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P10185

- GL_HHV11

UniProt

P10185 - GL_HHV11

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Protein

Envelope glycoprotein L

Gene

gL

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.1 Publication

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Keywords - Ligandi

Sialic acid

Protein family/group databases

TCDBi1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein L
Short name:
gL
Gene namesi
Name:gL
ORF Names:UL1
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane By similarity; Peripheral membrane protein By similarity; Extracellular side By similarity
Note: gL is not anchored to the viral envelope, but associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) (By similarity). A fraction of gL has also been found associated to the cell surface in the absence of gH, suggesting incomplete cleavage of the signal peptide or presence of a cell surface receptor for secreted gL.By similarity

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 224205Envelope glycoprotein LPRO_0000038264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...); by hostCurated

Post-translational modificationi

N-glycosylated, O-glycosylated, and sialylated.By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. Associates with the gB-gH/gL-gD complex (By similarity).By similarity

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 161142Interaction with gLAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi215 – 2184Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR022200. Herpes_gL_C.
IPR007923. Herpes_gL_N.
[Graphical view]
PfamiPF12524. GlyL_C. 1 hit.
PF05259. Herpes_UL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10185-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGILGWVGLI AVGVLCVRGG LPSTEYVIRS RVAREVGDIL KVPCVPLPSD
60 70 80 90 100
DLDWRYETPS AINYALIDGI FLRYHCPGLD TVLWDRHAQK AYWVNPFLFV
110 120 130 140 150
AGFLEDLSYP AFPANTQETE TRLALYKEIR QALDSRKQAA SHTPVKAGCV
160 170 180 190 200
NFDYSRTRRC VGRQDLGPTN GTSGRTPVLP PDDEAGLQPK PLTTPPPIIA
210 220
TSDPTPRRDA ATKSRRRRPH SRRL
Length:224
Mass (Da):24,934
Last modified:July 1, 1989 - v1
Checksum:iCED51D2FC1D7777F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901K → R in strain: Nonneuroinvasive mutant HF10.
Natural varianti100 – 1001V → G in strain: Nonneuroinvasive mutant HF10.
Natural varianti109 – 1091Y → H in strain: Nonneuroinvasive mutant HF10.
Natural varianti115 – 1151N → D in strain: Nonneuroinvasive mutant HF10.
Natural varianti168 – 1681P → L in strain: Nonneuroinvasive mutant HF10.
Natural varianti171 – 1711G → R in strain: Nonneuroinvasive mutant HF10.
Natural varianti181 – 1811P → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti196 – 1961P → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti224 – 2241L → I in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32337.1.
D00373 Genomic DNA. Translation: BAA00272.1.
DQ889502 Genomic DNA. Translation: ABI63463.1.
FJ593289 Genomic DNA. Translation: ACM62223.1.
PIRiA28133. WMBEX1.
RefSeqiNP_044602.1. NC_001806.1.

Genome annotation databases

GeneIDi2703393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32337.1 .
D00373 Genomic DNA. Translation: BAA00272.1 .
DQ889502 Genomic DNA. Translation: ABI63463.1 .
FJ593289 Genomic DNA. Translation: ACM62223.1 .
PIRi A28133. WMBEX1.
RefSeqi NP_044602.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2364696.

Protein family/group databases

TCDBi 1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703393.

Family and domain databases

InterProi IPR022200. Herpes_gL_C.
IPR007923. Herpes_gL_N.
[Graphical view ]
Pfami PF12524. GlyL_C. 1 hit.
PF05259. Herpes_UL1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1."
    Perry L.J., McGeoch D.J.
    J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. "Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras."
    Cairns T.M., Milne R.S., Ponce-de-Leon M., Tobin D.K., Cohen G.H., Eisenberg R.J.
    J. Virol. 77:6731-6742(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GH.
  6. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  7. "Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain."
    Gianni T., Amasio M., Campadelli-Fiume G.
    J. Biol. Chem. 284:17370-17382(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: F.
  8. "Insertional mutations in herpes simplex virus 1 gL identify functional domains for association with gH and for membrane fusion."
    Fan Q., Lin E., Spear P.G.
    J. Virol. 83:11607-11615(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GH, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGL_HHV11
AccessioniPrimary (citable) accession number: P10185
Secondary accession number(s): Q09ID2, Q76WT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3