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P10204 (UL20_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein UL20
Gene names
Name:UL20
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes. Ref.2 Ref.5

Subunit structure

Interacts with gK (via N-terminus); this interaction plays a role in the coordinate transport of UL20 and gK to the trans-Golgi network (TGN), and is required for their cell surface expression. Interacts with gB. Ref.6 Ref.8

Subcellular location

Virion. Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host nucleus membrane; Multi-pass membrane protein. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Ref.3 Ref.4

Sequence similarities

Belongs to the alphaherpesvirinae UL20 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

gKP683314EBI-7906325,EBI-7906305

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Protein UL20
PRO_0000115966

Regions

Transmembrane64 – 8421Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane180 – 20021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P10204 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: D10C373183E96218

FASTA22224,231
        10         20         30         40         50         60 
MTMRDDLPLV DRDLVDEAAF GGEEGELPLE EQFSLSSYGT SDFFVSSAYS RLPPHTQPVF 

        70         80         90        100        110        120 
SKRVILFLWS FLVLKPLEMV AAGMYYGLTG RVVAPACILA AIVGYYVTWA VRALLLYVNI 

       130        140        150        160        170        180 
KRDRLPLSAP VFWGMSVFLG GTALCALFAA AHETFSPDGL FHFIATNQML PPTDPLRTRA 

       190        200        210        220 
LGIACAAGAS MWVAAADSFA ASANFFLARF WTRAILNAPV AF 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress."
Baines J.D., Ward P.L., Campadelli-Fiume G., Roizman B.
J. Virol. 65:6414-6424(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: F.
[3]"Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1."
Ward P.L., Campadelli-Fiume G., Avitabile E., Roizman B.
J. Virol. 68:7406-7417(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[4]"Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression."
Avitabile E., Lombardi G., Gianni T., Capri M., Campadelli-Fiume G.
J. Virol. 78:8015-8025(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[5]"The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment."
Melancon J.M., Fulmer P.A., Kousoulas K.G.
Virol. J. 4:120-120(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: KOS.
[6]"Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein K."
Foster T.P., Chouljenko V.N., Kousoulas K.G.
J. Virol. 82:6310-6323(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GK.
Strain: KOS.
[7]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VIRION.
Strain: F.
[8]"The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB."
Chouljenko V.N., Iyer A.V., Chowdhury S., Kim J., Kousoulas K.G.
J. Virol. 84:8596-8606(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32333.1.
PIRWMBEWN. B30084.
RefSeqNP_044621.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP10204. 1 interaction.
MINTMINT-6741267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703371.

Phylogenomic databases

ProtClustDBCLSP2510151.

Family and domain databases

InterProIPR007629. Herpes_UL20.
[Graphical view]
PfamPF04544. Herpes_UL20. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUL20_HHV11
AccessionPrimary (citable) accession number: P10204
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families