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Protein

Protein UL24

Gene

UL24

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli.3 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL24
Gene namesi
ORF Names:UL24
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

  • Virion By similarity
  • Host cytoplasm 1 Publication
  • Host nucleushost nucleolus 1 Publication
  • Host Golgi apparatus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi99 – 1013ELK → ALA: Loss of about 75% of host NPM1 and 80% of host NCL dispersal. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Protein UL24PRO_0000115978Add
BLAST

Expressioni

Inductioni

Expressed late in the infection cycle.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 2026Poly-Arg

Sequence similaritiesi

Belongs to the herpesviridae UL24 family.Curated

Family and domain databases

InterProiIPR002580. Herpes_UL24.
[Graphical view]
PfamiPF01646. Herpes_UL24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARTRSLVE RRRVLMAGVR SHTRFYKALA EEVREFHATK ICGTLLTLLS
60 70 80 90 100
GSLQGRSVFE ATRVTLICEV DLGPRRPDCI CVFEFANDKT LGGVCVIIEL
110 120 130 140 150
KTCKYISSGD TASKREQRAT GMKQLRHSLK LLQSLAPPGD KIVYLCPVLV
160 170 180 190 200
FVAQRTLRVS RVTRLVPQKV SGNITAVVRM LQSLSTYTVP IEPRTQRARR
210 220 230 240 250
RRGGAARGSA SRPKRSHSGA RDPPESAARQ LPPADQTPTS TEGGGVLKRI
260
AALFCVPVAT KTKPRAASE
Length:269
Mass (Da):29,476
Last modified:July 1, 1989 - v1
Checksum:iCB089B7D72B09427
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911I → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti226 – 2261S → P in strain: Nonneuroinvasive mutant HF10.
Natural varianti239 – 2391T → A in strain: Nonneuroinvasive mutant HF10 and 17 syn+.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32316.1.
DQ889502 Genomic DNA. Translation: ABI63486.1.
FJ593289 Genomic DNA. Translation: ACM62246.1.
PIRiF30084. WMBEW4.
RefSeqiNP_044625.1. NC_001806.1.

Genome annotation databases

GeneIDi2703375.
KEGGivg:2703375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32316.1.
DQ889502 Genomic DNA. Translation: ABI63486.1.
FJ593289 Genomic DNA. Translation: ACM62246.1.
PIRiF30084. WMBEW4.
RefSeqiNP_044625.1. NC_001806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703375.
KEGGivg:2703375.

Family and domain databases

InterProiIPR002580. Herpes_UL24.
[Graphical view]
PfamiPF01646. Herpes_UL24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin."
    Bertrand L., Pearson A.
    J. Gen. Virol. 89:1142-1151(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin."
    Bertrand L., Leiva-Torres G.A., Hyjazie H., Pearson A.
    J. Virol. 84:109-118(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
  6. "Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress."
    Lymberopoulos M.H., Bourget A., Abdeljelil N.B., Pearson A.
    Virology 412:341-348(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
    Strain: KOS.

Entry informationi

Entry nameiUL24_HHV11
AccessioniPrimary (citable) accession number: P10208
Secondary accession number(s): B9VQF1, Q09IA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 1, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.