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P10205

- TEG4_HHV11

UniProt

P10205 - TEG4_HHV11

Protein

Tegument protein UL21

Gene

UL21

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tegument protein UL21
    Gene namesi
    ORF Names:UL21
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Tegument protein UL21PRO_0000115971Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with UL16.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR004936. Herpes_UL21.
    [Graphical view]
    PfamiPF03252. Herpes_UL21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10205-1 [UniParc]FASTAAdd to Basket

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    MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF    50
    GLVVRGTGPD DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV 100
    SSELDVINTN DVEVLDECLA EYCTSLRTSP GVLISGLRVR AQDRIIELFE 150
    HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL PSSLEALVSG LFDGIPAPRQ 200
    PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS EFVQVKHIDR 250
    VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE 300
    PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV 350
    YYYIIHRERR LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD 400
    ALAAGTTAEQ LLMFDLLPPK DVPVGSDVQA DSTALLRFIE SQRLAVPGGV 450
    ISPEHVAYLG AFLSVLYAGR GRMSAATHTA RLTGVTSLVL AVGDVDRLSA 500
    FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV 535
    Length:535
    Mass (Da):57,642
    Last modified:July 1, 1989 - v1
    Checksum:i9D0621FF490DA745
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401C → Y in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32334.1.
    DQ889502 Genomic DNA. Translation: ABI63483.1.
    FJ593289 Genomic DNA. Translation: ACM62243.1.
    PIRiC30084. WMBEW1.
    RefSeqiNP_044622.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32334.1 .
    DQ889502 Genomic DNA. Translation: ABI63483.1 .
    FJ593289 Genomic DNA. Translation: ACM62243.1 .
    PIRi C30084. WMBEW1.
    RefSeqi NP_044622.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703372.

    Family and domain databases

    InterProi IPR004936. Herpes_UL21.
    [Graphical view ]
    Pfami PF03252. Herpes_UL21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    3. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    4. "Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells."
      Takakuwa H., Goshima F., Koshizuka T., Murata T., Daikoku T., Nishiyama Y.
      Genes Cells 6:955-966(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    6. "Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus."
      Harper A.L., Meckes D.G. Jr., Marsh J.A., Ward M.D., Yeh P.C., Baird N.L., Wilson C.B., Semmes O.J., Wills J.W.
      J. Virol. 84:2963-2971(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL16.
      Strain: KOS.

    Entry informationi

    Entry nameiTEG4_HHV11
    AccessioniPrimary (citable) accession number: P10205
    Secondary accession number(s): B9VQE8, Q09IB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3