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Protein

Cytochrome c oxidase subunit 8B, mitochondrial

Gene

COX8B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-heart
Cytochrome c oxidase subunit 8-1
Cytochrome c oxidase subunit 8H
IX
VIIIb
Gene namesi
Name:COX8B
Synonyms:COX8H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 35Mitochondrial matrixAdd BLAST11
Transmembranei36 – 59HelicalAdd BLAST24
Topological domaini60 – 70Mitochondrial intermembraneAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion2 PublicationsAdd BLAST24
ChainiPRO_000000617625 – 70Cytochrome c oxidase subunit 8B, mitochondrialAdd BLAST46

Proteomic databases

PaxDbiP10175.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002046.

Interactioni

Protein-protein interaction databases

DIPiDIP-60941N.
STRINGi9913.ENSBTAP00000002651.

Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 59Combined sources24
Helixi61 – 65Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80M/Z25-70[»]
1OCOX-ray2.80M/Z25-70[»]
1OCRX-ray2.35M/Z25-70[»]
1OCZX-ray2.90M/Z25-70[»]
1V54X-ray1.80M/Z25-70[»]
1V55X-ray1.90M/Z25-70[»]
2DYRX-ray1.80M/Z25-70[»]
2DYSX-ray2.20M/Z25-70[»]
2EIJX-ray1.90M/Z25-70[»]
2EIKX-ray2.10M/Z25-70[»]
2EILX-ray2.10M/Z25-70[»]
2EIMX-ray2.60M/Z25-70[»]
2EINX-ray2.70M/Z25-70[»]
2OCCX-ray2.30M/Z25-70[»]
2Y69X-ray1.95M/Z1-70[»]
2YBBelectron microscopy19.00X25-70[»]
2ZXWX-ray2.50M/Z25-70[»]
3ABKX-ray2.00M/Z25-70[»]
3ABLX-ray2.10M/Z25-70[»]
3ABMX-ray1.95M/Z25-70[»]
3AG1X-ray2.20M/Z25-70[»]
3AG2X-ray1.80M/Z25-70[»]
3AG3X-ray1.80M/Z25-70[»]
3AG4X-ray2.05M/Z25-70[»]
3ASNX-ray3.00M/Z25-70[»]
3ASOX-ray2.30M/Z25-70[»]
3WG7X-ray1.90M/Z25-70[»]
3X2QX-ray2.00M/Z25-70[»]
5B1AX-ray1.50M/Z25-70[»]
5B1BX-ray1.60M/Z25-70[»]
ProteinModelPortaliP10175.
SMRiP10175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10175.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J43Z. Eukaryota.
ENOG4111DTJ. LUCA.
HOGENOMiHOG000230478.
InParanoidiP10175.
KOiK02273.
TreeFamiTF105070.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF
60 70
LLPAGWVLYH LDNYKKSSAA
Length:70
Mass (Da):7,639
Last modified:November 1, 1995 - v3
Checksum:i17BE70ADEC45FDD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → V in AAA30466 (PubMed:1689292).Curated1
Sequence conflicti31K → R in AAA30466 (PubMed:1689292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05202 mRNA. Translation: AAA30466.1.
U15540 Genomic DNA. Translation: AAA80279.1.
BC112717 mRNA. Translation: AAI12718.1.
PIRiA35537. OSBO8.
RefSeqiNP_001107989.1. NM_001114517.2.
UniGeneiBt.62953.

Genome annotation databases

GeneIDi615757.
KEGGibta:615757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05202 mRNA. Translation: AAA30466.1.
U15540 Genomic DNA. Translation: AAA80279.1.
BC112717 mRNA. Translation: AAI12718.1.
PIRiA35537. OSBO8.
RefSeqiNP_001107989.1. NM_001114517.2.
UniGeneiBt.62953.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80M/Z25-70[»]
1OCOX-ray2.80M/Z25-70[»]
1OCRX-ray2.35M/Z25-70[»]
1OCZX-ray2.90M/Z25-70[»]
1V54X-ray1.80M/Z25-70[»]
1V55X-ray1.90M/Z25-70[»]
2DYRX-ray1.80M/Z25-70[»]
2DYSX-ray2.20M/Z25-70[»]
2EIJX-ray1.90M/Z25-70[»]
2EIKX-ray2.10M/Z25-70[»]
2EILX-ray2.10M/Z25-70[»]
2EIMX-ray2.60M/Z25-70[»]
2EINX-ray2.70M/Z25-70[»]
2OCCX-ray2.30M/Z25-70[»]
2Y69X-ray1.95M/Z1-70[»]
2YBBelectron microscopy19.00X25-70[»]
2ZXWX-ray2.50M/Z25-70[»]
3ABKX-ray2.00M/Z25-70[»]
3ABLX-ray2.10M/Z25-70[»]
3ABMX-ray1.95M/Z25-70[»]
3AG1X-ray2.20M/Z25-70[»]
3AG2X-ray1.80M/Z25-70[»]
3AG3X-ray1.80M/Z25-70[»]
3AG4X-ray2.05M/Z25-70[»]
3ASNX-ray3.00M/Z25-70[»]
3ASOX-ray2.30M/Z25-70[»]
3WG7X-ray1.90M/Z25-70[»]
3X2QX-ray2.00M/Z25-70[»]
5B1AX-ray1.50M/Z25-70[»]
5B1BX-ray1.60M/Z25-70[»]
ProteinModelPortaliP10175.
SMRiP10175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60941N.
STRINGi9913.ENSBTAP00000002651.

Proteomic databases

PaxDbiP10175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi615757.
KEGGibta:615757.

Organism-specific databases

CTDi12869.

Phylogenomic databases

eggNOGiENOG410J43Z. Eukaryota.
ENOG4111DTJ. LUCA.
HOGENOMiHOG000230478.
InParanoidiP10175.
KOiK02273.
TreeFamiTF105070.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP10175.

Gene expression databases

BgeeiENSBTAG00000002046.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8B_BOVIN
AccessioniPrimary (citable) accession number: P10175
Secondary accession number(s): Q2KI98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.