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P10174

- COX7_YEAST

UniProt

P10174 - COX7_YEAST

Protein

Cytochrome c oxidase subunit 7

Gene

COX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC
    2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciMetaCyc:YMR256C-MONOMER.
    YEAST:YMR256C-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide VII
    Gene namesi
    Name:COX7
    Ordered Locus Names:YMR256C
    ORF Names:YM9920.10C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    SGDiS000004869. COX7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 6059Cytochrome c oxidase subunit 7PRO_0000183907Add
    BLAST

    Proteomic databases

    PaxDbiP10174.

    Expressioni

    Gene expression databases

    GenevestigatoriP10174.

    Interactioni

    Subunit structurei

    Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

    Protein-protein interaction databases

    BioGridi35434. 120 interactions.
    IntActiP10174. 6 interactions.
    MINTiMINT-3374763.
    STRINGi4932.YMR256C.

    Structurei

    3D structure databases

    ProteinModelPortaliP10174.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43076.
    HOGENOMiHOG000248810.
    KOiK02269.
    OMAiVYPFYAL.
    OrthoDBiEOG71ZPF7.

    Family and domain databases

    InterProiIPR014367. Cyt_c_oxidase_su7.
    [Graphical view]
    PIRSFiPIRSF000282. COX7. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10174-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANKVIQLQK IFQSSTKPLW WRHPRSALYL YPFYAIFAVA VVTPLLYIPN   50
    AIRGIKAKKA 60
    Length:60
    Mass (Da):6,932
    Last modified:January 23, 2007 - v3
    Checksum:i5798C96AF8134D6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51506 Genomic DNA. Translation: CAA35871.1.
    M31620 Genomic DNA. Translation: AAA34550.1.
    Z48639 Genomic DNA. Translation: CAA88583.1.
    AY558129 Genomic DNA. Translation: AAS56455.1.
    BK006946 Genomic DNA. Translation: DAA10156.1.
    PIRiS22248. OBBY7.
    RefSeqiNP_013983.1. NM_001182763.1.

    Genome annotation databases

    EnsemblFungiiYMR256C; YMR256C; YMR256C.
    GeneIDi855298.
    KEGGisce:YMR256C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51506 Genomic DNA. Translation: CAA35871.1 .
    M31620 Genomic DNA. Translation: AAA34550.1 .
    Z48639 Genomic DNA. Translation: CAA88583.1 .
    AY558129 Genomic DNA. Translation: AAS56455.1 .
    BK006946 Genomic DNA. Translation: DAA10156.1 .
    PIRi S22248. OBBY7.
    RefSeqi NP_013983.1. NM_001182763.1.

    3D structure databases

    ProteinModelPortali P10174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35434. 120 interactions.
    IntActi P10174. 6 interactions.
    MINTi MINT-3374763.
    STRINGi 4932.YMR256C.

    Protein family/group databases

    TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    PaxDbi P10174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR256C ; YMR256C ; YMR256C .
    GeneIDi 855298.
    KEGGi sce:YMR256C.

    Organism-specific databases

    SGDi S000004869. COX7.

    Phylogenomic databases

    eggNOGi NOG43076.
    HOGENOMi HOG000248810.
    KOi K02269.
    OMAi VYPFYAL.
    OrthoDBi EOG71ZPF7.

    Enzyme and pathway databases

    BioCyci MetaCyc:YMR256C-MONOMER.
    YEAST:YMR256C-MONOMER.

    Miscellaneous databases

    NextBioi 978958.

    Gene expression databases

    Genevestigatori P10174.

    Family and domain databases

    InterProi IPR014367. Cyt_c_oxidase_su7.
    [Graphical view ]
    PIRSFi PIRSF000282. COX7. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Yeast cytochrome c oxidase subunit VII is essential for assembly of an active enzyme. Cloning, sequencing, and characterization of the nuclear-encoded gene."
      Aggeler R., Capaldi R.A.
      J. Biol. Chem. 265:16389-16393(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of the gene encoding cytochrome c oxidase subunit VII from Saccharomyces cerevisiae."
      Calder K.M., McEwen J.E.
      Nucleic Acids Res. 18:1632-1632(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204510 / AB320.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis."
      Power S.D., Lochrie M.A., Poyton R.O.
      J. Biol. Chem. 261:9206-9209(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-58.
    7. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
      Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
      Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX7_YEAST
    AccessioniPrimary (citable) accession number: P10174
    Secondary accession number(s): D6W082
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 639 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3