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Protein

Basic salivary proline-rich protein 4

Gene

PRB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Basic salivary proline-rich protein 4
Short name:
Salivary proline-rich protein Po
Alternative name(s):
Parotid o protein
Salivary proline-rich protein II-1
Cleaved into the following 3 chains:
Alternative name(s):
Proline-rich peptide IB-5
Gene namesi
Name:PRB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9340. PRB4.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5545.
PharmGKBiPA33702.

Polymorphism and mutation databases

BioMutaiPRB4.
DMDMi158517854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000002210217 – 310Basic salivary proline-rich protein 4Add BLAST294
PeptideiPRO_000002210317 – 39Protein N1Add BLAST23
ChainiPRO_000002210440 – 177Glycosylated protein AAdd BLAST138
ChainiPRO_0000022099241 – 310Peptide P-DAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)1 Publication1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P3 position is mostly lysine. The endoprotease may be of microbial origin. Pyroglutamate formation found on at least Gln-46, Gln-48, Gln-67, Gln-88; Gln-90; Gln-193; Gln-288 Gln-214 and Gln-295, preferentially in diabetic, and head and neck cancer patients.1 Publication

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlasiP10163.
PRIDEiP10163.
TopDownProteomicsiP10163.

Expressioni

Gene expression databases

CleanExiHS_PRB4.

Structurei

3D structure databases

DisProtiDP00119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 551Add BLAST21
Repeati56 – 762Add BLAST21
Repeati77 – 973Add BLAST21
Repeati98 – 1184Add BLAST21
Repeati119 – 1395Add BLAST21
Repeati140 – 1606Add BLAST21
Repeati161 – 1817Add BLAST21
Repeati182 – 2028Add BLAST21
Repeati203 – 2239Add BLAST21
Repeati224 – 23410; truncatedAdd BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 2349.5 X 21 AA tandem repeats of K-P-[EQ]-[GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]-[RG]-[PT]-P-P-[PH]-P-GAdd BLAST200

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

InParanoidiP10163.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 3 hits.
[Graphical view]
SMARTiSM01412. Pro-rich. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLILLSVAL LALSSAESSS EDVSQEESLF LISGKPEGRR PQGGNQPQRP
60 70 80 90 100
PPPPGKPQGP PPQGGNQSQG PPPPPGKPEG RPPQGGNQSQ GPPPHPGKPE
110 120 130 140 150
RPPPQGGNQS QGPPPHPGKP ESRPPQGGHQ SQGPPPTPGK PEGPPPQGGN
160 170 180 190 200
QSQGTPPPPG KPEGRPPQGG NQSQGPPPHP GKPERPPPQG GNQSHRPPPP
210 220 230 240 250
PGKPERPPPQ GGNQSQGPPP HPGKPEGPPP QEGNKSRSAR SPPGKPQGPP
260 270 280 290 300
QQEGNKPQGP PPPGKPQGPP PAGGNPQQPQ APPAGKPQGP PPPPQGGRPP
310
RPAQGQQPPQ
Length:310
Mass (Da):31,326
Last modified:May 14, 2014 - v4
Checksum:i079538A1BC412D0F
GO

Sequence cautioni

The sequence CAA30543 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA30729 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28S → P AA sequence (PubMed:8373986).Curated1
Sequence conflicti31 – 39LISGKPEGR → IIPPKPPG AA sequence (PubMed:8373986).Curated9
Sequence conflicti31 – 33LIS → PPP in AAB50687 (PubMed:8554050).Curated3
Sequence conflicti37E → Q in CAA30543 (PubMed:2851479).Curated1
Sequence conflicti37E → Q in CAA30542 (PubMed:3220251).Curated1
Sequence conflicti66N → D AA sequence (PubMed:8373986).Curated1
Sequence conflicti74 – 94Missing in CAA30542 (PubMed:3220251).CuratedAdd BLAST21
Sequence conflicti96P → PP AA sequence (PubMed:8373986).Curated1
Sequence conflicti101R → E AA sequence (PubMed:8373986).Curated1
Sequence conflicti122 – 123SR → RP in CAA30542 (PubMed:3220251).Curated2
Sequence conflicti129H → N in CAA30542 (PubMed:3220251).Curated1
Sequence conflicti154 – 174Missing in CAA30542 (PubMed:3220251).CuratedAdd BLAST21
Sequence conflicti169 – 171GGN → QGG AA sequence (PubMed:8373986).Curated3
Sequence conflicti192N → D AA sequence (PubMed:8373986).Curated1
Sequence conflicti213N → D AA sequence (PubMed:8373986).Curated1

Polymorphismi

The number of repeats is polymorphic and varies among different alleles. Allele S (short), allele M (medium) and allele L (long) contain 6, 7 and 9 tandem repeats respectively.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035034113 – 154Missing in allele M and allele S. Add BLAST42
Natural variantiVAR_035035164 – 184Missing in allele S. Add BLAST21
Natural variantiVAR_031548185R → G.Corresponds to variant rs11054244dbSNPEnsembl.1
Natural variantiVAR_031549186P → R.Corresponds to variant rs11054243dbSNPEnsembl.1
Natural variantiVAR_031550200P → H.Corresponds to variant rs12308244dbSNPEnsembl.1
Natural variantiVAR_031551272A → P.3 PublicationsCorresponds to variant rs1052808dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03207 mRNA. Translation: AAA60188.1.
X07882 Genomic DNA. Translation: CAA30729.1. Sequence problems.
X07715 Genomic DNA. Translation: CAA30543.1. Sequence problems.
AC010176 Genomic DNA. No translation available.
BC130386 mRNA. Translation: AAI30387.1.
S80916 Genomic DNA. Translation: AAB50687.2.
X07704 Genomic DNA. Translation: CAA30542.1.
PIRiS03176. PIHUSD.
UniGeneiHs.528651.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03207 mRNA. Translation: AAA60188.1.
X07882 Genomic DNA. Translation: CAA30729.1. Sequence problems.
X07715 Genomic DNA. Translation: CAA30543.1. Sequence problems.
AC010176 Genomic DNA. No translation available.
BC130386 mRNA. Translation: AAI30387.1.
S80916 Genomic DNA. Translation: AAB50687.2.
X07704 Genomic DNA. Translation: CAA30542.1.
PIRiS03176. PIHUSD.
UniGeneiHs.528651.

3D structure databases

DisProtiDP00119.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiPRB4.
DMDMi158517854.

Proteomic databases

PeptideAtlasiP10163.
PRIDEiP10163.
TopDownProteomicsiP10163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi5545.
GeneCardsiPRB4.
H-InvDBHIX0079490.
HGNCiHGNC:9340. PRB4.
MIMi180990. gene.
neXtProtiNX_P10163.
PharmGKBiPA33702.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP10163.

Miscellaneous databases

ChiTaRSiPRB4. human.
GeneWikiiPRB4.
GenomeRNAii5545.
PROiP10163.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PRB4.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 3 hits.
[Graphical view]
SMARTiSM01412. Pro-rich. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRB4_HUMAN
AccessioniPrimary (citable) accession number: P10163
Secondary accession number(s): A1L439
, O00600, P02813, P10161, P10162, P81489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 14, 2014
Last modified: November 2, 2016
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.