Cytochrome c oxidase subunit 8B, mitochondrial precursor

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P10175 (COX8B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 112. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 8B, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide VIII-heart
Cytochrome c oxidase subunit 8-1
Cytochrome c oxidase subunit 8H
IX
VIIIb

Gene names

Name:	COX8B
Synonyms:	COX8H

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase VIII family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 24

Mitochondrion Ref.4 Ref.5

Chain

25 – 70

Cytochrome c oxidase subunit 8B, mitochondrial Ref.1

PRO_0000006176

Regions

Topological domain

25 – 35

Mitochondrial matrix

Transmembrane

36 – 59

Helical

Topological domain

60 – 70

Mitochondrial intermembrane

Experimental info

Sequence conflict

A → V in AAA30466. Ref.1

Sequence conflict

K → R in AAA30466. Ref.1

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P10175 [UniParc].

Last modified November 1, 1995. Version 3.
Checksum: 17BE70ADEC45FDD8
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FASTA

7,639

        10         20         30         40         50         60 
MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF LLPAGWVLYH 

        70 
LDNYKKSSAA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the cDNAs encoding two isoforms of subunit CIX of bovine cytochrome c oxidase." Lightowlers R.N., Ewart G.D., Aggeler R.J., Zhang Y.-Z., Calavetta L., Capaldi R.A. J. Biol. Chem. 265:2677-2681(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII." Lomax M.I., Riggs P.K., Womack J.E. Mamm. Genome 6:118-122(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Rumen.
[4]	"Studies on cytochrome c oxidase, X. Isolation and amino-acid sequence of polypeptide VIIIb." Meinecke L., Steffens G.J., Buse G. Hoppe-Seyler's Z. Physiol. Chem. 365:313-320(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-70. Tissue: Heart.
[5]	"Different isozymes of cytochrome c oxidase are expressed in bovine smooth muscle and skeletal or heart muscle." Anthony G., Stroh A., Lottspeich F., Kadenbach B. FEBS Lett. 277:97-100(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-30. Tissue: Heart.
[6]	"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A." Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-70.
[7]	"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-70. Tissue: Heart.
[8]	"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution." Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S. Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 25-70. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J05202 mRNA. Translation: AAA30466.1.
U15540 Genomic DNA. Translation: AAA80279.1.
BC112717 mRNA. Translation: AAI12718.1.

IPI

IPI00686687.

PIR

OSBO8. A35537.

RefSeq

NP_001107989.1. NM_001114517.2.

UniGene

Bt.62953.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OCC	X-ray	2.80	M/Z	25-70	[»]
1OCO	X-ray	2.80	M/Z	25-70	[»]
1OCR	X-ray	2.35	M/Z	25-70	[»]
1OCZ	X-ray	2.90	M/Z	25-70	[»]
1V54	X-ray	1.80	M/Z	25-70	[»]
1V55	X-ray	1.90	M/Z	25-70	[»]
2DYR	X-ray	1.80	M/Z	25-70	[»]
2DYS	X-ray	2.20	M/Z	25-70	[»]
2EIJ	X-ray	1.90	M/Z	25-70	[»]
2EIK	X-ray	2.10	M/Z	25-70	[»]
2EIL	X-ray	2.10	M/Z	25-70	[»]
2EIM	X-ray	2.60	M/Z	25-70	[»]
2EIN	X-ray	2.70	M/Z	25-70	[»]
2OCC	X-ray	2.30	M/Z	25-70	[»]
2Y69	X-ray	1.95	M/Z	1-70	[»]
2YBB	electron microscopy	19.00	X	25-70	[»]
2ZXW	X-ray	2.50	M/Z	25-70	[»]
3ABK	X-ray	2.00	M/Z	25-70	[»]
3ABL	X-ray	2.10	M/Z	25-70	[»]
3ABM	X-ray	1.95	M/Z	25-70	[»]
3AG1	X-ray	2.20	M/Z	25-70	[»]
3AG2	X-ray	1.80	M/Z	25-70	[»]
3AG3	X-ray	1.80	M/Z	25-70	[»]
3AG4	X-ray	2.05	M/Z	25-70	[»]
3ASN	X-ray	3.00	M/Z	25-70	[»]
3ASO	X-ray	2.30	M/Z	25-70	[»]

ProteinModelPortal

P10175.

SMR

P10175. Positions 25-67.

ModBase

Search...

Protein-protein interaction databases

STRING

9913.ENSBTAP00000002651.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000002651; ENSBTAP00000002651; ENSBTAG00000002046.

GeneID

615757.

KEGG

bta:615757.

Organism-specific databases

CTD

12869.

Phylogenomic databases

eggNOG

NOG83531.

GeneTree

ENSGT00530000065013.

HOGENOM

HOG000230478.

InParanoid

P10175.

K02273.

OrthoDB

EOG4VX271.

Enzyme and pathway databases

BioCyc

CATTLE:281091-MONOMER.
CATTLE:ENSBTAG00000002046-MONOMER.

Family and domain databases

Gene3D

4.10.81.10. 1 hit.

InterPro

IPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]

PANTHER

PTHR16717. PTHR16717. 1 hit.

Pfam

PF02285. COX8. 1 hit.
[Graphical view]

SUPFAM

SSF81431. Cyt_c_oxidase_8. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P10175.

NextBio

20899771.

Entry information

Entry name

COX8B_BOVIN

Accession

Primary (citable) accession number: P10175
Secondary accession number(s): Q2KI98

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 112 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents