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Protein

Triplex capsid protein 2

Gene

TRX2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation5 Publications

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 2UniRule annotation
Gene namesi
Name:TRX2UniRule annotation
Ordered Locus Names:UL18
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

  • host cell nucleus Source: UniProtKB-SubCell
  • viral capsid Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004363361 – 318Triplex capsid protein 2Add BLAST318

Proteomic databases

PRIDEiP10202.

Interactioni

Subunit structurei

Interacts with TRX1 and major capisd protein/MCP.UniRule annotation

Protein-protein interaction databases

DIPiDIP-1093N.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX2 protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04019. HSV_TRX2. 1 hit.
InterProiIPR002690. Herpes_capsid_2.
[Graphical view]
PfamiPF01802. Herpes_V23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLADGFETDI AIPSGISRPD AAALQRCEGR VVFLPTIRRQ LTLADVAHES
60 70 80 90 100
FVSGGVSPDT LGLLLAYRRR FPAVITRVLP TRIVACPLDV GLTHAGTVNL
110 120 130 140 150
RNTSPVDLCN GDPISLVPPV FEGQATDVRL DSLDLTLRFP VPLPSPLARE
160 170 180 190 200
IVARLVARGI RDLNPSPRNP GGLPDLNVLY YNGSRLSLLA DVQQLGPVNA
210 220 230 240 250
ELRSLVLNMV YSITEGTTII LTLIPRLFAL SAQDGYVNAL LQMQSVTREA
260 270 280 290 300
AQLIHPEAPA LMQDGERRLP LYEALVAWLT HAGQLGDTLA LAPVVRVCTF
310
DGAAVVRSGD MAPVIRYP
Length:318
Mass (Da):34,271
Last modified:July 1, 1989 - v1
Checksum:i6D9925F5179B5B3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32331.1.
PIRiI30083. WMBET8.
RefSeqiYP_009137092.1. NC_001806.2.

Genome annotation databases

GeneIDi2703366.
KEGGivg:2703366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32331.1.
PIRiI30083. WMBET8.
RefSeqiYP_009137092.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-1093N.

Proteomic databases

PRIDEiP10202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703366.
KEGGivg:2703366.

Family and domain databases

HAMAPiMF_04019. HSV_TRX2. 1 hit.
InterProiIPR002690. Herpes_capsid_2.
[Graphical view]
PfamiPF01802. Herpes_V23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRX2_HHV11
AccessioniPrimary (citable) accession number: P10202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.