P10158 (FOSL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fos-related antigen 1
Short name=FRA-1

Gene names

Name:	Fosl1
Synonyms:	Fra1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Induction	By serum.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to extracellular stimulus Inferred from electronic annotation. Source: Compara female pregnancy Inferred from expression pattern PubMed 12080023. Source: RGD in utero embryonic development Inferred from electronic annotation. Source: Compara learning Inferred from expression pattern PubMed 16377429. Source: RGD negative regulation of cell proliferation Inferred from mutant phenotype PubMed 14597411. Source: RGD placenta blood vessel development Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from mutant phenotype PubMed 14597411. Source: RGD positive regulation of cell cycle Inferred from mutant phenotype PubMed 17347653. Source: RGD positive regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 12371906. Source: RGD response to cAMP Inferred from expression pattern PubMed 10934195. Source: RGD response to corticosterone stimulus Inferred from expression pattern PubMed 18485334. Source: RGD response to cytokine stimulus Inferred from expression pattern PubMed 12770614. Source: RGD response to drug Inferred from expression pattern PubMed 11488404. Source: RGD response to gravity Inferred from expression pattern PubMed 17274184. Source: RGD response to hydrogen peroxide Inferred from expression pattern PubMed 11053775. Source: RGD response to mechanical stimulus Inferred from expression pattern PubMed 16373449. Source: RGD response to progesterone stimulus Inferred from expression pattern PubMed 12080023. Source: RGD vitellogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from direct assay PubMed 10891591. Source: RGD neuron projection Inferred from direct assay PubMed 10891591. Source: RGD nucleus Inferred from direct assay PubMed 10891591PubMed 11036094. Source: RGD presynaptic membrane Inferred from direct assay PubMed 10891591. Source: RGD
Molecular_function	DNA binding Inferred from direct assay PubMed 12371906. Source: RGD RNA polymerase II regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Fos-related antigen 1		PRO_0000076481
Regions
	Domain	107 – 170	64	bZIP
	Region	109 – 129	21	Basic motif By similarity
	Region	135 – 163	29	Leucine-zipper By similarity
	Compositional bias	105 – 108	4	Poly-Glu
	Compositional bias	255 – 259	5	Poly-Ser
Amino acid modifications
	Modified residue	269	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P10158 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 103726AD5D1FAB2F	FASTA	275	30,115
	10 20 30 40 50 60 MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ ELQWMVQPHF 70 80 90 100 110 120 LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE QISPEEEERR RVRRERNKLA 130 140 150 160 170 180 AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ REIEELQKQK ERLELVLEAH RPICKIPEED 190 200 210 220 230 240 KKDTGGTSST SGAGSPPGPC RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT 250 260 270 YPSTPEPCSS AHRKSSSSSG DPSSDPLGSP TLLAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen." Cohen D.R., Curran T. Mol. Cell. Biol. 8:2063-2069(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron." Bergers G., Graninger P., Braselmann S., Wrighton C., Busslinger M. Mol. Cell. Biol. 15:3748-3758(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M19651 mRNA. Translation: AAA41171.1. BC097342 mRNA. Translation: AAH97342.1. U24154 Genomic DNA. Translation: AAA82045.1.
IPI	IPI00187901.
PIR	TVRTFR. A27722.
RefSeq	NP_037085.1. NM_012953.1.
UniGene	Rn.11306.
3D structure databases
ProteinModelPortal	P10158.
SMR	P10158. Positions 109-167.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1071N.
STRING	10116.ENSRNOP00000027891.
PTM databases
PhosphoSite	P10158.
Proteomic databases
PaxDb	P10158.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552.
GeneID	25445.
KEGG	rno:25445.
UCSC	RGD:2627. rat.
Organism-specific databases
CTD	8061.
RGD	2627. Fosl1.
Phylogenomic databases
eggNOG	NOG252534.
GeneTree	ENSGT00550000074426.
HOGENOM	HOG000234334.
HOVERGEN	HBG005743.
InParanoid	P10158.
KO	K04502.
OMA	CASAHRK.
OrthoDB	EOG41C6XG.
Gene expression databases
Genevestigator	P10158.
GermOnline	ENSRNOG00000020552. Rattus norvegicus.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	606675.

Entry information

Entry name

FOSL1_RAT

Accession

Primary (citable) accession number: P10158
Secondary accession number(s): Q4V8K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program