Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10185

- GL_HHV11

UniProt

P10185 - GL_HHV11

Protein

Envelope glycoprotein L

Gene

gL

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.1 Publication

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

    Keywords - Ligandi

    Sialic acid

    Protein family/group databases

    TCDBi1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein L
    Short name:
    gL
    Gene namesi
    Name:gL
    ORF Names:UL1
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane By similarity; Peripheral membrane protein By similarity; Extracellular side By similarity
    Note: gL is not anchored to the viral envelope, but associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) By similarity. A fraction of gL has also been found associated to the cell surface in the absence of gH, suggesting incomplete cleavage of the signal peptide or presence of a cell surface receptor for secreted gL.By similarity

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. viral envelope Source: UniProtKB-KW
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 224205Envelope glycoprotein LPRO_0000038264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi170 – 1701N-linked (GlcNAc...); by hostCurated

    Post-translational modificationi

    N-glycosylated, O-glycosylated, and sialylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. Associates with the gB-gH/gL-gD complex By similarity.By similarity

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 161142Interaction with gLAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi215 – 2184Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR022200. Herpes_gL_C.
    IPR007923. Herpes_gL_N.
    [Graphical view]
    PfamiPF12524. GlyL_C. 1 hit.
    PF05259. Herpes_UL1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10185-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGILGWVGLI AVGVLCVRGG LPSTEYVIRS RVAREVGDIL KVPCVPLPSD    50
    DLDWRYETPS AINYALIDGI FLRYHCPGLD TVLWDRHAQK AYWVNPFLFV 100
    AGFLEDLSYP AFPANTQETE TRLALYKEIR QALDSRKQAA SHTPVKAGCV 150
    NFDYSRTRRC VGRQDLGPTN GTSGRTPVLP PDDEAGLQPK PLTTPPPIIA 200
    TSDPTPRRDA ATKSRRRRPH SRRL 224
    Length:224
    Mass (Da):24,934
    Last modified:July 1, 1989 - v1
    Checksum:iCED51D2FC1D7777F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901K → R in strain: Nonneuroinvasive mutant HF10.
    Natural varianti100 – 1001V → G in strain: Nonneuroinvasive mutant HF10.
    Natural varianti109 – 1091Y → H in strain: Nonneuroinvasive mutant HF10.
    Natural varianti115 – 1151N → D in strain: Nonneuroinvasive mutant HF10.
    Natural varianti168 – 1681P → L in strain: Nonneuroinvasive mutant HF10.
    Natural varianti171 – 1711G → R in strain: Nonneuroinvasive mutant HF10.
    Natural varianti181 – 1811P → S in strain: Nonneuroinvasive mutant HF10.
    Natural varianti196 – 1961P → S in strain: Nonneuroinvasive mutant HF10.
    Natural varianti224 – 2241L → I in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32337.1.
    D00373 Genomic DNA. Translation: BAA00272.1.
    DQ889502 Genomic DNA. Translation: ABI63463.1.
    FJ593289 Genomic DNA. Translation: ACM62223.1.
    PIRiA28133. WMBEX1.
    RefSeqiNP_044602.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32337.1 .
    D00373 Genomic DNA. Translation: BAA00272.1 .
    DQ889502 Genomic DNA. Translation: ABI63463.1 .
    FJ593289 Genomic DNA. Translation: ACM62223.1 .
    PIRi A28133. WMBEX1.
    RefSeqi NP_044602.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364696.

    Protein family/group databases

    TCDBi 1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703393.

    Family and domain databases

    InterProi IPR022200. Herpes_gL_C.
    IPR007923. Herpes_gL_N.
    [Graphical view ]
    Pfami PF12524. GlyL_C. 1 hit.
    PF05259. Herpes_UL1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1."
      Perry L.J., McGeoch D.J.
      J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    4. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    5. "Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras."
      Cairns T.M., Milne R.S., Ponce-de-Leon M., Tobin D.K., Cohen G.H., Eisenberg R.J.
      J. Virol. 77:6731-6742(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GH.
    6. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    7. "Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain."
      Gianni T., Amasio M., Campadelli-Fiume G.
      J. Biol. Chem. 284:17370-17382(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: F.
    8. "Insertional mutations in herpes simplex virus 1 gL identify functional domains for association with gH and for membrane fusion."
      Fan Q., Lin E., Spear P.G.
      J. Virol. 83:11607-11615(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GH, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGL_HHV11
    AccessioniPrimary (citable) accession number: P10185
    Secondary accession number(s): Q09ID2, Q76WT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3