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P10144

- GRAB_HUMAN

UniProt

P10144 - GRAB_HUMAN

Protein

Granzyme B

Gene

GZMB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

    Catalytic activityi

    Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.1 Publication

    Enzyme regulationi

    Inactivated by the serine protease inhibitor diisopropylfluorophosphate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Charge relay system
    Active sitei108 – 1081Charge relay system
    Active sitei203 – 2031Charge relay system
    Sitei228 – 2281Mediates preference for Asp-containing substratesBy similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. serine-type endopeptidase activity Source: UniProtKB
    3. serine-type peptidase activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. cytolysis Source: UniProtKB-KW
    3. intrinsic apoptotic signaling pathway Source: Reactome
    4. Notch signaling pathway Source: Reactome
    5. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Apoptosis, Cytolysis

    Enzyme and pathway databases

    ReactomeiREACT_163910. NOTCH2 intracellular domain regulates transcription.
    REACT_701. Activation, myristolyation of BID and translocation to mitochondria.

    Protein family/group databases

    MEROPSiS01.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Granzyme B (EC:3.4.21.79)
    Alternative name(s):
    C11
    CTLA-1
    Cathepsin G-like 1
    Short name:
    CTSGL1
    Cytotoxic T-lymphocyte proteinase 2
    Short name:
    Lymphocyte protease
    Fragmentin-2
    Granzyme-2
    Human lymphocyte protein
    Short name:
    HLP
    SECT
    T-cell serine protease 1-3E
    Gene namesi
    Name:GZMB
    Synonyms:CGL1, CSPB, CTLA1, GRB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:4709. GZMB.

    Subcellular locationi

    Cytoplasmic granule 1 Publication
    Note: Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. immunological synapse Source: UniProtKB
    4. intracellular membrane-bounded organelle Source: HPA
    5. membrane Source: UniProtKB
    6. nucleus Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Propeptidei19 – 202Activation peptide4 PublicationsPRO_0000027399
    Chaini21 – 247227Granzyme BPRO_0000027400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 65
    Glycosylationi71 – 711N-linked (GlcNAc...)
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 209
    Disulfide bondi173 ↔ 188

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP10144.
    PRIDEiP10144.

    PTM databases

    PhosphoSiteiP10144.

    Miscellaneous databases

    PMAP-CutDBP10144.

    Expressioni

    Inductioni

    By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.

    Gene expression databases

    ArrayExpressiP10144.
    BgeeiP10144.
    CleanExiHS_GZMB.
    GenevestigatoriP10144.

    Organism-specific databases

    HPAiCAB000376.
    HPA003418.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRF1P142223EBI-2505785,EBI-724466
    SRGNP101242EBI-2505785,EBI-744915

    Protein-protein interaction databases

    BioGridi109257. 30 interactions.
    IntActiP10144. 6 interactions.
    MINTiMINT-4528791.
    STRINGi9606.ENSP00000216341.

    Structurei

    Secondary structure

    1
    247
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 417
    Beta strandi46 – 5510
    Beta strandi58 – 614
    Helixi63 – 653
    Beta strandi68 – 758
    Turni79 – 824
    Beta strandi87 – 9610
    Turni102 – 1043
    Beta strandi110 – 1167
    Beta strandi141 – 1488
    Beta strandi150 – 1545
    Beta strandi161 – 1677
    Helixi170 – 1767
    Turni177 – 1804
    Turni183 – 1853
    Beta strandi186 – 1905
    Beta strandi205 – 2095
    Beta strandi212 – 2209
    Beta strandi228 – 2325
    Helixi233 – 2364
    Helixi237 – 2459

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FQ3X-ray3.10A/B21-247[»]
    1IAUX-ray2.00A21-247[»]
    ProteinModelPortaliP10144.
    SMRiP10144. Positions 21-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10144.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 245225Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP10144.
    KOiK01353.
    PhylomeDBiP10144.
    TreeFamiTF333630.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10144-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPILLLLAF LLLPRADAGE IIGGHEAKPH SRPYMAYLMI WDQKSLKRCG    50
    GFLIRDDFVL TAAHCWGSSI NVTLGAHNIK EQEPTQQFIP VKRPIPHPAY 100
    NPKNFSNDIM LLQLERKAKR TRAVQPLRLP SNKAQVKPGQ TCSVAGWGQT 150
    APLGKHSHTL QEVKMTVQED RKCESDLRHY YDSTIELCVG DPEIKKTSFK 200
    GDSGGPLVCN KVAQGIVSYG RNNGMPPRAC TKVSSFVHWI KKTMKRY 247
    Length:247
    Mass (Da):27,716
    Last modified:January 11, 2011 - v2
    Checksum:iC652271918EF24F9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 332RP → PR AA sequence (PubMed:8258716)Curated
    Sequence conflicti72 – 721V → G in AAA52118. (PubMed:3261871)Curated
    Sequence conflicti212 – 2121V → C in AAB59528. (PubMed:2788607)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551R → Q.7 Publications
    Corresponds to variant rs8192917 [ dbSNP | Ensembl ].
    VAR_018371
    Natural varianti94 – 941P → A.2 Publications
    Corresponds to variant rs11539752 [ dbSNP | Ensembl ].
    VAR_047409
    Natural varianti247 – 2471Y → H.2 Publications
    Corresponds to variant rs2236338 [ dbSNP | Ensembl ].
    VAR_018381

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17016 mRNA. Translation: AAA36627.1.
    J03189 mRNA. Translation: AAA36603.1.
    J04071 mRNA. Translation: AAA52118.1.
    J03072 Genomic DNA. Translation: AAB59528.1.
    M38193 Genomic DNA. Translation: AAA67124.1.
    M28879 Genomic DNA. Translation: AAA75490.1.
    AL136018 Genomic DNA. No translation available.
    BC030195 mRNA. Translation: AAH30195.1.
    CCDSiCCDS9633.1.
    PIRiA61021.
    RefSeqiNP_004122.2. NM_004131.4.
    UniGeneiHs.1051.

    Genome annotation databases

    EnsembliENST00000216341; ENSP00000216341; ENSG00000100453.
    GeneIDi3002.
    KEGGihsa:3002.
    UCSCiuc001wps.2. human.

    Polymorphism databases

    DMDMi317373361.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17016 mRNA. Translation: AAA36627.1 .
    J03189 mRNA. Translation: AAA36603.1 .
    J04071 mRNA. Translation: AAA52118.1 .
    J03072 Genomic DNA. Translation: AAB59528.1 .
    M38193 Genomic DNA. Translation: AAA67124.1 .
    M28879 Genomic DNA. Translation: AAA75490.1 .
    AL136018 Genomic DNA. No translation available.
    BC030195 mRNA. Translation: AAH30195.1 .
    CCDSi CCDS9633.1.
    PIRi A61021.
    RefSeqi NP_004122.2. NM_004131.4.
    UniGenei Hs.1051.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FQ3 X-ray 3.10 A/B 21-247 [» ]
    1IAU X-ray 2.00 A 21-247 [» ]
    ProteinModelPortali P10144.
    SMRi P10144. Positions 21-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109257. 30 interactions.
    IntActi P10144. 6 interactions.
    MINTi MINT-4528791.
    STRINGi 9606.ENSP00000216341.

    Chemistry

    BindingDBi P10144.
    ChEMBLi CHEMBL2316.

    Protein family/group databases

    MEROPSi S01.010.

    PTM databases

    PhosphoSitei P10144.

    Polymorphism databases

    DMDMi 317373361.

    Proteomic databases

    PaxDbi P10144.
    PRIDEi P10144.

    Protocols and materials databases

    DNASUi 3002.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216341 ; ENSP00000216341 ; ENSG00000100453 .
    GeneIDi 3002.
    KEGGi hsa:3002.
    UCSCi uc001wps.2. human.

    Organism-specific databases

    CTDi 3002.
    GeneCardsi GC14M025100.
    H-InvDB HIX0011578.
    HGNCi HGNC:4709. GZMB.
    HPAi CAB000376.
    HPA003418.
    MIMi 123910. gene.
    neXtProti NX_P10144.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P10144.
    KOi K01353.
    PhylomeDBi P10144.
    TreeFami TF333630.

    Enzyme and pathway databases

    Reactomei REACT_163910. NOTCH2 intracellular domain regulates transcription.
    REACT_701. Activation, myristolyation of BID and translocation to mitochondria.

    Miscellaneous databases

    ChiTaRSi GZMB. human.
    EvolutionaryTracei P10144.
    GeneWikii GZMB.
    GenomeRNAii 3002.
    NextBioi 11904.
    PMAP-CutDB P10144.
    PROi P10144.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10144.
    Bgeei P10144.
    CleanExi HS_GZMB.
    Genevestigatori P10144.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes."
      Schmid J., Weissmann C.
      J. Immunol. 139:250-256(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-55.
    2. "Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes."
      Caputo A., Fahey D., Lloyd C., Vozab R., McCairns E., Rowe P.B.
      J. Biol. Chem. 263:6363-6369(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-94.
    3. "Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes."
      Trapani J.A., Klein J.L., White P.C., Dupont B.
      Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-55.
    4. "Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes."
      Klein J.L., Shows T.B., Dupont B., Trapani J.A.
      Genomics 5:110-117(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-55.
    5. "Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene."
      Caputo A., Sauer D.E., Rowe P.B.
      J. Immunol. 145:737-744(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-55.
    6. "Structural organization of the hCTLA-1 gene encoding human granzyme B."
      Haddad P., Clement M.-V., Bernard O., Larsen C.-J., Degos L., Sasportes M., Mathieu-Mahul D.
      Gene 87:265-271(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-55 AND ALA-94.
    7. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-55 AND HIS-247.
      Tissue: Pancreas.
    9. "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14."
      Dahl C.A., Bach F.H., Chan W., Huebner K., Russo G., Croce C.M., Herfurth T., Cairns J.S.
      Hum. Genet. 84:465-470(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23.
    10. "Characterization of three serine esterases isolated from human IL-2 activated killer cells."
      Hameed A., Lowrey D.M., Lichtenheld M., Podack E.R.
      J. Immunol. 141:3142-3147(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-40, CHARACTERIZATION.
    11. "Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes."
      Kraehenbuhl O., Rey C., Jenne D.E., Lanzavecchia A., Groscurth P., Carrel S., Tschopp J.
      J. Immunol. 141:3471-3477(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-40, CHARACTERIZATION.
    12. "Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes."
      Froelich C.J., Zhang X., Turbov J., Hudig D., Winkler U., Hanna W.L.
      J. Immunol. 151:7161-7171(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-39, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION.
      Tissue: Lymphocyte.
    13. "Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity."
      Poe M., Blake J.T., Boulton D.A., Gammon M., Sigal N.H., Wu J.K., Zweerink H.J.
      J. Biol. Chem. 266:98-103(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-38.
    14. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-33.
    15. "Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue."
      Estebanez-Perpina E., Fuentes-Prior P., Belorgey D., Braun M., Kiefersauer R., Maskos K., Huber R., Rubin H., Bode W.
      Biol. Chem. 381:1203-1214(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 21-247.
    16. "The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1."
      Rotonda J., Garcia-Calvo M., Bull H.G., Geissler W.M., McKeever B.M., Willoughby C.A., Thornberry N.A., Becker J.W.
      Chem. Biol. 8:357-368(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 21-247.
    17. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
      Saito S., Iida A., Sekine A., Kawauchi S., Higuchi S., Ogawa C., Nakamura Y.
      J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLN-55 AND HIS-247.

    Entry informationi

    Entry nameiGRAB_HUMAN
    AccessioniPrimary (citable) accession number: P10144
    Secondary accession number(s): Q8N1D2, Q9UCC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 165 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3