ID OBP_HHV11 Reviewed; 851 AA. AC P10193; B9VQD6; Q09IC4; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 24-NOV-2009, entry version 57. DE RecName: Full=Replication origin-binding protein; DE Short=OBP; DE AltName: Full=OriBP; GN ORFNames=UL9; OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus OS 1). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. OX NCBI_TaxID=10299; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=88274327; PubMed=2839594; RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., RA McNab D., Perry L.J., Scott J.E., Taylor P.; RT "The complete DNA sequence of the long unique region in the genome of RT herpes simplex virus type 1."; RL J. Gen. Virol. 69:1531-1574(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=88091053; PubMed=2826807; RA McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., RA Taylor P., Challberg M.D.; RT "Structures of herpes simplex virus type 1 genes required for RT replication of virus DNA."; RL J. Virol. 62:444-453(1988). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nonneuroinvasive mutant HF10; RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019; RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.; RT "Determination and analysis of the DNA sequence of highly attenuated RT herpes simplex virus type 1 mutant HF10, a potential oncolytic RT virus."; RL Microbes Infect. 9:142-149(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17 syn+; RA Cunningham C., Davison A.J.; RT "Herpes simplex virus type 1 bacterial artificial chromosome."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [5] RP INTERACTION WITH UL8. RX PubMed=7931156; RA McLean G.W., Abbotts A.P., Parry M.E., Marsden H.S., Stow N.D.; RT "The herpes simplex virus type 1 origin-binding protein interacts RT specifically with the viral UL8 protein."; RL J. Gen. Virol. 75:2699-2706(1994). RN [6] RP INTERACTION WITH ICP8, AND FUNCTION. RX PubMed=7961904; RA Boehmer P.E., Craigie M.C., Stow N.D., Lehman I.R.; RT "Association of origin binding protein and single strand DNA-binding RT protein, ICP8, during herpes simplex virus type 1 DNA replication in RT vivo."; RL J. Biol. Chem. 269:29329-29334(1994). RN [7] RP INTERACTION WITH UL42. RX PubMed=9454723; DOI=10.1006/viro.1997.8953; RA Monahan S.J., Grinstead L.A., Olivieri W., Parris D.S.; RT "Interaction between the herpes simplex virus type 1 origin-binding RT and DNA polymerase accessory proteins."; RL Virology 241:122-130(1998). RN [8] RP SUBUNIT. RX PubMed=17942532; DOI=10.1128/JVI.01204-07; RA Chattopadhyay S., Weller S.K.; RT "Direct interaction between the N- and C-terminal portions of the RT herpes simplex virus type 1 origin binding protein UL9 implies the RT formation of a head-to-tail dimer."; RL J. Virol. 81:13659-13667(2007). CC -!- FUNCTION: Functions as a docking protein to recruit essential CC components of the viral replication machinery to viral DNA CC origins. In the presence of the major DNA-binding protein, opens CC dsDNA leading to a conformational change in the origin that CC facilitates DNA unwinding and subsequent replication. CC -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein CC ICP8. Interacts with the helicase/primase component UL8 and the CC polymerase accessory protein UL42. CC -!- SUBCELLULAR LOCATION: Host nucleus (Potential). CC -!- SIMILARITY: Belongs to the herpesviridae OriBP family. CC -!- SIMILARITY: Contains 1 helicase ATP-binding domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X14112; CAA32345.1; -; Genomic_DNA. DR EMBL; M19120; AAA45822.1; -; Genomic_DNA. DR EMBL; DQ889502; ABI63471.1; -; Genomic_DNA. DR EMBL; FJ593289; ACM62231.1; -; Genomic_DNA. DR PIR; B29890; WMBEU9. DR RefSeq; NP_044610.1; -. DR DIP; DIP:1095N; -. DR GeneID; 2703434; -. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR InterPro; IPR014001; DEAD-like_N. DR InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd. DR InterPro; IPR003450; Herpes_oriBP. DR Pfam; PF02399; Herpes_ori_bp; 1. DR SMART; SM00487; DEXDc; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. PE 1: Evidence at protein level; KW ATP-binding; Complete proteome; DNA replication; DNA-binding; KW Host nucleus; Nucleotide-binding; Virus reference strain. FT CHAIN 1 851 Replication origin-binding protein. FT /FTId=PRO_0000115866. FT DOMAIN 68 233 Helicase ATP-binding. FT NP_BIND 81 88 ATP (Potential). FT VARIANT 149 149 R -> Q (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 204 204 I -> T (in strain: Nonneuroinvasive FT mutant HF10 and 17 syn+). FT VARIANT 280 280 E -> D (in strain: Nonneuroinvasive FT mutant HF10 and 17 syn+). FT VARIANT 668 669 GP -> SH (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 745 745 A -> T (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 797 797 A -> V (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 818 818 S -> N (in strain: 17 syn+). SQ SEQUENCE 851 AA; 94262 MW; 961A133FE7A30CA7 CRC64; MPFVGGAESG DPLGAGRPIG DDECEQYTSS VSLARMLYGG DLAEWVPRVH PKTTIERQQH GPVTFPNASA PTARCVTVVR APMGSGKTTA LIRWLREAIH SPDTSVLVVS CRRSFTQTLA TRFAESGLVD FVTYFSSTNY IMNDRPFHRL IVQVESLHRV GPNLLNNYDV LVLDEVMSTL GQLYSPTMQQ LGRVDALMLR LLRICPRIIA MDATANAQLV DFLCGLRGEK NVHVVVGEYA MPGFSARRCL FLPRLGTELL QAALRPPGPP SGPSPDASPE ARGATFFGEL EARLGGGDNI CIFSSTVSFA EIVARFCRQF TDRVLLLHSL TPLGDVTTWG QYRVVIYTTV VTVGLSFDPL HFDGMFAYVK PMNYGPDMVS VYQSLGRVRT LRKGELLIYM DGSGARSEPV FTPMLLNHVV SSCGQWPAQF SQVTNLLCRR FKGRCDASAC DTSLGRGSRI YNKFRYKHYF ERCTLACLSD SLNILHMLLT LNCIRVRFWG HDDTLTPKDF CLFLRGVHFD ALRAQRDLRE LRCRDPEASL PAQAAETEEV GLFVEKYLRS DVAPAEIVAL MRNLNSLMGR TRFIYLALLE ACLRVPMATR SSAIFRRIYD HYATGVIPTI NVTGELELVA LPPTLNVTPV WELLCLCSTM AARLHWDSAA GGSGRTFGPD DVLDLLTPHY DRYMQLVFEL GHCNVTDGLL LSEEAVKRVA DALSGCPPRG SVSETDHAVA LFKIIWGELF GVQMAKSTQT FPGAGRVKNL TKQTIVGLLD AHHIDHSACR THRQLYALLM AHKREFAGAR FKLRVPAWGR CLRTHSSSAN PNADIILEAA LSELPTEAWP MMQGAVNFST L //