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P10190

- PORTL_HHV11

UniProt

P10190 - PORTL_HHV11

Protein

Portal protein UL6

Gene

UL6

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase.1 Publication

    GO - Biological processi

    1. DNA packaging Source: InterPro
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Viral genome packaging, Virus exit from host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Portal protein UL6
    Gene namesi
    Name:UL6
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676Portal protein UL6PRO_0000115903Add
    BLAST

    Interactioni

    Subunit structurei

    Homododecamerizes. Interacts with putative terminase subunit UL15 and UL28.1 Publication

    Protein-protein interaction databases

    IntActiP10190. 2 interactions.
    MINTiMINT-6732669.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002660. Herpes_UL6.
    [Graphical view]
    PfamiPF01763. Herpes_UL6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10190-1 [UniParc]FASTAAdd to Basket

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    MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT    50
    EGQGVYNVVR SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ 100
    PQRLVRRYRN AREADIAGVA ERVFDTWRNT LRTTLLDFAH GLVACFAPGG 150
    PSGPSSFPKY IDWLTCLGLV PILRKRQEGG VTQGLRAFLK QHPLTRQLAT 200
    VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD WLVRDPISGQ 250
    RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS 300
    VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG 350
    MRHVGDINDT VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG 400
    GRAPQLRQAF RTAVVNNING VLEGYINNLF GTIERLRETN AGLATQLQER 450
    DRELRRATAG ALERQQRAAD LAAESVTGGC GSRPAGADLL RADYDIIDVS 500
    KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF KILCHRNNQG 550
    QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF 600
    KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS 650
    PGRTARGAPD QGGGIGHRDG RRDGRR 676
    Length:676
    Mass (Da):74,092
    Last modified:July 1, 1989 - v1
    Checksum:i8CF9D73C6313FAE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32342.1.
    M19119 Genomic DNA. Translation: AAA45818.2.
    PIRiF28133. WMBEX6.
    RefSeqiNP_044607.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703429.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32342.1 .
    M19119 Genomic DNA. Translation: AAA45818.2 .
    PIRi F28133. WMBEX6.
    RefSeqi NP_044607.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10190. 2 interactions.
    MINTi MINT-6732669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703429.

    Family and domain databases

    InterProi IPR002660. Herpes_UL6.
    [Graphical view ]
    Pfami PF01763. Herpes_UL6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
      McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
      J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
    3. "The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid."
      Newcomb W.W., Juhas R.M., Thomsen D.R., Homa F.L., Burch A.D., Weller S.K., Brown J.C.
      J. Virol. 75:10923-10932(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
      White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
      J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL15 AND UL28, SUBCELLULAR LOCATION.
    5. "Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1."
      Trus B.L., Cheng N., Newcomb W.W., Homa F.L., Brown J.C., Steven A.C.
      J. Virol. 78:12668-12671(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: HOMODODECAMERIZATION.
    6. "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
      Wills E., Scholtes L., Baines J.D.
      J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPORTL_HHV11
    AccessioniPrimary (citable) accession number: P10190
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3