P10168 (IL7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-7
Short name=IL-7

Gene names

Name:	Il7
Synonyms:	Il-7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
Subcellular location	Secreted.
Post-translational modification	Three disulfide bonds are present Probable.
Sequence similarities	Belongs to the IL-7/IL-9 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell lineage commitment Inferred from mutant phenotype PubMed 9252127. Source: MGI bone resorption Inferred from direct assay PubMed 12490655. Source: MGI homeostasis of number of cells within a tissue Inferred from mutant phenotype PubMed 9252127. Source: MGI immune response Inferred from electronic annotation. Source: InterPro negative regulation of apoptotic process Inferred from direct assay PubMed 10429671PubMed 8950980. Source: MGI negative regulation of catalytic activity Inferred from direct assay PubMed 8950980. Source: MGI positive regulation of B cell proliferation Inferred from direct assay PubMed 12970760. Source: MGI positive regulation of T cell differentiation Inferred from direct assay PubMed 12431371. Source: MGI positive regulation of organ growth Inferred from mutant phenotype PubMed 9252127. Source: MGI regulation of gene expression Inferred from direct assay PubMed 8950980. Source: MGI
Cellular_component	extracellular space Inferred from direct assay PubMed 8950980. Source: MGI
Molecular_function	cytokine activity Inferred from direct assay PubMed 12490655PubMed 12970760. Source: MGI growth factor activity Inferred from direct assay PubMed 12970760. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25
	Chain	26 – 154	129	Interleukin-7		PRO_0000015624
Amino acid modifications
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Glycosylation	115	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P10168 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: CBAAB7A1A7516A42	FASTA	154	17,727
	10 20 30 40 50 60 MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK MTGTDSNCPN 70 80 90 100 110 120 NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN VHLLTVSQGT QTLVNCTSKE 130 140 150 EKNVKEQKKN DACFLKRLLR EIKTCWNKIL KGSI

References

[1]	"Stimulation of B-cell progenitors by cloned murine interleukin-7." Namen A.E., Lupton S., Hjerrild K., Wignall J., Mochizuki D.Y., Schmierer A., Mosley B., March C.J., Urdal D., Gillis S., Cosman D., Goodwin R.G. Nature 333:571-573(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	"Characterization of the human and murine IL-7 genes." Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G. J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07962 mRNA. Translation: CAA30779.1. M29057 , M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
IPI	IPI00108154.
PIR	S03171.
RefSeq	NP_032397.1. NM_008371.4.
UniGene	Mm.3825.
3D structure databases
ProteinModelPortal	P10168.
SMR	P10168. Positions 32-150.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000168269; ENSMUSP00000126219; ENSMUSG00000040329.
GeneID	16196.
KEGG	mmu:16196.
Organism-specific databases
CTD	3574.
MGI	MGI:96561. Il7.
Phylogenomic databases
eggNOG	NOG41411.
HOGENOM	HOG000036891.
HOVERGEN	HBG004609.
InParanoid	P10168.
KO	K05431.
OMA	CFLKILL.
OrthoDB	EOG4QNMXR.
Enzyme and pathway databases
Reactome	REACT_107772. Immune System.
Gene expression databases
ArrayExpress	P10168.
Bgee	P10168.
CleanEx	MM_IL7.
Genevestigator	P10168.
GermOnline	ENSMUSG00000040329. Mus musculus.
Family and domain databases
InterPro	IPR001181. Interleukin-7. IPR018049. Interleukin-7/-9_CS. IPR000226. Interleukin_7_9. [Graphical view]
PANTHER	PTHR10526. PTHR10526. 1 hit.
Pfam	PF01415. IL7. 1 hit. [Graphical view]
PIRSF	PIRSF001942. IL-7. 1 hit.
PRINTS	PR00435. INTERLEUKIN7.
SMART	SM00127. IL7. 1 hit. [Graphical view]
PROSITE	PS00255. INTERLEUKIN_7_9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289121.
SOURCE	Search...

Entry information

Entry name

IL7_MOUSE

Accession

Primary (citable) accession number: P10168

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program