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P10166

- MYCL_MOUSE

UniProt

P10166 - MYCL_MOUSE

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Protein

Protein L-Myc

Gene
Mycl, Lmyc1, Mycl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein L-Myc
Gene namesi
Name:Mycl
Synonyms:Lmyc1, Mycl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:96799. Mycl.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Protein L-MycPRO_0000127334Add
BLAST

Proteomic databases

PRIDEiP10166.

PTM databases

PhosphoSiteiP10166.

Expressioni

Gene expression databases

ArrayExpressiP10166.
BgeeiP10166.
GenevestigatoriP10166.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

Protein-protein interaction databases

BioGridi201184. 1 interaction.
STRINGi10090.ENSMUSP00000030407.

Structurei

3D structure databases

ProteinModelPortaliP10166.
SMRiP10166. Positions 286-367.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 33753bHLHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni337 – 36529Leucine-zipperAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG43031.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP10166.
KOiK09110.
OMAiEAAQSCH.
PhylomeDBiP10166.
TreeFamiTF106001.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF01056. Myc_N. 2 hits.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10166-1 [UniParc]FASTAAdd to Basket

« Hide

MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG    50
AVDPASGINP GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS 100
ARERLERVVS DRLAPGAPRG NPPKAPATPD GTPSLEASNP APATQCQLGE 150
PKTQACSGSE SPSDSEGEEI DVVTVEKRRS LDIRKPVTIT VRADPLDPCM 200
KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI EAPKEKEEEE 250
EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND 300
LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ 350
LRCRQQQLQK RIAYLSGY 368
Length:368
Mass (Da):40,848
Last modified:July 1, 1989 - v1
Checksum:i9174F6FD7C03321E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13945 Genomic DNA. Translation: CAA32128.1.
BC053059 mRNA. Translation: AAH53059.1.
BC089346 mRNA. Translation: AAH89346.1.
CCDSiCCDS18606.1.
PIRiS03017. TVMSML.
RefSeqiNP_032532.1. NM_008506.2.
XP_006502884.1. XM_006502821.1.
UniGeneiMm.1055.
Mm.479066.

Genome annotation databases

EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
GeneIDi16918.
KEGGimmu:16918.
UCSCiuc008uop.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13945 Genomic DNA. Translation: CAA32128.1 .
BC053059 mRNA. Translation: AAH53059.1 .
BC089346 mRNA. Translation: AAH89346.1 .
CCDSi CCDS18606.1.
PIRi S03017. TVMSML.
RefSeqi NP_032532.1. NM_008506.2.
XP_006502884.1. XM_006502821.1.
UniGenei Mm.1055.
Mm.479066.

3D structure databases

ProteinModelPortali P10166.
SMRi P10166. Positions 286-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201184. 1 interaction.
STRINGi 10090.ENSMUSP00000030407.

PTM databases

PhosphoSitei P10166.

Proteomic databases

PRIDEi P10166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030407 ; ENSMUSP00000030407 ; ENSMUSG00000028654 .
ENSMUST00000106252 ; ENSMUSP00000101859 ; ENSMUSG00000028654 .
GeneIDi 16918.
KEGGi mmu:16918.
UCSCi uc008uop.1. mouse.

Organism-specific databases

CTDi 4610.
MGIi MGI:96799. Mycl.

Phylogenomic databases

eggNOGi NOG43031.
HOGENOMi HOG000043075.
HOVERGENi HBG000472.
InParanoidi P10166.
KOi K09110.
OMAi EAAQSCH.
PhylomeDBi P10166.
TreeFami TF106001.

Miscellaneous databases

NextBioi 290968.
PROi P10166.
SOURCEi Search...

Gene expression databases

ArrayExpressi P10166.
Bgeei P10166.
Genevestigatori P10166.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF01056. Myc_N. 2 hits.
[Graphical view ]
PIRSFi PIRSF001705. Myc_protein. 1 hit.
PRINTSi PR00044. LEUZIPPRMYC.
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the murine L-myc gene."
    Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D., Mitsock L., Kriz R., Alt F.W.
    EMBO J. 6:3359-3366(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMYCL_MOUSE
AccessioniPrimary (citable) accession number: P10166
Secondary accession number(s): Q5FWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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