P10202 (VP23_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triplex capsid protein VP23

Gene names

Name:

UL18

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between capsid hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6
Subunit structure	Interacts with VP19C and VP5.
Subcellular location	Virion. Host nucleus.
Sequence similarities	Belongs to the herpesviridae VP23 family.

Ontologies

Keywords
Cellular component	Host nucleus Virion
Molecular function	Capsid protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Triplex capsid protein VP23		PRO_0000115725

Sequences

	Sequence		Length	Mass (Da)
	P10202 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 6D9925F5179B5B3A	FASTA	318	34,271
	10 20 30 40 50 60 MLADGFETDI AIPSGISRPD AAALQRCEGR VVFLPTIRRQ LTLADVAHES FVSGGVSPDT 70 80 90 100 110 120 LGLLLAYRRR FPAVITRVLP TRIVACPLDV GLTHAGTVNL RNTSPVDLCN GDPISLVPPV 130 140 150 160 170 180 FEGQATDVRL DSLDLTLRFP VPLPSPLARE IVARLVARGI RDLNPSPRNP GGLPDLNVLY 190 200 210 220 230 240 YNGSRLSLLA DVQQLGPVNA ELRSLVLNMV YSITEGTTII LTLIPRLFAL SAQDGYVNAL 250 260 270 280 290 300 LQMQSVTREA AQLIHPEAPA LMQDGERRLP LYEALVAWLT HAGQLGDTLA LAPVVRVCTF 310 DGAAVVRSGD MAPVIRYP

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing." Rixon F.J., Davison M.D., Davison A.J. J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[3]	"The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly." Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C. J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"The herpes simplex virus triplex protein, VP23, exists as a molten globule." Kirkitadze M.D., Barlow P.N., Price N.C., Kelly S.M., Boutell C.J., Rixon F.J., McClelland D.A. J. Virol. 72:10066-10072(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles." Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J. J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1." Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P. J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1." Davison M.D., Rixon F.J., Davison A.J. J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-13.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32331.1.
PIR	WMBET8. I30083.
RefSeq	NP_044619.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1093N.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703366.
Phylogenomic databases
ProtClustDB	PHA3257.
Family and domain databases
InterPro	IPR002690. Herpes_V23. [Graphical view]
Pfam	PF01802. Herpes_V23. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP23_HHV11

Accession

Primary (citable) accession number: P10202

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program