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P10168 (IL7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-7

Short name=IL-7
Gene names
Name:Il7
Synonyms:Il-7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Subcellular location

Secreted.

Post-translational modification

Three disulfide bonds are present Probable.

Sequence similarities

Belongs to the IL-7/IL-9 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT cell lineage commitment

Inferred from mutant phenotype PubMed 9252127. Source: MGI

bone resorption

Inferred from direct assay PubMed 12490655. Source: MGI

homeostasis of number of cells within a tissue

Inferred from mutant phenotype PubMed 9252127. Source: MGI

immune response

Inferred from electronic annotation. Source: InterPro

negative regulation of catalytic activity

Inferred from direct assay PubMed 8950980. Source: MGI

negative regulation of extrinsic apoptotic signaling pathway

Inferred from direct assay PubMed 10429671. Source: MGI

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from direct assay PubMed 8950980. Source: MGI

positive regulation of B cell proliferation

Inferred from direct assay PubMed 12970760. Source: MGI

positive regulation of T cell differentiation

Inferred from direct assay PubMed 12431371. Source: MGI

positive regulation of organ growth

Inferred from mutant phenotype PubMed 9252127. Source: MGI

regulation of gene expression

Inferred from direct assay PubMed 8950980. Source: MGI

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 8950980. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 12490655PubMed 12970760. Source: MGI

growth factor activity

Inferred from direct assay PubMed 12970760. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525
Chain26 – 154129Interleukin-7
PRO_0000015624

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P10168 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: CBAAB7A1A7516A42

FASTA15417,727
        10         20         30         40         50         60 
MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK MTGTDSNCPN 

        70         80         90        100        110        120 
NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN VHLLTVSQGT QTLVNCTSKE 

       130        140        150 
EKNVKEQKKN DACFLKRLLR EIKTCWNKIL KGSI 

« Hide

References

[1]"Stimulation of B-cell progenitors by cloned murine interleukin-7."
Namen A.E., Lupton S., Hjerrild K., Wignall J., Mochizuki D.Y., Schmierer A., Mosley B., March C.J., Urdal D., Gillis S., Cosman D., Goodwin R.G.
Nature 333:571-573(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Characterization of the human and murine IL-7 genes."
Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07962 mRNA. Translation: CAA30779.1.
M29057 expand/collapse EMBL AC list , M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
CCDSCCDS50859.1.
PIRS03171.
RefSeqNP_032397.1. NM_008371.4.
UniGeneMm.3825.

3D structure databases

ProteinModelPortalP10168.
SMRP10168. Positions 32-150.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP10168.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000168269; ENSMUSP00000126219; ENSMUSG00000040329.
GeneID16196.
KEGGmmu:16196.
UCSCuc008ooi.1. mouse.

Organism-specific databases

CTD3574.
MGIMGI:96561. Il7.

Phylogenomic databases

eggNOGNOG41411.
HOGENOMHOG000036891.
HOVERGENHBG004609.
InParanoidP10168.
KOK05431.
OMANNEPNFF.
OrthoDBEOG7S220M.
PhylomeDBP10168.
TreeFamTF338065.

Gene expression databases

ArrayExpressP10168.
BgeeP10168.
CleanExMM_IL7.
GenevestigatorP10168.

Family and domain databases

InterProIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERPTHR10526. PTHR10526. 1 hit.
PfamPF01415. IL7. 1 hit.
[Graphical view]
PIRSFPIRSF001942. IL-7. 1 hit.
PRINTSPR00435. INTERLEUKIN7.
SMARTSM00127. IL7. 1 hit.
[Graphical view]
PROSITEPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289121.
PROP10168.
SOURCESearch...

Entry information

Entry nameIL7_MOUSE
AccessionPrimary (citable) accession number: P10168
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot