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Protein

Portal protein UL6

Gene

UL6

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase.1 Publication

GO - Biological processi

  1. DNA packaging Source: InterPro
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Portal protein UL6
Gene namesi
Name:UL6
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Portal protein UL6PRO_0000115903Add
BLAST

Interactioni

Subunit structurei

Homododecamerizes. Interacts with putative terminase subunit UL15 and UL28.1 Publication

Protein-protein interaction databases

IntActiP10190. 2 interactions.
MINTiMINT-6732669.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR002660. Herpes_UL6.
[Graphical view]
PfamiPF01763. Herpes_UL6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT
60 70 80 90 100
EGQGVYNVVR SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ
110 120 130 140 150
PQRLVRRYRN AREADIAGVA ERVFDTWRNT LRTTLLDFAH GLVACFAPGG
160 170 180 190 200
PSGPSSFPKY IDWLTCLGLV PILRKRQEGG VTQGLRAFLK QHPLTRQLAT
210 220 230 240 250
VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD WLVRDPISGQ
260 270 280 290 300
RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS
310 320 330 340 350
VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG
360 370 380 390 400
MRHVGDINDT VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG
410 420 430 440 450
GRAPQLRQAF RTAVVNNING VLEGYINNLF GTIERLRETN AGLATQLQER
460 470 480 490 500
DRELRRATAG ALERQQRAAD LAAESVTGGC GSRPAGADLL RADYDIIDVS
510 520 530 540 550
KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF KILCHRNNQG
560 570 580 590 600
QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF
610 620 630 640 650
KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS
660 670
PGRTARGAPD QGGGIGHRDG RRDGRR
Length:676
Mass (Da):74,092
Last modified:July 1, 1989 - v1
Checksum:i8CF9D73C6313FAE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32342.1.
M19119 Genomic DNA. Translation: AAA45818.2.
PIRiF28133. WMBEX6.
RefSeqiNP_044607.1. NC_001806.1.

Genome annotation databases

GeneIDi2703429.
KEGGivg:2703429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32342.1.
M19119 Genomic DNA. Translation: AAA45818.2.
PIRiF28133. WMBEX6.
RefSeqiNP_044607.1. NC_001806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10190. 2 interactions.
MINTiMINT-6732669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703429.
KEGGivg:2703429.

Family and domain databases

InterProiIPR002660. Herpes_UL6.
[Graphical view]
PfamiPF01763. Herpes_UL6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
    McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
    J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
  3. "The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid."
    Newcomb W.W., Juhas R.M., Thomsen D.R., Homa F.L., Burch A.D., Weller S.K., Brown J.C.
    J. Virol. 75:10923-10932(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
    White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
    J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL15 AND UL28, SUBCELLULAR LOCATION.
  5. "Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1."
    Trus B.L., Cheng N., Newcomb W.W., Homa F.L., Brown J.C., Steven A.C.
    J. Virol. 78:12668-12671(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODODECAMERIZATION.
  6. "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
    Wills E., Scholtes L., Baines J.D.
    J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPORTL_HHV11
AccessioniPrimary (citable) accession number: P10190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.