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P10146 (CCL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 1
Alternative name(s):
P500
SIS-epsilon
Small-inducible cytokine A1
T-cell activation protein 3
Short name=TCA-3
Short name=TCA3
Gene names
Name:Ccl1
Synonyms:Scya1, Tca3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that is chemotactic for neutrophils.

Induction

Produced by T-cell after stimulation by antigen or induction by concanavalin a (Con-A).

Polymorphism

The polymorphisms in strains DBA/2J and SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

chemotaxis

Inferred from direct assay PubMed 9670926. Source: MGI

immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 9670926. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P10146-1)

Also known as: TCA3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P10146-2)

Also known as: P500; SIS-epsilon;

The sequence of this isoform differs from the canonical sequence as follows:
     65-86: FRLNKGRESCASTNKTWVQNHL → VRSSGVPGLTEAEKTVTDSSE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9269C-C motif chemokine 1
PRO_0000005142

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 74 By similarity
Disulfide bond49 ↔ 92 By similarity

Natural variations

Alternative sequence65 – 8622FRLNK…VQNHL → VRSSGVPGLTEAEKTVTDSS E in isoform 2.
VSP_001059
Natural variant361N → T in strain: DBA/2J and SJL/J. Ref.5
Natural variant641V → I in strain: DBA/2J and SJL/J. Ref.5
Natural variant681N → K in strain: DBA/2J and SJL/J. Ref.5
Natural variant701G → D in strain: DBA/2J and SJL/J. Ref.5

Experimental info

Sequence conflict261M → V in CAB57869. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (TCA3) [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: BF057DEAA1771096

FASTA9210,276
        10         20         30         40         50         60 
MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY RKMGSSCPDP 

        70         80         90 
PAVVFRLNKG RESCASTNKT WVQNHLKKVN PC 

« Hide

Isoform 2 (P500) (SIS-epsilon) [UniParc].

Checksum: B28B9AC360F94DBE
Show »

FASTA919,836

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel T cell activation gene."
Burd P.R., Freeman G.J., Wilson S.D., Berman M., Dekruyff R., Billings P.R., Dorf M.E.
J. Immunol. 139:3126-3131(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Molecular and functional characterization of TCA3: a novel inflammatory cytokine."
Wilson S.D., Billings P.R., D'Eustachio P., Fournier R., Gessler E., Lalley P.A., Burd P.R., Housman D.E., Taylor B.A., Dorf M.E.
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Pancreas.
[5]"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76 (ISOFORM 1), VARIANTS THR-36; ILE-64; LYS-68 AND ASP-70.
Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17957 mRNA. Translation: AAB39499.1.
M23501 mRNA. Translation: AAA40147.1.
X52401 Genomic DNA. Translation: CAB57869.1.
AK019040 mRNA. Translation: BAB31521.1.
AF065924 mRNA. Translation: AAF15374.1.
AF065925 mRNA. Translation: AAF15375.1.
AF065926 mRNA. Translation: AAF15376.1.
AF065927 mRNA. Translation: AAF15377.1.
AF065928 mRNA. Translation: AAF15378.1.
PIRS24236.
RefSeqNP_035459.1. NM_011329.3.
XP_006532692.1. XM_006532629.1.
UniGeneMm.1283.

3D structure databases

ProteinModelPortalP10146.
SMRP10146. Positions 27-89.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP10146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702. [P10146-1]
GeneID20290.
KEGGmmu:20290.
UCSCuc007kmu.1. mouse. [P10146-1]

Organism-specific databases

CTD6346.
MGIMGI:98258. Ccl1.

Phylogenomic databases

eggNOGNOG68213.
HOGENOMHOG000036686.
HOVERGENHBG098128.
InParanoidP10146.
KOK05514.
OMASSICSNE.
OrthoDBEOG7K9K59.
PhylomeDBP10146.
TreeFamTF334888.

Gene expression databases

ArrayExpressP10146.
BgeeP10146.
CleanExMM_CCL1.
GenevestigatorP10146.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298003.
PROP10146.
SOURCESearch...

Entry information

Entry nameCCL1_MOUSE
AccessionPrimary (citable) accession number: P10146
Secondary accession number(s): P14098, Q9QUR9, Q9QUS5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot