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Protein

Interleukin-7

Gene

Il7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI
  3. interleukin-7 receptor binding Source: GO_Central

GO - Biological processi

  1. bone resorption Source: MGI
  2. cell-cell signaling Source: GO_Central
  3. homeostasis of number of cells within a tissue Source: MGI
  4. humoral immune response Source: GO_Central
  5. negative regulation of catalytic activity Source: MGI
  6. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  7. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  8. organ morphogenesis Source: GO_Central
  9. positive regulation of B cell proliferation Source: MGI
  10. positive regulation of organ growth Source: MGI
  11. positive regulation of T cell differentiation Source: MGI
  12. regulation of gene expression Source: MGI
  13. T cell lineage commitment Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_276590. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:Il7
Synonyms:Il-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96561. Il7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 154129Interleukin-7PRO_0000015624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Three disulfide bonds are present.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP10168.

Expressioni

Gene expression databases

BgeeiP10168.
CleanExiMM_IL7.
ExpressionAtlasiP10168. baseline and differential.
GenevestigatoriP10168.

Structurei

3D structure databases

ProteinModelPortaliP10168.
SMRiP10168. Positions 32-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41411.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP10168.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG7S220M.
PhylomeDBiP10168.
TreeFamiTF338065.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK
60 70 80 90 100
MTGTDSNCPN NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN
110 120 130 140 150
VHLLTVSQGT QTLVNCTSKE EKNVKEQKKN DACFLKRLLR EIKTCWNKIL

KGSI
Length:154
Mass (Da):17,727
Last modified:June 30, 1989 - v1
Checksum:iCBAAB7A1A7516A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07962 mRNA. Translation: CAA30779.1.
M29057
, M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
CCDSiCCDS50859.1.
PIRiS03171.
RefSeqiNP_032397.1. NM_008371.4.
UniGeneiMm.3825.

Genome annotation databases

EnsembliENSMUST00000194279; ENSMUSP00000141845; ENSMUSG00000040329.
GeneIDi16196.
KEGGimmu:16196.
UCSCiuc008ooi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07962 mRNA. Translation: CAA30779.1.
M29057
, M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
CCDSiCCDS50859.1.
PIRiS03171.
RefSeqiNP_032397.1. NM_008371.4.
UniGeneiMm.3825.

3D structure databases

ProteinModelPortaliP10168.
SMRiP10168. Positions 32-150.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP10168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000194279; ENSMUSP00000141845; ENSMUSG00000040329.
GeneIDi16196.
KEGGimmu:16196.
UCSCiuc008ooi.1. mouse.

Organism-specific databases

CTDi3574.
MGIiMGI:96561. Il7.

Phylogenomic databases

eggNOGiNOG41411.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP10168.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG7S220M.
PhylomeDBiP10168.
TreeFamiTF338065.

Enzyme and pathway databases

ReactomeiREACT_276590. Interleukin-7 signaling.

Miscellaneous databases

NextBioi289121.
PROiP10168.
SOURCEiSearch...

Gene expression databases

BgeeiP10168.
CleanExiMM_IL7.
ExpressionAtlasiP10168. baseline and differential.
GenevestigatoriP10168.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Characterization of the human and murine IL-7 genes."
    Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
    J. Immunol. 144:3592-3601(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.

Entry informationi

Entry nameiIL7_MOUSE
AccessioniPrimary (citable) accession number: P10168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1989
Last sequence update: June 30, 1989
Last modified: March 31, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.