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P10180

- CUT_DROME

UniProt

P10180 - CUT_DROME

Protein

Homeobox protein cut

Gene

ct

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi877 – 96488CUT 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1330 – 141788CUT 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1608 – 169588CUT 3PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1745 – 180460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: FlyBase
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. transcription regulatory region sequence-specific DNA binding Source: FlyBase

    GO - Biological processi

    1. antennal development Source: FlyBase
    2. antennal joint development Source: FlyBase
    3. central nervous system development Source: FlyBase
    4. dendrite guidance Source: FlyBase
    5. dendrite morphogenesis Source: FlyBase
    6. female gonad development Source: FlyBase
    7. formation of a compartment boundary Source: FlyBase
    8. imaginal disc-derived wing margin morphogenesis Source: FlyBase
    9. Malpighian tubule bud morphogenesis Source: FlyBase
    10. Malpighian tubule morphogenesis Source: FlyBase
    11. mitotic cell cycle Source: FlyBase
    12. negative regulation of Notch signaling pathway Source: FlyBase
    13. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
    14. oogenesis Source: FlyBase
    15. open tracheal system development Source: FlyBase
    16. ovarian follicle cell development Source: FlyBase
    17. ovarian follicle cell stalk formation Source: FlyBase
    18. peripheral nervous system development Source: FlyBase
    19. regulation of transcription, DNA-templated Source: FlyBase
    20. sensory perception of sound Source: FlyBase
    21. spiracle morphogenesis, open tracheal system Source: FlyBase
    22. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein cut
    Gene namesi
    Name:ct
    ORF Names:CG11387
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0004198. ct.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21752175Homeobox protein cutPRO_0000202390Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1940 – 19401Phosphoserine1 Publication
    Modified residuei1944 – 19441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP10180.
    PRIDEiP10180.

    Expressioni

    Tissue specificityi

    Detected in many cells in the central nervous system, all external sensory organs, some peripheral neurons, and in the non-neural cells of the spiracles and the Malpighian tubules.

    Developmental stagei

    Cell-specific pattern of expression. Broadly expressed during embryonic development.

    Gene expression databases

    BgeeiP10180.

    Interactioni

    Protein-protein interaction databases

    BioGridi69119. 23 interactions.
    DIPiDIP-19788N.
    IntActiP10180. 1 interaction.
    MINTiMINT-941430.

    Structurei

    3D structure databases

    ProteinModelPortaliP10180.
    SMRiP10180. Positions 856-968, 1330-1448, 1613-1797.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili265 – 34379Sequence AnalysisAdd
    BLAST
    Coiled coili433 – 49967Sequence AnalysisAdd
    BLAST
    Coiled coili1056 – 1161106Sequence AnalysisAdd
    BLAST
    Coiled coili1463 – 152260Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi194 – 21017Ala/Gln-richAdd
    BLAST
    Compositional biasi235 – 2439Ala-rich
    Compositional biasi271 – 29323Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi384 – 42845Asn-richAdd
    BLAST
    Compositional biasi547 – 5548Asp/Glu-rich (acidic)
    Compositional biasi574 – 58411Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi616 – 63015Ala-richAdd
    BLAST
    Compositional biasi665 – 69935Gln/His-rich (OPA repeat)Add
    BLAST
    Compositional biasi2004 – 201411Ala-richAdd
    BLAST
    Compositional biasi2071 – 20777Asp/Glu-rich (acidic)
    Compositional biasi2124 – 213613Ala/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG306581.
    GeneTreeiENSGT00530000063019.
    InParanoidiP10180.
    KOiK09313.
    OrthoDBiEOG7QNVKN.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProiIPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEiPS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10180-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPTLPQAAG TADMDLTAVQ SINDWFFKKE QIYLLAQFWQ QRATLAEKEV     50
    NTLKEQLSTG NPDSNLNSEN SDTAAAAATA AAVAAVVAGA TATNDIEDEQ 100
    QQQLQQTASG GILESDSDKL LNSSIVAAAI TLQQQNGSNL LANTNTPSPS 150
    PPLLSAEQQQ QLQSSLQQSG GVGGACLNPK LFFNHAQQMM MMEAAAAAAA 200
    AALQQQQQQQ SPLHSPANEV AIPTEQPAAT VATGAAAAAA AAATPIATGN 250
    VKSGSTTSNA NHTNSNNSHQ DEEELDDEEE DEEEDEDEDD EEENASMQSN 300
    ADDMELDAQQ ETRTEPSATT QQQHQQQDTE DLEENKDAGE ASLNVSNNHN 350
    TTDSNNSCSR KNNNGGNESE QHVASSAEDD DCANNNTNTS NNNNTSNTAT 400
    SNTNNNNNNN SSSGNSEKRK KKNNNNNNGQ PAVLLAAKDK EIKALLDELQ 450
    RLRAQEQTHL VQIQRLEEHL EVKRQHIIRL EARLDKQQIN EALAEATALS 500
    AAASTNNNNN SQSSDNNKKL NTAAERPMDA SSNADLPEST KAPVPAEDDE 550
    EDEDQAMLVD SEEAEDKPED SHHDDDEDED EDREAVNATT TDSNELKIKK 600
    EQHSPLDLNV LSPNSAIAAA AAAAAAAACA NDPNKFQALL IERTKALAAE 650
    ALKNGASDAL SEDAHHQQQQ HHQQQHQHQQ QHHQQQHLHQ QHHHHLQQQP 700
    NSGSNSNPAS NDHHHGHHLH GHGLLHPSSA HHLHHQTTES NSNSSTPTAA 750
    GNNNGSNNSS SNTNANSTAQ LAASLASTLN GTKSLMQEDS NGLAAVAMAA 800
    HAQHAAALGP GFLPGLPAFQ FAAAQVAAGG DGRGHYRFAD SELQLPPGAS 850
    MAGRLGESLI PKGDPMEAKL QEMLRYNMDK YANQALDTLH ISRRVRELLS 900
    VHNIGQRLFA KYILGLSQGT VSELLSKPKP WDKLTEKGRD SYRKMHAWAC 950
    DDNAVMLLKS LIPKKDSGLP QYAGRGAGGA GGDDSMSEDR IAHILSEASS 1000
    LMKQSSVAQH REQERRSHGG EDSHSNEDSK SPPQSCTSPF FKVENQLKQH 1050
    QHLNPEQAAA QQREREREQR EREQQQRLRH DDQDKMARLY QELIARTPRE 1100
    TAFPSFLFSP SLFGGAAGMP GAASNAFPAM ADENMRHVFE REIAKLQQHQ 1150
    QQQQAAQAQA QFPNFSSLMA LQQQVLNGAQ DLSLAAAAAK DIKLNGQRSS 1200
    LEHSAGSSSC SKDGERDDAY PSSLHGRKSE GGGTPAPPAP PSGPGTGAGA 1250
    PPTAAPPTGG ASSNSAAPSP LSNSILPPAL SSQGEEFAAT ASPLQRMASI 1300
    TNSLITQPPV TPHHSTPQRP TKAVLPPITQ QQFDMFNNLN TEDIVRRVKE 1350
    ALSQYSISQR LFGESVLGLS QGSVSDLLAR PKPWHMLTQK GREPFIRMKM 1400
    FLEDENAVHK LVASQYKIAP EKLMRTGSYS GSPQMPQGLA SKMQAASLPM 1450
    QKMMSELKLQ EPAQAQHLMQ QMQAAAMSAA MQQQQVAQAQ QQAQQAQQAQ 1500
    QHLQQQAQQH LQQQQHLAQQ QHPHQQHHQA AAAAAALHHQ SMLLTSPGLP 1550
    PQHAISLPPS AGGAQPGGPG GNQGSSNPSN SEKKPMLMPV HGTNAMRSLH 1600
    QHMSPTVYEM AALTQDLDTH DITTKIKEAL LANNIGQKIF GEAVLGLSQG 1650
    SVSELLSKPK PWHMLSIKGR EPFIRMQLWL SDANNVERLQ LLKNERREAS 1700
    KRRRSTGPNQ QDNSSDTSSN DTNDFYTSSP GPGSVGSGVG GAPPSKKQRV 1750
    LFSEEQKEAL RLAFALDPYP NVGTIEFLAN ELGLATRTIT NWFHNHRMRL 1800
    KQQVPHGPAG QDNPIPSRES TSATPFDPVQ FRILLQQRLL ELHKERMGMS 1850
    GAPIPYPPYF AAAAILGRSL AGIPGAAAAA GAAAAAAAVG ASGGDELQAL 1900
    NQAFKEQMSG LDLSMPTLKR ERSDDYQDDL ELEGGGHNLS DNESLEGQEP 1950
    EDKTTDYEKV LHKSALAAAA AYMSNAVRSS RRKPAAPQWV NPAGAVTNPS 2000
    AVVAAVAAAA AAAADNERII NGVCVMQASE YGRDDTDSNK PTDGGNDSDH 2050
    EHAQLEIDQR FMEPEVHIKQ EEDDDEEQSG SVNLDNEDNA TSEQKLKVIN 2100
    EEKLRMVRVR RLSSTGGGSS EEMPAPLAPP PPPPAASSSI VSGESTTSSS 2150
    SSSNTSSSTP AVTTAAATAA AGWNY 2175
    Length:2,175
    Mass (Da):233,629
    Last modified:July 1, 1989 - v1
    Checksum:i08BF80C4861BD0AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07985 mRNA. Translation: CAA30794.1.
    AE014298 Genomic DNA. Translation: AAF46264.2.
    PIRiS03170.
    RefSeqiNP_524764.1. NM_080025.2.
    UniGeneiDm.1827.

    Genome annotation databases

    EnsemblMetazoaiFBtr0071068; FBpp0071026; FBgn0004198.
    GeneIDi44540.
    KEGGidme:Dmel_CG11387.
    UCSCiCG11387-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07985 mRNA. Translation: CAA30794.1 .
    AE014298 Genomic DNA. Translation: AAF46264.2 .
    PIRi S03170.
    RefSeqi NP_524764.1. NM_080025.2.
    UniGenei Dm.1827.

    3D structure databases

    ProteinModelPortali P10180.
    SMRi P10180. Positions 856-968, 1330-1448, 1613-1797.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 69119. 23 interactions.
    DIPi DIP-19788N.
    IntActi P10180. 1 interaction.
    MINTi MINT-941430.

    Proteomic databases

    PaxDbi P10180.
    PRIDEi P10180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0071068 ; FBpp0071026 ; FBgn0004198 .
    GeneIDi 44540.
    KEGGi dme:Dmel_CG11387.
    UCSCi CG11387-RA. d. melanogaster.

    Organism-specific databases

    CTDi 44540.
    FlyBasei FBgn0004198. ct.

    Phylogenomic databases

    eggNOGi NOG306581.
    GeneTreei ENSGT00530000063019.
    InParanoidi P10180.
    KOi K09313.
    OrthoDBi EOG7QNVKN.

    Miscellaneous databases

    ChiTaRSi PCYT1A. drosophila.
    GenomeRNAii 44540.
    NextBioi 837385.

    Gene expression databases

    Bgeei P10180.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProi IPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEi PS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila."
      Blochlinger K., Bodmer R., Jack J., Jan L.Y., Jan Y.N.
      Nature 333:629-635(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940 AND SER-1944, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiCUT_DROME
    AccessioniPrimary (citable) accession number: P10180
    Secondary accession number(s): Q9W3Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 151 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Miscellaneous

    Asn-1791 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3