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P10193

- OBP_HHV11

UniProt

P10193 - OBP_HHV11

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Protein

Replication origin-binding protein

Gene

UL9

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 888ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA replication origin binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replication origin-binding protein
Short name:
OBP
Alternative name(s):
OriBP
Gene namesi
ORF Names:UL9
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host nucleus Curated

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 851851Replication origin-binding proteinPRO_0000115866Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with the major DNA-binding protein ICP8. Interacts with the helicase/primase component UL8 and the polymerase accessory protein UL42.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLA1P098844EBI-8596799,EBI-850026From a different organism.
UL42P102263EBI-8596799,EBI-1029310

Protein-protein interaction databases

BioGridi971457. 1 interaction.
DIPiDIP-1095N.
IntActiP10193. 2 interactions.
MINTiMINT-191327.

Structurei

3D structure databases

ProteinModelPortaliP10193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 233166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the herpesviridae OriBP family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR003450. Replication_origin-bd.
[Graphical view]
PfamiPF02399. Herpes_ori_bp. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10193-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFVGGAESG DPLGAGRPIG DDECEQYTSS VSLARMLYGG DLAEWVPRVH
60 70 80 90 100
PKTTIERQQH GPVTFPNASA PTARCVTVVR APMGSGKTTA LIRWLREAIH
110 120 130 140 150
SPDTSVLVVS CRRSFTQTLA TRFAESGLVD FVTYFSSTNY IMNDRPFHRL
160 170 180 190 200
IVQVESLHRV GPNLLNNYDV LVLDEVMSTL GQLYSPTMQQ LGRVDALMLR
210 220 230 240 250
LLRICPRIIA MDATANAQLV DFLCGLRGEK NVHVVVGEYA MPGFSARRCL
260 270 280 290 300
FLPRLGTELL QAALRPPGPP SGPSPDASPE ARGATFFGEL EARLGGGDNI
310 320 330 340 350
CIFSSTVSFA EIVARFCRQF TDRVLLLHSL TPLGDVTTWG QYRVVIYTTV
360 370 380 390 400
VTVGLSFDPL HFDGMFAYVK PMNYGPDMVS VYQSLGRVRT LRKGELLIYM
410 420 430 440 450
DGSGARSEPV FTPMLLNHVV SSCGQWPAQF SQVTNLLCRR FKGRCDASAC
460 470 480 490 500
DTSLGRGSRI YNKFRYKHYF ERCTLACLSD SLNILHMLLT LNCIRVRFWG
510 520 530 540 550
HDDTLTPKDF CLFLRGVHFD ALRAQRDLRE LRCRDPEASL PAQAAETEEV
560 570 580 590 600
GLFVEKYLRS DVAPAEIVAL MRNLNSLMGR TRFIYLALLE ACLRVPMATR
610 620 630 640 650
SSAIFRRIYD HYATGVIPTI NVTGELELVA LPPTLNVTPV WELLCLCSTM
660 670 680 690 700
AARLHWDSAA GGSGRTFGPD DVLDLLTPHY DRYMQLVFEL GHCNVTDGLL
710 720 730 740 750
LSEEAVKRVA DALSGCPPRG SVSETDHAVA LFKIIWGELF GVQMAKSTQT
760 770 780 790 800
FPGAGRVKNL TKQTIVGLLD AHHIDHSACR THRQLYALLM AHKREFAGAR
810 820 830 840 850
FKLRVPAWGR CLRTHSSSAN PNADIILEAA LSELPTEAWP MMQGAVNFST

L
Length:851
Mass (Da):94,262
Last modified:July 1, 1989 - v1
Checksum:i961A133FE7A30CA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491R → Q in strain: Nonneuroinvasive mutant HF10.
Natural varianti204 – 2041I → T in strain: Nonneuroinvasive mutant HF10 and 17 syn+.
Natural varianti280 – 2801E → D in strain: Nonneuroinvasive mutant HF10 and 17 syn+.
Natural varianti668 – 6692GP → SH in strain: Nonneuroinvasive mutant HF10.
Natural varianti745 – 7451A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti797 – 7971A → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti818 – 8181S → N in strain: 17 syn+.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32345.1.
M19120 Genomic DNA. Translation: AAA45822.1.
DQ889502 Genomic DNA. Translation: ABI63471.1.
FJ593289 Genomic DNA. Translation: ACM62231.1.
PIRiB29890. WMBEU9.
RefSeqiNP_044610.1. NC_001806.1.

Genome annotation databases

GeneIDi2703434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32345.1 .
M19120 Genomic DNA. Translation: AAA45822.1 .
DQ889502 Genomic DNA. Translation: ABI63471.1 .
FJ593289 Genomic DNA. Translation: ACM62231.1 .
PIRi B29890. WMBEU9.
RefSeqi NP_044610.1. NC_001806.1.

3D structure databases

ProteinModelPortali P10193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 971457. 1 interaction.
DIPi DIP-1095N.
IntActi P10193. 2 interactions.
MINTi MINT-191327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703434.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR003450. Replication_origin-bd.
[Graphical view ]
Pfami PF02399. Herpes_ori_bp. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
    McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
    J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. "The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein."
    McLean G.W., Abbotts A.P., Parry M.E., Marsden H.S., Stow N.D.
    J. Gen. Virol. 75:2699-2706(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL8.
  6. "Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo."
    Boehmer P.E., Craigie M.C., Stow N.D., Lehman I.R.
    J. Biol. Chem. 269:29329-29334(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ICP8, FUNCTION.
  7. "Interaction between the herpes simplex virus type 1 origin-binding and DNA polymerase accessory proteins."
    Monahan S.J., Grinstead L.A., Olivieri W., Parris D.S.
    Virology 241:122-130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL42.
  8. "Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer."
    Chattopadhyay S., Weller S.K.
    J. Virol. 81:13659-13667(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiOBP_HHV11
AccessioniPrimary (citable) accession number: P10193
Secondary accession number(s): B9VQD6, Q09IC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3