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P10175 (COX8B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 8B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-heart
Cytochrome c oxidase subunit 8-1
Cytochrome c oxidase subunit 8H
IX
VIIIb
Gene names
Name:COX8B
Synonyms:COX8H
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase VIII family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion Ref.4 Ref.5
Chain25 – 7046Cytochrome c oxidase subunit 8B, mitochondrial Ref.1
PRO_0000006176

Regions

Topological domain25 – 3511Mitochondrial matrix
Transmembrane36 – 5924Helical
Topological domain60 – 7011Mitochondrial intermembrane

Experimental info

Sequence conflict191A → V in AAA30466. Ref.1
Sequence conflict311K → R in AAA30466. Ref.1

Secondary structure

..... 70
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P10175 [UniParc].

Last modified November 1, 1995. Version 3.
Checksum: 17BE70ADEC45FDD8

FASTA707,639
        10         20         30         40         50         60 
MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF LLPAGWVLYH 

        70 
LDNYKKSSAA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the cDNAs encoding two isoforms of subunit CIX of bovine cytochrome c oxidase."
Lightowlers R.N., Ewart G.D., Aggeler R.J., Zhang Y.-Z., Calavetta L., Capaldi R.A.
J. Biol. Chem. 265:2677-2681(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII."
Lomax M.I., Riggs P.K., Womack J.E.
Mamm. Genome 6:118-122(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Rumen.
[4]"Studies on cytochrome c oxidase, X. Isolation and amino-acid sequence of polypeptide VIIIb."
Meinecke L., Steffens G.J., Buse G.
Hoppe-Seyler's Z. Physiol. Chem. 365:313-320(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-70.
Tissue: Heart.
[5]"Different isozymes of cytochrome c oxidase are expressed in bovine smooth muscle and skeletal or heart muscle."
Anthony G., Stroh A., Lottspeich F., Kadenbach B.
FEBS Lett. 277:97-100(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-30.
Tissue: Heart.
[6]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-70.
[7]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-70.
Tissue: Heart.
[8]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 25-70.
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05202 mRNA. Translation: AAA30466.1.
U15540 Genomic DNA. Translation: AAA80279.1.
BC112717 mRNA. Translation: AAI12718.1.
PIROSBO8. A35537.
RefSeqNP_001107989.1. NM_001114517.2.
UniGeneBt.62953.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80M/Z25-70[»]
1OCOX-ray2.80M/Z25-70[»]
1OCRX-ray2.35M/Z25-70[»]
1OCZX-ray2.90M/Z25-70[»]
1V54X-ray1.80M/Z25-70[»]
1V55X-ray1.90M/Z25-70[»]
2DYRX-ray1.80M/Z25-70[»]
2DYSX-ray2.20M/Z25-70[»]
2EIJX-ray1.90M/Z25-70[»]
2EIKX-ray2.10M/Z25-70[»]
2EILX-ray2.10M/Z25-70[»]
2EIMX-ray2.60M/Z25-70[»]
2EINX-ray2.70M/Z25-70[»]
2OCCX-ray2.30M/Z25-70[»]
2Y69X-ray1.95M/Z1-70[»]
2YBBelectron microscopy19.00X25-70[»]
2ZXWX-ray2.50M/Z25-70[»]
3ABKX-ray2.00M/Z25-70[»]
3ABLX-ray2.10M/Z25-70[»]
3ABMX-ray1.95M/Z25-70[»]
3AG1X-ray2.20M/Z25-70[»]
3AG2X-ray1.80M/Z25-70[»]
3AG3X-ray1.80M/Z25-70[»]
3AG4X-ray2.05M/Z25-70[»]
3ASNX-ray3.00M/Z25-70[»]
3ASOX-ray2.30M/Z25-70[»]
ProteinModelPortalP10175.
SMRP10175. Positions 25-67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000002651.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002651; ENSBTAP00000002651; ENSBTAG00000002046.
GeneID615757.
KEGGbta:615757.

Organism-specific databases

CTD12869.

Phylogenomic databases

eggNOGNOG83531.
GeneTreeENSGT00530000065013.
HOGENOMHOG000230478.
InParanoidP10175.
KOK02273.
OrthoDBEOG769ZNX.
TreeFamTF105070.

Family and domain databases

Gene3D4.10.81.10. 1 hit.
InterProIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERPTHR16717. PTHR16717. 1 hit.
PfamPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMSSF81431. SSF81431. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP10175.
NextBio20899771.

Entry information

Entry nameCOX8B_BOVIN
AccessionPrimary (citable) accession number: P10175
Secondary accession number(s): Q2KI98
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references