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Protein

Virion-packaging protein UL17

Gene

UL17

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role at the late stage in the encapsidation of viral DNA, assuring correct genome cleavage and presumably stabilizing capsids that contain full-lengtht viral genomes.

GO - Biological processi

  1. DNA packaging Source: InterPro
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Virion-packaging protein UL17
Gene namesi
Name:UL17
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Virion-packaging protein UL17PRO_0000115958Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Heterodimerizes with UL25.

Protein-protein interaction databases

DIPiDIP-60386N.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL17 family.Curated

Family and domain databases

InterProiIPR007640. Herpes_U64.
[Graphical view]
PfamiPF04559. Herpes_UL17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10201-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAHLANEVQ TISATARVGP RSLVHVIISS ECLAAAGIPL AALMRGRPGL
60 70 80 90 100
GTAANFQVEI QTRAHATGDC TPWCTAFAAY VPADAVGELL APVVPAHPGL
110 120 130 140 150
LPRASSAGGL FVSLPVVCDA QGVYDPYAVA ALRLAWGSGA SCARVILFSY
160 170 180 190 200
DELVPPNTRY AADSTRIMRV CRHLCRYVAL LGAAAPPAAK EAAAHLSMGL
210 220 230 240 250
GESASPRPQP LARPHAGAPA DPPIVGASDP PISPEEQLTA PGGDTTAAQD
260 270 280 290 300
VSIAQENEEI LALVQRAVQD VTRRHPVRAR TGRAACGVAS GLRQGALVHQ
310 320 330 340 350
AVSGGAMGAA DADAVLAGLE PPGGGRFVAP APHGPGGEDI LNDVLTLTPG
360 370 380 390 400
TAKPRSLVEW LDRGWEALAG GDRPDWLWSR RSISVVLRHH YGTKQRFVVV
410 420 430 440 450
SYENSVAWGG RRARPPLLSS ALATALTEAC AAERVVRPHQ LSPAGQAELL
460 470 480 490 500
LRFPALEVPL RHPRPVLPPF DIAAEVAFTA RIHLACLRAL GQAIRAALQG
510 520 530 540 550
GPRISQRLRY DFGPDQRAWL GEVTRRFPIL LENLMRAVEG TAPDAFFHTA
560 570 580 590 600
YALAVLAHLG GRGGRGRRVV PLGDDLPARF ADSDGHYVFD YYSTSGDTLR
610 620 630 640 650
LNNRPIAVAM DGDVSKREQS KCRFMEAVPS TAPRRVCEQY LPGESYAYLC
660 670 680 690 700
LGFNRRLCGI VVFPGGFAFT INIAAYLSLS DPVARAAVLR FCRKVSSGNG

RSR
Length:703
Mass (Da):74,582
Last modified:July 1, 1989 - v1
Checksum:i536DAF5421BD6B4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32329.1.
PIRiH30083. WMBET7.
RefSeqiNP_044618.1. NC_001806.1.

Genome annotation databases

GeneIDi2703388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32329.1.
PIRiH30083. WMBET7.
RefSeqiNP_044618.1. NC_001806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60386N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703388.

Family and domain databases

InterProiIPR007640. Herpes_U64.
[Graphical view]
PfamiPF04559. Herpes_UL17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids."
    Trus B.L., Newcomb W.W., Cheng N., Cardone G., Marekov L., Homa F.L., Brown J.C., Steven A.C.
    Mol. Cell 26:479-489(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL25.

Entry informationi

Entry nameiUL17_HHV11
AccessioniPrimary (citable) accession number: P10201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.