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P10184 (IOV7_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ovoinhibitor
Gene names
Name:OIH
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have at least five active inhibitory domains; two for trypsin, two for chymotrypsin and one for elastase.

Subcellular location

Secreted.

Tissue specificity

Egg white and plasma.

Sequence similarities

Contains 7 Kazal-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 472449Ovoinhibitor
PRO_0000016578

Regions

Domain24 – 8764Kazal-like 1
Domain88 – 15265Kazal-like 2
Domain153 – 21866Kazal-like 3
Domain219 – 28466Kazal-like 4
Domain285 – 34965Kazal-like 5
Domain350 – 41566Kazal-like 6
Domain416 – 47257Kazal-like 7

Sites

Site47 – 482Reactive bond 1 for trypsin Potential
Site112 – 1132Reactive bond 2 for trypsin Potential
Site178 – 1792Reactive bond 3 for trypsin Potential
Site244 – 2452Reactive bond 4 for trypsin Potential
Site309 – 3102Reactive bond 5 for chymotrypsin Potential
Site375 – 3762Reactive bond 6 for chymotrypsin and elastase Potential
Site434 – 4352Reactive bond 7 for chymotrypsin and elastase Potential

Amino acid modifications

Disulfide bond28 ↔ 67
Disulfide bond45 ↔ 64
Disulfide bond53 ↔ 85
Disulfide bond94 ↔ 132
Disulfide bond110 ↔ 129
Disulfide bond118 ↔ 150
Disulfide bond159 ↔ 198
Disulfide bond176 ↔ 195
Disulfide bond184 ↔ 216
Disulfide bond225 ↔ 264
Disulfide bond242 ↔ 261
Disulfide bond250 ↔ 282
Disulfide bond291 ↔ 329
Disulfide bond307 ↔ 326
Disulfide bond315 ↔ 347
Disulfide bond356 ↔ 395
Disulfide bond373 ↔ 392
Disulfide bond381 ↔ 413
Disulfide bond422 ↔ 454
Disulfide bond432 ↔ 451
Disulfide bond440 ↔ 472

Experimental info

Sequence conflict3331Missing AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P10184 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: A30211B297B800E5

FASTA47251,920
        10         20         30         40         50         60 
MRTARQFVQV ALALCCFADI AFGIEVNCSL YASGIGKDGT SWVACPRNLK PVCGTDGSTY 

        70         80         90        100        110        120 
SNECGICLYN REHGANVEKE YDGECRPKHV MIDCSPYLQV VRDGNTMVAC PRILKPVCGS 

       130        140        150        160        170        180 
DSFTYDNECG ICAYNAEHHT NISKLHDGEC KLEIGSVDCS KYPSTVSKDG RTLVACPRIL 

       190        200        210        220        230        240 
SPVCGTDGFT YDNECGICAH NAEQRTHVSK KHDGKCRQEI PEIDCDQYPT RKTTGGKLLV 

       250        260        270        280        290        300 
RCPRILLPVC GTDGFTYDNE CGICAHNAQH GTEVKKSHDG RCKERSTPLD CTQYLSNTQN 

       310        320        330        340        350        360 
GEAITACPFI LQEVCGTDGV TYSNDCSLCA HNIELGTSVA KKHDGRCREE VPELDCSKYK 

       370        380        390        400        410        420 
TSTLKDGRQV VACTMIYDPV CATNGVTYAS ECTLCAHNLE QRTNLGKRKN GRCEEDITKE 

       430        440        450        460        470 
HCREFQKVSP ICTMEYVPHC GSDGVTYSNR CFFCNAYVQS NRTLNLVSMA AC

« Hide

References

[1]"Ovoinhibitor introns specify functional domains as in the related and linked ovomucoid gene."
Scott M.J., Huckaby C.S., Kato I., Kohr W.J., Laskowski M. Jr., Tsai M.-J., O'Malley B.W.
J. Biol. Chem. 262:5899-5907(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-472.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M16141 expand/collapse EMBL AC list , M15962, M16127, M16128, M16129, M16130, M16131, M16132, M16133, M16134, M16135, M16136, M16137, M16138, M16139, M16140 Genomic DNA. Translation: AAA48994.1.
IPIIPI00587313.
PIRA26730.
RefSeqNP_001025783.1. NM_001030612.1.
UniGeneGga.8729.

3D structure databases

ProteinModelPortalP10184.
SMRP10184. Positions 157-216, 242-280.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000033955.

Protein family/group databases

Allergome10163. Gal d OIH.
MEROPSI01.004.

Proteomic databases

PaxDbP10184.
PRIDEP10184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID416235.
KEGGgga:416235.

Organism-specific databases

CTD11005.

Phylogenomic databases

eggNOGNOG275797.
HOGENOMHOG000208095.
InParanoidP10184.
OrthoDBEOG4V4371.

Family and domain databases

InterProIPR002350. Kazal_dom.
[Graphical view]
PfamPF00050. Kazal_1. 6 hits.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 7 hits.
[Graphical view]
PROSITEPS00282. KAZAL_1. 7 hits.
PS51465. KAZAL_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20819724.

Entry information

Entry nameIOV7_CHICK
AccessionPrimary (citable) accession number: P10184
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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