P10190 (PORTL_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Portal protein UL6

Gene names

Name:

UL6

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	676 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase. Ref.3
Subunit structure	Homododecamerizes. Interacts with putative terminase subunit UL15 and UL28. Ref.4 Ref.5
Subcellular location	Virion. Host nucleus Ref.4 Ref.6.
Sequence similarities	Belongs to the herpesviridae portal protein family.

Ontologies

Keywords
Biological process	Viral genome packaging
Cellular component	Host nucleus Virion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA packaging Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 676	676	Portal protein UL6		PRO_0000115903

Sequences

	Sequence		Length	Mass (Da)
	P10190 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 8CF9D73C6313FAE9	FASTA	676	74,092
	10 20 30 40 50 60 MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT EGQGVYNVVR 70 80 90 100 110 120 SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ PQRLVRRYRN AREADIAGVA 130 140 150 160 170 180 ERVFDTWRNT LRTTLLDFAH GLVACFAPGG PSGPSSFPKY IDWLTCLGLV PILRKRQEGG 190 200 210 220 230 240 VTQGLRAFLK QHPLTRQLAT VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD 250 260 270 280 290 300 WLVRDPISGQ RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS 310 320 330 340 350 360 VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG MRHVGDINDT 370 380 390 400 410 420 VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG GRAPQLRQAF RTAVVNNING 430 440 450 460 470 480 VLEGYINNLF GTIERLRETN AGLATQLQER DRELRRATAG ALERQQRAAD LAAESVTGGC 490 500 510 520 530 540 GSRPAGADLL RADYDIIDVS KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF 550 560 570 580 590 600 KILCHRNNQG QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF 610 620 630 640 650 660 KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS PGRTARGAPD 670 QGGGIGHRDG RRDGRR

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structures of herpes simplex virus type 1 genes required for replication of virus DNA." McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D. J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
[3]	"The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid." Newcomb W.W., Juhas R.M., Thomsen D.R., Homa F.L., Burch A.D., Weller S.K., Brown J.C. J. Virol. 75:10923-10932(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28." White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G. J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UL15 AND UL28, SUBCELLULAR LOCATION.
[5]	"Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1." Trus B.L., Cheng N., Newcomb W.W., Homa F.L., Brown J.C., Steven A.C. J. Virol. 78:12668-12671(2004) [PubMed] [Europe PMC] [Abstract] Cited for: HOMODODECAMERIZATION.
[6]	"Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid." Wills E., Scholtes L., Baines J.D. J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32342.1. M19119 Genomic DNA. Translation: AAA45818.2.
PIR	WMBEX6. F28133.
RefSeq	NP_044607.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6732669.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703429.
Phylogenomic databases
ProtClustDB	CLSP2509632.
Family and domain databases
InterPro	IPR002660. Herpes_UL6. [Graphical view]
Pfam	PF01763. Herpes_UL6. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORTL_HHV11

Accession

Primary (citable) accession number: P10190

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program