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Protein

Basic phospholipase A2 2

Gene
N/A
Organism
Laticauda colubrina (Yellow-lipped sea krait) (Banded sea krait)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28Calcium; via carbonyl oxygenBy similarity1
Metal bindingi30Calcium; via carbonyl oxygenBy similarity1
Metal bindingi32Calcium; via carbonyl oxygenBy similarity1
Active sitei48By similarity1
Metal bindingi49CalciumBy similarity1
Active sitei92By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Neurotoxin, Presynaptic neurotoxin, Toxin
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic phospholipase A2 2 (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
Phospholipase A2 isozyme II
Short name:
PLA-II
OrganismiLaticauda colubrina (Yellow-lipped sea krait) (Banded sea krait)
Taxonomic identifieri8628 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeLaticaudinaeLaticauda

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.045 mg/kg by intravenous injection into mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001616511 – 118Basic phospholipase A2 2Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 71By similarity
Disulfide bondi27 ↔ 117By similarity
Disulfide bondi29 ↔ 45By similarity
Disulfide bondi44 ↔ 98By similarity
Disulfide bondi51 ↔ 91By similarity
Disulfide bondi60 ↔ 84By similarity
Disulfide bondi78 ↔ 89By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP10116.
SMRiP10116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008137.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiView protein in InterPro
IPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiView protein in Pfam
PF00068. Phospholip_A2_1. 1 hit.
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiView protein in SMART
SM00085. PA2c. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiView protein in PROSITE
PS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

P10116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NLIQFSELIQ CANKGKRATY YYMDYGCYCG KGGSGTPVDD LDRCCKTHDD
60 70 80 90 100
CYGQAEKKGC FPFLTLYNFI CFPGGPTCDR GTTCQRFVCD CDIQAAFCFA
110
RSPYNNKNYN INISKRCK
Length:118
Mass (Da):13,353
Last modified:July 1, 1989 - v1
Checksum:i278BA549DA61AEBC
GO

Sequence databases

PIRiS01140.

Cross-referencesi

Sequence databases

PIRiS01140.

3D structure databases

ProteinModelPortaliP10116.
SMRiP10116.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008137.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiView protein in InterPro
IPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiView protein in Pfam
PF00068. Phospholip_A2_1. 1 hit.
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiView protein in SMART
SM00085. PA2c. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiView protein in PROSITE
PS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPA2B2_LATCO
AccessioniPrimary (citable) accession number: P10116
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.