ID   PORTL_HHV11             Reviewed;         676 AA.
AC   P10190;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   21-SEP-2011, entry version 56.
DE   RecName: Full=Portal protein UL6;
GN   Name=UL6;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RX   MEDLINE=88091053; PubMed=2826807;
RA   McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J.,
RA   Taylor P., Challberg M.D.;
RT   "Structures of herpes simplex virus type 1 genes required for
RT   replication of virus DNA.";
RL   J. Virol. 62:444-453(1988).
RN   [3]
RP   FUNCTION.
RX   PubMed=11602732; DOI=10.1128/JVI.75.22.10923-10932.2001;
RA   Newcomb W.W., Juhas R.M., Thomsen D.R., Homa F.L., Burch A.D.,
RA   Weller S.K., Brown J.C.;
RT   "The UL6 gene product forms the portal for entry of DNA into the
RT   herpes simplex virus capsid.";
RL   J. Virol. 75:10923-10932(2001).
RN   [4]
RP   INTERACTION WITH UL15 AND UL28, AND SUBCELLULAR LOCATION.
RX   PubMed=12743292; DOI=10.1128/JVI.77.11.6351-6358.2003;
RA   White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.;
RT   "Herpes simplex virus type 1 portal protein UL6 interacts with the
RT   putative terminase subunits UL15 and UL28.";
RL   J. Virol. 77:6351-6358(2003).
RN   [5]
RP   HOMODODECAMERIZATION.
RX   PubMed=15507654; DOI=10.1128/JVI.78.22.12668-12671.2004;
RA   Trus B.L., Cheng N., Newcomb W.W., Homa F.L., Brown J.C., Steven A.C.;
RT   "Structure and polymorphism of the UL6 portal protein of herpes
RT   simplex virus type 1.";
RL   J. Virol. 78:12668-12671(2004).
RN   [6]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16920825; DOI=10.1128/JVI.01364-06;
RA   Wills E., Scholtes L., Baines J.D.;
RT   "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15,
RT   UL17, UL28, and UL33 are located on the external surface of the viral
RT   capsid.";
RL   J. Virol. 80:10894-10899(2006).
CC   -!- FUNCTION: Forms a portal in the viral capsid through which viral
CC       DNA is translocated during DNA packaging. Assembles as a dodecamer
CC       at a single fivefold axe of the T=16 icosahedric capsid. Binds to
CC       the molecular motor that translocate the viral DNA, termed
CC       terminase.
CC   -!- SUBUNIT: Homododecamerizes. Interacts with putative terminase
CC       subunit UL15 and UL28.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae portal protein family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X14112; CAA32342.1; -; Genomic_DNA.
DR   EMBL; M19119; AAA45818.2; -; Genomic_DNA.
DR   PIR; F28133; WMBEX6.
DR   RefSeq; NP_044607.1; NC_001806.1.
DR   MINT; MINT-6732669; -.
DR   GeneID; 2703429; -.
DR   ProtClustDB; CLSP2509632; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006323; P:DNA packaging; IEA:UniProtKB-KW.
DR   InterPro; IPR002660; Herpes_UL6.
DR   Pfam; PF01763; Herpes_UL6; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA packaging; Host nucleus; Reference proteome;
KW   Virion.
FT   CHAIN         1    676       Portal protein UL6.
FT                                /FTId=PRO_0000115903.
SQ   SEQUENCE   676 AA;  74092 MW;  8CF9D73C6313FAE9 CRC64;
     MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT EGQGVYNVVR
     SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ PQRLVRRYRN AREADIAGVA
     ERVFDTWRNT LRTTLLDFAH GLVACFAPGG PSGPSSFPKY IDWLTCLGLV PILRKRQEGG
     VTQGLRAFLK QHPLTRQLAT VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD
     WLVRDPISGQ RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS
     VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG MRHVGDINDT
     VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG GRAPQLRQAF RTAVVNNING
     VLEGYINNLF GTIERLRETN AGLATQLQER DRELRRATAG ALERQQRAAD LAAESVTGGC
     GSRPAGADLL RADYDIIDVS KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF
     KILCHRNNQG QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF
     KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS PGRTARGAPD
     QGGGIGHRDG RRDGRR
//