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Protein

Fos-related antigen 1

Gene

Fosl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: RGD
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB

GO - Biological processi

  • cellular response to extracellular stimulus Source: Ensembl
  • female pregnancy Source: RGD
  • in utero embryonic development Source: Ensembl
  • learning Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • placenta blood vessel development Source: Ensembl
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cell cycle Source: RGD
  • positive regulation of DNA-templated transcription, initiation Source: Ensembl
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • response to cAMP Source: RGD
  • response to corticosterone Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to gravity Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to progesterone Source: RGD
  • transcription from RNA polymerase II promoter Source: GOC
  • vitellogenesis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:Fosl1
Synonyms:Fra1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2627. Fosl1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • presynaptic membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Fos-related antigen 1PRO_0000076481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10158.

PTM databases

PhosphoSiteiP10158.

Expressioni

Inductioni

By serum.

Gene expression databases

GenevisibleiP10158. RN.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

DIPiDIP-1071N.
STRINGi10116.ENSRNOP00000027891.

Structurei

3D structure databases

ProteinModelPortaliP10158.
SMRiP10158. Positions 109-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 17064bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 12921Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni135 – 16329Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 1084Poly-Glu
Compositional biasi255 – 2595Poly-Ser

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP10158.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG73V6MN.
PhylomeDBiP10158.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ
60 70 80 90 100
ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE
110 120 130 140 150
QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ
160 170 180 190 200
REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC
210 220 230 240 250
RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS
260 270
AHRKSSSSSG DPSSDPLGSP TLLAL
Length:275
Mass (Da):30,115
Last modified:July 1, 1989 - v1
Checksum:i103726AD5D1FAB2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19651 mRNA. Translation: AAA41171.1.
BC097342 mRNA. Translation: AAH97342.1.
U24154 Genomic DNA. Translation: AAA82045.1.
PIRiA27722. TVRTFR.
RefSeqiNP_037085.1. NM_012953.1.
UniGeneiRn.11306.

Genome annotation databases

EnsembliENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552.
GeneIDi25445.
KEGGirno:25445.
UCSCiRGD:2627. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19651 mRNA. Translation: AAA41171.1.
BC097342 mRNA. Translation: AAH97342.1.
U24154 Genomic DNA. Translation: AAA82045.1.
PIRiA27722. TVRTFR.
RefSeqiNP_037085.1. NM_012953.1.
UniGeneiRn.11306.

3D structure databases

ProteinModelPortaliP10158.
SMRiP10158. Positions 109-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-1071N.
STRINGi10116.ENSRNOP00000027891.

PTM databases

PhosphoSiteiP10158.

Proteomic databases

PaxDbiP10158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552.
GeneIDi25445.
KEGGirno:25445.
UCSCiRGD:2627. rat.

Organism-specific databases

CTDi8061.
RGDi2627. Fosl1.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP10158.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG73V6MN.
PhylomeDBiP10158.
TreeFamiTF326301.

Miscellaneous databases

NextBioi606675.
PROiP10158.

Gene expression databases

GenevisibleiP10158. RN.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen."
    Cohen D.R., Curran T.
    Mol. Cell. Biol. 8:2063-2069(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron."
    Bergers G., Graninger P., Braselmann S., Wrighton C., Busslinger M.
    Mol. Cell. Biol. 15:3748-3758(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFOSL1_RAT
AccessioniPrimary (citable) accession number: P10158
Secondary accession number(s): Q4V8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.