P10208 (UL24_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein UL24

Gene names

ORF Names:

UL24

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli. Ref.4 Ref.5 Ref.6
Subcellular location	Virion By similarity. Host cytoplasm. Host nucleus › host nucleolus. Host Golgi apparatus Ref.4.
Induction	Expressed late in the infection cycle.
Sequence similarities	Belongs to the herpesviridae UL24 family.

Ontologies

Keywords
Cellular component	Host Golgi apparatus Host cytoplasm Host nucleus Virion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Protein UL24		PRO_0000115978
Regions
	Compositional bias	197 – 202	6	Poly-Arg
Natural variations
	Natural variant	191	1	I → M in strain: Nonneuroinvasive mutant HF10.
	Natural variant	226	1	S → P in strain: Nonneuroinvasive mutant HF10.
	Natural variant	239	1	T → A in strain: Nonneuroinvasive mutant HF10 and 17 syn+.
Experimental info
	Mutagenesis	99 – 101	3	ELK → ALA: Loss of about 75% of host NPM1 and 80% of host NCL dispersal. Ref.5 Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P10208 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: CB089B7D72B09427	FASTA	269	29,476
	10 20 30 40 50 60 MAARTRSLVE RRRVLMAGVR SHTRFYKALA EEVREFHATK ICGTLLTLLS GSLQGRSVFE 70 80 90 100 110 120 ATRVTLICEV DLGPRRPDCI CVFEFANDKT LGGVCVIIEL KTCKYISSGD TASKREQRAT 130 140 150 160 170 180 GMKQLRHSLK LLQSLAPPGD KIVYLCPVLV FVAQRTLRVS RVTRLVPQKV SGNITAVVRM 190 200 210 220 230 240 LQSLSTYTVP IEPRTQRARR RRGGAARGSA SRPKRSHSGA RDPPESAARQ LPPADQTPTS 250 260 TEGGGVLKRI AALFCVPVAT KTKPRAASE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[4]	"The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin." Bertrand L., Pearson A. J. Gen. Virol. 89:1142-1151(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]	"Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin." Bertrand L., Leiva-Torres G.A., Hyjazie H., Pearson A. J. Virol. 84:109-118(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
[6]	"Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress." Lymberopoulos M.H., Bourget A., Abdeljelil N.B., Pearson A. Virology 412:341-348(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101. Strain: KOS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32316.1. DQ889502 Genomic DNA. Translation: ABI63486.1. FJ593289 Genomic DNA. Translation: ACM62246.1.
PIR	WMBEW4. F30084.
RefSeq	NP_044625.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703375.
Phylogenomic databases
ProtClustDB	PHA3215.
Family and domain databases
InterPro	IPR002580. Herpes_UL24. [Graphical view]
Pfam	PF01646. Herpes_UL24. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL24_HHV11

Accession

Primary (citable) accession number: P10208
Secondary accession number(s): B9VQF1, Q09IA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program