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Protein

Tegument protein UL21

Gene

UL21

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) (By similarity).By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL21
Gene namesi
ORF Names:UL21
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159711 – 535Tegument protein UL21Add BLAST535

Proteomic databases

PRIDEiP10205.

Interactioni

Subunit structurei

Interacts (via C-terminus) with UL16.1 Publication

Protein-protein interaction databases

BioGridi971413. 1 interactor.

Structurei

Secondary structure

1535
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 4Combined sources4
Beta strandi6 – 11Combined sources6
Beta strandi14 – 18Combined sources5
Beta strandi22 – 29Combined sources8
Beta strandi32 – 37Combined sources6
Beta strandi47 – 54Combined sources8
Helixi63 – 75Combined sources13
Helixi90 – 94Combined sources5
Helixi103 – 106Combined sources4
Beta strandi111 – 114Combined sources4
Helixi117 – 124Combined sources8
Beta strandi132 – 140Combined sources9
Turni141 – 144Combined sources4
Beta strandi145 – 156Combined sources12
Turni157 – 159Combined sources3
Turni167 – 169Combined sources3
Beta strandi170 – 179Combined sources10
Helixi182 – 184Combined sources3
Helixi185 – 188Combined sources4
Helixi191 – 194Combined sources4
Helixi284 – 298Combined sources15
Helixi303 – 306Combined sources4
Helixi309 – 326Combined sources18
Beta strandi329 – 332Combined sources4
Helixi344 – 355Combined sources12
Helixi364 – 378Combined sources15
Helixi390 – 412Combined sources23
Helixi427 – 441Combined sources15
Helixi453 – 466Combined sources14
Turni467 – 469Combined sources3
Helixi472 – 483Combined sources12
Helixi488 – 496Combined sources9
Helixi504 – 529Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U4HX-ray2.05A1-198[»]
5ED7X-ray2.72A279-530[»]
SMRiP10205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004936. Herpes_UL21.
[Graphical view]
PfamiPF03252. Herpes_UL21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF
60 70 80 90 100
GLVVRGTGPD DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV
110 120 130 140 150
SSELDVINTN DVEVLDECLA EYCTSLRTSP GVLISGLRVR AQDRIIELFE
160 170 180 190 200
HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL PSSLEALVSG LFDGIPAPRQ
210 220 230 240 250
PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS EFVQVKHIDR
260 270 280 290 300
VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
310 320 330 340 350
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV
360 370 380 390 400
YYYIIHRERR LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD
410 420 430 440 450
ALAAGTTAEQ LLMFDLLPPK DVPVGSDVQA DSTALLRFIE SQRLAVPGGV
460 470 480 490 500
ISPEHVAYLG AFLSVLYAGR GRMSAATHTA RLTGVTSLVL AVGDVDRLSA
510 520 530
FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV
Length:535
Mass (Da):57,642
Last modified:July 1, 1989 - v1
Checksum:i9D0621FF490DA745
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti40C → Y in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32334.1.
DQ889502 Genomic DNA. Translation: ABI63483.1.
FJ593289 Genomic DNA. Translation: ACM62243.1.
PIRiC30084. WMBEW1.
RefSeqiYP_009137095.1. NC_001806.2.

Genome annotation databases

GeneIDi2703372.
KEGGivg:2703372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32334.1.
DQ889502 Genomic DNA. Translation: ABI63483.1.
FJ593289 Genomic DNA. Translation: ACM62243.1.
PIRiC30084. WMBEW1.
RefSeqiYP_009137095.1. NC_001806.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U4HX-ray2.05A1-198[»]
5ED7X-ray2.72A279-530[»]
SMRiP10205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971413. 1 interactor.

Proteomic databases

PRIDEiP10205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703372.
KEGGivg:2703372.

Family and domain databases

InterProiIPR004936. Herpes_UL21.
[Graphical view]
PfamiPF03252. Herpes_UL21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEG4_HHV11
AccessioniPrimary (citable) accession number: P10205
Secondary accession number(s): B9VQE8, Q09IB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.