Reviewed, UniProtKB/Swiss-Prot P10158 (FOSL1_RAT)

Names and origin

Protein names

Recommended name:
    Fos-related antigen 1
      Short name=FRA-1

Gene names

Name:	Fosl1
Synonyms:	Fra1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Induction	By serum.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	female pregnancy Inferred from expression pattern. Source: RGD learning Inferred from expression pattern. Source: RGD negative regulation of cell proliferation Inferred from mutant phenotype. Source: RGD positive regulation of apoptosis Inferred from mutant phenotype. Source: RGD positive regulation of cell cycle Inferred from mutant phenotype. Source: RGD positive regulation of transcription from RNA polymerase II promoter, mitotic Inferred from direct assay. Source: RGD response to cAMP Inferred from expression pattern. Source: RGD response to corticosterone stimulus Inferred from expression pattern. Source: RGD response to cytokine stimulus Inferred from expression pattern. Source: RGD response to drug Inferred from expression pattern. Source: RGD response to gravity Inferred from expression pattern. Source: RGD response to hydrogen peroxide Inferred from expression pattern. Source: RGD response to mechanical stimulus Inferred from expression pattern. Source: RGD response to organic cyclic substance Inferred from expression pattern. Source: RGD response to progesterone stimulus Inferred from expression pattern. Source: RGD
Cellular component	cytosol Inferred from direct assay. Source: RGD microsome Inferred from direct assay. Source: RGD nucleus Inferred from direct assay. Source: RGD presynaptic membrane Inferred from direct assay. Source: RGD synaptosome Inferred from direct assay. Source: RGD
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription activator activity Inferred from mutant phenotype. Source: RGD transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Fos-related antigen 1		PRO_0000076481
Regions
	Domain	135 – 163	29	Leucine-zipper
	DNA binding	113 – 131	19	Basic motif
	Compositional bias	105 – 108	4	Poly-Glu
	Compositional bias	255 – 259	5	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	P10158-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 103726AD5D1FAB2F	FASTA	275	30,115
	10 20 30 40 50 60 MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ ELQWMVQPHF 70 80 90 100 110 120 LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE QISPEEEERR RVRRERNKLA 130 140 150 160 170 180 AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ REIEELQKQK ERLELVLEAH RPICKIPEED 190 200 210 220 230 240 KKDTGGTSST SGAGSPPGPC RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT 250 260 270 YPSTPEPCSS AHRKSSSSSG DPSSDPLGSP TLLAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen." Cohen D.R., Curran T. Mol. Cell. Biol. 8:2063-2069(1988) [PubMed: 3133553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron." Bergers G., Graninger P., Braselmann S., Wrighton C., Busslinger M. Mol. Cell. Biol. 15:3748-3758(1995) [PubMed: 7791782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M19651 mRNA. Translation: AAA41171.1. BC097342 mRNA. Translation: AAH97342.1. U24154 Genomic DNA. Translation: AAA82045.1.
IPI	IPI00187901.
PIR	TVRTFR. A27722.
RefSeq	NP_037085.1.
UniGene	Rn.11306
3D structure databases
HSSP	HSSP built from PDB template 1A02 based on UniProtKB P01100.
SMR	P10158. Positions 109-167.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1071N.
STRING	P10158.
PTM databases
PhosphoSite	P10158.
Genome annotation databases
Ensembl	ENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552; Rattus norvegicus. [Genome view]
GeneID	25445.
KEGG	rno:25445.
UCSC	NM_012953. rat.
Organism-specific databases
CTD	25445.
RGD	2627. Fosl1.
Phylogenomic databases
HOVERGEN	P10158.
OMA	PVPCISL.
Gene expression databases
ArrayExpress	P10158.
Genevestigator	P10158.
GermOnline	ENSRNOG00000020552. Rattus norvegicus.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR000837. Leuzip_Fos. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	606675.

Entry information

Entry name

FOSL1_RAT

Accession

Primary (citable) accession number: P10158
Secondary accession number(s): Q4V8K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 3, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)