Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10202

- VP23_HHV11

UniProt

P10202 - VP23_HHV11

Protein

Triplex capsid protein VP23

Gene

UL18

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between capsid hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly.5 Publications

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triplex capsid protein VP23
    Gene namesi
    Name:UL18
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. viral capsid Source: CACAO

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Triplex capsid protein VP23PRO_0000115725Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with VP19C and VP5.

    Protein-protein interaction databases

    DIPiDIP-1093N.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae VP23 family.Curated

    Family and domain databases

    InterProiIPR002690. Herpes_V23.
    [Graphical view]
    PfamiPF01802. Herpes_V23. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10202-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLADGFETDI AIPSGISRPD AAALQRCEGR VVFLPTIRRQ LTLADVAHES    50
    FVSGGVSPDT LGLLLAYRRR FPAVITRVLP TRIVACPLDV GLTHAGTVNL 100
    RNTSPVDLCN GDPISLVPPV FEGQATDVRL DSLDLTLRFP VPLPSPLARE 150
    IVARLVARGI RDLNPSPRNP GGLPDLNVLY YNGSRLSLLA DVQQLGPVNA 200
    ELRSLVLNMV YSITEGTTII LTLIPRLFAL SAQDGYVNAL LQMQSVTREA 250
    AQLIHPEAPA LMQDGERRLP LYEALVAWLT HAGQLGDTLA LAPVVRVCTF 300
    DGAAVVRSGD MAPVIRYP 318
    Length:318
    Mass (Da):34,271
    Last modified:July 1, 1989 - v1
    Checksum:i6D9925F5179B5B3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32331.1.
    PIRiI30083. WMBET8.
    RefSeqiNP_044619.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32331.1 .
    PIRi I30083. WMBET8.
    RefSeqi NP_044619.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-1093N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703366.

    Family and domain databases

    InterProi IPR002690. Herpes_V23.
    [Graphical view ]
    Pfami PF01802. Herpes_V23. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing."
      Rixon F.J., Davison M.D., Davison A.J.
      J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly."
      Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C.
      J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "The herpes simplex virus triplex protein, VP23, exists as a molten globule."
      Kirkitadze M.D., Barlow P.N., Price N.C., Kelly S.M., Boutell C.J., Rixon F.J., McClelland D.A.
      J. Virol. 72:10066-10072(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles."
      Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J.
      J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1."
      Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P.
      J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
      Davison M.D., Rixon F.J., Davison A.J.
      J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-13.

    Entry informationi

    Entry nameiVP23_HHV11
    AccessioniPrimary (citable) accession number: P10202
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3