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P10205 (TEG4_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified June 26, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tegument protein UL21
Gene names
ORF Names:UL21
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) By similarity. Ref.4

Subunit structure

Interacts (via C-terminus) with UL16. Ref.6

Subcellular location

Virion tegument. Host cytoplasm. Host nucleus Ref.4 Ref.5.

Sequence similarities

Belongs to the alphaherpesvirinae UL21 protein family.

Ontologies

Keywords
   Cellular componentHost cytoplasm
Host nucleus
Virion
Virion tegument
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral tegument

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535Tegument protein UL21
PRO_0000115971

Natural variations

Natural variant401C → Y in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P10205 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 9D0621FF490DA745

FASTA53557,642
        10         20         30         40         50         60 
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF GLVVRGTGPD 

        70         80         90        100        110        120 
DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV SSELDVINTN DVEVLDECLA 

       130        140        150        160        170        180 
EYCTSLRTSP GVLISGLRVR AQDRIIELFE HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL 

       190        200        210        220        230        240 
PSSLEALVSG LFDGIPAPRQ PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS 

       250        260        270        280        290        300 
EFVQVKHIDR VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE 

       310        320        330        340        350        360 
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV YYYIIHRERR 

       370        380        390        400        410        420 
LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD ALAAGTTAEQ LLMFDLLPPK 

       430        440        450        460        470        480 
DVPVGSDVQA DSTALLRFIE SQRLAVPGGV ISPEHVAYLG AFLSVLYAGR GRMSAATHTA 

       490        500        510        520        530 
RLTGVTSLVL AVGDVDRLSA FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells."
Takakuwa H., Goshima F., Koshizuka T., Murata T., Daikoku T., Nishiyama Y.
Genes Cells 6:955-966(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[5]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[6]"Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus."
Harper A.L., Meckes D.G. Jr., Marsh J.A., Ward M.D., Yeh P.C., Baird N.L., Wilson C.B., Semmes O.J., Wills J.W.
J. Virol. 84:2963-2971(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL16.
Strain: KOS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32334.1.
DQ889502 Genomic DNA. Translation: ABI63483.1.
FJ593289 Genomic DNA. Translation: ACM62243.1.
PIRWMBEW1. C30084.
RefSeqNP_044622.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703372.

Phylogenomic databases

ProtClustDBPHA3348.

Family and domain databases

InterProIPR004936. Herpes_UL21.
[Graphical view]
PfamPF03252. Herpes_UL21. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTEG4_HHV11
AccessionPrimary (citable) accession number: P10205
Secondary accession number(s): B9VQE8, Q09IB2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 26, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families