ID UL24_HHV11 Reviewed; 269 AA. AC P10208; B9VQF1; Q09IA9; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 24-JAN-2024, entry version 71. DE RecName: Full=Protein UL24; GN ORFNames=UL24; OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus; OC Simplexvirus humanalpha1; Human herpesvirus 1. OX NCBI_TaxID=10299; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531; RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., RA Perry L.J., Scott J.E., Taylor P.; RT "The complete DNA sequence of the long unique region in the genome of RT herpes simplex virus type 1."; RL J. Gen. Virol. 69:1531-1574(1988). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nonneuroinvasive mutant HF10; RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019; RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.; RT "Determination and analysis of the DNA sequence of highly attenuated herpes RT simplex virus type 1 mutant HF10, a potential oncolytic virus."; RL Microbes Infect. 9:142-149(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17 syn+; RA Cunningham C., Davison A.J.; RT "Herpes simplex virus type 1 bacterial artificial chromosome."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [4] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=18420791; DOI=10.1099/vir.0.83573-0; RA Bertrand L., Pearson A.; RT "The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is RT sufficient to induce the spatial redistribution of nucleolin."; RL J. Gen. Virol. 89:1142-1151(2008). RN [5] RP FUNCTION, AND MUTAGENESIS OF 99-ASP--LYS-101. RX PubMed=19864385; DOI=10.1128/jvi.01428-09; RA Bertrand L., Leiva-Torres G.A., Hyjazie H., Pearson A.; RT "Conserved residues in the UL24 protein of herpes simplex virus 1 are RT important for dispersal of the nucleolar protein nucleolin."; RL J. Virol. 84:109-118(2010). RN [6] RP FUNCTION, AND MUTAGENESIS OF 99-ASP--LYS-101. RC STRAIN=KOS; RX PubMed=21316727; DOI=10.1016/j.virol.2011.01.016; RA Lymberopoulos M.H., Bourget A., Abdeljelil N.B., Pearson A.; RT "Involvement of the UL24 protein in herpes simplex virus 1-induced RT dispersal of B23 and in nuclear egress."; RL Virology 412:341-348(2011). CC -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a CC role in the dispersal of several host nucleolar proteins including CC NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively CC impact on nuclear egress, UL24 supposedly acts on this process through CC its effect on host nucleoli. {ECO:0000269|PubMed:18420791, CC ECO:0000269|PubMed:19864385, ECO:0000269|PubMed:21316727}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm CC {ECO:0000269|PubMed:18420791}. Host nucleus, host nucleolus CC {ECO:0000269|PubMed:18420791}. Host Golgi apparatus CC {ECO:0000269|PubMed:18420791}. CC -!- INDUCTION: Expressed late in the infection cycle. CC -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X14112; CAA32316.1; -; Genomic_DNA. DR EMBL; DQ889502; ABI63486.1; -; Genomic_DNA. DR EMBL; FJ593289; ACM62246.1; -; Genomic_DNA. DR PIR; F30084; WMBEW4. DR RefSeq; YP_009137098.1; NC_001806.2. DR BioGRID; 971416; 1. DR GeneID; 24271468; -. DR KEGG; vg:24271468; -. DR Proteomes; UP000009294; Genome. DR Proteomes; UP000180652; Genome. DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW. DR InterPro; IPR002580; Herpes_UL24. DR Pfam; PF01646; Herpes_UL24; 1. PE 1: Evidence at protein level; KW Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome; KW Virion. FT CHAIN 1..269 FT /note="Protein UL24" FT /id="PRO_0000115978" FT REGION 191..244 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 191 FT /note="I -> M (in strain: Nonneuroinvasive mutant HF10)" FT VARIANT 226 FT /note="S -> P (in strain: Nonneuroinvasive mutant HF10)" FT VARIANT 239 FT /note="T -> A (in strain: Nonneuroinvasive mutant HF10 and FT 17 syn+)" FT MUTAGEN 99..101 FT /note="ELK->ALA: Loss of about 75% of host NPM1 and 80% of FT host NCL dispersal." FT /evidence="ECO:0000269|PubMed:19864385, FT ECO:0000269|PubMed:21316727" SQ SEQUENCE 269 AA; 29476 MW; CB089B7D72B09427 CRC64; MAARTRSLVE RRRVLMAGVR SHTRFYKALA EEVREFHATK ICGTLLTLLS GSLQGRSVFE ATRVTLICEV DLGPRRPDCI CVFEFANDKT LGGVCVIIEL KTCKYISSGD TASKREQRAT GMKQLRHSLK LLQSLAPPGD KIVYLCPVLV FVAQRTLRVS RVTRLVPQKV SGNITAVVRM LQSLSTYTVP IEPRTQRARR RRGGAARGSA SRPKRSHSGA RDPPESAARQ LPPADQTPTS TEGGGVLKRI AALFCVPVAT KTKPRAASE //