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Reviewed, UniProtKB/Swiss-Prot P10158 (FOSL1_RAT)

Last modified November 3, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fos-related antigen 1
      Short name=FRA-1
Gene names
Name: Fosl1
Synonyms: Fra1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subunit structure

Heterodimer By similarity.

Subcellular location

Nucleus.

Induction

By serum.

Sequence similarities

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
Gene Ontology (GO)
   Biological processfemale pregnancy

Inferred from expression pattern. Source: RGD

learning

Inferred from expression pattern. Source: RGD

negative regulation of cell proliferation

Inferred from mutant phenotype. Source: RGD

positive regulation of apoptosis

Inferred from mutant phenotype. Source: RGD

positive regulation of cell cycle

Inferred from mutant phenotype. Source: RGD

positive regulation of transcription from RNA polymerase II promoter, mitotic

Inferred from direct assay. Source: RGD

response to cAMP

Inferred from expression pattern. Source: RGD

response to corticosterone stimulus

Inferred from expression pattern. Source: RGD

response to cytokine stimulus

Inferred from expression pattern. Source: RGD

response to drug

Inferred from expression pattern. Source: RGD

response to gravity

Inferred from expression pattern. Source: RGD

response to hydrogen peroxide

Inferred from expression pattern. Source: RGD

response to mechanical stimulus

Inferred from expression pattern. Source: RGD

response to organic cyclic substance

Inferred from expression pattern. Source: RGD

response to progesterone stimulus

Inferred from expression pattern. Source: RGD

   Cellular componentcytosol

Inferred from direct assay. Source: RGD

microsome

Inferred from direct assay. Source: RGD

nucleus

Inferred from direct assay. Source: RGD

presynaptic membrane

Inferred from direct assay. Source: RGD

synaptosome

Inferred from direct assay. Source: RGD

   Molecular functionprotein dimerization activity

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription activator activity

Inferred from mutant phenotype. Source: RGD

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Fos-related antigen 1
PRO_0000076481

Regions

Domain135 – 16329Leucine-zipper
DNA binding113 – 13119Basic motif
Compositional bias105 – 1084Poly-Glu
Compositional bias255 – 2595Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
P10158-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 103726AD5D1FAB2F

FASTA27530,115
        10         20         30         40         50         60 
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ ELQWMVQPHF 

        70         80         90        100        110        120 
LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE QISPEEEERR RVRRERNKLA 

       130        140        150        160        170        180 
AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ REIEELQKQK ERLELVLEAH RPICKIPEED 

       190        200        210        220        230        240 
KKDTGGTSST SGAGSPPGPC RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT 

       250        260        270 
YPSTPEPCSS AHRKSSSSSG DPSSDPLGSP TLLAL 

« Hide

References

« Hide 'large scale' references
[1]"fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen."
Cohen D.R., Curran T.
Mol. Cell. Biol. 8:2063-2069(1988) [PubMed: 3133553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron."
Bergers G., Graninger P., Braselmann S., Wrighton C., Busslinger M.
Mol. Cell. Biol. 15:3748-3758(1995) [PubMed: 7791782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

M19651 mRNA. Translation: AAA41171.1.
BC097342 mRNA. Translation: AAH97342.1.
U24154 Genomic DNA. Translation: AAA82045.1.
IPIIPI00187901.
PIRTVRTFR. A27722.
RefSeqNP_037085.1.
UniGeneRn.11306

3D structure databases

HSSPHSSP built from PDB template 1A02 based on UniProtKB P01100.
SMRP10158. Positions 109-167.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1071N.
STRINGP10158.

PTM databases

PhosphoSiteP10158.

Genome annotation databases

EnsemblENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552; Rattus norvegicus. [Genome view]
GeneID25445.
KEGGrno:25445.
UCSCNM_012953. rat.

Organism-specific databases

CTD25445.
RGD2627. Fosl1.

Phylogenomic databases

HOVERGENP10158.
OMAPVPCISL.

Gene expression databases

ArrayExpressP10158.
GenevestigatorP10158.
GermOnlineENSRNOG00000020552. Rattus norvegicus.

Family and domain databases

InterProIPR011616. bZIP_1.
IPR000837. Leuzip_Fos.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio606675.

Entry information

Entry nameFOSL1_RAT
AccessionPrimary (citable) accession number: P10158
Secondary accession number(s): Q4V8K7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 3, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents