Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P10180 (CUT_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein cut
Gene names
Name:ct
ORF Names:CG11387
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length2175 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs.

Subcellular location

Nucleus Probable.

Tissue specificity

Detected in many cells in the central nervous system, all external sensory organs, some peripheral neurons, and in the non-neural cells of the spiracles and the Malpighian tubules.

Developmental stage

Cell-specific pattern of expression. Broadly expressed during embryonic development.

Miscellaneous

Asn-1791 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Sequence similarities

Belongs to the CUT homeobox family.

Contains 3 CUT DNA-binding domains.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainCoiled coil
Homeobox
Repeat
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMalpighian tubule bud morphogenesis

Inferred from genetic interaction PubMed 17190812. Source: FlyBase

Malpighian tubule morphogenesis

Traceable author statement PubMed 10512197PubMed 11810238. Source: FlyBase

antennal development

Inferred from mutant phenotype PubMed 18037276. Source: FlyBase

antennal joint development

Inferred from mutant phenotype PubMed 18820445. Source: FlyBase

central nervous system development

Traceable author statement PubMed 11810238. Source: FlyBase

dendrite guidance

Inferred from mutant phenotype PubMed 17276922. Source: FlyBase

dendrite morphogenesis

Inferred from mutant phenotype PubMed 12654247PubMed 15363392PubMed 15363393PubMed 18093520PubMed 23977298. Source: FlyBase

female gonad development

Traceable author statement PubMed 11810238. Source: FlyBase

formation of a compartment boundary

Inferred from mutant phenotype PubMed 21795284. Source: FlyBase

imaginal disc-derived wing margin morphogenesis

Inferred from mutant phenotype PubMed 11810238. Source: FlyBase

mitotic cell cycle

Inferred from mutant phenotype PubMed 16141223. Source: FlyBase

negative regulation of Notch signaling pathway

Inferred from mutant phenotype PubMed 16141223. Source: FlyBase

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 9774673. Source: FlyBase

oogenesis

Inferred from mutant phenotype PubMed 10471713. Source: FlyBase

open tracheal system development

Traceable author statement PubMed 11810238. Source: FlyBase

ovarian follicle cell development

Inferred from mutant phenotype PubMed 16141223. Source: FlyBase

ovarian follicle cell stalk formation

Traceable author statement PubMed 10822261. Source: FlyBase

peripheral nervous system development

Traceable author statement PubMed 11810238PubMed 15018941. Source: FlyBase

regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 18037276. Source: FlyBase

sensory perception of sound

Inferred from mutant phenotype PubMed 18820445. Source: FlyBase

spiracle morphogenesis, open tracheal system

Inferred from mutant phenotype PubMed 10491268. Source: FlyBase

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 1977661PubMed 9774673. Source: FlyBase

   Molecular_functionDNA binding

Traceable author statement PubMed 11810238. Source: FlyBase

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from direct assay PubMed 9774673. Source: FlyBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21752175Homeobox protein cut
PRO_0000202390

Regions

DNA binding877 – 96488CUT 1
DNA binding1330 – 141788CUT 2
DNA binding1608 – 169588CUT 3
DNA binding1745 – 180460Homeobox
Coiled coil265 – 34379 Potential
Coiled coil433 – 49967 Potential
Coiled coil1056 – 1161106 Potential
Coiled coil1463 – 152260 Potential
Compositional bias194 – 21017Ala/Gln-rich
Compositional bias235 – 2439Ala-rich
Compositional bias271 – 29323Asp/Glu-rich (acidic)
Compositional bias384 – 42845Asn-rich
Compositional bias547 – 5548Asp/Glu-rich (acidic)
Compositional bias574 – 58411Asp/Glu-rich (acidic)
Compositional bias616 – 63015Ala-rich
Compositional bias665 – 69935Gln/His-rich (OPA repeat)
Compositional bias2004 – 201411Ala-rich
Compositional bias2071 – 20777Asp/Glu-rich (acidic)
Compositional bias2124 – 213613Ala/Pro-rich

Amino acid modifications

Modified residue19401Phosphoserine Ref.4
Modified residue19441Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P10180 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 08BF80C4861BD0AB

FASTA2,175233,629
        10         20         30         40         50         60 
MQPTLPQAAG TADMDLTAVQ SINDWFFKKE QIYLLAQFWQ QRATLAEKEV NTLKEQLSTG 

        70         80         90        100        110        120 
NPDSNLNSEN SDTAAAAATA AAVAAVVAGA TATNDIEDEQ QQQLQQTASG GILESDSDKL 

       130        140        150        160        170        180 
LNSSIVAAAI TLQQQNGSNL LANTNTPSPS PPLLSAEQQQ QLQSSLQQSG GVGGACLNPK 

       190        200        210        220        230        240 
LFFNHAQQMM MMEAAAAAAA AALQQQQQQQ SPLHSPANEV AIPTEQPAAT VATGAAAAAA 

       250        260        270        280        290        300 
AAATPIATGN VKSGSTTSNA NHTNSNNSHQ DEEELDDEEE DEEEDEDEDD EEENASMQSN 

       310        320        330        340        350        360 
ADDMELDAQQ ETRTEPSATT QQQHQQQDTE DLEENKDAGE ASLNVSNNHN TTDSNNSCSR 

       370        380        390        400        410        420 
KNNNGGNESE QHVASSAEDD DCANNNTNTS NNNNTSNTAT SNTNNNNNNN SSSGNSEKRK 

       430        440        450        460        470        480 
KKNNNNNNGQ PAVLLAAKDK EIKALLDELQ RLRAQEQTHL VQIQRLEEHL EVKRQHIIRL 

       490        500        510        520        530        540 
EARLDKQQIN EALAEATALS AAASTNNNNN SQSSDNNKKL NTAAERPMDA SSNADLPEST 

       550        560        570        580        590        600 
KAPVPAEDDE EDEDQAMLVD SEEAEDKPED SHHDDDEDED EDREAVNATT TDSNELKIKK 

       610        620        630        640        650        660 
EQHSPLDLNV LSPNSAIAAA AAAAAAAACA NDPNKFQALL IERTKALAAE ALKNGASDAL 

       670        680        690        700        710        720 
SEDAHHQQQQ HHQQQHQHQQ QHHQQQHLHQ QHHHHLQQQP NSGSNSNPAS NDHHHGHHLH 

       730        740        750        760        770        780 
GHGLLHPSSA HHLHHQTTES NSNSSTPTAA GNNNGSNNSS SNTNANSTAQ LAASLASTLN 

       790        800        810        820        830        840 
GTKSLMQEDS NGLAAVAMAA HAQHAAALGP GFLPGLPAFQ FAAAQVAAGG DGRGHYRFAD 

       850        860        870        880        890        900 
SELQLPPGAS MAGRLGESLI PKGDPMEAKL QEMLRYNMDK YANQALDTLH ISRRVRELLS 

       910        920        930        940        950        960 
VHNIGQRLFA KYILGLSQGT VSELLSKPKP WDKLTEKGRD SYRKMHAWAC DDNAVMLLKS 

       970        980        990       1000       1010       1020 
LIPKKDSGLP QYAGRGAGGA GGDDSMSEDR IAHILSEASS LMKQSSVAQH REQERRSHGG 

      1030       1040       1050       1060       1070       1080 
EDSHSNEDSK SPPQSCTSPF FKVENQLKQH QHLNPEQAAA QQREREREQR EREQQQRLRH 

      1090       1100       1110       1120       1130       1140 
DDQDKMARLY QELIARTPRE TAFPSFLFSP SLFGGAAGMP GAASNAFPAM ADENMRHVFE 

      1150       1160       1170       1180       1190       1200 
REIAKLQQHQ QQQQAAQAQA QFPNFSSLMA LQQQVLNGAQ DLSLAAAAAK DIKLNGQRSS 

      1210       1220       1230       1240       1250       1260 
LEHSAGSSSC SKDGERDDAY PSSLHGRKSE GGGTPAPPAP PSGPGTGAGA PPTAAPPTGG 

      1270       1280       1290       1300       1310       1320 
ASSNSAAPSP LSNSILPPAL SSQGEEFAAT ASPLQRMASI TNSLITQPPV TPHHSTPQRP 

      1330       1340       1350       1360       1370       1380 
TKAVLPPITQ QQFDMFNNLN TEDIVRRVKE ALSQYSISQR LFGESVLGLS QGSVSDLLAR 

      1390       1400       1410       1420       1430       1440 
PKPWHMLTQK GREPFIRMKM FLEDENAVHK LVASQYKIAP EKLMRTGSYS GSPQMPQGLA 

      1450       1460       1470       1480       1490       1500 
SKMQAASLPM QKMMSELKLQ EPAQAQHLMQ QMQAAAMSAA MQQQQVAQAQ QQAQQAQQAQ 

      1510       1520       1530       1540       1550       1560 
QHLQQQAQQH LQQQQHLAQQ QHPHQQHHQA AAAAAALHHQ SMLLTSPGLP PQHAISLPPS 

      1570       1580       1590       1600       1610       1620 
AGGAQPGGPG GNQGSSNPSN SEKKPMLMPV HGTNAMRSLH QHMSPTVYEM AALTQDLDTH 

      1630       1640       1650       1660       1670       1680 
DITTKIKEAL LANNIGQKIF GEAVLGLSQG SVSELLSKPK PWHMLSIKGR EPFIRMQLWL 

      1690       1700       1710       1720       1730       1740 
SDANNVERLQ LLKNERREAS KRRRSTGPNQ QDNSSDTSSN DTNDFYTSSP GPGSVGSGVG 

      1750       1760       1770       1780       1790       1800 
GAPPSKKQRV LFSEEQKEAL RLAFALDPYP NVGTIEFLAN ELGLATRTIT NWFHNHRMRL 

      1810       1820       1830       1840       1850       1860 
KQQVPHGPAG QDNPIPSRES TSATPFDPVQ FRILLQQRLL ELHKERMGMS GAPIPYPPYF 

      1870       1880       1890       1900       1910       1920 
AAAAILGRSL AGIPGAAAAA GAAAAAAAVG ASGGDELQAL NQAFKEQMSG LDLSMPTLKR 

      1930       1940       1950       1960       1970       1980 
ERSDDYQDDL ELEGGGHNLS DNESLEGQEP EDKTTDYEKV LHKSALAAAA AYMSNAVRSS 

      1990       2000       2010       2020       2030       2040 
RRKPAAPQWV NPAGAVTNPS AVVAAVAAAA AAAADNERII NGVCVMQASE YGRDDTDSNK 

      2050       2060       2070       2080       2090       2100 
PTDGGNDSDH EHAQLEIDQR FMEPEVHIKQ EEDDDEEQSG SVNLDNEDNA TSEQKLKVIN 

      2110       2120       2130       2140       2150       2160 
EEKLRMVRVR RLSSTGGGSS EEMPAPLAPP PPPPAASSSI VSGESTTSSS SSSNTSSSTP 

      2170 
AVTTAAATAA AGWNY 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila."
Blochlinger K., Bodmer R., Jack J., Jan L.Y., Jan Y.N.
Nature 333:629-635(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1940 AND SER-1944, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07985 mRNA. Translation: CAA30794.1.
AE014298 Genomic DNA. Translation: AAF46264.2.
PIRS03170.
RefSeqNP_524764.1. NM_080025.2.
UniGeneDm.1827.

3D structure databases

ProteinModelPortalP10180.
SMRP10180. Positions 856-968, 1330-1448, 1613-1797.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid69119. 23 interactions.
DIPDIP-19788N.
IntActP10180. 1 interaction.
MINTMINT-941430.

Proteomic databases

PaxDbP10180.
PRIDEP10180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0071068; FBpp0071026; FBgn0004198.
GeneID44540.
KEGGdme:Dmel_CG11387.
UCSCCG11387-RA. d. melanogaster.

Organism-specific databases

CTD44540.
FlyBaseFBgn0004198. ct.

Phylogenomic databases

eggNOGNOG306581.
GeneTreeENSGT00530000063019.
InParanoidP10180.
KOK09313.
OrthoDBEOG7QNVKN.

Gene expression databases

BgeeP10180.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPCYT1A. drosophila.
GenomeRNAi44540.
NextBio837385.

Entry information

Entry nameCUT_DROME
AccessionPrimary (citable) accession number: P10180
Secondary accession number(s): Q9W3Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase