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Protein

C-C motif chemokine 2

Gene

Ccl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: MGI
  • cytokine activity Source: MGI
  • G-protein coupled receptor binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Platelet-derived growth factor-inducible protein JE
Small-inducible cytokine A2
Gene namesi
Name:Ccl2
Synonyms:Je, Mcp1, Scya2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98259 Ccl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000514924 – 148C-C motif chemokine 2Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP10148
PeptideAtlasiP10148
PRIDEiP10148

PTM databases

iPTMnetiP10148
PhosphoSitePlusiP10148

Expressioni

Inductioni

By platelet-derived growth factor. Up-regulated upon hypertonic conditions.1 Publication

Gene expression databases

BgeeiENSMUSG00000035385
CleanExiMM_CCL2
ExpressionAtlasiP10148 baseline and differential
GenevisibleiP10148 MM

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RHVP.R17E9M5R02EBI-16188285,EBI-16188152From Cricetid gammaherpesvirus 2.

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: MGI
  • cytokine activity Source: MGI
  • G-protein coupled receptor binding Source: MGI

Protein-protein interaction databases

BioGridi203121, 2 interactors
DIPiDIP-61917N
IntActiP10148, 1 interactor
STRINGi10090.ENSMUSP00000000193

Structurei

3D structure databases

ProteinModelPortaliP10148
SMRiP10148
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP10148
KOiK14624
OMAiNAPLTCC
OrthoDBiEOG091G14KV
PhylomeDBiP10148
TreeFamiTF339372

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES
60 70 80 90 100
YKRITSSRCP KEAVVFVTKL KREVCADPKK EWVQTYIKNL DRNQMRSEPT
110 120 130 140
TLFKTASALR SSAPLNVKLT RKSEANASTT FSTTTSSTSV GVTSVTVN
Length:148
Mass (Da):16,326
Last modified:July 1, 1989 - v1
Checksum:i29A5505FC6D94837
GO

Polymorphismi

The polymorphisms in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti50S → G in strain: SJL/J. 1 Publication1
Natural varianti92R → Q in strain: SJL/J. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04467 Genomic DNA Translation: AAA37685.1
M19681 Genomic DNA Translation: AAA37684.1
AF065929 mRNA Translation: AAF15379.1
AF065930 mRNA Translation: AAF15380.1
AF065931 mRNA Translation: AAF15381.1
AF065932 mRNA Translation: AAF15382.1
AF065933 mRNA Translation: AAF15383.1
CCDSiCCDS25139.1
PIRiA30209
S16226
RefSeqiNP_035463.1, NM_011333.3
UniGeneiMm.290320

Genome annotation databases

EnsembliENSMUST00000000193; ENSMUSP00000000193; ENSMUSG00000035385
GeneIDi20296
KEGGimmu:20296
UCSCiuc007kmp.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCL2_MOUSE
AccessioniPrimary (citable) accession number: P10148
Secondary accession number(s): Q9QYD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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