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P10166 (MYCL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein L-Myc
Gene names
Name:Mycl
Synonyms:Lmyc1, Mycl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Protein L-Myc
PRO_0000127334

Regions

Domain285 – 33753bHLH
Region337 – 36529Leucine-zipper

Sequences

Sequence LengthMass (Da)Tools
P10166 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 9174F6FD7C03321E

FASTA36840,848
        10         20         30         40         50         60 
MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG AVDPASGINP 

        70         80         90        100        110        120 
GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS ARERLERVVS DRLAPGAPRG 

       130        140        150        160        170        180 
NPPKAPATPD GTPSLEASNP APATQCQLGE PKTQACSGSE SPSDSEGEEI DVVTVEKRRS 

       190        200        210        220        230        240 
LDIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI 

       250        260        270        280        290        300 
EAPKEKEEEE EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND 

       310        320        330        340        350        360 
LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ LRCRQQQLQK 


RIAYLSGY 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the murine L-myc gene."
Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D., Mitsock L., Kriz R., Alt F.W.
EMBO J. 6:3359-3366(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13945 Genomic DNA. Translation: CAA32128.1.
BC053059 mRNA. Translation: AAH53059.1.
BC089346 mRNA. Translation: AAH89346.1.
PIRTVMSML. S03017.
RefSeqNP_032532.1. NM_008506.2.
XP_006502884.1. XM_006502821.1.
UniGeneMm.1055.
Mm.479066.

3D structure databases

ProteinModelPortalP10166.
SMRP10166. Positions 286-365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201184. 1 interaction.
STRING10090.ENSMUSP00000030407.

PTM databases

PhosphoSiteP10166.

Proteomic databases

PRIDEP10166.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
GeneID16918.
KEGGmmu:16918.
UCSCuc008uop.1. mouse.

Organism-specific databases

CTD4610.
MGIMGI:96799. Mycl.

Phylogenomic databases

eggNOGNOG43031.
HOGENOMHOG000043075.
HOVERGENHBG000472.
InParanoidP10166.
KOK09110.
OMAEAAQSCH.
PhylomeDBP10166.
TreeFamTF106001.

Gene expression databases

ArrayExpressP10166.
BgeeP10166.
GenevestigatorP10166.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF01056. Myc_N. 2 hits.
[Graphical view]
PIRSFPIRSF001705. Myc_protein. 1 hit.
PRINTSPR00044. LEUZIPPRMYC.
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290968.
PROP10166.
SOURCESearch...

Entry information

Entry nameMYCL_MOUSE
AccessionPrimary (citable) accession number: P10166
Secondary accession number(s): Q5FWI7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot