P10205 (TG21_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tegument protein UL21

Gene names

ORF Names:

UL21

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) By similarity. Ref.4
Subunit structure	Interacts (via C-terminus) with UL16. Ref.6
Subcellular location	Virion tegument. Host cytoplasm. Host nucleus Ref.4 Ref.5.
Sequence similarities	Belongs to the alphaherpesvirinae UL21 protein family.

Ontologies

Keywords
Cellular component	Host cytoplasm Host nucleus Virion Virion tegument
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 535	535	Tegument protein UL21		PRO_0000115971
Natural variations
	Natural variant	40	1	C → Y in strain: Nonneuroinvasive mutant HF10.

Sequences

	Sequence		Length	Mass (Da)
	P10205 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 9D0621FF490DA745	FASTA	535	57,642
	10 20 30 40 50 60 MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF GLVVRGTGPD 70 80 90 100 110 120 DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV SSELDVINTN DVEVLDECLA 130 140 150 160 170 180 EYCTSLRTSP GVLISGLRVR AQDRIIELFE HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL 190 200 210 220 230 240 PSSLEALVSG LFDGIPAPRQ PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS 250 260 270 280 290 300 EFVQVKHIDR VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE 310 320 330 340 350 360 PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV YYYIIHRERR 370 380 390 400 410 420 LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD ALAAGTTAEQ LLMFDLLPPK 430 440 450 460 470 480 DVPVGSDVQA DSTALLRFIE SQRLAVPGGV ISPEHVAYLG AFLSVLYAGR GRMSAATHTA 490 500 510 520 530 RLTGVTSLVL AVGDVDRLSA FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[4]	"Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells." Takakuwa H., Goshima F., Koshizuka T., Murata T., Daikoku T., Nishiyama Y. Genes Cells 6:955-966(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, FUNCTION.
[5]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.
[6]	"Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus." Harper A.L., Meckes D.G. Jr., Marsh J.A., Ward M.D., Yeh P.C., Baird N.L., Wilson C.B., Semmes O.J., Wills J.W. J. Virol. 84:2963-2971(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UL16. Strain: KOS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32334.1. DQ889502 Genomic DNA. Translation: ABI63483.1. FJ593289 Genomic DNA. Translation: ACM62243.1.
PIR	WMBEW1. C30084.
RefSeq	NP_044622.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703372.
Phylogenomic databases
ProtClustDB	PHA3348.
Family and domain databases
InterPro	IPR004936. Herpes_UL21. [Graphical view]
Pfam	PF03252. Herpes_UL21. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TG21_HHV11

Accession

Primary (citable) accession number: P10205
Secondary accession number(s): B9VQE8, Q09IB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program