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P10146

- CCL1_MOUSE

UniProt

P10146 - CCL1_MOUSE

Protein

C-C motif chemokine 1

Gene

Ccl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cytokine that is chemotactic for neutrophils.

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. chemotaxis Source: MGI
    3. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 1
    Alternative name(s):
    P500
    SIS-epsilon
    Small-inducible cytokine A1
    T-cell activation protein 3
    Short name:
    TCA-3
    Short name:
    TCA3
    Gene namesi
    Name:Ccl1
    Synonyms:Scya1, Tca3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98258. Ccl1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 1PRO_0000005142Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 74By similarity
    Disulfide bondi49 ↔ 92By similarity
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP10146.

    Expressioni

    Inductioni

    Produced by T-cell after stimulation by antigen or induction by concanavalin a (Con-A).

    Gene expression databases

    ArrayExpressiP10146.
    BgeeiP10146.
    CleanExiMM_CCL1.
    GenevestigatoriP10146.

    Structurei

    3D structure databases

    ProteinModelPortaliP10146.
    SMRiP10146. Positions 27-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68213.
    HOGENOMiHOG000036686.
    HOVERGENiHBG098128.
    InParanoidiP10146.
    KOiK05514.
    OMAiITHGVIN.
    OrthoDBiEOG7K9K59.
    PhylomeDBiP10146.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P10146-1) [UniParc]FASTAAdd to Basket

    Also known as: TCA3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY   50
    RKMGSSCPDP PAVVFRLNKG RESCASTNKT WVQNHLKKVN PC 92
    Length:92
    Mass (Da):10,276
    Last modified:July 1, 1989 - v1
    Checksum:iBF057DEAA1771096
    GO
    Isoform 2 (identifier: P10146-2) [UniParc]FASTAAdd to Basket

    Also known as: P500, SIS-epsilon

    The sequence of this isoform differs from the canonical sequence as follows:
         65-86: FRLNKGRESCASTNKTWVQNHL → VRSSGVPGLTEAEKTVTDSSE

    Show »
    Length:91
    Mass (Da):9,836
    Checksum:iB28B9AC360F94DBE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261M → V in CAB57869. 1 PublicationCurated

    Polymorphismi

    The polymorphisms in strains DBA/2J and SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361N → T in strain: DBA/2J and SJL/J. 1 Publication
    Natural varianti64 – 641V → I in strain: DBA/2J and SJL/J. 1 Publication
    Natural varianti68 – 681N → K in strain: DBA/2J and SJL/J. 1 Publication
    Natural varianti70 – 701G → D in strain: DBA/2J and SJL/J. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei65 – 8622FRLNK…VQNHL → VRSSGVPGLTEAEKTVTDSS E in isoform 2. 1 PublicationVSP_001059Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17957 mRNA. Translation: AAB39499.1.
    M23501 mRNA. Translation: AAA40147.1.
    X52401 Genomic DNA. Translation: CAB57869.1.
    AK019040 mRNA. Translation: BAB31521.1.
    AF065924 mRNA. Translation: AAF15374.1.
    AF065925 mRNA. Translation: AAF15375.1.
    AF065926 mRNA. Translation: AAF15376.1.
    AF065927 mRNA. Translation: AAF15377.1.
    AF065928 mRNA. Translation: AAF15378.1.
    CCDSiCCDS36249.1. [P10146-1]
    PIRiS24236.
    RefSeqiNP_035459.1. NM_011329.3. [P10146-1]
    XP_006532692.1. XM_006532629.1.
    UniGeneiMm.1283.

    Genome annotation databases

    EnsembliENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702. [P10146-1]
    GeneIDi20290.
    KEGGimmu:20290.
    UCSCiuc007kmu.1. mouse. [P10146-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17957 mRNA. Translation: AAB39499.1 .
    M23501 mRNA. Translation: AAA40147.1 .
    X52401 Genomic DNA. Translation: CAB57869.1 .
    AK019040 mRNA. Translation: BAB31521.1 .
    AF065924 mRNA. Translation: AAF15374.1 .
    AF065925 mRNA. Translation: AAF15375.1 .
    AF065926 mRNA. Translation: AAF15376.1 .
    AF065927 mRNA. Translation: AAF15377.1 .
    AF065928 mRNA. Translation: AAF15378.1 .
    CCDSi CCDS36249.1. [P10146-1 ]
    PIRi S24236.
    RefSeqi NP_035459.1. NM_011329.3. [P10146-1 ]
    XP_006532692.1. XM_006532629.1.
    UniGenei Mm.1283.

    3D structure databases

    ProteinModelPortali P10146.
    SMRi P10146. Positions 27-89.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P10146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108189 ; ENSMUSP00000103824 ; ENSMUSG00000020702 . [P10146-1 ]
    GeneIDi 20290.
    KEGGi mmu:20290.
    UCSCi uc007kmu.1. mouse. [P10146-1 ]

    Organism-specific databases

    CTDi 6346.
    MGIi MGI:98258. Ccl1.

    Phylogenomic databases

    eggNOGi NOG68213.
    HOGENOMi HOG000036686.
    HOVERGENi HBG098128.
    InParanoidi P10146.
    KOi K05514.
    OMAi ITHGVIN.
    OrthoDBi EOG7K9K59.
    PhylomeDBi P10146.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298003.
    PROi P10146.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10146.
    Bgeei P10146.
    CleanExi MM_CCL1.
    Genevestigatori P10146.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel T cell activation gene."
      Burd P.R., Freeman G.J., Wilson S.D., Berman M., Dekruyff R., Billings P.R., Dorf M.E.
      J. Immunol. 139:3126-3131(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
      Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
      J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Molecular and functional characterization of TCA3: a novel inflammatory cytokine."
      Wilson S.D., Billings P.R., D'Eustachio P., Fournier R., Gessler E., Lalley P.A., Burd P.R., Housman D.E., Taylor B.A., Dorf M.E.
      Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Pancreas.
    5. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76 (ISOFORM 1), VARIANTS THR-36; ILE-64; LYS-68 AND ASP-70.
      Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCCL1_MOUSE
    AccessioniPrimary (citable) accession number: P10146
    Secondary accession number(s): P14098, Q9QUR9, Q9QUS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3