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P10202 (VP23_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triplex capsid protein VP23
Gene names
Name:UL18
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between capsid hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6

Subunit structure

Interacts with VP19C and VP5.

Subcellular location

Virion. Host nucleus.

Sequence similarities

Belongs to the herpesviridae VP23 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Triplex capsid protein VP23
PRO_0000115725

Sequences

Sequence LengthMass (Da)Tools
P10202 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 6D9925F5179B5B3A

FASTA31834,271
        10         20         30         40         50         60 
MLADGFETDI AIPSGISRPD AAALQRCEGR VVFLPTIRRQ LTLADVAHES FVSGGVSPDT 

        70         80         90        100        110        120 
LGLLLAYRRR FPAVITRVLP TRIVACPLDV GLTHAGTVNL RNTSPVDLCN GDPISLVPPV 

       130        140        150        160        170        180 
FEGQATDVRL DSLDLTLRFP VPLPSPLARE IVARLVARGI RDLNPSPRNP GGLPDLNVLY 

       190        200        210        220        230        240 
YNGSRLSLLA DVQQLGPVNA ELRSLVLNMV YSITEGTTII LTLIPRLFAL SAQDGYVNAL 

       250        260        270        280        290        300 
LQMQSVTREA AQLIHPEAPA LMQDGERRLP LYEALVAWLT HAGQLGDTLA LAPVVRVCTF 

       310 
DGAAVVRSGD MAPVIRYP 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing."
Rixon F.J., Davison M.D., Davison A.J.
J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly."
Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C.
J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"The herpes simplex virus triplex protein, VP23, exists as a molten globule."
Kirkitadze M.D., Barlow P.N., Price N.C., Kelly S.M., Boutell C.J., Rixon F.J., McClelland D.A.
J. Virol. 72:10066-10072(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles."
Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J.
J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1."
Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P.
J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
Davison M.D., Rixon F.J., Davison A.J.
J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32331.1.
PIRWMBET8. I30083.
RefSeqNP_044619.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-1093N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703366.

Phylogenomic databases

ProtClustDBPHA3257.

Family and domain databases

InterProIPR002690. Herpes_V23.
[Graphical view]
PfamPF01802. Herpes_V23. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP23_HHV11
AccessionPrimary (citable) accession number: P10202
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 13, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families