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Protein

Protein L-Myc

Gene

Mycl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein L-Myc
Gene namesi
Name:Mycl
Synonyms:Lmyc1, Mycl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:96799. Mycl.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Protein L-MycPRO_0000127334Add
BLAST

Proteomic databases

PRIDEiP10166.

PTM databases

PhosphoSiteiP10166.

Expressioni

Gene expression databases

BgeeiP10166.
ExpressionAtlasiP10166. baseline and differential.
GenevestigatoriP10166.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

Protein-protein interaction databases

BioGridi201184. 1 interaction.
STRINGi10090.ENSMUSP00000030407.

Structurei

3D structure databases

ProteinModelPortaliP10166.
SMRiP10166. Positions 286-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 33753bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni337 – 36529Leucine-zipperAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG43031.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP10166.
KOiK09110.
OMAiEAAQSCH.
PhylomeDBiP10166.
TreeFamiTF106001.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF01056. Myc_N. 2 hits.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG
60 70 80 90 100
AVDPASGINP GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS
110 120 130 140 150
ARERLERVVS DRLAPGAPRG NPPKAPATPD GTPSLEASNP APATQCQLGE
160 170 180 190 200
PKTQACSGSE SPSDSEGEEI DVVTVEKRRS LDIRKPVTIT VRADPLDPCM
210 220 230 240 250
KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI EAPKEKEEEE
260 270 280 290 300
EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND
310 320 330 340 350
LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ
360
LRCRQQQLQK RIAYLSGY
Length:368
Mass (Da):40,848
Last modified:July 1, 1989 - v1
Checksum:i9174F6FD7C03321E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13945 Genomic DNA. Translation: CAA32128.1.
BC053059 mRNA. Translation: AAH53059.1.
BC089346 mRNA. Translation: AAH89346.1.
CCDSiCCDS18606.1.
PIRiS03017. TVMSML.
RefSeqiNP_001290050.1. NM_001303121.1.
NP_032532.1. NM_008506.3.
XP_006502884.1. XM_006502821.1.
UniGeneiMm.1055.
Mm.479066.

Genome annotation databases

EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
GeneIDi16918.
KEGGimmu:16918.
UCSCiuc008uop.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13945 Genomic DNA. Translation: CAA32128.1.
BC053059 mRNA. Translation: AAH53059.1.
BC089346 mRNA. Translation: AAH89346.1.
CCDSiCCDS18606.1.
PIRiS03017. TVMSML.
RefSeqiNP_001290050.1. NM_001303121.1.
NP_032532.1. NM_008506.3.
XP_006502884.1. XM_006502821.1.
UniGeneiMm.1055.
Mm.479066.

3D structure databases

ProteinModelPortaliP10166.
SMRiP10166. Positions 286-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201184. 1 interaction.
STRINGi10090.ENSMUSP00000030407.

PTM databases

PhosphoSiteiP10166.

Proteomic databases

PRIDEiP10166.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
GeneIDi16918.
KEGGimmu:16918.
UCSCiuc008uop.1. mouse.

Organism-specific databases

CTDi4610.
MGIiMGI:96799. Mycl.

Phylogenomic databases

eggNOGiNOG43031.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP10166.
KOiK09110.
OMAiEAAQSCH.
PhylomeDBiP10166.
TreeFamiTF106001.

Miscellaneous databases

NextBioi290968.
PROiP10166.
SOURCEiSearch...

Gene expression databases

BgeeiP10166.
ExpressionAtlasiP10166. baseline and differential.
GenevestigatoriP10166.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF01056. Myc_N. 2 hits.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the murine L-myc gene."
    Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D., Mitsock L., Kriz R., Alt F.W.
    EMBO J. 6:3359-3366(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMYCL_MOUSE
AccessioniPrimary (citable) accession number: P10166
Secondary accession number(s): Q5FWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.