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Protein

Fos-related antigen 1

Gene

Fosl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to extracellular stimulus Source: RGD
  • female pregnancy Source: RGD
  • in utero embryonic development Source: RGD
  • learning Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • placenta blood vessel development Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cell cycle Source: RGD
  • positive regulation of DNA-templated transcription, initiation Source: RGD
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • pri-miRNA transcription from RNA polymerase II promoter Source: RGD
  • response to cAMP Source: RGD
  • response to corticosterone Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to gravity Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to progesterone Source: RGD
  • vitellogenesis Source: RGD

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:Fosl1
Synonyms:Fra1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2627. Fosl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764811 – 275Fos-related antigen 1Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10158.
PRIDEiP10158.

PTM databases

PhosphoSitePlusiP10158.

Expressioni

Inductioni

By serum.

Gene expression databases

BgeeiENSRNOG00000020552.
GenevisibleiP10158. RN.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

CORUMiP10158.
DIPiDIP-1071N.
STRINGi10116.ENSRNOP00000027891.

Structurei

3D structure databases

ProteinModelPortaliP10158.
SMRiP10158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 170bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 129Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni135 – 163Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 108Poly-Glu4
Compositional biasi255 – 259Poly-Ser5

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP10158.
KOiK04502.
OMAiPCEQISP.
OrthoDBiEOG091G0GGW.
PhylomeDBiP10158.
TreeFamiTF326301.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029815. Fra1.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF6. PTHR23351:SF6. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P10158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ
60 70 80 90 100
ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE
110 120 130 140 150
QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ
160 170 180 190 200
REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC
210 220 230 240 250
RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS
260 270
AHRKSSSSSG DPSSDPLGSP TLLAL
Length:275
Mass (Da):30,115
Last modified:July 1, 1989 - v1
Checksum:i103726AD5D1FAB2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19651 mRNA. Translation: AAA41171.1.
BC097342 mRNA. Translation: AAH97342.1.
U24154 Genomic DNA. Translation: AAA82045.1.
PIRiA27722. TVRTFR.
RefSeqiNP_037085.1. NM_012953.1.
UniGeneiRn.11306.

Genome annotation databases

EnsembliENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552.
GeneIDi25445.
KEGGirno:25445.
UCSCiRGD:2627. rat.

Similar proteinsi

Entry informationi

Entry nameiFOSL1_RAT
AccessioniPrimary (citable) accession number: P10158
Secondary accession number(s): Q4V8K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families