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P10168

- IL7_MOUSE

UniProt

P10168 - IL7_MOUSE

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Protein

Interleukin-7

Gene

Il7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI

GO - Biological processi

  1. bone resorption Source: MGI
  2. homeostasis of number of cells within a tissue Source: MGI
  3. immune response Source: InterPro
  4. negative regulation of catalytic activity Source: MGI
  5. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  7. positive regulation of B cell proliferation Source: MGI
  8. positive regulation of organ growth Source: MGI
  9. positive regulation of T cell differentiation Source: MGI
  10. regulation of gene expression Source: MGI
  11. T cell lineage commitment Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_198701. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:Il7
Synonyms:Il-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:96561. Il7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 154129Interleukin-7PRO_0000015624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Three disulfide bonds are present.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP10168.

Expressioni

Gene expression databases

BgeeiP10168.
CleanExiMM_IL7.
ExpressionAtlasiP10168. baseline and differential.
GenevestigatoriP10168.

Structurei

3D structure databases

ProteinModelPortaliP10168.
SMRiP10168. Positions 32-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41411.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP10168.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG7S220M.
PhylomeDBiP10168.
TreeFamiTF338065.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10168-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK
60 70 80 90 100
MTGTDSNCPN NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN
110 120 130 140 150
VHLLTVSQGT QTLVNCTSKE EKNVKEQKKN DACFLKRLLR EIKTCWNKIL

KGSI
Length:154
Mass (Da):17,727
Last modified:July 1, 1989 - v1
Checksum:iCBAAB7A1A7516A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07962 mRNA. Translation: CAA30779.1.
M29057
, M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
CCDSiCCDS50859.1.
PIRiS03171.
RefSeqiNP_032397.1. NM_008371.4.
UniGeneiMm.3825.

Genome annotation databases

EnsembliENSMUST00000168269; ENSMUSP00000126219; ENSMUSG00000040329.
GeneIDi16196.
KEGGimmu:16196.
UCSCiuc008ooi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07962 mRNA. Translation: CAA30779.1 .
M29057
, M29054 , M29055 , M29056 Genomic DNA. Translation: AAA39303.1 .
CCDSi CCDS50859.1.
PIRi S03171.
RefSeqi NP_032397.1. NM_008371.4.
UniGenei Mm.3825.

3D structure databases

ProteinModelPortali P10168.
SMRi P10168. Positions 32-150.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P10168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000168269 ; ENSMUSP00000126219 ; ENSMUSG00000040329 .
GeneIDi 16196.
KEGGi mmu:16196.
UCSCi uc008ooi.1. mouse.

Organism-specific databases

CTDi 3574.
MGIi MGI:96561. Il7.

Phylogenomic databases

eggNOGi NOG41411.
HOGENOMi HOG000036891.
HOVERGENi HBG004609.
InParanoidi P10168.
KOi K05431.
OMAi NNEPNFF.
OrthoDBi EOG7S220M.
PhylomeDBi P10168.
TreeFami TF338065.

Enzyme and pathway databases

Reactomei REACT_198701. Interleukin-7 signaling.

Miscellaneous databases

NextBioi 289121.
PROi P10168.
SOURCEi Search...

Gene expression databases

Bgeei P10168.
CleanExi MM_IL7.
ExpressionAtlasi P10168. baseline and differential.
Genevestigatori P10168.

Family and domain databases

InterProi IPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view ]
PANTHERi PTHR10526. PTHR10526. 1 hit.
Pfami PF01415. IL7. 1 hit.
[Graphical view ]
PIRSFi PIRSF001942. IL-7. 1 hit.
PRINTSi PR00435. INTERLEUKIN7.
SMARTi SM00127. IL7. 1 hit.
[Graphical view ]
PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Characterization of the human and murine IL-7 genes."
    Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
    J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.

Entry informationi

Entry nameiIL7_MOUSE
AccessioniPrimary (citable) accession number: P10168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3