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Protein

Cytochrome c oxidase subunit 7

Gene

COX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YMR256C-MONOMER.
YEAST:YMR256C-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VII
Gene namesi
Name:COX7
Ordered Locus Names:YMR256C
ORF Names:YM9920.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR256C.
SGDiS000004869. COX7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 6059Cytochrome c oxidase subunit 7PRO_0000183907Add
BLAST

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi35434. 120 interactions.
IntActiP10174. 6 interactions.
MINTiMINT-3374763.

Structurei

3D structure databases

ProteinModelPortaliP10174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000248810.
InParanoidiP10174.
KOiK02269.
OMAiWWRHPRS.
OrthoDBiEOG092C5ZBW.

Family and domain databases

InterProiIPR014367. Cox7.
[Graphical view]
PIRSFiPIRSF000282. COX7. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKVIQLQK IFQSSTKPLW WRHPRSALYL YPFYAIFAVA VVTPLLYIPN
60
AIRGIKAKKA
Length:60
Mass (Da):6,932
Last modified:January 23, 2007 - v3
Checksum:i5798C96AF8134D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51506 Genomic DNA. Translation: CAA35871.1.
M31620 Genomic DNA. Translation: AAA34550.1.
Z48639 Genomic DNA. Translation: CAA88583.1.
AY558129 Genomic DNA. Translation: AAS56455.1.
BK006946 Genomic DNA. Translation: DAA10156.1.
PIRiS22248. OBBY7.
RefSeqiNP_013983.1. NM_001182763.1.

Genome annotation databases

EnsemblFungiiYMR256C; YMR256C; YMR256C.
GeneIDi855298.
KEGGisce:YMR256C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51506 Genomic DNA. Translation: CAA35871.1.
M31620 Genomic DNA. Translation: AAA34550.1.
Z48639 Genomic DNA. Translation: CAA88583.1.
AY558129 Genomic DNA. Translation: AAS56455.1.
BK006946 Genomic DNA. Translation: DAA10156.1.
PIRiS22248. OBBY7.
RefSeqiNP_013983.1. NM_001182763.1.

3D structure databases

ProteinModelPortaliP10174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35434. 120 interactions.
IntActiP10174. 6 interactions.
MINTiMINT-3374763.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR256C; YMR256C; YMR256C.
GeneIDi855298.
KEGGisce:YMR256C.

Organism-specific databases

EuPathDBiFungiDB:YMR256C.
SGDiS000004869. COX7.

Phylogenomic databases

HOGENOMiHOG000248810.
InParanoidiP10174.
KOiK02269.
OMAiWWRHPRS.
OrthoDBiEOG092C5ZBW.

Enzyme and pathway databases

BioCyciMetaCyc:YMR256C-MONOMER.
YEAST:YMR256C-MONOMER.

Miscellaneous databases

PROiP10174.

Family and domain databases

InterProiIPR014367. Cox7.
[Graphical view]
PIRSFiPIRSF000282. COX7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7_YEAST
AccessioniPrimary (citable) accession number: P10174
Secondary accession number(s): D6W082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.