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P10205

- TEG4_HHV11

UniProt

P10205 - TEG4_HHV11

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Protein

Tegument protein UL21

Gene

UL21

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL21
Gene namesi
ORF Names:UL21
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
  3. viral tegument Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Tegument protein UL21PRO_0000115971Add
BLAST

Interactioni

Subunit structurei

Interacts (via C-terminus) with UL16.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004936. Herpes_UL21.
[Graphical view]
PfamiPF03252. Herpes_UL21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF
60 70 80 90 100
GLVVRGTGPD DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV
110 120 130 140 150
SSELDVINTN DVEVLDECLA EYCTSLRTSP GVLISGLRVR AQDRIIELFE
160 170 180 190 200
HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL PSSLEALVSG LFDGIPAPRQ
210 220 230 240 250
PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS EFVQVKHIDR
260 270 280 290 300
VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
310 320 330 340 350
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV
360 370 380 390 400
YYYIIHRERR LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD
410 420 430 440 450
ALAAGTTAEQ LLMFDLLPPK DVPVGSDVQA DSTALLRFIE SQRLAVPGGV
460 470 480 490 500
ISPEHVAYLG AFLSVLYAGR GRMSAATHTA RLTGVTSLVL AVGDVDRLSA
510 520 530
FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV
Length:535
Mass (Da):57,642
Last modified:July 1, 1989 - v1
Checksum:i9D0621FF490DA745
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401C → Y in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32334.1.
DQ889502 Genomic DNA. Translation: ABI63483.1.
FJ593289 Genomic DNA. Translation: ACM62243.1.
PIRiC30084. WMBEW1.
RefSeqiNP_044622.1. NC_001806.1.

Genome annotation databases

GeneIDi2703372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32334.1 .
DQ889502 Genomic DNA. Translation: ABI63483.1 .
FJ593289 Genomic DNA. Translation: ACM62243.1 .
PIRi C30084. WMBEW1.
RefSeqi NP_044622.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703372.

Family and domain databases

InterProi IPR004936. Herpes_UL21.
[Graphical view ]
Pfami PF03252. Herpes_UL21. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells."
    Takakuwa H., Goshima F., Koshizuka T., Murata T., Daikoku T., Nishiyama Y.
    Genes Cells 6:955-966(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  6. "Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus."
    Harper A.L., Meckes D.G. Jr., Marsh J.A., Ward M.D., Yeh P.C., Baird N.L., Wilson C.B., Semmes O.J., Wills J.W.
    J. Virol. 84:2963-2971(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL16.
    Strain: KOS.

Entry informationi

Entry nameiTEG4_HHV11
AccessioniPrimary (citable) accession number: P10205
Secondary accession number(s): B9VQE8, Q09IB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3