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P10190 (PORTL_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Portal protein UL6
Gene names
Name:UL6
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length676 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase. Ref.3

Subunit structure

Homododecamerizes. Interacts with putative terminase subunit UL15 and UL28. Ref.4 Ref.5

Subcellular location

Virion. Host nucleus Ref.4 Ref.6.

Sequence similarities

Belongs to the herpesviridae portal protein family.

Ontologies

Keywords
   Biological processViral genome packaging
Virus exit from host cell
   Cellular componentHost nucleus
Virion
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA packaging

Inferred from electronic annotation. Source: InterPro

viral release from host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

virion

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 676676Portal protein UL6
PRO_0000115903

Sequences

Sequence LengthMass (Da)Tools
P10190 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 8CF9D73C6313FAE9

FASTA67674,092
        10         20         30         40         50         60 
MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT EGQGVYNVVR 

        70         80         90        100        110        120 
SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ PQRLVRRYRN AREADIAGVA 

       130        140        150        160        170        180 
ERVFDTWRNT LRTTLLDFAH GLVACFAPGG PSGPSSFPKY IDWLTCLGLV PILRKRQEGG 

       190        200        210        220        230        240 
VTQGLRAFLK QHPLTRQLAT VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD 

       250        260        270        280        290        300 
WLVRDPISGQ RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS 

       310        320        330        340        350        360 
VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG MRHVGDINDT 

       370        380        390        400        410        420 
VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG GRAPQLRQAF RTAVVNNING 

       430        440        450        460        470        480 
VLEGYINNLF GTIERLRETN AGLATQLQER DRELRRATAG ALERQQRAAD LAAESVTGGC 

       490        500        510        520        530        540 
GSRPAGADLL RADYDIIDVS KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF 

       550        560        570        580        590        600 
KILCHRNNQG QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF 

       610        620        630        640        650        660 
KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS PGRTARGAPD 

       670 
QGGGIGHRDG RRDGRR 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
[3]"The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid."
Newcomb W.W., Juhas R.M., Thomsen D.R., Homa F.L., Burch A.D., Weller S.K., Brown J.C.
J. Virol. 75:10923-10932(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL15 AND UL28, SUBCELLULAR LOCATION.
[5]"Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1."
Trus B.L., Cheng N., Newcomb W.W., Homa F.L., Brown J.C., Steven A.C.
J. Virol. 78:12668-12671(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: HOMODODECAMERIZATION.
[6]"Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
Wills E., Scholtes L., Baines J.D.
J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32342.1.
M19119 Genomic DNA. Translation: AAA45818.2.
PIRWMBEX6. F28133.
RefSeqNP_044607.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP10190. 2 interactions.
MINTMINT-6732669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703429.

Family and domain databases

InterProIPR002660. Herpes_UL6.
[Graphical view]
PfamPF01763. Herpes_UL6. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePORTL_HHV11
AccessionPrimary (citable) accession number: P10190
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families