P10146 (CCL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 1

Alternative name(s):
P500
SIS-epsilon
Small-inducible cytokine A1
T-cell activation protein 3
Short name=TCA-3
Short name=TCA3

Gene names

Name:	Ccl1
Synonyms:	Scya1, Tca3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine that is chemotactic for neutrophils.
Induction	Produced by T-cell after stimulation by antigen or induction by concanavalin a (Con-A).
Polymorphism	The polymorphisms in strains DBA/2J and SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from direct assay PubMed 9670926. Source: MGI immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Inferred from direct assay PubMed 9670926. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P10146-1)

Also known as: TCA3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P10146-2)

Also known as: P500; SIS-epsilon;

The sequence of this isoform differs from the canonical sequence as follows:
     65-86: FRLNKGRESCASTNKTWVQNHL → VRSSGVPGLTEAEKTVTDSSE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 92	69	C-C motif chemokine 1		PRO_0000005142
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Disulfide bond	33 ↔ 57		By similarity
	Disulfide bond	34 ↔ 74		By similarity
	Disulfide bond	49 ↔ 92		By similarity
Natural variations
	Alternative sequence	65 – 86	22	FRLNK…VQNHL → VRSSGVPGLTEAEKTVTDSS E in isoform 2.		VSP_001059
	Natural variant	36	1	N → T in strain: DBA/2J and SJL/J. Ref.5
	Natural variant	64	1	V → I in strain: DBA/2J and SJL/J. Ref.5
	Natural variant	68	1	N → K in strain: DBA/2J and SJL/J. Ref.5
	Natural variant	70	1	G → D in strain: DBA/2J and SJL/J. Ref.5
Experimental info
	Sequence conflict	26	1	M → V in CAB57869. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TCA3) [UniParc]. Last modified July 1, 1989. Version 1. Checksum: BF057DEAA1771096	FASTA	92	10,276
	10 20 30 40 50 60 MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY RKMGSSCPDP 70 80 90 PAVVFRLNKG RESCASTNKT WVQNHLKKVN PC
	Isoform 2 (P500) (SIS-epsilon) [UniParc]. Checksum: B28B9AC360F94DBE	FASTA	91	9,836
	10 20 30 40 50 60 MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY RKMGSSCPDP 70 80 90 PAVVVRSSGV PGLTEAEKTV TDSSEKKVNP C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel T cell activation gene." Burd P.R., Freeman G.J., Wilson S.D., Berman M., Dekruyff R., Billings P.R., Dorf M.E. J. Immunol. 139:3126-3131(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes." Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G. J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Molecular and functional characterization of TCA3: a novel inflammatory cytokine." Wilson S.D., Billings P.R., D'Eustachio P., Fournier R., Gessler E., Lalley P.A., Burd P.R., Housman D.E., Taylor B.A., Dorf M.E. Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Pancreas.
[5]	"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis." Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P. J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76 (ISOFORM 1), VARIANTS THR-36; ILE-64; LYS-68 AND ASP-70. Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J. Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17957 mRNA. Translation: AAB39499.1. M23501 mRNA. Translation: AAA40147.1. X52401 Genomic DNA. Translation: CAB57869.1. AK019040 mRNA. Translation: BAB31521.1. AF065924 mRNA. Translation: AAF15374.1. AF065925 mRNA. Translation: AAF15375.1. AF065926 mRNA. Translation: AAF15376.1. AF065927 mRNA. Translation: AAF15377.1. AF065928 mRNA. Translation: AAF15378.1.
IPI	IPI00108086. IPI00221612.
PIR	S24236.
RefSeq	NP_035459.1. NM_011329.3.
UniGene	Mm.1283.
3D structure databases
ProteinModelPortal	P10146.
SMR	P10146. Positions 27-89.
ModBase	Search...
Proteomic databases
PRIDE	P10146.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702.
GeneID	20290.
KEGG	mmu:20290.
UCSC	uc007kmu.1. mouse.
Organism-specific databases
CTD	6346.
MGI	MGI:98258. Ccl1.
Phylogenomic databases
eggNOG	NOG68213.
HOGENOM	HOG000036686.
HOVERGEN	HBG098128.
InParanoid	P10146.
KO	K05514.
OMA	SSICSNE.
OrthoDB	EOG4J119T.
Gene expression databases
ArrayExpress	P10146.
Bgee	P10146.
CleanEx	MM_CCL1.
Genevestigator	P10146.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298003.
SOURCE	Search...

Entry information

Entry name

CCL1_MOUSE

Accession

Primary (citable) accession number: P10146
Secondary accession number(s): P14098, Q9QUR9, Q9QUS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 29, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program