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P10200

- UL16_HHV11

UniProt

P10200 - UL16_HHV11

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Protein

Capsid-binding protein UL16

Gene
UL16
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in virion morphogenesis and budding by interacting with the capsid. Interacts also in the virion with the membrane bound tegument protein UL11. Upon virion binding to target cell, a signaling is triggered through UL11 to disrupt UL16-capsid interaction, thereby preparing capsid uncoating.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid-binding protein UL16
Gene namesi
Name:UL16
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion tegument Reviewed prediction. Host cytoplasm. Host nucleus
Note: Found in the nucleus up to 18 hours postinfection, but at later times is localized to punctate, cytoplasmic structures.1 Publication

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi221 – 2211C → S: No effect on the interaction with UL11. 1 Publication
Mutagenesisi244 – 2441C → S: No effect on the interaction with UL11. 1 Publication
Mutagenesisi247 – 2471C → S: Complete loss of interaction with UL11. 1 Publication
Mutagenesisi269 – 2691C → S: Complete loss of interaction with UL11. 1 Publication
Mutagenesisi271 – 2711C → S: Complete loss of interaction with UL11. 1 Publication
Mutagenesisi275 – 2751C → S: Complete loss of interaction with UL11. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Capsid-binding protein UL16PRO_0000115949Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with UL11 and with capsid proteins.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL11P042893EBI-7044955,EBI-7044930

Protein-protein interaction databases

IntActiP10200. 2 interactions.
MINTiMINT-6732685.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004286. Herpes_UL16/UL94.
[Graphical view]
PfamiPF03044. Herpes_UL16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10200-1 [UniParc]FASTAAdd to Basket

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MAQLGPRRPL APPGPPGTLP RPDSRAGARG TRDRVDDLGT DVDSIARIVN    50
SVFVWRVVRA DERLKIFRCL TVLTEPLCQV ALPNPDPGRA LFCEIFLYLT 100
RPKALRLPPN TFFALFFFNR ERRYCAIVHL RSVTHPLTPL LCTLTFARIR 150
AATPPEETPD PTTEQLAEEP VVGELDGAYL VPAKTPPEPG ACCALGPGAW 200
WHLPSGQIYC WAMDSDLGSL CPPGSRARHL GWLLARITNH PGGCESCAPP 250
PHIDSANALW LSSVVTESCP CVAPCLWAKM AQCTLAVQGD ASLCPLLFGH 300
PVDTVTLLQA PRRPCITDRL QEVVGGRCGA DNIPPTSAGW RLCVFSSYIS 350
RLFATSCPTV ARAVARASSS DPE 373
Length:373
Mass (Da):40,443
Last modified:July 1, 1989 - v1
Checksum:i85D9914C533FE34B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32328.1.
PIRiG30083. WMBET6.
RefSeqiNP_044617.1. NC_001806.1.

Genome annotation databases

GeneIDi2703386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32328.1 .
PIRi G30083. WMBET6.
RefSeqi NP_044617.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10200. 2 interactions.
MINTi MINT-6732685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703386.

Family and domain databases

InterProi IPR004286. Herpes_UL16/UL94.
[Graphical view ]
Pfami PF03044. Herpes_UL16. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Binding partners for the UL11 tegument protein of herpes simplex virus type 1."
    Loomis J.S., Courtney R.J., Wills J.W.
    J. Virol. 77:11417-11424(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL11.
    Strain: KOS.
  3. "Dynamic interactions of the UL16 tegument protein with the capsid of herpes simplex virus."
    Meckes D.G. Jr., Wills J.W.
    J. Virol. 81:13028-13036(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CAPSID, SUBCELLULAR LOCATION.
    Strain: KOS.
  4. "Structural rearrangement within an enveloped virus upon binding to the host cell."
    Meckes D.G. Jr., Wills J.W.
    J. Virol. 82:10429-10435(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: KOS.
  5. "Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus."
    Yeh P.-C., Meckes D.G. Jr., Wills J.W.
    J. Virol. 82:10693-10700(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL11, MUTAGENESIS OF CYS-221; CYS-244; CYS-247; CYS-269; CYS-271 AND CYS-275.
    Strain: KOS.

Entry informationi

Entry nameiUL16_HHV11
AccessioniPrimary (citable) accession number: P10200
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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