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Protein

Cytochrome c oxidase subunit 8A, mitochondrial

Gene

COX8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

  • generation of precursor metabolites and energy Source: ProtInc
  • mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-liver/heart
Cytochrome c oxidase subunit 8-2
Gene namesi
Name:COX8A
Synonyms:COX8, COX8L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2294. COX8A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 3611Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei37 – 6024HelicalBy similarityAdd
BLAST
Topological domaini61 – 699Mitochondrial intermembraneBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26814.

Chemistry

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX8A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion1 PublicationAdd
BLAST
Chaini26 – 6944Cytochrome c oxidase subunit 8A, mitochondrialPRO_0000006186Add
BLAST

Proteomic databases

EPDiP10176.
PaxDbiP10176.
PeptideAtlasiP10176.
PRIDEiP10176.
TopDownProteomicsiP10176.

PTM databases

PhosphoSiteiP10176.

Expressioni

Gene expression databases

BgeeiENSG00000176340.
CleanExiHS_COX8A.
ExpressionAtlasiP10176. baseline and differential.
GenevisibleiP10176. HS.

Organism-specific databases

HPAiHPA055942.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NPM1P067483EBI-3904738,EBI-78579

Protein-protein interaction databases

BioGridi107744. 2 interactions.
IntActiP10176. 2 interactions.
STRINGi9606.ENSP00000321260.

Structurei

3D structure databases

ProteinModelPortaliP10176.
SMRiP10176. Positions 26-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4WR. Eukaryota.
ENOG410ZEYR. LUCA.
GeneTreeiENSGT00390000006255.
HOGENOMiHOG000230478.
InParanoidiP10176.
KOiK02273.
OMAiIGLTSCF.
OrthoDBiEOG091G11UL.
PhylomeDBiP10176.
TreeFamiTF105070.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT
60
FLLPAGWILS HLETYRRPE
Length:69
Mass (Da):7,579
Last modified:February 1, 1991 - v2
Checksum:iE1736E52AD0F76E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04823 mRNA. Translation: AAA99313.1.
BC063025 mRNA. Translation: AAH63025.1.
CCDSiCCDS8054.1.
PIRiA34103. OSHU8.
RefSeqiNP_004065.1. NM_004074.2.
UniGeneiHs.743989.

Genome annotation databases

EnsembliENST00000314133; ENSP00000321260; ENSG00000176340.
GeneIDi1351.
KEGGihsa:1351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04823 mRNA. Translation: AAA99313.1.
BC063025 mRNA. Translation: AAH63025.1.
CCDSiCCDS8054.1.
PIRiA34103. OSHU8.
RefSeqiNP_004065.1. NM_004074.2.
UniGeneiHs.743989.

3D structure databases

ProteinModelPortaliP10176.
SMRiP10176. Positions 26-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107744. 2 interactions.
IntActiP10176. 2 interactions.
STRINGi9606.ENSP00000321260.

Chemistry

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteiP10176.

Polymorphism and mutation databases

BioMutaiCOX8A.

Proteomic databases

EPDiP10176.
PaxDbiP10176.
PeptideAtlasiP10176.
PRIDEiP10176.
TopDownProteomicsiP10176.

Protocols and materials databases

DNASUi1351.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314133; ENSP00000321260; ENSG00000176340.
GeneIDi1351.
KEGGihsa:1351.

Organism-specific databases

CTDi1351.
GeneCardsiCOX8A.
HGNCiHGNC:2294. COX8A.
HPAiHPA055942.
MIMi123870. gene.
neXtProtiNX_P10176.
PharmGKBiPA26814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4WR. Eukaryota.
ENOG410ZEYR. LUCA.
GeneTreeiENSGT00390000006255.
HOGENOMiHOG000230478.
InParanoidiP10176.
KOiK02273.
OMAiIGLTSCF.
OrthoDBiEOG091G11UL.
PhylomeDBiP10176.
TreeFamiTF105070.

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiCOX8A. human.
GenomeRNAii1351.
PROiP10176.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176340.
CleanExiHS_COX8A.
ExpressionAtlasiP10176. baseline and differential.
GenevisibleiP10176. HS.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8A_HUMAN
AccessioniPrimary (citable) accession number: P10176
Secondary accession number(s): P15955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.