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P10180

- CUT_DROME

UniProt

P10180 - CUT_DROME

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Protein

Homeobox protein cut

Gene
ct, CG11387
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi877 – 96488CUT 1Add
BLAST
DNA bindingi1330 – 141788CUT 2Add
BLAST
DNA bindingi1608 – 169588CUT 3Add
BLAST
DNA bindingi1745 – 180460HomeoboxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: FlyBase
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. transcription regulatory region sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  1. antennal development Source: FlyBase
  2. antennal joint development Source: FlyBase
  3. central nervous system development Source: FlyBase
  4. dendrite guidance Source: FlyBase
  5. dendrite morphogenesis Source: FlyBase
  6. female gonad development Source: FlyBase
  7. formation of a compartment boundary Source: FlyBase
  8. imaginal disc-derived wing margin morphogenesis Source: FlyBase
  9. Malpighian tubule bud morphogenesis Source: FlyBase
  10. Malpighian tubule morphogenesis Source: FlyBase
  11. mitotic cell cycle Source: FlyBase
  12. negative regulation of Notch signaling pathway Source: FlyBase
  13. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  14. oogenesis Source: FlyBase
  15. open tracheal system development Source: FlyBase
  16. ovarian follicle cell development Source: FlyBase
  17. ovarian follicle cell stalk formation Source: FlyBase
  18. peripheral nervous system development Source: FlyBase
  19. regulation of transcription, DNA-templated Source: FlyBase
  20. sensory perception of sound Source: FlyBase
  21. spiracle morphogenesis, open tracheal system Source: FlyBase
  22. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut
Gene namesi
Name:ct
ORF Names:CG11387
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004198. ct.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21752175Homeobox protein cutPRO_0000202390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1940 – 19401Phosphoserine1 Publication
Modified residuei1944 – 19441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10180.
PRIDEiP10180.

Expressioni

Tissue specificityi

Detected in many cells in the central nervous system, all external sensory organs, some peripheral neurons, and in the non-neural cells of the spiracles and the Malpighian tubules.

Developmental stagei

Cell-specific pattern of expression. Broadly expressed during embryonic development.

Gene expression databases

BgeeiP10180.

Interactioni

Protein-protein interaction databases

BioGridi69119. 23 interactions.
DIPiDIP-19788N.
IntActiP10180. 1 interaction.
MINTiMINT-941430.

Structurei

3D structure databases

ProteinModelPortaliP10180.
SMRiP10180. Positions 856-968, 1330-1448, 1613-1797.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili265 – 34379 Reviewed predictionAdd
BLAST
Coiled coili433 – 49967 Reviewed predictionAdd
BLAST
Coiled coili1056 – 1161106 Reviewed predictionAdd
BLAST
Coiled coili1463 – 152260 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi194 – 21017Ala/Gln-richAdd
BLAST
Compositional biasi235 – 2439Ala-rich
Compositional biasi271 – 29323Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi384 – 42845Asn-richAdd
BLAST
Compositional biasi547 – 5548Asp/Glu-rich (acidic)
Compositional biasi574 – 58411Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi616 – 63015Ala-richAdd
BLAST
Compositional biasi665 – 69935Gln/His-rich (OPA repeat)Add
BLAST
Compositional biasi2004 – 201411Ala-richAdd
BLAST
Compositional biasi2071 – 20777Asp/Glu-rich (acidic)
Compositional biasi2124 – 213613Ala/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG306581.
GeneTreeiENSGT00530000063019.
InParanoidiP10180.
KOiK09313.
OrthoDBiEOG7QNVKN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10180-1 [UniParc]FASTAAdd to Basket

« Hide

MQPTLPQAAG TADMDLTAVQ SINDWFFKKE QIYLLAQFWQ QRATLAEKEV     50
NTLKEQLSTG NPDSNLNSEN SDTAAAAATA AAVAAVVAGA TATNDIEDEQ 100
QQQLQQTASG GILESDSDKL LNSSIVAAAI TLQQQNGSNL LANTNTPSPS 150
PPLLSAEQQQ QLQSSLQQSG GVGGACLNPK LFFNHAQQMM MMEAAAAAAA 200
AALQQQQQQQ SPLHSPANEV AIPTEQPAAT VATGAAAAAA AAATPIATGN 250
VKSGSTTSNA NHTNSNNSHQ DEEELDDEEE DEEEDEDEDD EEENASMQSN 300
ADDMELDAQQ ETRTEPSATT QQQHQQQDTE DLEENKDAGE ASLNVSNNHN 350
TTDSNNSCSR KNNNGGNESE QHVASSAEDD DCANNNTNTS NNNNTSNTAT 400
SNTNNNNNNN SSSGNSEKRK KKNNNNNNGQ PAVLLAAKDK EIKALLDELQ 450
RLRAQEQTHL VQIQRLEEHL EVKRQHIIRL EARLDKQQIN EALAEATALS 500
AAASTNNNNN SQSSDNNKKL NTAAERPMDA SSNADLPEST KAPVPAEDDE 550
EDEDQAMLVD SEEAEDKPED SHHDDDEDED EDREAVNATT TDSNELKIKK 600
EQHSPLDLNV LSPNSAIAAA AAAAAAAACA NDPNKFQALL IERTKALAAE 650
ALKNGASDAL SEDAHHQQQQ HHQQQHQHQQ QHHQQQHLHQ QHHHHLQQQP 700
NSGSNSNPAS NDHHHGHHLH GHGLLHPSSA HHLHHQTTES NSNSSTPTAA 750
GNNNGSNNSS SNTNANSTAQ LAASLASTLN GTKSLMQEDS NGLAAVAMAA 800
HAQHAAALGP GFLPGLPAFQ FAAAQVAAGG DGRGHYRFAD SELQLPPGAS 850
MAGRLGESLI PKGDPMEAKL QEMLRYNMDK YANQALDTLH ISRRVRELLS 900
VHNIGQRLFA KYILGLSQGT VSELLSKPKP WDKLTEKGRD SYRKMHAWAC 950
DDNAVMLLKS LIPKKDSGLP QYAGRGAGGA GGDDSMSEDR IAHILSEASS 1000
LMKQSSVAQH REQERRSHGG EDSHSNEDSK SPPQSCTSPF FKVENQLKQH 1050
QHLNPEQAAA QQREREREQR EREQQQRLRH DDQDKMARLY QELIARTPRE 1100
TAFPSFLFSP SLFGGAAGMP GAASNAFPAM ADENMRHVFE REIAKLQQHQ 1150
QQQQAAQAQA QFPNFSSLMA LQQQVLNGAQ DLSLAAAAAK DIKLNGQRSS 1200
LEHSAGSSSC SKDGERDDAY PSSLHGRKSE GGGTPAPPAP PSGPGTGAGA 1250
PPTAAPPTGG ASSNSAAPSP LSNSILPPAL SSQGEEFAAT ASPLQRMASI 1300
TNSLITQPPV TPHHSTPQRP TKAVLPPITQ QQFDMFNNLN TEDIVRRVKE 1350
ALSQYSISQR LFGESVLGLS QGSVSDLLAR PKPWHMLTQK GREPFIRMKM 1400
FLEDENAVHK LVASQYKIAP EKLMRTGSYS GSPQMPQGLA SKMQAASLPM 1450
QKMMSELKLQ EPAQAQHLMQ QMQAAAMSAA MQQQQVAQAQ QQAQQAQQAQ 1500
QHLQQQAQQH LQQQQHLAQQ QHPHQQHHQA AAAAAALHHQ SMLLTSPGLP 1550
PQHAISLPPS AGGAQPGGPG GNQGSSNPSN SEKKPMLMPV HGTNAMRSLH 1600
QHMSPTVYEM AALTQDLDTH DITTKIKEAL LANNIGQKIF GEAVLGLSQG 1650
SVSELLSKPK PWHMLSIKGR EPFIRMQLWL SDANNVERLQ LLKNERREAS 1700
KRRRSTGPNQ QDNSSDTSSN DTNDFYTSSP GPGSVGSGVG GAPPSKKQRV 1750
LFSEEQKEAL RLAFALDPYP NVGTIEFLAN ELGLATRTIT NWFHNHRMRL 1800
KQQVPHGPAG QDNPIPSRES TSATPFDPVQ FRILLQQRLL ELHKERMGMS 1850
GAPIPYPPYF AAAAILGRSL AGIPGAAAAA GAAAAAAAVG ASGGDELQAL 1900
NQAFKEQMSG LDLSMPTLKR ERSDDYQDDL ELEGGGHNLS DNESLEGQEP 1950
EDKTTDYEKV LHKSALAAAA AYMSNAVRSS RRKPAAPQWV NPAGAVTNPS 2000
AVVAAVAAAA AAAADNERII NGVCVMQASE YGRDDTDSNK PTDGGNDSDH 2050
EHAQLEIDQR FMEPEVHIKQ EEDDDEEQSG SVNLDNEDNA TSEQKLKVIN 2100
EEKLRMVRVR RLSSTGGGSS EEMPAPLAPP PPPPAASSSI VSGESTTSSS 2150
SSSNTSSSTP AVTTAAATAA AGWNY 2175
Length:2,175
Mass (Da):233,629
Last modified:July 1, 1989 - v1
Checksum:i08BF80C4861BD0AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07985 mRNA. Translation: CAA30794.1.
AE014298 Genomic DNA. Translation: AAF46264.2.
PIRiS03170.
RefSeqiNP_524764.1. NM_080025.2.
UniGeneiDm.1827.

Genome annotation databases

EnsemblMetazoaiFBtr0071068; FBpp0071026; FBgn0004198.
GeneIDi44540.
KEGGidme:Dmel_CG11387.
UCSCiCG11387-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07985 mRNA. Translation: CAA30794.1 .
AE014298 Genomic DNA. Translation: AAF46264.2 .
PIRi S03170.
RefSeqi NP_524764.1. NM_080025.2.
UniGenei Dm.1827.

3D structure databases

ProteinModelPortali P10180.
SMRi P10180. Positions 856-968, 1330-1448, 1613-1797.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 69119. 23 interactions.
DIPi DIP-19788N.
IntActi P10180. 1 interaction.
MINTi MINT-941430.

Proteomic databases

PaxDbi P10180.
PRIDEi P10180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071068 ; FBpp0071026 ; FBgn0004198 .
GeneIDi 44540.
KEGGi dme:Dmel_CG11387.
UCSCi CG11387-RA. d. melanogaster.

Organism-specific databases

CTDi 44540.
FlyBasei FBgn0004198. ct.

Phylogenomic databases

eggNOGi NOG306581.
GeneTreei ENSGT00530000063019.
InParanoidi P10180.
KOi K09313.
OrthoDBi EOG7QNVKN.

Miscellaneous databases

ChiTaRSi PCYT1A. drosophila.
GenomeRNAii 44540.
NextBioi 837385.

Gene expression databases

Bgeei P10180.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila."
    Blochlinger K., Bodmer R., Jack J., Jan L.Y., Jan Y.N.
    Nature 333:629-635(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940 AND SER-1944, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiCUT_DROME
AccessioniPrimary (citable) accession number: P10180
Secondary accession number(s): Q9W3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Asn-1791 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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