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Protein

Protein L-Myc

Gene

Mycl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • regulation of auditory receptor cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein L-Myc
Gene namesi
Name:Mycl
Synonyms:Lmyc1, Mycl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96799. Mycl.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273341 – 368Protein L-MycAdd BLAST368

Proteomic databases

PaxDbiP10166.
PeptideAtlasiP10166.
PRIDEiP10166.

PTM databases

iPTMnetiP10166.
PhosphoSitePlusiP10166.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028654.
ExpressionAtlasiP10166. baseline and differential.
GenevisibleiP10166. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201184. 1 interactor.
STRINGi10090.ENSMUSP00000030407.

Structurei

3D structure databases

ProteinModelPortaliP10166.
SMRiP10166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 337bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni337 – 365Leucine-zipperAdd BLAST29

Phylogenomic databases

eggNOGiENOG410IFII. Eukaryota.
ENOG410Y7JV. LUCA.
GeneTreeiENSGT00510000046414.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiP10166.
KOiK09110.
OMAiAWGRNYA.
OrthoDBiEOG091G0ZJQ.
PhylomeDBiP10166.
TreeFamiTF106001.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
PF01056. Myc_N. 2 hits.
PIRSFiPIRSF001705. Myc_protein. 2 hits.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

P10166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG
60 70 80 90 100
AVDPASGINP GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS
110 120 130 140 150
ARERLERVVS DRLAPGAPRG NPPKAPATPD GTPSLEASNP APATQCQLGE
160 170 180 190 200
PKTQACSGSE SPSDSEGEEI DVVTVEKRRS LDIRKPVTIT VRADPLDPCM
210 220 230 240 250
KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI EAPKEKEEEE
260 270 280 290 300
EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND
310 320 330 340 350
LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ
360
LRCRQQQLQK RIAYLSGY
Length:368
Mass (Da):40,848
Last modified:July 1, 1989 - v1
Checksum:i9174F6FD7C03321E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13945 Genomic DNA. Translation: CAA32128.1.
BC053059 mRNA. Translation: AAH53059.1.
BC089346 mRNA. Translation: AAH89346.1.
CCDSiCCDS18606.1.
PIRiS03017. TVMSML.
RefSeqiNP_001290050.1. NM_001303121.1.
NP_032532.1. NM_008506.3.
XP_006502884.1. XM_006502821.3.
UniGeneiMm.1055.
Mm.479066.

Genome annotation databases

EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
GeneIDi16918.
KEGGimmu:16918.
UCSCiuc008uop.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMYCL_MOUSE
AccessioniPrimary (citable) accession number: P10166
Secondary accession number(s): Q5FWI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 5, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot