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Protein

Nuclear protein UL4

Gene

UL4

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear protein UL4
Gene namesi
ORF Names:UL4
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Nuclear protein UL4PRO_0000115898Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP10188. 1 interaction.
MINTiMINT-6732590.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1594Poly-Pro

Sequence similaritiesi

Family and domain databases

InterProiIPR004958. Herpes_UL4.
[Graphical view]
PfamiPF03277. Herpes_UL4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPQTTIAY SLCHARASLT SALPDAAQVV HVFEYGTRAI MVRGRERQDR
60 70 80 90 100
LPRGGVVIQH TPIGLLVIID CRAEFCAYRF IGRDSNQKLE RGWDAHMYAY
110 120 130 140 150
PFDSWVSSSR GESARSATAG ILTVVWTADT IYITATIYGS PPEETPGAAH
160 170 180 190
GVGAAPPPPT TACPGTAEFL QPTADLLVEV LREIQLSPAL EYADKLLGS
Length:199
Mass (Da):21,517
Last modified:July 1, 1989 - v1
Checksum:iA50C0AB9FB9AA3F0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071S → I in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32340.1.
DQ889502 Genomic DNA. Translation: ABI63466.1.
M19119 Genomic DNA. Translation: AAA45820.1.
PIRiD28133. WMBEX4.
RefSeqiNP_044605.1. NC_001806.1.

Genome annotation databases

GeneIDi2703362.
KEGGivg:2703362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32340.1.
DQ889502 Genomic DNA. Translation: ABI63466.1.
M19119 Genomic DNA. Translation: AAA45820.1.
PIRiD28133. WMBEX4.
RefSeqiNP_044605.1. NC_001806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10188. 1 interaction.
MINTiMINT-6732590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703362.
KEGGivg:2703362.

Family and domain databases

InterProiIPR004958. Herpes_UL4.
[Graphical view]
PfamiPF03277. Herpes_UL4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
    McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
    J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
  4. "Identification of the UL4 protein of herpes simplex virus type 1."
    Eide T., Marsden H.S., Leib D.A., Cunningham C., Davison A.J., Langeland N., Haarr L.
    J. Gen. Virol. 79:3033-3038(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
    Strain: 17 syn+.

Entry informationi

Entry nameiNP04_HHV11
AccessioniPrimary (citable) accession number: P10188
Secondary accession number(s): Q09IC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 1, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.