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Protein

Tegument protein UL21

Gene

UL21

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL21
Gene namesi
ORF Names:UL21
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Tegument protein UL21PRO_0000115971Add
BLAST

Interactioni

Subunit structurei

Interacts (via C-terminus) with UL16.1 Publication

Structurei

Secondary structure

535
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 44Combined sources
Beta strandi6 – 116Combined sources
Beta strandi14 – 185Combined sources
Beta strandi22 – 298Combined sources
Beta strandi32 – 376Combined sources
Beta strandi47 – 548Combined sources
Helixi63 – 7513Combined sources
Helixi90 – 945Combined sources
Helixi103 – 1064Combined sources
Beta strandi111 – 1144Combined sources
Helixi117 – 1248Combined sources
Beta strandi132 – 1409Combined sources
Turni141 – 1444Combined sources
Beta strandi145 – 15612Combined sources
Turni157 – 1593Combined sources
Turni167 – 1693Combined sources
Beta strandi170 – 17910Combined sources
Helixi182 – 1843Combined sources
Helixi185 – 1884Combined sources
Helixi191 – 1944Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4U4HX-ray2.05A1-198[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004936. Herpes_UL21.
[Graphical view]
PfamiPF03252. Herpes_UL21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF
60 70 80 90 100
GLVVRGTGPD DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV
110 120 130 140 150
SSELDVINTN DVEVLDECLA EYCTSLRTSP GVLISGLRVR AQDRIIELFE
160 170 180 190 200
HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL PSSLEALVSG LFDGIPAPRQ
210 220 230 240 250
PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS EFVQVKHIDR
260 270 280 290 300
VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
310 320 330 340 350
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV
360 370 380 390 400
YYYIIHRERR LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD
410 420 430 440 450
ALAAGTTAEQ LLMFDLLPPK DVPVGSDVQA DSTALLRFIE SQRLAVPGGV
460 470 480 490 500
ISPEHVAYLG AFLSVLYAGR GRMSAATHTA RLTGVTSLVL AVGDVDRLSA
510 520 530
FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV
Length:535
Mass (Da):57,642
Last modified:July 1, 1989 - v1
Checksum:i9D0621FF490DA745
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401C → Y in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32334.1.
DQ889502 Genomic DNA. Translation: ABI63483.1.
FJ593289 Genomic DNA. Translation: ACM62243.1.
PIRiC30084. WMBEW1.
RefSeqiNP_044622.1. NC_001806.1.

Genome annotation databases

GeneIDi2703372.
KEGGivg:2703372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32334.1.
DQ889502 Genomic DNA. Translation: ABI63483.1.
FJ593289 Genomic DNA. Translation: ACM62243.1.
PIRiC30084. WMBEW1.
RefSeqiNP_044622.1. NC_001806.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4U4HX-ray2.05A1-198[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703372.
KEGGivg:2703372.

Family and domain databases

InterProiIPR004936. Herpes_UL21.
[Graphical view]
PfamiPF03252. Herpes_UL21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells."
    Takakuwa H., Goshima F., Koshizuka T., Murata T., Daikoku T., Nishiyama Y.
    Genes Cells 6:955-966(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  6. "Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus."
    Harper A.L., Meckes D.G. Jr., Marsh J.A., Ward M.D., Yeh P.C., Baird N.L., Wilson C.B., Semmes O.J., Wills J.W.
    J. Virol. 84:2963-2971(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL16.
    Strain: KOS.

Entry informationi

Entry nameiTEG4_HHV11
AccessioniPrimary (citable) accession number: P10205
Secondary accession number(s): B9VQE8, Q09IB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 1, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.