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Protein

Cytochrome c oxidase subunit 8B, mitochondrial

Gene

COX8B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-heart
Cytochrome c oxidase subunit 8-1
Cytochrome c oxidase subunit 8H
IX
VIIIb
Gene namesi
Name:COX8B
Synonyms:COX8H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 35Mitochondrial matrixAdd BLAST11
Transmembranei36 – 59HelicalAdd BLAST24
Topological domaini60 – 70Mitochondrial intermembraneAdd BLAST11

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion2 PublicationsAdd BLAST24
ChainiPRO_000000617625 – 70Cytochrome c oxidase subunit 8B, mitochondrialAdd BLAST46

Proteomic databases

PaxDbiP10175.

Interactioni

Protein-protein interaction databases

CORUMiP10175.
DIPiDIP-60941N.
IntActiP10175. 1 interactor.
STRINGi9913.ENSBTAP00000002651.

Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 59Combined sources24
Helixi61 – 65Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80M/Z25-70[»]
1OCOX-ray2.80M/Z25-70[»]
1OCRX-ray2.35M/Z25-70[»]
1OCZX-ray2.90M/Z25-70[»]
1V54X-ray1.80M/Z25-70[»]
1V55X-ray1.90M/Z25-70[»]
2DYRX-ray1.80M/Z25-70[»]
2DYSX-ray2.20M/Z25-70[»]
2EIJX-ray1.90M/Z25-70[»]
2EIKX-ray2.10M/Z25-70[»]
2EILX-ray2.10M/Z25-70[»]
2EIMX-ray2.60M/Z25-70[»]
2EINX-ray2.70M/Z25-70[»]
2OCCX-ray2.30M/Z25-70[»]
2Y69X-ray1.95M/Z1-70[»]
2YBBelectron microscopy19.00X25-70[»]
2ZXWX-ray2.50M/Z25-70[»]
3ABKX-ray2.00M/Z25-70[»]
3ABLX-ray2.10M/Z25-70[»]
3ABMX-ray1.95M/Z25-70[»]
3AG1X-ray2.20M/Z25-70[»]
3AG2X-ray1.80M/Z25-70[»]
3AG3X-ray1.80M/Z25-70[»]
3AG4X-ray2.05M/Z25-70[»]
3ASNX-ray3.00M/Z25-70[»]
3ASOX-ray2.30M/Z25-70[»]
3WG7X-ray1.90M/Z25-70[»]
3X2QX-ray2.00M/Z25-70[»]
5B1AX-ray1.50M/Z25-70[»]
5B1BX-ray1.60M/Z25-70[»]
5B3SX-ray1.68M/Z25-70[»]
5GPNelectron microscopy5.40s25-70[»]
5IY5X-ray2.00M/Z25-67[»]
5LUFelectron microscopy9.10025-70[»]
5W97X-ray2.30M/m25-70[»]
5WAUX-ray1.95M/m25-70[»]
5X19X-ray2.20M/Z25-70[»]
5X1BX-ray2.40M/Z25-70[»]
5X1FX-ray2.20M/Z25-70[»]
5XDQX-ray1.77M/Z25-70[»]
5XTHelectron microscopy3.90925-67[»]
5XTIelectron microscopy17.409/B925-67[»]
DisProtiDP00780.
ProteinModelPortaliP10175.
SMRiP10175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10175.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J43Z. Eukaryota.
ENOG4111DTJ. LUCA.
HOGENOMiHOG000230478.
InParanoidiP10175.
KOiK02273.
TreeFamiTF105070.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiView protein in InterPro
IPR003205. Cyt_c_oxidase_su8.
IPR036548. Cyt_c_oxidase_su8_sf.
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiView protein in Pfam
PF02285. COX8. 1 hit.
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF
60 70
LLPAGWVLYH LDNYKKSSAA
Length:70
Mass (Da):7,639
Last modified:November 1, 1995 - v3
Checksum:i17BE70ADEC45FDD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → V in AAA30466 (PubMed:1689292).Curated1
Sequence conflicti31K → R in AAA30466 (PubMed:1689292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05202 mRNA. Translation: AAA30466.1.
U15540 Genomic DNA. Translation: AAA80279.1.
BC112717 mRNA. Translation: AAI12718.1.
PIRiA35537. OSBO8.
RefSeqiNP_001107989.1. NM_001114517.2.
UniGeneiBt.62953.

Genome annotation databases

GeneIDi615757.
KEGGibta:615757.

Similar proteinsi

Entry informationi

Entry nameiCOX8B_BOVIN
AccessioniPrimary (citable) accession number: P10175
Secondary accession number(s): Q2KI98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families