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P10188 (NP04_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear protein UL4
Gene names
ORF Names:UL4
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Host nucleus Ref.4.

Sequence similarities

Belongs to the alphaherpesvirinae HHV-1 UL4 family.

Ontologies

Keywords
   Cellular componentHost nucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Nuclear protein UL4
PRO_0000115898

Regions

Compositional bias156 – 1594Poly-Pro

Natural variations

Natural variant1071S → I in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P10188 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: A50C0AB9FB9AA3F0

FASTA19921,517
        10         20         30         40         50         60 
MSNPQTTIAY SLCHARASLT SALPDAAQVV HVFEYGTRAI MVRGRERQDR LPRGGVVIQH 

        70         80         90        100        110        120 
TPIGLLVIID CRAEFCAYRF IGRDSNQKLE RGWDAHMYAY PFDSWVSSSR GESARSATAG 

       130        140        150        160        170        180 
ILTVVWTADT IYITATIYGS PPEETPGAAH GVGAAPPPPT TACPGTAEFL QPTADLLVEV 

       190 
LREIQLSPAL EYADKLLGS 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
[4]"Identification of the UL4 protein of herpes simplex virus type 1."
Eide T., Marsden H.S., Leib D.A., Cunningham C., Davison A.J., Langeland N., Haarr L.
J. Gen. Virol. 79:3033-3038(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
Strain: 17 syn+.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32340.1.
DQ889502 Genomic DNA. Translation: ABI63466.1.
M19119 Genomic DNA. Translation: AAA45820.1.
PIRWMBEX4. D28133.
RefSeqNP_044605.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP10188. 1 interaction.
MINTMINT-6732590.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703362.

Phylogenomic databases

ProtClustDBCLSP2510146.

Family and domain databases

InterProIPR004958. Herpes_UL4.
[Graphical view]
PfamPF03277. Herpes_UL4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNP04_HHV11
AccessionPrimary (citable) accession number: P10188
Secondary accession number(s): Q09IC9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families