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P10200

- UL16_HHV11

UniProt

P10200 - UL16_HHV11

Protein

Capsid-binding protein UL16

Gene

UL16

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Plays a role in virion morphogenesis and budding by interacting with the capsid. Interacts also in the virion with the membrane bound tegument protein UL11. Upon virion binding to target cell, a signaling is triggered through UL11 to disrupt UL16-capsid interaction, thereby preparing capsid uncoating.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid-binding protein UL16
    Gene namesi
    Name:UL16
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion tegument Curated. Host cytoplasm 1 Publication. Host nucleus 1 Publication
    Note: Found in the nucleus up to 18 hours postinfection, but at later times is localized to punctate, cytoplasmic structures.

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus, Virion, Virion tegument

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi221 – 2211C → S: No effect on the interaction with UL11. 1 Publication
    Mutagenesisi244 – 2441C → S: No effect on the interaction with UL11. 1 Publication
    Mutagenesisi247 – 2471C → S: Complete loss of interaction with UL11. 1 Publication
    Mutagenesisi269 – 2691C → S: Complete loss of interaction with UL11. 1 Publication
    Mutagenesisi271 – 2711C → S: Complete loss of interaction with UL11. 1 Publication
    Mutagenesisi275 – 2751C → S: Complete loss of interaction with UL11. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Capsid-binding protein UL16PRO_0000115949Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Interacts with UL11 and with capsid proteins.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UL11P042893EBI-7044955,EBI-7044930

    Protein-protein interaction databases

    IntActiP10200. 2 interactions.
    MINTiMINT-6732685.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae HHV-1 UL16 family.Curated

    Family and domain databases

    InterProiIPR004286. Herpes_UL16/UL94.
    [Graphical view]
    PfamiPF03044. Herpes_UL16. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10200-1 [UniParc]FASTAAdd to Basket

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    MAQLGPRRPL APPGPPGTLP RPDSRAGARG TRDRVDDLGT DVDSIARIVN    50
    SVFVWRVVRA DERLKIFRCL TVLTEPLCQV ALPNPDPGRA LFCEIFLYLT 100
    RPKALRLPPN TFFALFFFNR ERRYCAIVHL RSVTHPLTPL LCTLTFARIR 150
    AATPPEETPD PTTEQLAEEP VVGELDGAYL VPAKTPPEPG ACCALGPGAW 200
    WHLPSGQIYC WAMDSDLGSL CPPGSRARHL GWLLARITNH PGGCESCAPP 250
    PHIDSANALW LSSVVTESCP CVAPCLWAKM AQCTLAVQGD ASLCPLLFGH 300
    PVDTVTLLQA PRRPCITDRL QEVVGGRCGA DNIPPTSAGW RLCVFSSYIS 350
    RLFATSCPTV ARAVARASSS DPE 373
    Length:373
    Mass (Da):40,443
    Last modified:July 1, 1989 - v1
    Checksum:i85D9914C533FE34B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32328.1.
    PIRiG30083. WMBET6.
    RefSeqiNP_044617.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32328.1 .
    PIRi G30083. WMBET6.
    RefSeqi NP_044617.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10200. 2 interactions.
    MINTi MINT-6732685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703386.

    Family and domain databases

    InterProi IPR004286. Herpes_UL16/UL94.
    [Graphical view ]
    Pfami PF03044. Herpes_UL16. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Binding partners for the UL11 tegument protein of herpes simplex virus type 1."
      Loomis J.S., Courtney R.J., Wills J.W.
      J. Virol. 77:11417-11424(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL11.
      Strain: KOS.
    3. "Dynamic interactions of the UL16 tegument protein with the capsid of herpes simplex virus."
      Meckes D.G. Jr., Wills J.W.
      J. Virol. 81:13028-13036(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CAPSID, SUBCELLULAR LOCATION.
      Strain: KOS.
    4. "Structural rearrangement within an enveloped virus upon binding to the host cell."
      Meckes D.G. Jr., Wills J.W.
      J. Virol. 82:10429-10435(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: KOS.
    5. "Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus."
      Yeh P.-C., Meckes D.G. Jr., Wills J.W.
      J. Virol. 82:10693-10700(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL11, MUTAGENESIS OF CYS-221; CYS-244; CYS-247; CYS-269; CYS-271 AND CYS-275.
      Strain: KOS.

    Entry informationi

    Entry nameiUL16_HHV11
    AccessioniPrimary (citable) accession number: P10200
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3