ YEQGLGLLAQ QARIGLGSNT
560 570 580
KRFSAFNVSS DYDMLYFLCL GFIPQYLSAV
Length:580
Mass (Da):62,670
Last modified:July 1, 1989 - v1
Checksum:i3F8F0B7C122B2E36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32317.1.
PIRiG30084. WMBEW5.
RefSeqiYP_009137099.1. NC_001806.2.

Genome annotation databases

GeneIDi2703377.
KEGGivg:2703377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32317.1.
PIRiG30084. WMBEW5.
RefSeqiYP_009137099.1. NC_001806.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F5UX-ray2.10A134-580[»]
ProteinModelPortaliP10209.
SMRiP10209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971417. 1 interactor.
DIPiDIP-60387N.
IntActiP10209. 7 interactors.

Proteomic databases

PRIDEiP10209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703377.
KEGGivg:2703377.

Miscellaneous databases

EvolutionaryTraceiP10209.

Family and domain databases

HAMAPiMF_04025. HSV_CVC2. 1 hit.
InterProiIPR002493. Herpes_UL25.
[Graphical view]
PfamiPF01499. Herpes_UL25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCVC2_HHV11
AccessioniPrimary (citable) accession number: P10209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.