P10188 (NP04_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear protein UL4

Gene names

ORF Names:

UL4

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Host nucleus Ref.4.
Sequence similarities	Belongs to the alphaherpesvirinae HHV-1 UL4 family.

Ontologies

Keywords
Cellular component	Host nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Nuclear protein UL4		PRO_0000115898
Regions
	Compositional bias	156 – 159	4	Poly-Pro
Natural variations
	Natural variant	107	1	S → I in strain: Nonneuroinvasive mutant HF10.

Sequences

	Sequence		Length	Mass (Da)
	P10188 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: A50C0AB9FB9AA3F0	FASTA	199	21,517
	10 20 30 40 50 60 MSNPQTTIAY SLCHARASLT SALPDAAQVV HVFEYGTRAI MVRGRERQDR LPRGGVVIQH 70 80 90 100 110 120 TPIGLLVIID CRAEFCAYRF IGRDSNQKLE RGWDAHMYAY PFDSWVSSSR GESARSATAG 130 140 150 160 170 180 ILTVVWTADT IYITATIYGS PPEETPGAAH GVGAAPPPPT TACPGTAEFL QPTADLLVEV 190 LREIQLSPAL EYADKLLGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Structures of herpes simplex virus type 1 genes required for replication of virus DNA." McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D. J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
[4]	"Identification of the UL4 protein of herpes simplex virus type 1." Eide T., Marsden H.S., Leib D.A., Cunningham C., Davison A.J., Langeland N., Haarr L. J. Gen. Virol. 79:3033-3038(1998) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, SUBCELLULAR LOCATION. Strain: 17 syn+.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32340.1. DQ889502 Genomic DNA. Translation: ABI63466.1. M19119 Genomic DNA. Translation: AAA45820.1.
PIR	WMBEX4. D28133.
RefSeq	NP_044605.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6732590.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703362.
Phylogenomic databases
ProtClustDB	CLSP2510146.
Family and domain databases
InterPro	IPR004958. Herpes_UL4. [Graphical view]
Pfam	PF03277. Herpes_UL4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NP04_HHV11

Accession

Primary (citable) accession number: P10188
Secondary accession number(s): Q09IC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program