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P10146

- CCL1_MOUSE

UniProt

P10146 - CCL1_MOUSE

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Protein

C-C motif chemokine 1

Gene

Ccl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine that is chemotactic for neutrophils.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. chemotaxis Source: MGI
  3. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 1
Alternative name(s):
P500
SIS-epsilon
Small-inducible cytokine A1
T-cell activation protein 3
Short name:
TCA-3
Short name:
TCA3
Gene namesi
Name:Ccl1
Synonyms:Scya1, Tca3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98258. Ccl1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9269C-C motif chemokine 1PRO_0000005142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 74By similarity
Disulfide bondi49 ↔ 92By similarity
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP10146.

Expressioni

Inductioni

Produced by T-cell after stimulation by antigen or induction by concanavalin a (Con-A).

Gene expression databases

BgeeiP10146.
CleanExiMM_CCL1.
ExpressionAtlasiP10146. baseline and differential.
GenevestigatoriP10146.

Structurei

3D structure databases

ProteinModelPortaliP10146.
SMRiP10146. Positions 33-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68213.
HOGENOMiHOG000036686.
HOVERGENiHBG098128.
InParanoidiP10146.
KOiK05514.
OMAiITHGVIN.
OrthoDBiEOG7K9K59.
PhylomeDBiP10146.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P10146-1) [UniParc]FASTAAdd to Basket

Also known as: TCA3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY
60 70 80 90
RKMGSSCPDP PAVVFRLNKG RESCASTNKT WVQNHLKKVN PC
Length:92
Mass (Da):10,276
Last modified:July 1, 1989 - v1
Checksum:iBF057DEAA1771096
GO
Isoform 2 (identifier: P10146-2) [UniParc]FASTAAdd to Basket

Also known as: P500, SIS-epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     65-86: FRLNKGRESCASTNKTWVQNHL → VRSSGVPGLTEAEKTVTDSSE

Show »
Length:91
Mass (Da):9,836
Checksum:iB28B9AC360F94DBE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261M → V in CAB57869. 1 PublicationCurated

Polymorphismi

The polymorphisms in strains DBA/2J and SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361N → T in strain: DBA/2J and SJL/J. 1 Publication
Natural varianti64 – 641V → I in strain: DBA/2J and SJL/J. 1 Publication
Natural varianti68 – 681N → K in strain: DBA/2J and SJL/J. 1 Publication
Natural varianti70 – 701G → D in strain: DBA/2J and SJL/J. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei65 – 8622FRLNK…VQNHL → VRSSGVPGLTEAEKTVTDSS E in isoform 2. 1 PublicationVSP_001059Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17957 mRNA. Translation: AAB39499.1.
M23501 mRNA. Translation: AAA40147.1.
X52401 Genomic DNA. Translation: CAB57869.1.
AK019040 mRNA. Translation: BAB31521.1.
AF065924 mRNA. Translation: AAF15374.1.
AF065925 mRNA. Translation: AAF15375.1.
AF065926 mRNA. Translation: AAF15376.1.
AF065927 mRNA. Translation: AAF15377.1.
AF065928 mRNA. Translation: AAF15378.1.
CCDSiCCDS36249.1. [P10146-1]
PIRiS24236.
RefSeqiNP_035459.1. NM_011329.3. [P10146-1]
XP_006532692.1. XM_006532629.1.
UniGeneiMm.1283.

Genome annotation databases

EnsembliENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702. [P10146-1]
GeneIDi20290.
KEGGimmu:20290.
UCSCiuc007kmu.1. mouse. [P10146-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17957 mRNA. Translation: AAB39499.1 .
M23501 mRNA. Translation: AAA40147.1 .
X52401 Genomic DNA. Translation: CAB57869.1 .
AK019040 mRNA. Translation: BAB31521.1 .
AF065924 mRNA. Translation: AAF15374.1 .
AF065925 mRNA. Translation: AAF15375.1 .
AF065926 mRNA. Translation: AAF15376.1 .
AF065927 mRNA. Translation: AAF15377.1 .
AF065928 mRNA. Translation: AAF15378.1 .
CCDSi CCDS36249.1. [P10146-1 ]
PIRi S24236.
RefSeqi NP_035459.1. NM_011329.3. [P10146-1 ]
XP_006532692.1. XM_006532629.1.
UniGenei Mm.1283.

3D structure databases

ProteinModelPortali P10146.
SMRi P10146. Positions 33-92.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P10146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108189 ; ENSMUSP00000103824 ; ENSMUSG00000020702 . [P10146-1 ]
GeneIDi 20290.
KEGGi mmu:20290.
UCSCi uc007kmu.1. mouse. [P10146-1 ]

Organism-specific databases

CTDi 6346.
MGIi MGI:98258. Ccl1.

Phylogenomic databases

eggNOGi NOG68213.
HOGENOMi HOG000036686.
HOVERGENi HBG098128.
InParanoidi P10146.
KOi K05514.
OMAi ITHGVIN.
OrthoDBi EOG7K9K59.
PhylomeDBi P10146.
TreeFami TF334888.

Miscellaneous databases

NextBioi 298003.
PROi P10146.
SOURCEi Search...

Gene expression databases

Bgeei P10146.
CleanExi MM_CCL1.
ExpressionAtlasi P10146. baseline and differential.
Genevestigatori P10146.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel T cell activation gene."
    Burd P.R., Freeman G.J., Wilson S.D., Berman M., Dekruyff R., Billings P.R., Dorf M.E.
    J. Immunol. 139:3126-3131(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
    Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
    J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Molecular and functional characterization of TCA3: a novel inflammatory cytokine."
    Wilson S.D., Billings P.R., D'Eustachio P., Fournier R., Gessler E., Lalley P.A., Burd P.R., Housman D.E., Taylor B.A., Dorf M.E.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Pancreas.
  5. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76 (ISOFORM 1), VARIANTS THR-36; ILE-64; LYS-68 AND ASP-70.
    Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.

Entry informationi

Entry nameiCCL1_MOUSE
AccessioniPrimary (citable) accession number: P10146
Secondary accession number(s): P14098, Q9QUR9, Q9QUS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3