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Protein

Ovoinhibitor

Gene

OIH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have at least five active inhibitory domains; two for trypsin, two for chymotrypsin and one for elastase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei47 – 48Reactive bond 1 for trypsinPROSITE-ProRule annotation2
Sitei112 – 113Reactive bond 2 for trypsinPROSITE-ProRule annotation2
Sitei178 – 179Reactive bond 3 for trypsinPROSITE-ProRule annotation2
Sitei244 – 245Reactive bond 4 for trypsinPROSITE-ProRule annotation2
Sitei309 – 310Reactive bond 5 for chymotrypsinPROSITE-ProRule annotation2
Sitei375 – 376Reactive bond 6 for chymotrypsin and elastasePROSITE-ProRule annotation2
Sitei434 – 435Reactive bond 7 for chymotrypsin and elastasePROSITE-ProRule annotation2

GO - Molecular functioni

  • ion channel inhibitor activity Source: AgBase
  • peptidase inhibitor activity Source: AgBase
  • potassium channel inhibitor activity Source: AgBase
  • protease binding Source: AgBase
  • serine-type endopeptidase inhibitor activity Source: AgBase

GO - Biological processi

  • negative regulation of viral genome replication Source: AgBase
  • response to corticosterone Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovoinhibitor
Gene namesi
Name:OIH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: AgBase
  • extracellular space Source: AgBase
  • protein complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10163. Gal d OIH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001657824 – 472OvoinhibitorAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 67
Disulfide bondi45 ↔ 64
Disulfide bondi53 ↔ 85
Disulfide bondi94 ↔ 132
Disulfide bondi110 ↔ 129
Disulfide bondi118 ↔ 150
Disulfide bondi159 ↔ 198
Disulfide bondi176 ↔ 195
Disulfide bondi184 ↔ 216
Disulfide bondi225 ↔ 264
Disulfide bondi242 ↔ 261
Disulfide bondi250 ↔ 282
Disulfide bondi291 ↔ 329
Disulfide bondi307 ↔ 326
Disulfide bondi315 ↔ 347
Disulfide bondi356 ↔ 395
Disulfide bondi373 ↔ 392
Disulfide bondi381 ↔ 413
Disulfide bondi422 ↔ 454
Disulfide bondi432 ↔ 451
Disulfide bondi440 ↔ 472

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP10184.

Expressioni

Tissue specificityi

Egg white and plasma.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P007662EBI-6663991,EBI-6664027From a different organism.

GO - Molecular functioni

  • protease binding Source: AgBase

Protein-protein interaction databases

IntActiP10184. 1 interactor.
STRINGi9031.ENSGALP00000033955.

Structurei

3D structure databases

ProteinModelPortaliP10184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 87Kazal-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini88 – 152Kazal-like 2PROSITE-ProRule annotationAdd BLAST65
Domaini153 – 218Kazal-like 3PROSITE-ProRule annotationAdd BLAST66
Domaini219 – 284Kazal-like 4PROSITE-ProRule annotationAdd BLAST66
Domaini285 – 349Kazal-like 5PROSITE-ProRule annotationAdd BLAST65
Domaini350 – 415Kazal-like 6PROSITE-ProRule annotationAdd BLAST66
Domaini416 – 472Kazal-like 7PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Contains 7 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0D. Eukaryota.
ENOG4111TR7. LUCA.
HOGENOMiHOG000208095.
InParanoidiP10184.
PhylomeDBiP10184.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 7 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 7 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 7 hits.
PS51465. KAZAL_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTARQFVQV ALALCCFADI AFGIEVNCSL YASGIGKDGT SWVACPRNLK
60 70 80 90 100
PVCGTDGSTY SNECGICLYN REHGANVEKE YDGECRPKHV MIDCSPYLQV
110 120 130 140 150
VRDGNTMVAC PRILKPVCGS DSFTYDNECG ICAYNAEHHT NISKLHDGEC
160 170 180 190 200
KLEIGSVDCS KYPSTVSKDG RTLVACPRIL SPVCGTDGFT YDNECGICAH
210 220 230 240 250
NAEQRTHVSK KHDGKCRQEI PEIDCDQYPT RKTTGGKLLV RCPRILLPVC
260 270 280 290 300
GTDGFTYDNE CGICAHNAQH GTEVKKSHDG RCKERSTPLD CTQYLSNTQN
310 320 330 340 350
GEAITACPFI LQEVCGTDGV TYSNDCSLCA HNIELGTSVA KKHDGRCREE
360 370 380 390 400
VPELDCSKYK TSTLKDGRQV VACTMIYDPV CATNGVTYAS ECTLCAHNLE
410 420 430 440 450
QRTNLGKRKN GRCEEDITKE HCREFQKVSP ICTMEYVPHC GSDGVTYSNR
460 470
CFFCNAYVQS NRTLNLVSMA AC
Length:472
Mass (Da):51,920
Last modified:October 1, 1996 - v2
Checksum:iA30211B297B800E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333Missing AA sequence (PubMed:3571241).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16141
, M15962, M16127, M16128, M16129, M16130, M16131, M16132, M16133, M16134, M16135, M16136, M16137, M16138, M16139, M16140 Genomic DNA. Translation: AAA48994.1.
PIRiA26730.
UniGeneiGga.8729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16141
, M15962, M16127, M16128, M16129, M16130, M16131, M16132, M16133, M16134, M16135, M16136, M16137, M16138, M16139, M16140 Genomic DNA. Translation: AAA48994.1.
PIRiA26730.
UniGeneiGga.8729.

3D structure databases

ProteinModelPortaliP10184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10184. 1 interactor.
STRINGi9031.ENSGALP00000033955.

Protein family/group databases

Allergomei10163. Gal d OIH.
MEROPSiI01.007.

Proteomic databases

PaxDbiP10184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IP0D. Eukaryota.
ENOG4111TR7. LUCA.
HOGENOMiHOG000208095.
InParanoidiP10184.
PhylomeDBiP10184.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 7 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 7 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 7 hits.
PS51465. KAZAL_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIOV7_CHICK
AccessioniPrimary (citable) accession number: P10184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.