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Protein

Cytoplasmic envelopment protein 2

Gene

UL16

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.UniRule annotation1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 2UniRule annotation
Gene namesi
Name:UL16
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion tegument UniRule annotation1 Publication
  • Host cytoplasm UniRule annotation1 Publication
  • Host nucleus UniRule annotation1 Publication

  • Note: Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.UniRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi221C → S: No effect on the interaction with UL11. 1 Publication1
Mutagenesisi244C → S: No effect on the interaction with UL11. 1 Publication1
Mutagenesisi247C → S: Complete loss of interaction with UL11. 1 Publication1
Mutagenesisi269C → S: Complete loss of interaction with UL11. 1 Publication1
Mutagenesisi271C → S: Complete loss of interaction with UL11. 1 Publication1
Mutagenesisi275C → S: Complete loss of interaction with UL11. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159491 – 373Cytoplasmic envelopment protein 2Add BLAST373

Proteomic databases

PRIDEiP10200.

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 3 and with the capsid.UniRule annotation3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL11P042893EBI-7044955,EBI-7044930

Protein-protein interaction databases

IntActiP10200. 2 interactors.
MINTiMINT-6732685.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.UniRule annotation

Family and domain databases

HAMAPiMF_04039. HSV_CEP2. 1 hit.
InterProiIPR004286. Herpes_UL16/UL94.
[Graphical view]
PfamiPF03044. Herpes_UL16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLGPRRPL APPGPPGTLP RPDSRAGARG TRDRVDDLGT DVDSIARIVN
60 70 80 90 100
SVFVWRVVRA DERLKIFRCL TVLTEPLCQV ALPNPDPGRA LFCEIFLYLT
110 120 130 140 150
RPKALRLPPN TFFALFFFNR ERRYCAIVHL RSVTHPLTPL LCTLTFARIR
160 170 180 190 200
AATPPEETPD PTTEQLAEEP VVGELDGAYL VPAKTPPEPG ACCALGPGAW
210 220 230 240 250
WHLPSGQIYC WAMDSDLGSL CPPGSRARHL GWLLARITNH PGGCESCAPP
260 270 280 290 300
PHIDSANALW LSSVVTESCP CVAPCLWAKM AQCTLAVQGD ASLCPLLFGH
310 320 330 340 350
PVDTVTLLQA PRRPCITDRL QEVVGGRCGA DNIPPTSAGW RLCVFSSYIS
360 370
RLFATSCPTV ARAVARASSS DPE
Length:373
Mass (Da):40,443
Last modified:July 1, 1989 - v1
Checksum:i85D9914C533FE34B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32328.1.
PIRiG30083. WMBET6.
RefSeqiYP_009137090.1. NC_001806.2.

Genome annotation databases

GeneIDi24271465.
KEGGivg:24271465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32328.1.
PIRiG30083. WMBET6.
RefSeqiYP_009137090.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10200. 2 interactors.
MINTiMINT-6732685.

Proteomic databases

PRIDEiP10200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271465.
KEGGivg:24271465.

Family and domain databases

HAMAPiMF_04039. HSV_CEP2. 1 hit.
InterProiIPR004286. Herpes_UL16/UL94.
[Graphical view]
PfamiPF03044. Herpes_UL16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEP2_HHV11
AccessioniPrimary (citable) accession number: P10200
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.