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P10148

- CCL2_MOUSE

UniProt

P10148 - CCL2_MOUSE

Protein

C-C motif chemokine 2

Gene

Ccl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.

    GO - Molecular functioni

    1. CCR2 chemokine receptor binding Source: BHF-UCL
    2. G-protein coupled receptor binding Source: MGI
    3. heparin binding Source: Ensembl
    4. protein binding Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. angiogenesis Source: BHF-UCL
    3. astrocyte cell migration Source: BHF-UCL
    4. cellular calcium ion homeostasis Source: Ensembl
    5. cellular response to fibroblast growth factor stimulus Source: Ensembl
    6. cellular response to interferon-gamma Source: BHF-UCL
    7. cellular response to interleukin-1 Source: BHF-UCL
    8. cellular response to lipopolysaccharide Source: BHF-UCL
    9. cellular response to organic cyclic compound Source: Ensembl
    10. cellular response to tumor necrosis factor Source: BHF-UCL
    11. chemokine-mediated signaling pathway Source: Ensembl
    12. cytoskeleton organization Source: Ensembl
    13. helper T cell extravasation Source: BHF-UCL
    14. inflammatory response Source: UniProtKB-KW
    15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    16. lymphocyte chemotaxis Source: Ensembl
    17. macrophage chemotaxis Source: BHF-UCL
    18. MAPK cascade Source: Ensembl
    19. maternal process involved in parturition Source: Ensembl
    20. monocyte chemotaxis Source: Ensembl
    21. monocyte homeostasis Source: BHF-UCL
    22. negative regulation of angiogenesis Source: BHF-UCL
    23. negative regulation of glial cell apoptotic process Source: Ensembl
    24. negative regulation of natural killer cell chemotaxis Source: Ensembl
    25. negative regulation of neuron apoptotic process Source: Ensembl
    26. neutrophil chemotaxis Source: Ensembl
    27. organ regeneration Source: Ensembl
    28. positive regulation of apoptotic cell clearance Source: BHF-UCL
    29. positive regulation of endothelial cell proliferation Source: Ensembl
    30. positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
    31. positive regulation of macrophage chemotaxis Source: BHF-UCL
    32. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
    33. positive regulation of synaptic transmission Source: Ensembl
    34. positive regulation of T cell activation Source: BHF-UCL
    35. protein kinase B signaling Source: Ensembl
    36. regulation of cell shape Source: Ensembl
    37. regulation of vascular endothelial growth factor production Source: BHF-UCL
    38. response to activity Source: Ensembl
    39. response to amino acid Source: Ensembl
    40. response to antibiotic Source: Ensembl
    41. response to drug Source: Ensembl
    42. response to ethanol Source: Ensembl
    43. response to gamma radiation Source: Ensembl
    44. response to glucocorticoid Source: Ensembl
    45. response to heat Source: Ensembl
    46. response to hypoxia Source: Ensembl
    47. response to mechanical stimulus Source: Ensembl
    48. response to progesterone Source: Ensembl
    49. response to vitamin B3 Source: Ensembl
    50. response to wounding Source: MGI
    51. transforming growth factor beta receptor signaling pathway Source: Ensembl
    52. vascular endothelial growth factor receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Platelet-derived growth factor-inducible protein JE
    Small-inducible cytokine A2
    Gene namesi
    Name:Ccl2
    Synonyms:Je, Mcp1, Scya2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98259. Ccl2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: MGI
    3. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 148125C-C motif chemokine 2PRO_0000005149Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiP10148.

    PTM databases

    PhosphoSiteiP10148.

    Expressioni

    Inductioni

    By platelet-derived growth factor. Up-regulated upon hypertonic conditions.1 Publication

    Gene expression databases

    ArrayExpressiP10148.
    BgeeiP10148.
    CleanExiMM_CCL2.
    GenevestigatoriP10148.

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    BioGridi203121. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP10148.
    SMRiP10148. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP10148.
    KOiK14624.
    OMAiVWNISAQ.
    OrthoDBiEOG7673DP.
    PhylomeDBiP10148.
    TreeFamiTF339372.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10148-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES    50
    YKRITSSRCP KEAVVFVTKL KREVCADPKK EWVQTYIKNL DRNQMRSEPT 100
    TLFKTASALR SSAPLNVKLT RKSEANASTT FSTTTSSTSV GVTSVTVN 148
    Length:148
    Mass (Da):16,326
    Last modified:July 1, 1989 - v1
    Checksum:i29A5505FC6D94837
    GO

    Polymorphismi

    The polymorphisms in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501S → G in strain: SJL/J. 1 Publication
    Natural varianti92 – 921R → Q in strain: SJL/J. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04467 Genomic DNA. Translation: AAA37685.1.
    M19681 Genomic DNA. Translation: AAA37684.1.
    AF065929 mRNA. Translation: AAF15379.1.
    AF065930 mRNA. Translation: AAF15380.1.
    AF065931 mRNA. Translation: AAF15381.1.
    AF065932 mRNA. Translation: AAF15382.1.
    AF065933 mRNA. Translation: AAF15383.1.
    CCDSiCCDS25139.1.
    PIRiA30209.
    S16226.
    RefSeqiNP_035463.1. NM_011333.3.
    UniGeneiMm.290320.

    Genome annotation databases

    EnsembliENSMUST00000000193; ENSMUSP00000000193; ENSMUSG00000035385.
    GeneIDi20296.
    KEGGimmu:20296.
    UCSCiuc007kmp.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04467 Genomic DNA. Translation: AAA37685.1 .
    M19681 Genomic DNA. Translation: AAA37684.1 .
    AF065929 mRNA. Translation: AAF15379.1 .
    AF065930 mRNA. Translation: AAF15380.1 .
    AF065931 mRNA. Translation: AAF15381.1 .
    AF065932 mRNA. Translation: AAF15382.1 .
    AF065933 mRNA. Translation: AAF15383.1 .
    CCDSi CCDS25139.1.
    PIRi A30209.
    S16226.
    RefSeqi NP_035463.1. NM_011333.3.
    UniGenei Mm.290320.

    3D structure databases

    ProteinModelPortali P10148.
    SMRi P10148. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203121. 2 interactions.

    PTM databases

    PhosphoSitei P10148.

    Proteomic databases

    PRIDEi P10148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000193 ; ENSMUSP00000000193 ; ENSMUSG00000035385 .
    GeneIDi 20296.
    KEGGi mmu:20296.
    UCSCi uc007kmp.1. mouse.

    Organism-specific databases

    CTDi 6347.
    MGIi MGI:98259. Ccl2.

    Phylogenomic databases

    eggNOGi NOG46819.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P10148.
    KOi K14624.
    OMAi VWNISAQ.
    OrthoDBi EOG7673DP.
    PhylomeDBi P10148.
    TreeFami TF339372.

    Miscellaneous databases

    NextBioi 298021.
    PROi P10148.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10148.
    Bgeei P10148.
    CleanExi MM_CCL2.
    Genevestigatori P10148.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4."
      Kawahara R.S., Deuel T.F.
      J. Biol. Chem. 264:679-682(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties."
      Rollins B.J., Morrison E.D., Stiles C.D.
      Proc. Natl. Acad. Sci. U.S.A. 85:3738-3742(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-50 AND GLN-92.
      Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    4. "Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene."
      van Damme J., Decock B., Bertini R., Conings R., Lenaerts J.-P., Put W., Opdenakker G., Mantovani A.
      Eur. J. Biochem. 199:223-229(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-42.
    5. "Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress."
      Ueno M., Shen W.J., Patel S., Greenberg A.S., Azhar S., Kraemer F.B.
      J. Lipid Res. 54:734-743(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY OSMOTIC STRESS.

    Entry informationi

    Entry nameiCCL2_MOUSE
    AccessioniPrimary (citable) accession number: P10148
    Secondary accession number(s): Q9QYD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3