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Protein

C-C motif chemokine 1

Gene

Ccl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that is chemotactic for neutrophils.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central
  • cytokine activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 1
Alternative name(s):
P500
SIS-epsilon
Small-inducible cytokine A1
T-cell activation protein 3
Short name:
TCA-3
Short name:
TCA3
Gene namesi
Name:Ccl1
Synonyms:Scya1, Tca3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98258. Ccl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000514224 – 92C-C motif chemokine 1Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 74By similarity
Disulfide bondi49 ↔ 92By similarity
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10146.
PRIDEiP10146.

Expressioni

Inductioni

Produced by T-cell after stimulation by antigen or induction by concanavalin a (Con-A).

Gene expression databases

BgeeiENSMUSG00000020702.
CleanExiMM_CCL1.
ExpressionAtlasiP10146. baseline and differential.
GenevisibleiP10146. MM.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central
  • cytokine activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103824.

Structurei

3D structure databases

ProteinModelPortaliP10146.
SMRiP10146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J85U. Eukaryota.
ENOG4111AVY. LUCA.
GeneTreeiENSGT00530000064270.
HOGENOMiHOG000036686.
HOVERGENiHBG098128.
InParanoidiP10146.
KOiK05514.
OMAiMQIITTA.
OrthoDBiEOG091G15E8.
PhylomeDBiP10146.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10146-1) [UniParc]FASTAAdd to basket
Also known as: TCA3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY
60 70 80 90
RKMGSSCPDP PAVVFRLNKG RESCASTNKT WVQNHLKKVN PC
Length:92
Mass (Da):10,276
Last modified:July 1, 1989 - v1
Checksum:iBF057DEAA1771096
GO
Isoform 2 (identifier: P10146-2) [UniParc]FASTAAdd to basket
Also known as: P500, SIS-epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     65-86: FRLNKGRESCASTNKTWVQNHL → VRSSGVPGLTEAEKTVTDSSE

Show »
Length:91
Mass (Da):9,836
Checksum:iB28B9AC360F94DBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26M → V in CAB57869 (Ref. 3) Curated1

Polymorphismi

The polymorphisms in strains DBA/2J and SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti36N → T in strain: DBA/2J and SJL/J. 1 Publication1
Natural varianti64V → I in strain: DBA/2J and SJL/J. 1 Publication1
Natural varianti68N → K in strain: DBA/2J and SJL/J. 1 Publication1
Natural varianti70G → D in strain: DBA/2J and SJL/J. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00105965 – 86FRLNK…VQNHL → VRSSGVPGLTEAEKTVTDSS E in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17957 mRNA. Translation: AAB39499.1.
M23501 mRNA. Translation: AAA40147.1.
X52401 Genomic DNA. Translation: CAB57869.1.
AK019040 mRNA. Translation: BAB31521.1.
AF065924 mRNA. Translation: AAF15374.1.
AF065925 mRNA. Translation: AAF15375.1.
AF065926 mRNA. Translation: AAF15376.1.
AF065927 mRNA. Translation: AAF15377.1.
AF065928 mRNA. Translation: AAF15378.1.
CCDSiCCDS36249.1. [P10146-1]
PIRiS24236.
RefSeqiNP_035459.1. NM_011329.3. [P10146-1]
UniGeneiMm.1283.

Genome annotation databases

EnsembliENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702. [P10146-1]
GeneIDi20290.
KEGGimmu:20290.
UCSCiuc007kmu.1. mouse. [P10146-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17957 mRNA. Translation: AAB39499.1.
M23501 mRNA. Translation: AAA40147.1.
X52401 Genomic DNA. Translation: CAB57869.1.
AK019040 mRNA. Translation: BAB31521.1.
AF065924 mRNA. Translation: AAF15374.1.
AF065925 mRNA. Translation: AAF15375.1.
AF065926 mRNA. Translation: AAF15376.1.
AF065927 mRNA. Translation: AAF15377.1.
AF065928 mRNA. Translation: AAF15378.1.
CCDSiCCDS36249.1. [P10146-1]
PIRiS24236.
RefSeqiNP_035459.1. NM_011329.3. [P10146-1]
UniGeneiMm.1283.

3D structure databases

ProteinModelPortaliP10146.
SMRiP10146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103824.

Proteomic databases

PaxDbiP10146.
PRIDEiP10146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702. [P10146-1]
GeneIDi20290.
KEGGimmu:20290.
UCSCiuc007kmu.1. mouse. [P10146-1]

Organism-specific databases

CTDi6346.
MGIiMGI:98258. Ccl1.

Phylogenomic databases

eggNOGiENOG410J85U. Eukaryota.
ENOG4111AVY. LUCA.
GeneTreeiENSGT00530000064270.
HOGENOMiHOG000036686.
HOVERGENiHBG098128.
InParanoidiP10146.
KOiK05514.
OMAiMQIITTA.
OrthoDBiEOG091G15E8.
PhylomeDBiP10146.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Miscellaneous databases

PROiP10146.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020702.
CleanExiMM_CCL1.
ExpressionAtlasiP10146. baseline and differential.
GenevisibleiP10146. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL1_MOUSE
AccessioniPrimary (citable) accession number: P10146
Secondary accession number(s): P14098, Q9QUR9, Q9QUS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.