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P10168

- IL7_MOUSE

UniProt

P10168 - IL7_MOUSE

Protein

Interleukin-7

Gene

Il7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. growth factor activity Source: MGI

    GO - Biological processi

    1. bone resorption Source: MGI
    2. homeostasis of number of cells within a tissue Source: MGI
    3. immune response Source: InterPro
    4. negative regulation of catalytic activity Source: MGI
    5. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
    6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    7. positive regulation of B cell proliferation Source: MGI
    8. positive regulation of organ growth Source: MGI
    9. positive regulation of T cell differentiation Source: MGI
    10. regulation of gene expression Source: MGI
    11. T cell lineage commitment Source: MGI

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_198701. Interleukin-7 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-7
    Short name:
    IL-7
    Gene namesi
    Name:Il7
    Synonyms:Il-7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:96561. Il7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 154129Interleukin-7PRO_0000015624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Three disulfide bonds are present.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP10168.

    Expressioni

    Gene expression databases

    ArrayExpressiP10168.
    BgeeiP10168.
    CleanExiMM_IL7.
    GenevestigatoriP10168.

    Structurei

    3D structure databases

    ProteinModelPortaliP10168.
    SMRiP10168. Positions 32-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-7/IL-9 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41411.
    HOGENOMiHOG000036891.
    HOVERGENiHBG004609.
    InParanoidiP10168.
    KOiK05431.
    OMAiNNEPNFF.
    OrthoDBiEOG7S220M.
    PhylomeDBiP10168.
    TreeFamiTF338065.

    Family and domain databases

    InterProiIPR001181. IL-7.
    IPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    [Graphical view]
    PANTHERiPTHR10526. PTHR10526. 1 hit.
    PfamiPF01415. IL7. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001942. IL-7. 1 hit.
    PRINTSiPR00435. INTERLEUKIN7.
    SMARTiSM00127. IL7. 1 hit.
    [Graphical view]
    PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10168-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK    50
    MTGTDSNCPN NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN 100
    VHLLTVSQGT QTLVNCTSKE EKNVKEQKKN DACFLKRLLR EIKTCWNKIL 150
    KGSI 154
    Length:154
    Mass (Da):17,727
    Last modified:July 1, 1989 - v1
    Checksum:iCBAAB7A1A7516A42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07962 mRNA. Translation: CAA30779.1.
    M29057
    , M29054, M29055, M29056 Genomic DNA. Translation: AAA39303.1.
    CCDSiCCDS50859.1.
    PIRiS03171.
    RefSeqiNP_032397.1. NM_008371.4.
    UniGeneiMm.3825.

    Genome annotation databases

    EnsembliENSMUST00000168269; ENSMUSP00000126219; ENSMUSG00000040329.
    GeneIDi16196.
    KEGGimmu:16196.
    UCSCiuc008ooi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07962 mRNA. Translation: CAA30779.1 .
    M29057
    , M29054 , M29055 , M29056 Genomic DNA. Translation: AAA39303.1 .
    CCDSi CCDS50859.1.
    PIRi S03171.
    RefSeqi NP_032397.1. NM_008371.4.
    UniGenei Mm.3825.

    3D structure databases

    ProteinModelPortali P10168.
    SMRi P10168. Positions 32-150.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P10168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000168269 ; ENSMUSP00000126219 ; ENSMUSG00000040329 .
    GeneIDi 16196.
    KEGGi mmu:16196.
    UCSCi uc008ooi.1. mouse.

    Organism-specific databases

    CTDi 3574.
    MGIi MGI:96561. Il7.

    Phylogenomic databases

    eggNOGi NOG41411.
    HOGENOMi HOG000036891.
    HOVERGENi HBG004609.
    InParanoidi P10168.
    KOi K05431.
    OMAi NNEPNFF.
    OrthoDBi EOG7S220M.
    PhylomeDBi P10168.
    TreeFami TF338065.

    Enzyme and pathway databases

    Reactomei REACT_198701. Interleukin-7 signaling.

    Miscellaneous databases

    NextBioi 289121.
    PROi P10168.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10168.
    Bgeei P10168.
    CleanExi MM_IL7.
    Genevestigatori P10168.

    Family and domain databases

    InterProi IPR001181. IL-7.
    IPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    [Graphical view ]
    PANTHERi PTHR10526. PTHR10526. 1 hit.
    Pfami PF01415. IL7. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001942. IL-7. 1 hit.
    PRINTSi PR00435. INTERLEUKIN7.
    SMARTi SM00127. IL7. 1 hit.
    [Graphical view ]
    PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "Characterization of the human and murine IL-7 genes."
      Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
      J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.

    Entry informationi

    Entry nameiIL7_MOUSE
    AccessioniPrimary (citable) accession number: P10168
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3