P10123 (RLBP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinaldehyde-binding protein 1

Alternative name(s):
Cellular retinaldehyde-binding protein

Gene names

Name:	RLBP1
Synonyms:	CRALBP

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Subcellular location	Cytoplasm.
Tissue specificity	Retina and pineal gland.
Sequence similarities	Contains 1 CRAL-TRIO domain.

Ontologies

Keywords
Biological process	Sensory transduction Transport Vision
Cellular component	Cytoplasm
Ligand	Retinol-binding
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	11-cis retinal binding Inferred from electronic annotation. Source: Compara retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 317	316	Retinaldehyde-binding protein 1		PRO_0000079329
Regions
	Domain	136 – 297	162	CRAL-TRIO
Sites
	Binding site	180	1	11-cis-retinal By similarity
	Binding site	202	1	11-cis-retinal By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.3
Experimental info
	Sequence conflict	162	1	N → I in AAA30751. Ref.1
	Sequence conflict	272	1	D → E in AAA30751. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P10123 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 7CAD389A9FF8CF15	FASTA	317	36,505
	10 20 30 40 50 60 MSEGAGTFRM VPEEEQELRA QLERLTTKDH GPVFGPCSQL PRHTLQKAKD ELNEKEETRE 70 80 90 100 110 120 EAVRELQELV QAEAASGQEL AVAVAERVQG KDSAFFLRFI RARKFHVGRA YELLRGYVNF 130 140 150 160 170 180 RLQYPELFDS LSPEAVRCTV EAGYPGVLST RDKYGRVVML FNIENWDSEE ITFDEILQAY 190 200 210 220 230 240 CVILEKLLEN EETQINGFCI IENFKGFTMQ QAAGLRPSDL RKMVDMLQDS FPARFKAIHF 250 260 270 280 290 300 IYQPWYFTTT YNVVKPFLKS KLLQRVFVHG EDLSSFYQEF DEDILPSDFG GTLPKYDGKA 310 VAEQLFGPRD QTENTAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures." Crabb J.W., Goldflam S., Harris S.E., Saari J.C. J. Biol. Chem. 263:18688-18692(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.
[3]	"The complete primary structure of the cellular retinaldehyde-binding protein from bovine retina." Crabb J.W., Johnson C.M., Carr S.A., Armes L.G., Saari J.C. J. Biol. Chem. 263:18678-18687(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-317.
[4]	"Topological and epitope mapping of the cellular retinaldehyde-binding protein from retina." Crabb J.W., Gaur V.P., Garwin G.G., Marx S.V., Chapline C., Johnson C.M., Saari J.C. J. Biol. Chem. 266:16674-16683(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04214 mRNA. Translation: AAA30751.1. BC118140 mRNA. Translation: AAI18141.1.
IPI	IPI00712695.
PIR	A31955.
RefSeq	NP_776876.2. NM_174451.3.
UniGene	Bt.88426.
3D structure databases
ProteinModelPortal	P10123.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000026581.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000047900; ENSBTAP00000045055; ENSBTAG00000033721.
GeneID	282038.
KEGG	bta:282038.
Organism-specific databases
CTD	6017.
Phylogenomic databases
eggNOG	NOG317741.
GeneTree	ENSGT00550000074253.
HOGENOM	HOG000059544.
HOVERGEN	HBG004720.
InParanoid	P10123.
OMA	GYVNFRL.
OrthoDB	EOG42FSJ0.
Family and domain databases
Gene3D	3.40.525.10. 1 hit.
InterPro	IPR001071. CRAL-bd_toc_tran. IPR001251. CRAL-TRIO_dom. IPR011074. CRAL/TRIO_N_dom. [Graphical view]
Pfam	PF00650. CRAL_TRIO. 1 hit. PF03765. CRAL_TRIO_N. 1 hit. [Graphical view]
PRINTS	PR00180. CRETINALDHBP.
SMART	SM01100. CRAL_TRIO_N. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF46938. Sec14p_like_N. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805901.

Entry information

Entry name

RLBP1_BOVIN

Accession

Primary (citable) accession number: P10123
Secondary accession number(s): Q17QW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 92 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program