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P10180

- CUT_DROME

UniProt

P10180 - CUT_DROME

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Protein

Homeobox protein cut

Gene

ct

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi877 – 96488CUT 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1330 – 141788CUT 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1608 – 169588CUT 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1745 – 180460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: FlyBase
  2. transcription regulatory region sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  1. antennal development Source: FlyBase
  2. antennal joint development Source: FlyBase
  3. central nervous system development Source: FlyBase
  4. dendrite guidance Source: FlyBase
  5. dendrite morphogenesis Source: FlyBase
  6. female gonad development Source: FlyBase
  7. formation of a compartment boundary Source: FlyBase
  8. imaginal disc-derived wing margin morphogenesis Source: FlyBase
  9. Malpighian tubule bud morphogenesis Source: FlyBase
  10. Malpighian tubule morphogenesis Source: FlyBase
  11. mitotic cell cycle Source: FlyBase
  12. negative regulation of Notch signaling pathway Source: FlyBase
  13. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  14. oogenesis Source: FlyBase
  15. open tracheal system development Source: FlyBase
  16. ovarian follicle cell development Source: FlyBase
  17. ovarian follicle cell stalk formation Source: FlyBase
  18. peripheral nervous system development Source: FlyBase
  19. regulation of transcription, DNA-templated Source: FlyBase
  20. sensory perception of sound Source: FlyBase
  21. spiracle morphogenesis, open tracheal system Source: FlyBase
  22. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut
Gene namesi
Name:ct
ORF Names:CG11387
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004198. ct.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21752175Homeobox protein cutPRO_0000202390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1940 – 19401Phosphoserine1 Publication
Modified residuei1944 – 19441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10180.
PRIDEiP10180.

Expressioni

Tissue specificityi

Detected in many cells in the central nervous system, all external sensory organs, some peripheral neurons, and in the non-neural cells of the spiracles and the Malpighian tubules.

Developmental stagei

Cell-specific pattern of expression. Broadly expressed during embryonic development.

Gene expression databases

BgeeiP10180.
ExpressionAtlasiP10180. differential.

Interactioni

Protein-protein interaction databases

BioGridi69119. 23 interactions.
DIPiDIP-19788N.
IntActiP10180. 1 interaction.
MINTiMINT-941430.

Structurei

3D structure databases

ProteinModelPortaliP10180.
SMRiP10180. Positions 886-968, 1330-1448, 1613-1797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili265 – 34379Sequence AnalysisAdd
BLAST
Coiled coili433 – 49967Sequence AnalysisAdd
BLAST
Coiled coili1056 – 1161106Sequence AnalysisAdd
BLAST
Coiled coili1463 – 152260Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi194 – 21017Ala/Gln-richAdd
BLAST
Compositional biasi235 – 2439Ala-rich
Compositional biasi271 – 29323Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi384 – 42845Asn-richAdd
BLAST
Compositional biasi547 – 5548Asp/Glu-rich (acidic)
Compositional biasi574 – 58411Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi616 – 63015Ala-richAdd
BLAST
Compositional biasi665 – 69935Gln/His-rich (OPA repeat)Add
BLAST
Compositional biasi2004 – 201411Ala-richAdd
BLAST
Compositional biasi2071 – 20777Asp/Glu-rich (acidic)
Compositional biasi2124 – 213613Ala/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG306581.
GeneTreeiENSGT00530000063019.
InParanoidiP10180.
KOiK09313.
OrthoDBiEOG7QNVKN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10180-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPTLPQAAG TADMDLTAVQ SINDWFFKKE QIYLLAQFWQ QRATLAEKEV
60 70 80 90 100
NTLKEQLSTG NPDSNLNSEN SDTAAAAATA AAVAAVVAGA TATNDIEDEQ
110 120 130 140 150
QQQLQQTASG GILESDSDKL LNSSIVAAAI TLQQQNGSNL LANTNTPSPS
160 170 180 190 200
PPLLSAEQQQ QLQSSLQQSG GVGGACLNPK LFFNHAQQMM MMEAAAAAAA
210 220 230 240 250
AALQQQQQQQ SPLHSPANEV AIPTEQPAAT VATGAAAAAA AAATPIATGN
260 270 280 290 300
VKSGSTTSNA NHTNSNNSHQ DEEELDDEEE DEEEDEDEDD EEENASMQSN
310 320 330 340 350
ADDMELDAQQ ETRTEPSATT QQQHQQQDTE DLEENKDAGE ASLNVSNNHN
360 370 380 390 400
TTDSNNSCSR KNNNGGNESE QHVASSAEDD DCANNNTNTS NNNNTSNTAT
410 420 430 440 450
SNTNNNNNNN SSSGNSEKRK KKNNNNNNGQ PAVLLAAKDK EIKALLDELQ
460 470 480 490 500
RLRAQEQTHL VQIQRLEEHL EVKRQHIIRL EARLDKQQIN EALAEATALS
510 520 530 540 550
AAASTNNNNN SQSSDNNKKL NTAAERPMDA SSNADLPEST KAPVPAEDDE
560 570 580 590 600
EDEDQAMLVD SEEAEDKPED SHHDDDEDED EDREAVNATT TDSNELKIKK
610 620 630 640 650
EQHSPLDLNV LSPNSAIAAA AAAAAAAACA NDPNKFQALL IERTKALAAE
660 670 680 690 700
ALKNGASDAL SEDAHHQQQQ HHQQQHQHQQ QHHQQQHLHQ QHHHHLQQQP
710 720 730 740 750
NSGSNSNPAS NDHHHGHHLH GHGLLHPSSA HHLHHQTTES NSNSSTPTAA
760 770 780 790 800
GNNNGSNNSS SNTNANSTAQ LAASLASTLN GTKSLMQEDS NGLAAVAMAA
810 820 830 840 850
HAQHAAALGP GFLPGLPAFQ FAAAQVAAGG DGRGHYRFAD SELQLPPGAS
860 870 880 890 900
MAGRLGESLI PKGDPMEAKL QEMLRYNMDK YANQALDTLH ISRRVRELLS
910 920 930 940 950
VHNIGQRLFA KYILGLSQGT VSELLSKPKP WDKLTEKGRD SYRKMHAWAC
960 970 980 990 1000
DDNAVMLLKS LIPKKDSGLP QYAGRGAGGA GGDDSMSEDR IAHILSEASS
1010 1020 1030 1040 1050
LMKQSSVAQH REQERRSHGG EDSHSNEDSK SPPQSCTSPF FKVENQLKQH
1060 1070 1080 1090 1100
QHLNPEQAAA QQREREREQR EREQQQRLRH DDQDKMARLY QELIARTPRE
1110 1120 1130 1140 1150
TAFPSFLFSP SLFGGAAGMP GAASNAFPAM ADENMRHVFE REIAKLQQHQ
1160 1170 1180 1190 1200
QQQQAAQAQA QFPNFSSLMA LQQQVLNGAQ DLSLAAAAAK DIKLNGQRSS
1210 1220 1230 1240 1250
LEHSAGSSSC SKDGERDDAY PSSLHGRKSE GGGTPAPPAP PSGPGTGAGA
1260 1270 1280 1290 1300
PPTAAPPTGG ASSNSAAPSP LSNSILPPAL SSQGEEFAAT ASPLQRMASI
1310 1320 1330 1340 1350
TNSLITQPPV TPHHSTPQRP TKAVLPPITQ QQFDMFNNLN TEDIVRRVKE
1360 1370 1380 1390 1400
ALSQYSISQR LFGESVLGLS QGSVSDLLAR PKPWHMLTQK GREPFIRMKM
1410 1420 1430 1440 1450
FLEDENAVHK LVASQYKIAP EKLMRTGSYS GSPQMPQGLA SKMQAASLPM
1460 1470 1480 1490 1500
QKMMSELKLQ EPAQAQHLMQ QMQAAAMSAA MQQQQVAQAQ QQAQQAQQAQ
1510 1520 1530 1540 1550
QHLQQQAQQH LQQQQHLAQQ QHPHQQHHQA AAAAAALHHQ SMLLTSPGLP
1560 1570 1580 1590 1600
PQHAISLPPS AGGAQPGGPG GNQGSSNPSN SEKKPMLMPV HGTNAMRSLH
1610 1620 1630 1640 1650
QHMSPTVYEM AALTQDLDTH DITTKIKEAL LANNIGQKIF GEAVLGLSQG
1660 1670 1680 1690 1700
SVSELLSKPK PWHMLSIKGR EPFIRMQLWL SDANNVERLQ LLKNERREAS
1710 1720 1730 1740 1750
KRRRSTGPNQ QDNSSDTSSN DTNDFYTSSP GPGSVGSGVG GAPPSKKQRV
1760 1770 1780 1790 1800
LFSEEQKEAL RLAFALDPYP NVGTIEFLAN ELGLATRTIT NWFHNHRMRL
1810 1820 1830 1840 1850
KQQVPHGPAG QDNPIPSRES TSATPFDPVQ FRILLQQRLL ELHKERMGMS
1860 1870 1880 1890 1900
GAPIPYPPYF AAAAILGRSL AGIPGAAAAA GAAAAAAAVG ASGGDELQAL
1910 1920 1930 1940 1950
NQAFKEQMSG LDLSMPTLKR ERSDDYQDDL ELEGGGHNLS DNESLEGQEP
1960 1970 1980 1990 2000
EDKTTDYEKV LHKSALAAAA AYMSNAVRSS RRKPAAPQWV NPAGAVTNPS
2010 2020 2030 2040 2050
AVVAAVAAAA AAAADNERII NGVCVMQASE YGRDDTDSNK PTDGGNDSDH
2060 2070 2080 2090 2100
EHAQLEIDQR FMEPEVHIKQ EEDDDEEQSG SVNLDNEDNA TSEQKLKVIN
2110 2120 2130 2140 2150
EEKLRMVRVR RLSSTGGGSS EEMPAPLAPP PPPPAASSSI VSGESTTSSS
2160 2170
SSSNTSSSTP AVTTAAATAA AGWNY
Length:2,175
Mass (Da):233,629
Last modified:July 1, 1989 - v1
Checksum:i08BF80C4861BD0AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07985 mRNA. Translation: CAA30794.1.
AE014298 Genomic DNA. Translation: AAF46264.2.
PIRiS03170.
RefSeqiNP_524764.1. NM_080025.2.
UniGeneiDm.1827.

Genome annotation databases

EnsemblMetazoaiFBtr0071068; FBpp0071026; FBgn0004198.
GeneIDi44540.
KEGGidme:Dmel_CG11387.
UCSCiCG11387-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07985 mRNA. Translation: CAA30794.1 .
AE014298 Genomic DNA. Translation: AAF46264.2 .
PIRi S03170.
RefSeqi NP_524764.1. NM_080025.2.
UniGenei Dm.1827.

3D structure databases

ProteinModelPortali P10180.
SMRi P10180. Positions 886-968, 1330-1448, 1613-1797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 69119. 23 interactions.
DIPi DIP-19788N.
IntActi P10180. 1 interaction.
MINTi MINT-941430.

Proteomic databases

PaxDbi P10180.
PRIDEi P10180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071068 ; FBpp0071026 ; FBgn0004198 .
GeneIDi 44540.
KEGGi dme:Dmel_CG11387.
UCSCi CG11387-RA. d. melanogaster.

Organism-specific databases

CTDi 44540.
FlyBasei FBgn0004198. ct.

Phylogenomic databases

eggNOGi NOG306581.
GeneTreei ENSGT00530000063019.
InParanoidi P10180.
KOi K09313.
OrthoDBi EOG7QNVKN.

Miscellaneous databases

ChiTaRSi PCYT1A. drosophila.
GenomeRNAii 44540.
NextBioi 837385.

Gene expression databases

Bgeei P10180.
ExpressionAtlasi P10180. differential.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila."
    Blochlinger K., Bodmer R., Jack J., Jan L.Y., Jan Y.N.
    Nature 333:629-635(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940 AND SER-1944, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiCUT_DROME
AccessioniPrimary (citable) accession number: P10180
Secondary accession number(s): Q9W3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Asn-1791 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3