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P10204

- UL20_HHV11

UniProt

P10204 - UL20_HHV11

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Protein

Protein UL20

Gene

UL20

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes.2 Publications

GO - Biological processi

  1. viral life cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL20
Gene namesi
Name:UL20
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion. Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host nucleus membrane; Multi-pass membrane protein
Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell endosome Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell nucleus Source: UniProtKB-KW
  4. host cell plasma membrane Source: UniProtKB-KW
  5. integral component of membrane Source: UniProtKB-KW
  6. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Protein UL20PRO_0000115966Add
BLAST

Interactioni

Subunit structurei

Interacts with gK (via N-terminus); this interaction plays a role in the coordinate transport of UL20 and gK to the trans-Golgi network (TGN), and is required for their cell surface expression. Interacts with gB.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
gKP683314EBI-7906325,EBI-7906305

Protein-protein interaction databases

IntActiP10204. 1 interaction.
MINTiMINT-6741267.

Family & Domainsi

Sequence similaritiesi

Belongs to the alphaherpesvirinae UL20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR007629. Herpes_UL20.
[Graphical view]
PfamiPF04544. Herpes_UL20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10204-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMRDDLPLV DRDLVDEAAF GGEEGELPLE EQFSLSSYGT SDFFVSSAYS
60 70 80 90 100
RLPPHTQPVF SKRVILFLWS FLVLKPLEMV AAGMYYGLTG RVVAPACILA
110 120 130 140 150
AIVGYYVTWA VRALLLYVNI KRDRLPLSAP VFWGMSVFLG GTALCALFAA
160 170 180 190 200
AHETFSPDGL FHFIATNQML PPTDPLRTRA LGIACAAGAS MWVAAADSFA
210 220
ASANFFLARF WTRAILNAPV AF
Length:222
Mass (Da):24,231
Last modified:July 1, 1989 - v1
Checksum:iD10C373183E96218
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32333.1.
PIRiB30084. WMBEWN.
RefSeqiNP_044621.1. NC_001806.1.

Genome annotation databases

GeneIDi2703371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32333.1 .
PIRi B30084. WMBEWN.
RefSeqi NP_044621.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10204. 1 interaction.
MINTi MINT-6741267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703371.

Family and domain databases

InterProi IPR007629. Herpes_UL20.
[Graphical view ]
Pfami PF04544. Herpes_UL20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress."
    Baines J.D., Ward P.L., Campadelli-Fiume G., Roizman B.
    J. Virol. 65:6414-6424(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: F.
  3. "Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1."
    Ward P.L., Campadelli-Fiume G., Avitabile E., Roizman B.
    J. Virol. 68:7406-7417(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  4. "Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression."
    Avitabile E., Lombardi G., Gianni T., Capri M., Campadelli-Fiume G.
    J. Virol. 78:8015-8025(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  5. "The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment."
    Melancon J.M., Fulmer P.A., Kousoulas K.G.
    Virol. J. 4:120-120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: KOS.
  6. "Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein K."
    Foster T.P., Chouljenko V.N., Kousoulas K.G.
    J. Virol. 82:6310-6323(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GK.
    Strain: KOS.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VIRION.
    Strain: F.
  8. "The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB."
    Chouljenko V.N., Iyer A.V., Chowdhury S., Kim J., Kousoulas K.G.
    J. Virol. 84:8596-8606(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GB.

Entry informationi

Entry nameiUL20_HHV11
AccessioniPrimary (citable) accession number: P10204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3