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Protein

Serglycin

Gene

SRGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Biomineralization

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122862-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serglycin
Alternative name(s):
Hematopoietic proteoglycan core protein
Platelet proteoglycan core protein
Short name:
P.PG
Secretory granule proteoglycan core protein
Gene namesi
Name:SRGN
Synonyms:PRG, PRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9361. SRGN.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Ensembl
  • mast cell granule Source: UniProtKB
  • platelet alpha granule lumen Source: Reactome
  • zymogen granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5552.
OpenTargetsiENSG00000122862.
PharmGKBiPA33733.

Polymorphism and mutation databases

BioMutaiSRGN.
DMDMi269849659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 272 PublicationsAdd BLAST27
ChainiPRO_000002667928 – 158SerglycinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 49Sequence analysis
Glycosylationi94O-linked (Xyl...) (glycosaminoglycan)1 Publication1
Glycosylationi96O-linked (Xyl...) (glycosaminoglycan)1 Publication1
Glycosylationi100O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi102O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi104O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi106O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi108O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi110O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and heparan sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDiP10124.
MaxQBiP10124.
PaxDbiP10124.
PeptideAtlasiP10124.
PRIDEiP10124.

Expressioni

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiENSG00000122862.
CleanExiHS_SRGN.
GenevisibleiP10124. HS.

Organism-specific databases

HPAiHPA000759.

Interactioni

Subunit structurei

Binds to activated CD44 and to GZMB.

Binary interactionsi

WithEntry#Exp.IntActNotes
GZMBP101442EBI-744915,EBI-2505785
SGTAO437656EBI-744915,EBI-347996
UBQLN1Q9UMX05EBI-744915,EBI-741480
UBQLN1Q9UMX0-23EBI-744915,EBI-10173939

Protein-protein interaction databases

BioGridi111543. 10 interactors.
IntActiP10124. 19 interactors.
MINTiMINT-1466608.
STRINGi9606.ENSP00000242465.

Structurei

3D structure databases

ProteinModelPortaliP10124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati94 – 9512
Repeati96 – 9722
Repeati98 – 9932
Repeati100 – 10142
Repeati102 – 10352
Repeati104 – 10562
Repeati106 – 10772
Repeati108 – 10982
Repeati110 – 11192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 1119 X 2 AA tandem repeats of [SF]-GAdd BLAST18

Sequence similaritiesi

Belongs to the serglycin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J42T. Eukaryota.
ENOG4111DTK. LUCA.
GeneTreeiENSGT00390000000885.
HOGENOMiHOG000154415.
HOVERGENiHBG008180.
InParanoidiP10124.
KOiK06849.
OMAiSNSANCI.
OrthoDBiEOG091G19FW.
PhylomeDBiP10124.
TreeFamiTF336310.

Family and domain databases

InterProiIPR007455. Serglycin.
[Graphical view]
PfamiPF04360. Serglycin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQKLLKCSR LVLALALILV LESSVQGYPT RRARYQWVRC NPDSNSANCL
60 70 80 90 100
EEKGPMFELL PGESNKIPRL RTDLFPKTRI QDLNRIFPLS EDYSGSGFGS
110 120 130 140 150
GSGSGSGSGS GFLTEMEQDY QLVDESDAFH DNLRSLDRNL PSDSQDLGQH

GLEEDFML
Length:158
Mass (Da):17,652
Last modified:November 24, 2009 - v3
Checksum:iBD7767F39FFBC477
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139N → S in CAA31255 (PubMed:3402609).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03276131R → Q.6 PublicationsCorresponds to variant rs2805910dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03223 mRNA. Translation: AAA60179.1.
X17042 mRNA. Translation: CAA34900.1.
M33651, M33649, M33650 Genomic DNA. Translation: AAA60322.1.
M90058 Genomic DNA. No translation available.
AK311873 mRNA. Translation: BAG34814.1.
AL442635 Genomic DNA. Translation: CAH71778.1.
CH471083 Genomic DNA. Translation: EAW54309.1.
BC015516 mRNA. Translation: AAH15516.1.
X12765 mRNA. Translation: CAA31255.1.
CCDSiCCDS7285.1.
PIRiA35183. A28058.
RefSeqiNP_001307982.1. NM_001321053.1.
NP_001307983.1. NM_001321054.1.
NP_002718.2. NM_002727.3.
XP_016871881.1. XM_017016392.1.
UniGeneiHs.1908.

Genome annotation databases

EnsembliENST00000242465; ENSP00000242465; ENSG00000122862.
GeneIDi5552.
KEGGihsa:5552.
UCSCiuc001joz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03223 mRNA. Translation: AAA60179.1.
X17042 mRNA. Translation: CAA34900.1.
M33651, M33649, M33650 Genomic DNA. Translation: AAA60322.1.
M90058 Genomic DNA. No translation available.
AK311873 mRNA. Translation: BAG34814.1.
AL442635 Genomic DNA. Translation: CAH71778.1.
CH471083 Genomic DNA. Translation: EAW54309.1.
BC015516 mRNA. Translation: AAH15516.1.
X12765 mRNA. Translation: CAA31255.1.
CCDSiCCDS7285.1.
PIRiA35183. A28058.
RefSeqiNP_001307982.1. NM_001321053.1.
NP_001307983.1. NM_001321054.1.
NP_002718.2. NM_002727.3.
XP_016871881.1. XM_017016392.1.
UniGeneiHs.1908.

3D structure databases

ProteinModelPortaliP10124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111543. 10 interactors.
IntActiP10124. 19 interactors.
MINTiMINT-1466608.
STRINGi9606.ENSP00000242465.

Polymorphism and mutation databases

BioMutaiSRGN.
DMDMi269849659.

Proteomic databases

EPDiP10124.
MaxQBiP10124.
PaxDbiP10124.
PeptideAtlasiP10124.
PRIDEiP10124.

Protocols and materials databases

DNASUi5552.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242465; ENSP00000242465; ENSG00000122862.
GeneIDi5552.
KEGGihsa:5552.
UCSCiuc001joz.4. human.

Organism-specific databases

CTDi5552.
DisGeNETi5552.
GeneCardsiSRGN.
HGNCiHGNC:9361. SRGN.
HPAiHPA000759.
MIMi177040. gene.
neXtProtiNX_P10124.
OpenTargetsiENSG00000122862.
PharmGKBiPA33733.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J42T. Eukaryota.
ENOG4111DTK. LUCA.
GeneTreeiENSGT00390000000885.
HOGENOMiHOG000154415.
HOVERGENiHBG008180.
InParanoidiP10124.
KOiK06849.
OMAiSNSANCI.
OrthoDBiEOG091G19FW.
PhylomeDBiP10124.
TreeFamiTF336310.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122862-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiSRGN. human.
GeneWikiiSRGN.
GenomeRNAii5552.
PROiP10124.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122862.
CleanExiHS_SRGN.
GenevisibleiP10124. HS.

Family and domain databases

InterProiIPR007455. Serglycin.
[Graphical view]
PfamiPF04360. Serglycin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRGN_HUMAN
AccessioniPrimary (citable) accession number: P10124
Secondary accession number(s): B2R4L7, Q5VW06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.