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P10204

- UL20_HHV11

UniProt

P10204 - UL20_HHV11

Protein

Protein UL20

Gene

UL20

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. viral life cycle Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein UL20
    Gene namesi
    Name:UL20
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion. Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host nucleus membrane; Multi-pass membrane protein
    Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. host cell nuclear membrane Source: UniProtKB-SubCell
    4. host cell plasma membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Protein UL20PRO_0000115966Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with gK (via N-terminus); this interaction plays a role in the coordinate transport of UL20 and gK to the trans-Golgi network (TGN), and is required for their cell surface expression. Interacts with gB.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    gKP683314EBI-7906325,EBI-7906305

    Protein-protein interaction databases

    IntActiP10204. 1 interaction.
    MINTiMINT-6741267.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alphaherpesvirinae UL20 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR007629. Herpes_UL20.
    [Graphical view]
    PfamiPF04544. Herpes_UL20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10204-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMRDDLPLV DRDLVDEAAF GGEEGELPLE EQFSLSSYGT SDFFVSSAYS    50
    RLPPHTQPVF SKRVILFLWS FLVLKPLEMV AAGMYYGLTG RVVAPACILA 100
    AIVGYYVTWA VRALLLYVNI KRDRLPLSAP VFWGMSVFLG GTALCALFAA 150
    AHETFSPDGL FHFIATNQML PPTDPLRTRA LGIACAAGAS MWVAAADSFA 200
    ASANFFLARF WTRAILNAPV AF 222
    Length:222
    Mass (Da):24,231
    Last modified:July 1, 1989 - v1
    Checksum:iD10C373183E96218
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32333.1.
    PIRiB30084. WMBEWN.
    RefSeqiNP_044621.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32333.1 .
    PIRi B30084. WMBEWN.
    RefSeqi NP_044621.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10204. 1 interaction.
    MINTi MINT-6741267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703371.

    Family and domain databases

    InterProi IPR007629. Herpes_UL20.
    [Graphical view ]
    Pfami PF04544. Herpes_UL20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress."
      Baines J.D., Ward P.L., Campadelli-Fiume G., Roizman B.
      J. Virol. 65:6414-6424(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: F.
    3. "Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1."
      Ward P.L., Campadelli-Fiume G., Avitabile E., Roizman B.
      J. Virol. 68:7406-7417(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    4. "Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression."
      Avitabile E., Lombardi G., Gianni T., Capri M., Campadelli-Fiume G.
      J. Virol. 78:8015-8025(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    5. "The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment."
      Melancon J.M., Fulmer P.A., Kousoulas K.G.
      Virol. J. 4:120-120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: KOS.
    6. "Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein K."
      Foster T.P., Chouljenko V.N., Kousoulas K.G.
      J. Virol. 82:6310-6323(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GK.
      Strain: KOS.
    7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VIRION.
      Strain: F.
    8. "The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB."
      Chouljenko V.N., Iyer A.V., Chowdhury S., Kim J., Kousoulas K.G.
      J. Virol. 84:8596-8606(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GB.

    Entry informationi

    Entry nameiUL20_HHV11
    AccessioniPrimary (citable) accession number: P10204
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3