SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10202

- VP23_HHV11

UniProt

P10202 - VP23_HHV11

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Triplex capsid protein VP23

Gene
UL18
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between capsid hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly.5 Publications

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein VP23
Gene namesi
Name:UL18
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral capsid Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Triplex capsid protein VP23PRO_0000115725Add
BLAST

Interactioni

Subunit structurei

Interacts with VP19C and VP5.

Protein-protein interaction databases

DIPiDIP-1093N.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR002690. Herpes_V23.
[Graphical view]
PfamiPF01802. Herpes_V23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10202-1 [UniParc]FASTAAdd to Basket

« Hide

MLADGFETDI AIPSGISRPD AAALQRCEGR VVFLPTIRRQ LTLADVAHES    50
FVSGGVSPDT LGLLLAYRRR FPAVITRVLP TRIVACPLDV GLTHAGTVNL 100
RNTSPVDLCN GDPISLVPPV FEGQATDVRL DSLDLTLRFP VPLPSPLARE 150
IVARLVARGI RDLNPSPRNP GGLPDLNVLY YNGSRLSLLA DVQQLGPVNA 200
ELRSLVLNMV YSITEGTTII LTLIPRLFAL SAQDGYVNAL LQMQSVTREA 250
AQLIHPEAPA LMQDGERRLP LYEALVAWLT HAGQLGDTLA LAPVVRVCTF 300
DGAAVVRSGD MAPVIRYP 318
Length:318
Mass (Da):34,271
Last modified:July 1, 1989 - v1
Checksum:i6D9925F5179B5B3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32331.1.
PIRiI30083. WMBET8.
RefSeqiNP_044619.1. NC_001806.1.

Genome annotation databases

GeneIDi2703366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32331.1 .
PIRi I30083. WMBET8.
RefSeqi NP_044619.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-1093N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703366.

Family and domain databases

InterProi IPR002690. Herpes_V23.
[Graphical view ]
Pfami PF01802. Herpes_V23. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing."
    Rixon F.J., Davison M.D., Davison A.J.
    J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly."
    Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C.
    J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The herpes simplex virus triplex protein, VP23, exists as a molten globule."
    Kirkitadze M.D., Barlow P.N., Price N.C., Kelly S.M., Boutell C.J., Rixon F.J., McClelland D.A.
    J. Virol. 72:10066-10072(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles."
    Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J.
    J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1."
    Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P.
    J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
    Davison M.D., Rixon F.J., Davison A.J.
    J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-13.

Entry informationi

Entry nameiVP23_HHV11
AccessioniPrimary (citable) accession number: P10202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi