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Protein

Cytochrome c oxidase subunit 7

Gene

COX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YMR256C-MONOMER.
YEAST:YMR256C-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VII
Gene namesi
Name:COX7
Ordered Locus Names:YMR256C
ORF Names:YM9920.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR256C.
SGDiS000004869. COX7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6059Cytochrome c oxidase subunit 7PRO_0000183907Add
BLAST

Proteomic databases

PaxDbiP10174.

Expressioni

Gene expression databases

GenevestigatoriP10174.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi35434. 120 interactions.
IntActiP10174. 6 interactions.
MINTiMINT-3374763.
STRINGi4932.YMR256C.

Structurei

3D structure databases

ProteinModelPortaliP10174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43076.
HOGENOMiHOG000248810.
InParanoidiP10174.
KOiK02269.
OMAiVYPFYAL.
OrthoDBiEOG71ZPF7.

Family and domain databases

InterProiIPR014367. Cyt_c_oxidase_su7.
[Graphical view]
PIRSFiPIRSF000282. COX7. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKVIQLQK IFQSSTKPLW WRHPRSALYL YPFYAIFAVA VVTPLLYIPN
60
AIRGIKAKKA
Length:60
Mass (Da):6,932
Last modified:January 23, 2007 - v3
Checksum:i5798C96AF8134D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51506 Genomic DNA. Translation: CAA35871.1.
M31620 Genomic DNA. Translation: AAA34550.1.
Z48639 Genomic DNA. Translation: CAA88583.1.
AY558129 Genomic DNA. Translation: AAS56455.1.
BK006946 Genomic DNA. Translation: DAA10156.1.
PIRiS22248. OBBY7.
RefSeqiNP_013983.1. NM_001182763.1.

Genome annotation databases

EnsemblFungiiYMR256C; YMR256C; YMR256C.
GeneIDi855298.
KEGGisce:YMR256C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51506 Genomic DNA. Translation: CAA35871.1.
M31620 Genomic DNA. Translation: AAA34550.1.
Z48639 Genomic DNA. Translation: CAA88583.1.
AY558129 Genomic DNA. Translation: AAS56455.1.
BK006946 Genomic DNA. Translation: DAA10156.1.
PIRiS22248. OBBY7.
RefSeqiNP_013983.1. NM_001182763.1.

3D structure databases

ProteinModelPortaliP10174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35434. 120 interactions.
IntActiP10174. 6 interactions.
MINTiMINT-3374763.
STRINGi4932.YMR256C.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbiP10174.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR256C; YMR256C; YMR256C.
GeneIDi855298.
KEGGisce:YMR256C.

Organism-specific databases

EuPathDBiFungiDB:YMR256C.
SGDiS000004869. COX7.

Phylogenomic databases

eggNOGiNOG43076.
HOGENOMiHOG000248810.
InParanoidiP10174.
KOiK02269.
OMAiVYPFYAL.
OrthoDBiEOG71ZPF7.

Enzyme and pathway databases

BioCyciMetaCyc:YMR256C-MONOMER.
YEAST:YMR256C-MONOMER.

Miscellaneous databases

NextBioi978958.
PROiP10174.

Gene expression databases

GenevestigatoriP10174.

Family and domain databases

InterProiIPR014367. Cyt_c_oxidase_su7.
[Graphical view]
PIRSFiPIRSF000282. COX7. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast cytochrome c oxidase subunit VII is essential for assembly of an active enzyme. Cloning, sequencing, and characterization of the nuclear-encoded gene."
    Aggeler R., Capaldi R.A.
    J. Biol. Chem. 265:16389-16393(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the gene encoding cytochrome c oxidase subunit VII from Saccharomyces cerevisiae."
    Calder K.M., McEwen J.E.
    Nucleic Acids Res. 18:1632-1632(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis."
    Power S.D., Lochrie M.A., Poyton R.O.
    J. Biol. Chem. 261:9206-9209(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-58.
  7. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX7_YEAST
AccessioniPrimary (citable) accession number: P10174
Secondary accession number(s): D6W082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.