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Protein

Envelope glycoprotein L

Gene

gL

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.UniRule annotation2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBi1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein LUniRule annotation
Short name:
gLUniRule annotation
Gene namesi
Name:gLUniRule annotation
ORF Names:UL1
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • Host cell membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • Host Golgi apparatushost trans-Golgi network UniRule annotation

  • Note: gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_000003826420 – 224Envelope glycoprotein LUniRule annotationAdd BLAST205

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP10185.

Interactioni

Subunit structurei

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi971430. 1 interactor.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 161Interaction with gHUniRule annotationAdd BLAST142

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi215 – 218Poly-Arg4

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein L family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK19435.

Family and domain databases

HAMAPiMF_04034. HSV_GL_alphagamma. 1 hit.
InterProiIPR022200. Herpes_gL_C.
IPR007923. Herpes_gL_N.
[Graphical view]
PfamiPF12524. GlyL_C. 1 hit.
PF05259. Herpes_UL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILGWVGLI AVGVLCVRGG LPSTEYVIRS RVAREVGDIL KVPCVPLPSD
60 70 80 90 100
DLDWRYETPS AINYALIDGI FLRYHCPGLD TVLWDRHAQK AYWVNPFLFV
110 120 130 140 150
AGFLEDLSYP AFPANTQETE TRLALYKEIR QALDSRKQAA SHTPVKAGCV
160 170 180 190 200
NFDYSRTRRC VGRQDLGPTN GTSGRTPVLP PDDEAGLQPK PLTTPPPIIA
210 220
TSDPTPRRDA ATKSRRRRPH SRRL
Length:224
Mass (Da):24,934
Last modified:July 1, 1989 - v1
Checksum:iCED51D2FC1D7777F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti90K → R in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti100V → G in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti109Y → H in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti115N → D in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti168P → L in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti171G → R in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti181P → S in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti196P → S in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti224L → I in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32337.1.
D00373 Genomic DNA. Translation: BAA00272.1.
DQ889502 Genomic DNA. Translation: ABI63463.1.
FJ593289 Genomic DNA. Translation: ACM62223.1.
PIRiA28133. WMBEX1.
RefSeqiYP_009137075.1. NC_001806.2.

Genome annotation databases

GeneIDi2703393.
KEGGivg:2703393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32337.1.
D00373 Genomic DNA. Translation: BAA00272.1.
DQ889502 Genomic DNA. Translation: ABI63463.1.
FJ593289 Genomic DNA. Translation: ACM62223.1.
PIRiA28133. WMBEX1.
RefSeqiYP_009137075.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971430. 1 interactor.

Chemistry databases

ChEMBLiCHEMBL2364696.

Protein family/group databases

TCDBi1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

Proteomic databases

PRIDEiP10185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703393.
KEGGivg:2703393.

Phylogenomic databases

KOiK19435.

Miscellaneous databases

PROiP10185.

Family and domain databases

HAMAPiMF_04034. HSV_GL_alphagamma. 1 hit.
InterProiIPR022200. Herpes_gL_C.
IPR007923. Herpes_gL_N.
[Graphical view]
PfamiPF12524. GlyL_C. 1 hit.
PF05259. Herpes_UL1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGL_HHV11
AccessioniPrimary (citable) accession number: P10185
Secondary accession number(s): Q09ID2, Q76WT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.