P10166 (MYCL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein L-Myc-1

Gene names

Name:	Mycl1
Synonyms:	Lmyc1, Mycl

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Protein L-Myc-1		PRO_0000127334
Regions
	Domain	285 – 337	53	bHLH
	Region	337 – 365	29	Leucine-zipper
Amino acid modifications
	Modified residue	314	1	Phosphothreonine Ref.3
	Modified residue	317	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P10166 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 9174F6FD7C03321E	FASTA	368	40,848
	10 20 30 40 50 60 MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG AVDPASGINP 70 80 90 100 110 120 GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS ARERLERVVS DRLAPGAPRG 130 140 150 160 170 180 NPPKAPATPD GTPSLEASNP APATQCQLGE PKTQACSGSE SPSDSEGEEI DVVTVEKRRS 190 200 210 220 230 240 LDIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI 250 260 270 280 290 300 EAPKEKEEEE EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND 310 320 330 340 350 360 LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ LRCRQQQLQK RIAYLSGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the murine L-myc gene." Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D., Mitsock L., Kriz R., Alt F.W. EMBO J. 6:3359-3366(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line." Shu H., Chen S., Bi Q., Mumby M., Brekken D.L. Mol. Cell. Proteomics 3:279-286(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-314 AND SER-317, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13945 Genomic DNA. Translation: CAA32128.1. BC053059 mRNA. Translation: AAH53059.1. BC089346 mRNA. Translation: AAH89346.1.
IPI	IPI00108151.
PIR	TVMSML. S03017.
RefSeq	NP_032532.1. NM_008506.2.
UniGene	Mm.1055. Mm.479066.
3D structure databases
ProteinModelPortal	P10166.
SMR	P10166. Positions 286-337.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000030407.
PTM databases
PhosphoSite	P10166.
Proteomic databases
PRIDE	P10166.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654. ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
GeneID	16918.
KEGG	mmu:16918.
Organism-specific databases
CTD	4610.
MGI	MGI:96799. Mycl1.
Phylogenomic databases
eggNOG	NOG43031.
HOGENOM	HOG000043075.
HOVERGEN	HBG000472.
InParanoid	P10166.
KO	K09110.
OMA	APQSCHP.
OrthoDB	EOG4H4642.
Gene expression databases
ArrayExpress	P10166.
Bgee	P10166.
Genevestigator	P10166.
GermOnline	ENSMUSG00000028654. Mus musculus.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF01056. Myc_N. 2 hits. [Graphical view]
PIRSF	PIRSF001705. Myc_protein. 1 hit.
PRINTS	PR00044. LEUZIPPRMYC.
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290968.
SOURCE	Search...

Entry information

Entry name

MYCL1_MOUSE

Accession

Primary (citable) accession number: P10166
Secondary accession number(s): Q5FWI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program