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P10148

- CCL2_MOUSE

UniProt

P10148 - CCL2_MOUSE

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Protein
C-C motif chemokine 2
Gene
Ccl2, Je, Mcp1, Scya2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Molecular functioni

  1. CCR2 chemokine receptor binding Source: BHF-UCL
  2. G-protein coupled receptor binding Source: MGI
  3. heparin binding Source: Ensembl
  4. protein binding Source: MGI

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. aging Source: Ensembl
  3. angiogenesis Source: BHF-UCL
  4. astrocyte cell migration Source: BHF-UCL
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular response to fibroblast growth factor stimulus Source: Ensembl
  7. cellular response to interferon-gamma Source: BHF-UCL
  8. cellular response to interleukin-1 Source: BHF-UCL
  9. cellular response to lipopolysaccharide Source: BHF-UCL
  10. cellular response to organic cyclic compound Source: Ensembl
  11. cellular response to tumor necrosis factor Source: BHF-UCL
  12. chemokine-mediated signaling pathway Source: Ensembl
  13. cytoskeleton organization Source: Ensembl
  14. helper T cell extravasation Source: BHF-UCL
  15. inflammatory response Source: UniProtKB-KW
  16. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  17. lymphocyte chemotaxis Source: Ensembl
  18. macrophage chemotaxis Source: BHF-UCL
  19. maternal process involved in parturition Source: Ensembl
  20. monocyte chemotaxis Source: Ensembl
  21. monocyte homeostasis Source: BHF-UCL
  22. negative regulation of angiogenesis Source: BHF-UCL
  23. negative regulation of glial cell apoptotic process Source: Ensembl
  24. negative regulation of natural killer cell chemotaxis Source: Ensembl
  25. negative regulation of neuron apoptotic process Source: Ensembl
  26. neutrophil chemotaxis Source: Ensembl
  27. organ regeneration Source: Ensembl
  28. positive regulation of T cell activation Source: BHF-UCL
  29. positive regulation of apoptotic cell clearance Source: BHF-UCL
  30. positive regulation of endothelial cell proliferation Source: Ensembl
  31. positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
  32. positive regulation of macrophage chemotaxis Source: BHF-UCL
  33. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  34. positive regulation of synaptic transmission Source: Ensembl
  35. protein kinase B signaling Source: Ensembl
  36. regulation of cell shape Source: Ensembl
  37. regulation of vascular endothelial growth factor production Source: BHF-UCL
  38. response to activity Source: Ensembl
  39. response to amino acid Source: Ensembl
  40. response to antibiotic Source: Ensembl
  41. response to drug Source: Ensembl
  42. response to ethanol Source: Ensembl
  43. response to gamma radiation Source: Ensembl
  44. response to glucocorticoid Source: Ensembl
  45. response to heat Source: Ensembl
  46. response to hypoxia Source: Ensembl
  47. response to mechanical stimulus Source: Ensembl
  48. response to progesterone Source: Ensembl
  49. response to vitamin B3 Source: Ensembl
  50. response to wounding Source: MGI
  51. transforming growth factor beta receptor signaling pathway Source: Ensembl
  52. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Platelet-derived growth factor-inducible protein JE
Small-inducible cytokine A2
Gene namesi
Name:Ccl2
Synonyms:Je, Mcp1, Scya2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98259. Ccl2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: MGI
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 148125C-C motif chemokine 2
PRO_0000005149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Disulfide bondi34 ↔ 59 By similarity
Disulfide bondi35 ↔ 75 By similarity
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP10148.

PTM databases

PhosphoSiteiP10148.

Expressioni

Inductioni

By platelet-derived growth factor. Up-regulated upon hypertonic conditions.1 Publication

Gene expression databases

ArrayExpressiP10148.
BgeeiP10148.
CleanExiMM_CCL2.
GenevestigatoriP10148.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium By similarity.

Protein-protein interaction databases

BioGridi203121. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP10148.
SMRiP10148. Positions 24-92.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP10148.
KOiK14624.
OMAiVWNISAQ.
OrthoDBiEOG7673DP.
PhylomeDBiP10148.
TreeFamiTF339372.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10148-1 [UniParc]FASTAAdd to Basket

« Hide

MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES    50
YKRITSSRCP KEAVVFVTKL KREVCADPKK EWVQTYIKNL DRNQMRSEPT 100
TLFKTASALR SSAPLNVKLT RKSEANASTT FSTTTSSTSV GVTSVTVN 148
Length:148
Mass (Da):16,326
Last modified:July 1, 1989 - v1
Checksum:i29A5505FC6D94837
GO

Polymorphismi

The polymorphisms in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501S → G in strain: SJL/J. 1 Publication
Natural varianti92 – 921R → Q in strain: SJL/J. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04467 Genomic DNA. Translation: AAA37685.1.
M19681 Genomic DNA. Translation: AAA37684.1.
AF065929 mRNA. Translation: AAF15379.1.
AF065930 mRNA. Translation: AAF15380.1.
AF065931 mRNA. Translation: AAF15381.1.
AF065932 mRNA. Translation: AAF15382.1.
AF065933 mRNA. Translation: AAF15383.1.
CCDSiCCDS25139.1.
PIRiA30209.
S16226.
RefSeqiNP_035463.1. NM_011333.3.
UniGeneiMm.290320.

Genome annotation databases

EnsembliENSMUST00000000193; ENSMUSP00000000193; ENSMUSG00000035385.
GeneIDi20296.
KEGGimmu:20296.
UCSCiuc007kmp.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04467 Genomic DNA. Translation: AAA37685.1 .
M19681 Genomic DNA. Translation: AAA37684.1 .
AF065929 mRNA. Translation: AAF15379.1 .
AF065930 mRNA. Translation: AAF15380.1 .
AF065931 mRNA. Translation: AAF15381.1 .
AF065932 mRNA. Translation: AAF15382.1 .
AF065933 mRNA. Translation: AAF15383.1 .
CCDSi CCDS25139.1.
PIRi A30209.
S16226.
RefSeqi NP_035463.1. NM_011333.3.
UniGenei Mm.290320.

3D structure databases

ProteinModelPortali P10148.
SMRi P10148. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203121. 2 interactions.

PTM databases

PhosphoSitei P10148.

Proteomic databases

PRIDEi P10148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000193 ; ENSMUSP00000000193 ; ENSMUSG00000035385 .
GeneIDi 20296.
KEGGi mmu:20296.
UCSCi uc007kmp.1. mouse.

Organism-specific databases

CTDi 6347.
MGIi MGI:98259. Ccl2.

Phylogenomic databases

eggNOGi NOG46819.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P10148.
KOi K14624.
OMAi VWNISAQ.
OrthoDBi EOG7673DP.
PhylomeDBi P10148.
TreeFami TF339372.

Miscellaneous databases

NextBioi 298021.
PROi P10148.
SOURCEi Search...

Gene expression databases

ArrayExpressi P10148.
Bgeei P10148.
CleanExi MM_CCL2.
Genevestigatori P10148.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4."
    Kawahara R.S., Deuel T.F.
    J. Biol. Chem. 264:679-682(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties."
    Rollins B.J., Morrison E.D., Stiles C.D.
    Proc. Natl. Acad. Sci. U.S.A. 85:3738-3742(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-50 AND GLN-92.
    Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  4. "Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene."
    van Damme J., Decock B., Bertini R., Conings R., Lenaerts J.-P., Put W., Opdenakker G., Mantovani A.
    Eur. J. Biochem. 199:223-229(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-42.
  5. "Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress."
    Ueno M., Shen W.J., Patel S., Greenberg A.S., Azhar S., Kraemer F.B.
    J. Lipid Res. 54:734-743(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY OSMOTIC STRESS.

Entry informationi

Entry nameiCCL2_MOUSE
AccessioniPrimary (citable) accession number: P10148
Secondary accession number(s): Q9QYD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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