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P10175

- COX8B_BOVIN

UniProt

P10175 - COX8B_BOVIN

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Protein
Cytochrome c oxidase subunit 8B, mitochondrial
Gene
COX8B, COX8H
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-heart
Cytochrome c oxidase subunit 8-1
Cytochrome c oxidase subunit 8H
IX
VIIIb
Gene namesi
Name:COX8B
Synonyms:COX8H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 3511Mitochondrial matrix
Add
BLAST
Transmembranei36 – 5924Helical
Add
BLAST
Topological domaini60 – 7011Mitochondrial intermembrane
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion2 Publications
Add
BLAST
Chaini25 – 7046Cytochrome c oxidase subunit 8B, mitochondrial1 Publication
PRO_0000006176Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002651.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 5924
Helixi61 – 655

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80M/Z25-70[»]
1OCOX-ray2.80M/Z25-70[»]
1OCRX-ray2.35M/Z25-70[»]
1OCZX-ray2.90M/Z25-70[»]
1V54X-ray1.80M/Z25-70[»]
1V55X-ray1.90M/Z25-70[»]
2DYRX-ray1.80M/Z25-70[»]
2DYSX-ray2.20M/Z25-70[»]
2EIJX-ray1.90M/Z25-70[»]
2EIKX-ray2.10M/Z25-70[»]
2EILX-ray2.10M/Z25-70[»]
2EIMX-ray2.60M/Z25-70[»]
2EINX-ray2.70M/Z25-70[»]
2OCCX-ray2.30M/Z25-70[»]
2Y69X-ray1.95M/Z1-70[»]
2YBBelectron microscopy19.00X25-70[»]
2ZXWX-ray2.50M/Z25-70[»]
3ABKX-ray2.00M/Z25-70[»]
3ABLX-ray2.10M/Z25-70[»]
3ABMX-ray1.95M/Z25-70[»]
3AG1X-ray2.20M/Z25-70[»]
3AG2X-ray1.80M/Z25-70[»]
3AG3X-ray1.80M/Z25-70[»]
3AG4X-ray2.05M/Z25-70[»]
3ASNX-ray3.00M/Z25-70[»]
3ASOX-ray2.30M/Z25-70[»]
3WG7X-ray1.90M/Z25-70[»]
ProteinModelPortaliP10175.
SMRiP10175. Positions 25-67.

Miscellaneous databases

EvolutionaryTraceiP10175.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83531.
GeneTreeiENSGT00530000065013.
HOGENOMiHOG000230478.
InParanoidiP10175.
KOiK02273.
OrthoDBiEOG769ZNX.
TreeFamiTF105070.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10175-1 [UniParc]FASTAAdd to Basket

« Hide

MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF   50
LLPAGWVLYH LDNYKKSSAA 70
Length:70
Mass (Da):7,639
Last modified:November 1, 1995 - v3
Checksum:i17BE70ADEC45FDD8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191A → V in AAA30466. 1 Publication
Sequence conflicti31 – 311K → R in AAA30466. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05202 mRNA. Translation: AAA30466.1.
U15540 Genomic DNA. Translation: AAA80279.1.
BC112717 mRNA. Translation: AAI12718.1.
PIRiA35537. OSBO8.
RefSeqiNP_001107989.1. NM_001114517.2.
UniGeneiBt.62953.

Genome annotation databases

EnsembliENSBTAT00000002651; ENSBTAP00000002651; ENSBTAG00000002046.
GeneIDi615757.
KEGGibta:615757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05202 mRNA. Translation: AAA30466.1 .
U15540 Genomic DNA. Translation: AAA80279.1 .
BC112717 mRNA. Translation: AAI12718.1 .
PIRi A35537. OSBO8.
RefSeqi NP_001107989.1. NM_001114517.2.
UniGenei Bt.62953.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 M/Z 25-70 [» ]
1OCO X-ray 2.80 M/Z 25-70 [» ]
1OCR X-ray 2.35 M/Z 25-70 [» ]
1OCZ X-ray 2.90 M/Z 25-70 [» ]
1V54 X-ray 1.80 M/Z 25-70 [» ]
1V55 X-ray 1.90 M/Z 25-70 [» ]
2DYR X-ray 1.80 M/Z 25-70 [» ]
2DYS X-ray 2.20 M/Z 25-70 [» ]
2EIJ X-ray 1.90 M/Z 25-70 [» ]
2EIK X-ray 2.10 M/Z 25-70 [» ]
2EIL X-ray 2.10 M/Z 25-70 [» ]
2EIM X-ray 2.60 M/Z 25-70 [» ]
2EIN X-ray 2.70 M/Z 25-70 [» ]
2OCC X-ray 2.30 M/Z 25-70 [» ]
2Y69 X-ray 1.95 M/Z 1-70 [» ]
2YBB electron microscopy 19.00 X 25-70 [» ]
2ZXW X-ray 2.50 M/Z 25-70 [» ]
3ABK X-ray 2.00 M/Z 25-70 [» ]
3ABL X-ray 2.10 M/Z 25-70 [» ]
3ABM X-ray 1.95 M/Z 25-70 [» ]
3AG1 X-ray 2.20 M/Z 25-70 [» ]
3AG2 X-ray 1.80 M/Z 25-70 [» ]
3AG3 X-ray 1.80 M/Z 25-70 [» ]
3AG4 X-ray 2.05 M/Z 25-70 [» ]
3ASN X-ray 3.00 M/Z 25-70 [» ]
3ASO X-ray 2.30 M/Z 25-70 [» ]
3WG7 X-ray 1.90 M/Z 25-70 [» ]
ProteinModelPortali P10175.
SMRi P10175. Positions 25-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000002651.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002651 ; ENSBTAP00000002651 ; ENSBTAG00000002046 .
GeneIDi 615757.
KEGGi bta:615757.

Organism-specific databases

CTDi 12869.

Phylogenomic databases

eggNOGi NOG83531.
GeneTreei ENSGT00530000065013.
HOGENOMi HOG000230478.
InParanoidi P10175.
KOi K02273.
OrthoDBi EOG769ZNX.
TreeFami TF105070.

Miscellaneous databases

EvolutionaryTracei P10175.
NextBioi 20899771.

Family and domain databases

Gene3Di 4.10.81.10. 1 hit.
InterProi IPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view ]
PANTHERi PTHR16717. PTHR16717. 1 hit.
Pfami PF02285. COX8. 1 hit.
[Graphical view ]
SUPFAMi SSF81431. SSF81431. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the cDNAs encoding two isoforms of subunit CIX of bovine cytochrome c oxidase."
    Lightowlers R.N., Ewart G.D., Aggeler R.J., Zhang Y.-Z., Calavetta L., Capaldi R.A.
    J. Biol. Chem. 265:2677-2681(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII."
    Lomax M.I., Riggs P.K., Womack J.E.
    Mamm. Genome 6:118-122(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Rumen.
  4. "Studies on cytochrome c oxidase, X. Isolation and amino-acid sequence of polypeptide VIIIb."
    Meinecke L., Steffens G.J., Buse G.
    Hoppe-Seyler's Z. Physiol. Chem. 365:313-320(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-70.
    Tissue: Heart.
  5. "Different isozymes of cytochrome c oxidase are expressed in bovine smooth muscle and skeletal or heart muscle."
    Anthony G., Stroh A., Lottspeich F., Kadenbach B.
    FEBS Lett. 277:97-100(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-30.
    Tissue: Heart.
  6. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-70.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-70.
    Tissue: Heart.
  8. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 25-70.
    Tissue: Heart.

Entry informationi

Entry nameiCOX8B_BOVIN
AccessioniPrimary (citable) accession number: P10175
Secondary accession number(s): Q2KI98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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