Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10208

- UL24_HHV11

UniProt

P10208 - UL24_HHV11

Protein

Protein UL24

Gene

UL24

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli.3 Publications

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein UL24
    Gene namesi
    ORF Names:UL24
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion By similarity. Host cytoplasm 1 Publication. Host nucleushost nucleolus 1 Publication. Host Golgi apparatus 1 Publication

    GO - Cellular componenti

    1. host cell Golgi apparatus Source: UniProtKB-SubCell
    2. host cell nucleolus Source: UniProtKB-SubCell
    3. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi99 – 1013ELK → ALA: Loss of about 75% of host NPM1 and 80% of host NCL dispersal. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Protein UL24PRO_0000115978Add
    BLAST

    Expressioni

    Inductioni

    Expressed late in the infection cycle.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi197 – 2026Poly-Arg

    Sequence similaritiesi

    Belongs to the herpesviridae UL24 family.Curated

    Family and domain databases

    InterProiIPR002580. Herpes_UL24.
    [Graphical view]
    PfamiPF01646. Herpes_UL24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARTRSLVE RRRVLMAGVR SHTRFYKALA EEVREFHATK ICGTLLTLLS    50
    GSLQGRSVFE ATRVTLICEV DLGPRRPDCI CVFEFANDKT LGGVCVIIEL 100
    KTCKYISSGD TASKREQRAT GMKQLRHSLK LLQSLAPPGD KIVYLCPVLV 150
    FVAQRTLRVS RVTRLVPQKV SGNITAVVRM LQSLSTYTVP IEPRTQRARR 200
    RRGGAARGSA SRPKRSHSGA RDPPESAARQ LPPADQTPTS TEGGGVLKRI 250
    AALFCVPVAT KTKPRAASE 269
    Length:269
    Mass (Da):29,476
    Last modified:July 1, 1989 - v1
    Checksum:iCB089B7D72B09427
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911I → M in strain: Nonneuroinvasive mutant HF10.
    Natural varianti226 – 2261S → P in strain: Nonneuroinvasive mutant HF10.
    Natural varianti239 – 2391T → A in strain: Nonneuroinvasive mutant HF10 and 17 syn+.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32316.1.
    DQ889502 Genomic DNA. Translation: ABI63486.1.
    FJ593289 Genomic DNA. Translation: ACM62246.1.
    PIRiF30084. WMBEW4.
    RefSeqiNP_044625.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703375.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32316.1 .
    DQ889502 Genomic DNA. Translation: ABI63486.1 .
    FJ593289 Genomic DNA. Translation: ACM62246.1 .
    PIRi F30084. WMBEW4.
    RefSeqi NP_044625.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703375.

    Family and domain databases

    InterProi IPR002580. Herpes_UL24.
    [Graphical view ]
    Pfami PF01646. Herpes_UL24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    3. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    4. "The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin."
      Bertrand L., Pearson A.
      J. Gen. Virol. 89:1142-1151(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. "Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin."
      Bertrand L., Leiva-Torres G.A., Hyjazie H., Pearson A.
      J. Virol. 84:109-118(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
    6. "Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress."
      Lymberopoulos M.H., Bourget A., Abdeljelil N.B., Pearson A.
      Virology 412:341-348(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
      Strain: KOS.

    Entry informationi

    Entry nameiUL24_HHV11
    AccessioniPrimary (citable) accession number: P10208
    Secondary accession number(s): B9VQF1, Q09IA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3