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P10193

- OBP_HHV11

UniProt

P10193 - OBP_HHV11

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Protein
Replication origin-binding protein
Gene
UL9
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 888ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA replication origin binding Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replication origin-binding protein
Short name:
OBP
Alternative name(s):
OriBP
Gene namesi
ORF Names:UL9
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host nucleus Reviewed prediction

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 851851Replication origin-binding protein
PRO_0000115866Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with the major DNA-binding protein ICP8. Interacts with the helicase/primase component UL8 and the polymerase accessory protein UL42.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLA1P098844EBI-8596799,EBI-850026From a different organism.
UL42P102263EBI-8596799,EBI-1029310

Protein-protein interaction databases

BioGridi971457. 1 interaction.
DIPiDIP-1095N.
IntActiP10193. 2 interactions.
MINTiMINT-191327.

Structurei

3D structure databases

ProteinModelPortaliP10193.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 233166Helicase ATP-binding
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR003450. Replication_origin-bd.
[Graphical view]
PfamiPF02399. Herpes_ori_bp. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10193-1 [UniParc]FASTAAdd to Basket

« Hide

MPFVGGAESG DPLGAGRPIG DDECEQYTSS VSLARMLYGG DLAEWVPRVH    50
PKTTIERQQH GPVTFPNASA PTARCVTVVR APMGSGKTTA LIRWLREAIH 100
SPDTSVLVVS CRRSFTQTLA TRFAESGLVD FVTYFSSTNY IMNDRPFHRL 150
IVQVESLHRV GPNLLNNYDV LVLDEVMSTL GQLYSPTMQQ LGRVDALMLR 200
LLRICPRIIA MDATANAQLV DFLCGLRGEK NVHVVVGEYA MPGFSARRCL 250
FLPRLGTELL QAALRPPGPP SGPSPDASPE ARGATFFGEL EARLGGGDNI 300
CIFSSTVSFA EIVARFCRQF TDRVLLLHSL TPLGDVTTWG QYRVVIYTTV 350
VTVGLSFDPL HFDGMFAYVK PMNYGPDMVS VYQSLGRVRT LRKGELLIYM 400
DGSGARSEPV FTPMLLNHVV SSCGQWPAQF SQVTNLLCRR FKGRCDASAC 450
DTSLGRGSRI YNKFRYKHYF ERCTLACLSD SLNILHMLLT LNCIRVRFWG 500
HDDTLTPKDF CLFLRGVHFD ALRAQRDLRE LRCRDPEASL PAQAAETEEV 550
GLFVEKYLRS DVAPAEIVAL MRNLNSLMGR TRFIYLALLE ACLRVPMATR 600
SSAIFRRIYD HYATGVIPTI NVTGELELVA LPPTLNVTPV WELLCLCSTM 650
AARLHWDSAA GGSGRTFGPD DVLDLLTPHY DRYMQLVFEL GHCNVTDGLL 700
LSEEAVKRVA DALSGCPPRG SVSETDHAVA LFKIIWGELF GVQMAKSTQT 750
FPGAGRVKNL TKQTIVGLLD AHHIDHSACR THRQLYALLM AHKREFAGAR 800
FKLRVPAWGR CLRTHSSSAN PNADIILEAA LSELPTEAWP MMQGAVNFST 850
L 851
Length:851
Mass (Da):94,262
Last modified:July 1, 1989 - v1
Checksum:i961A133FE7A30CA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491R → Q in strain: Nonneuroinvasive mutant HF10.
Natural varianti204 – 2041I → T in strain: Nonneuroinvasive mutant HF10 and 17 syn+.
Natural varianti280 – 2801E → D in strain: Nonneuroinvasive mutant HF10 and 17 syn+.
Natural varianti668 – 6692GP → SH in strain: Nonneuroinvasive mutant HF10.
Natural varianti745 – 7451A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti797 – 7971A → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti818 – 8181S → N in strain: 17 syn+.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32345.1.
M19120 Genomic DNA. Translation: AAA45822.1.
DQ889502 Genomic DNA. Translation: ABI63471.1.
FJ593289 Genomic DNA. Translation: ACM62231.1.
PIRiB29890. WMBEU9.
RefSeqiNP_044610.1. NC_001806.1.

Genome annotation databases

GeneIDi2703434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32345.1 .
M19120 Genomic DNA. Translation: AAA45822.1 .
DQ889502 Genomic DNA. Translation: ABI63471.1 .
FJ593289 Genomic DNA. Translation: ACM62231.1 .
PIRi B29890. WMBEU9.
RefSeqi NP_044610.1. NC_001806.1.

3D structure databases

ProteinModelPortali P10193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 971457. 1 interaction.
DIPi DIP-1095N.
IntActi P10193. 2 interactions.
MINTi MINT-191327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703434.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR003450. Replication_origin-bd.
[Graphical view ]
Pfami PF02399. Herpes_ori_bp. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
    McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
    J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. "The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein."
    McLean G.W., Abbotts A.P., Parry M.E., Marsden H.S., Stow N.D.
    J. Gen. Virol. 75:2699-2706(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL8.
  6. "Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo."
    Boehmer P.E., Craigie M.C., Stow N.D., Lehman I.R.
    J. Biol. Chem. 269:29329-29334(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ICP8, FUNCTION.
  7. "Interaction between the herpes simplex virus type 1 origin-binding and DNA polymerase accessory proteins."
    Monahan S.J., Grinstead L.A., Olivieri W., Parris D.S.
    Virology 241:122-130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL42.
  8. "Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer."
    Chattopadhyay S., Weller S.K.
    J. Virol. 81:13659-13667(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiOBP_HHV11
AccessioniPrimary (citable) accession number: P10193
Secondary accession number(s): B9VQD6, Q09IC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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