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Protein

Interleukin-7

Gene

Il7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • interleukin-7 receptor binding Source: InterPro

GO - Biological processi

  • bone resorption Source: MGI
  • cytokine-mediated signaling pathway Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • immune response Source: InterPro
  • negative regulation of catalytic activity Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of chemokine production Source: MGI
  • positive regulation of cytokine-mediated signaling pathway Source: MGI
  • positive regulation of organ growth Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • T cell lineage commitment Source: MGI

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-1266695 Interleukin-7 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:Il7
Synonyms:Il-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96561 Il7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000001562426 – 154Interleukin-7Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 145By similarity
Disulfide bondi58 ↔ 133By similarity
Disulfide bondi71 ↔ 116By similarity
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Three disulfide bonds are present.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10168
PRIDEiP10168

Expressioni

Gene expression databases

BgeeiENSMUSG00000040329
CleanExiMM_IL7
ExpressionAtlasiP10168 baseline and differential
GenevisibleiP10168 MM

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • interleukin-7 receptor binding Source: InterPro

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126219

Structurei

3D structure databases

ProteinModelPortaliP10168
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW6Q Eukaryota
ENOG41114MI LUCA
GeneTreeiENSGT00390000004451
HOGENOMiHOG000036891
HOVERGENiHBG004609
InParanoidiP10168
KOiK05431
OMAiNNEPNFF
OrthoDBiEOG091G0VZI
PhylomeDBiP10168
TreeFamiTF338065

Family and domain databases

Gene3Di1.20.1250.50, 1 hit
InterProiView protein in InterPro
IPR001181 IL-7
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR038325 IL7_sf
PANTHERiPTHR45542 PTHR45542, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PIRSFiPIRSF001942 IL-7, 1 hit
PRINTSiPR00435 INTERLEUKIN7
SMARTiView protein in SMART
SM00127 IL7, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK
60 70 80 90 100
MTGTDSNCPN NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN
110 120 130 140 150
VHLLTVSQGT QTLVNCTSKE EKNVKEQKKN DACFLKRLLR EIKTCWNKIL

KGSI
Length:154
Mass (Da):17,727
Last modified:July 1, 1989 - v1
Checksum:iCBAAB7A1A7516A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07962 mRNA Translation: CAA30779.1
M29057
, M29054, M29055, M29056 Genomic DNA Translation: AAA39303.1
CCDSiCCDS50859.1
PIRiS03171
RefSeqiNP_032397.1, NM_008371.5
UniGeneiMm.3825

Genome annotation databases

EnsembliENSMUST00000194279; ENSMUSP00000141845; ENSMUSG00000040329
GeneIDi16196
KEGGimmu:16196
UCSCiuc008ooi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL7_MOUSE
AccessioniPrimary (citable) accession number: P10168
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health