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P10168

- IL7_MOUSE

UniProt

P10168 - IL7_MOUSE

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Protein

Interleukin-7

Gene
Il7, Il-7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI

GO - Biological processi

  1. bone resorption Source: MGI
  2. homeostasis of number of cells within a tissue Source: MGI
  3. immune response Source: InterPro
  4. negative regulation of catalytic activity Source: MGI
  5. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  7. positive regulation of B cell proliferation Source: MGI
  8. positive regulation of organ growth Source: MGI
  9. positive regulation of T cell differentiation Source: MGI
  10. regulation of gene expression Source: MGI
  11. T cell lineage commitment Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_198701. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:Il7
Synonyms:Il-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:96561. Il7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 154129Interleukin-7PRO_0000015624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Three disulfide bonds are present Inferred.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP10168.

Expressioni

Gene expression databases

ArrayExpressiP10168.
BgeeiP10168.
CleanExiMM_IL7.
GenevestigatoriP10168.

Structurei

3D structure databases

ProteinModelPortaliP10168.
SMRiP10168. Positions 32-150.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41411.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP10168.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG7S220M.
PhylomeDBiP10168.
TreeFamiTF338065.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10168-1 [UniParc]FASTAAdd to Basket

« Hide

MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK    50
MTGTDSNCPN NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN 100
VHLLTVSQGT QTLVNCTSKE EKNVKEQKKN DACFLKRLLR EIKTCWNKIL 150
KGSI 154
Length:154
Mass (Da):17,727
Last modified:July 1, 1989 - v1
Checksum:iCBAAB7A1A7516A42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07962 mRNA. Translation: CAA30779.1.
M29057
, M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
CCDSiCCDS50859.1.
PIRiS03171.
RefSeqiNP_032397.1. NM_008371.4.
UniGeneiMm.3825.

Genome annotation databases

EnsembliENSMUST00000168269; ENSMUSP00000126219; ENSMUSG00000040329.
GeneIDi16196.
KEGGimmu:16196.
UCSCiuc008ooi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07962 mRNA. Translation: CAA30779.1 .
M29057
, M29054 , M29055 , M29056 Genomic DNA. Translation: AAA39303.1 .
CCDSi CCDS50859.1.
PIRi S03171.
RefSeqi NP_032397.1. NM_008371.4.
UniGenei Mm.3825.

3D structure databases

ProteinModelPortali P10168.
SMRi P10168. Positions 32-150.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P10168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000168269 ; ENSMUSP00000126219 ; ENSMUSG00000040329 .
GeneIDi 16196.
KEGGi mmu:16196.
UCSCi uc008ooi.1. mouse.

Organism-specific databases

CTDi 3574.
MGIi MGI:96561. Il7.

Phylogenomic databases

eggNOGi NOG41411.
HOGENOMi HOG000036891.
HOVERGENi HBG004609.
InParanoidi P10168.
KOi K05431.
OMAi NNEPNFF.
OrthoDBi EOG7S220M.
PhylomeDBi P10168.
TreeFami TF338065.

Enzyme and pathway databases

Reactomei REACT_198701. Interleukin-7 signaling.

Miscellaneous databases

NextBioi 289121.
PROi P10168.
SOURCEi Search...

Gene expression databases

ArrayExpressi P10168.
Bgeei P10168.
CleanExi MM_IL7.
Genevestigatori P10168.

Family and domain databases

InterProi IPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view ]
PANTHERi PTHR10526. PTHR10526. 1 hit.
Pfami PF01415. IL7. 1 hit.
[Graphical view ]
PIRSFi PIRSF001942. IL-7. 1 hit.
PRINTSi PR00435. INTERLEUKIN7.
SMARTi SM00127. IL7. 1 hit.
[Graphical view ]
PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Characterization of the human and murine IL-7 genes."
    Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
    J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.

Entry informationi

Entry nameiIL7_MOUSE
AccessioniPrimary (citable) accession number: P10168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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