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P10166

- MYCL_MOUSE

UniProt

P10166 - MYCL_MOUSE

Protein

Protein L-Myc

Gene

Mycl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein L-Myc
    Gene namesi
    Name:Mycl
    Synonyms:Lmyc1, Mycl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:96799. Mycl.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Protein L-MycPRO_0000127334Add
    BLAST

    Proteomic databases

    PRIDEiP10166.

    PTM databases

    PhosphoSiteiP10166.

    Expressioni

    Gene expression databases

    ArrayExpressiP10166.
    BgeeiP10166.
    GenevestigatoriP10166.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

    Protein-protein interaction databases

    BioGridi201184. 1 interaction.
    STRINGi10090.ENSMUSP00000030407.

    Structurei

    3D structure databases

    ProteinModelPortaliP10166.
    SMRiP10166. Positions 286-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 33753bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni337 – 36529Leucine-zipperAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43031.
    HOGENOMiHOG000043075.
    HOVERGENiHBG000472.
    InParanoidiP10166.
    KOiK09110.
    OMAiEAAQSCH.
    PhylomeDBiP10166.
    TreeFamiTF106001.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR002418. Tscrpt_reg_Myc.
    IPR012682. Tscrpt_reg_Myc_N.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF01056. Myc_N. 2 hits.
    [Graphical view]
    PIRSFiPIRSF001705. Myc_protein. 1 hit.
    PRINTSiPR00044. LEUZIPPRMYC.
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10166-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG    50
    AVDPASGINP GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS 100
    ARERLERVVS DRLAPGAPRG NPPKAPATPD GTPSLEASNP APATQCQLGE 150
    PKTQACSGSE SPSDSEGEEI DVVTVEKRRS LDIRKPVTIT VRADPLDPCM 200
    KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI EAPKEKEEEE 250
    EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND 300
    LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ 350
    LRCRQQQLQK RIAYLSGY 368
    Length:368
    Mass (Da):40,848
    Last modified:July 1, 1989 - v1
    Checksum:i9174F6FD7C03321E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13945 Genomic DNA. Translation: CAA32128.1.
    BC053059 mRNA. Translation: AAH53059.1.
    BC089346 mRNA. Translation: AAH89346.1.
    CCDSiCCDS18606.1.
    PIRiS03017. TVMSML.
    RefSeqiNP_032532.1. NM_008506.2.
    XP_006502884.1. XM_006502821.1.
    UniGeneiMm.1055.
    Mm.479066.

    Genome annotation databases

    EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
    ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
    GeneIDi16918.
    KEGGimmu:16918.
    UCSCiuc008uop.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13945 Genomic DNA. Translation: CAA32128.1 .
    BC053059 mRNA. Translation: AAH53059.1 .
    BC089346 mRNA. Translation: AAH89346.1 .
    CCDSi CCDS18606.1.
    PIRi S03017. TVMSML.
    RefSeqi NP_032532.1. NM_008506.2.
    XP_006502884.1. XM_006502821.1.
    UniGenei Mm.1055.
    Mm.479066.

    3D structure databases

    ProteinModelPortali P10166.
    SMRi P10166. Positions 286-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201184. 1 interaction.
    STRINGi 10090.ENSMUSP00000030407.

    PTM databases

    PhosphoSitei P10166.

    Proteomic databases

    PRIDEi P10166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030407 ; ENSMUSP00000030407 ; ENSMUSG00000028654 .
    ENSMUST00000106252 ; ENSMUSP00000101859 ; ENSMUSG00000028654 .
    GeneIDi 16918.
    KEGGi mmu:16918.
    UCSCi uc008uop.1. mouse.

    Organism-specific databases

    CTDi 4610.
    MGIi MGI:96799. Mycl.

    Phylogenomic databases

    eggNOGi NOG43031.
    HOGENOMi HOG000043075.
    HOVERGENi HBG000472.
    InParanoidi P10166.
    KOi K09110.
    OMAi EAAQSCH.
    PhylomeDBi P10166.
    TreeFami TF106001.

    Miscellaneous databases

    NextBioi 290968.
    PROi P10166.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10166.
    Bgeei P10166.
    Genevestigatori P10166.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR002418. Tscrpt_reg_Myc.
    IPR012682. Tscrpt_reg_Myc_N.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF01056. Myc_N. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF001705. Myc_protein. 1 hit.
    PRINTSi PR00044. LEUZIPPRMYC.
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the murine L-myc gene."
      Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D., Mitsock L., Kriz R., Alt F.W.
      EMBO J. 6:3359-3366(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiMYCL_MOUSE
    AccessioniPrimary (citable) accession number: P10166
    Secondary accession number(s): Q5FWI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3