P10187 (NP03_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear phosphoprotein UL3

Gene names

ORF Names:

UL3

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Host nucleus By similarity.
Post-translational modification	Phosphorylated By similarity.
Sequence similarities	Belongs to the alphaherpesvirinae HHV-1 UL3 family.
Caution	It is uncertain whether Met-1 or Met-12 is the initiator.

Ontologies

Keywords
Cellular component	Host nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Nuclear phosphoprotein UL3		PRO_0000115892

Sequences

	Sequence		Length	Mass (Da)
	P10187 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: FDA96829D742912D	FASTA	235	25,609
	10 20 30 40 50 60 MVKPLVSYGS VMSGVGGEGV PSALAILASW GWTFDTPNHE SGISPDTTPA DSIRGAAVAS 70 80 90 100 110 120 PDQPLHGGPE REATAPSFSP TRADDGPPCT DGPYVTFDTL FMVSSIDELG RRQLTDTIRK 130 140 150 160 170 180 DLRLSLAKFS IACTKTSSFS GNAPRHHRRG AFQRGTRAPR SNKSLQMFVL CKRAHAARVR 190 200 210 220 230 EQLRVVIQSR KPRKYYTRSS DGRLCPAVPV FVHEFVSSEP MRLHRDNVML ASGAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1." Perry L.J., McGeoch D.J. J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Oncolytic viruses derived from the gamma34.5-deleted herpes simplex virus recombinant R3616 encode a truncated UL3 protein." Dambach M.J., Trecki J., Martin N., Markovitz N.S. Mol. Ther. 13:891-898(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Patton.
[4]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[5]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32339.1. D00373 Genomic DNA. Translation: BAA00275.1. DQ073426 Genomic DNA. Translation: AAZ22830.1. FJ593289 Genomic DNA. Translation: ACM62225.1. DQ889502 Genomic DNA. Translation: ABI63465.1.
PIR	WMBEX3. C28133.
RefSeq	NP_044604.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703461.
Phylogenomic databases
ProtClustDB	CLSP2509635.
Family and domain databases
InterPro	IPR005035. Herpes_UL3. [Graphical view]
Pfam	PF03369. Herpes_UL3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NP03_HHV11

Accession

Primary (citable) accession number: P10187
Secondary accession number(s): Q76WT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program