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P10208 (UL24_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein UL24
Gene names
ORF Names:UL24
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli. Ref.4 Ref.5 Ref.6

Subcellular location

Virion By similarity. Host cytoplasm. Host nucleushost nucleolus. Host Golgi apparatus Ref.4.

Induction

Expressed late in the infection cycle.

Sequence similarities

Belongs to the herpesviridae UL24 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Protein UL24
PRO_0000115978

Regions

Compositional bias197 – 2026Poly-Arg

Natural variations

Natural variant1911I → M in strain: Nonneuroinvasive mutant HF10.
Natural variant2261S → P in strain: Nonneuroinvasive mutant HF10.
Natural variant2391T → A in strain: Nonneuroinvasive mutant HF10 and 17 syn+.

Experimental info

Mutagenesis99 – 1013ELK → ALA: Loss of about 75% of host NPM1 and 80% of host NCL dispersal. Ref.5 Ref.6

Sequences

Sequence LengthMass (Da)Tools
P10208 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: CB089B7D72B09427

FASTA26929,476
        10         20         30         40         50         60 
MAARTRSLVE RRRVLMAGVR SHTRFYKALA EEVREFHATK ICGTLLTLLS GSLQGRSVFE 

        70         80         90        100        110        120 
ATRVTLICEV DLGPRRPDCI CVFEFANDKT LGGVCVIIEL KTCKYISSGD TASKREQRAT 

       130        140        150        160        170        180 
GMKQLRHSLK LLQSLAPPGD KIVYLCPVLV FVAQRTLRVS RVTRLVPQKV SGNITAVVRM 

       190        200        210        220        230        240 
LQSLSTYTVP IEPRTQRARR RRGGAARGSA SRPKRSHSGA RDPPESAARQ LPPADQTPTS 

       250        260 
TEGGGVLKRI AALFCVPVAT KTKPRAASE 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin."
Bertrand L., Pearson A.
J. Gen. Virol. 89:1142-1151(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin."
Bertrand L., Leiva-Torres G.A., Hyjazie H., Pearson A.
J. Virol. 84:109-118(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
[6]"Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress."
Lymberopoulos M.H., Bourget A., Abdeljelil N.B., Pearson A.
Virology 412:341-348(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF 99-ASP--LYS-101.
Strain: KOS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32316.1.
DQ889502 Genomic DNA. Translation: ABI63486.1.
FJ593289 Genomic DNA. Translation: ACM62246.1.
PIRWMBEW4. F30084.
RefSeqNP_044625.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703375.

Family and domain databases

InterProIPR002580. Herpes_UL24.
[Graphical view]
PfamPF01646. Herpes_UL24. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUL24_HHV11
AccessionPrimary (citable) accession number: P10208
Secondary accession number(s): B9VQF1, Q09IA9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families