Reviewed,
UniProtKB/Swiss-Prot P10109 (ADX_HUMAN)
Last modified
November 25, 2008.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adrenodoxin, mitochondrial Alternative name(s): Adrenal ferredoxin Ferredoxin-1 Hepatoredoxin | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 184 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Participates in the synthesis of thyroid hormones. Transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450. |
| Cofactor | Binds 1 2Fe-2S cluster. |
| Subcellular location | |
| Sequence similarities | Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain. |
| Biophysicochemical properties | Redox potential: E0 is -448 mV. |
Ontologies
Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | 2Fe-2S Iron Iron-sulfur Metal-binding |
Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: InterPro electron carrier activityTraceable author statement. Source: ProtInc iron ion binding Ref.3Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 60 | 60 | Mitochondrion | ||||||
| Chain | 61 – 184 | 124 | Adrenodoxin, mitochondrial | PRO_0000000988 | |||||
Regions | |||||||||
| Domain | 67 – 171 | 105 | 2Fe-2S ferredoxin-type | ||||||
Sites | |||||||||
| Metal binding | 106 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 112 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 115 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 152 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and structure of the human adrenodoxin gene." Chang C.-Y., Wu D.-A., Lai C.-C., Miller W.L., Chung B.-C. DNA 7:609-615(1988) [PubMed: 3229285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells." Picado-Leonard J., Voutilainen R., Kao L.-C., Chung B.-C., Strauss J.F. III, Miller W.L. J. Biol. Chem. 263:3240-3244(1988) [PubMed: 3343244] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Molecular cloning and sequence analysis of human placental ferredoxin." Mittal S., Zhu Y.-Z., Vickery L.E. Arch. Biochem. Biophys. 264:383-391(1988) [PubMed: 2969697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [4] | "Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family." Chang C.-Y., Wu D.-A., Mohandas T.K., Chung B.-C. DNA Cell Biol. 9:205-212(1990) [PubMed: 2340092] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [5] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta. |
| [7] | "Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode." Johnson D., Norman S., Tuckey R.C., Martin L.L. Bioelectrochemistry 59:41-47(2003) [PubMed: 12699818] [Abstract] Cited for: CYCLIC VOLTAMMETRY. |
| [8] | "1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins." Skjeldal L., Markley J.L., Coghlan V.M., Vickery L.E. Biochemistry 30:9078-9083(1991) [PubMed: 1909889] [Abstract] Cited for: STRUCTURE BY NMR. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M23668 Genomic DNA. Translation: AAA50462.1. J03548 mRNA. Translation: AAA96806.1. M18003 mRNA. Translation: AAA76853.1. M34788 mRNA. Translation: AAA35829.1. M34786, M34784 Genomic DNA. Translation: AAA35856.1. M34785, M34783 Genomic DNA. Translation: AAA35855.1. BT006681 mRNA. Translation: AAP35327.1. BC010284 mRNA. Translation: AAH10284.1. BC017063 mRNA. Translation: AAH17063.1. | |
| PIR | AXHU. A31853. |
| RefSeq | NP_004100.1. |
| UniGene | Hs.744 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1L6U based on UniProtKB P00257. |
| SMR | P10109. Positions 65-168. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P10109. |
Genome annotation databases | |
| Ensembl | ENSG00000137714. Homo sapiens. [Contig view] |
| GeneID | 2230. |
| KEGG | hsa:2230. |
| NMPDR | fig|9606.3.peg.6579. |
Organism-specific databases | |
| H-InvDB | HIX0010099. HIX0059989. |
| HGNC | HGNC:3638. FDX1. |
| MIM | 103260. gene. |
| PharmGKB | PA28082. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P10109. |
| HOVERGEN | P10109. |
Gene expression databases | |
| ArrayExpress | P10109. |
| CleanEx | HS_FDX1. |
| GermOnline | ENSG00000137714. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001055. Adrenodoxin. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. [Graphical view] |
| Gene3D | G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. |
| Pfam | PF00111. Fer2. 1 hit. [Graphical view] |
| PRINTS | PR00355. ADRENODOXIN. |
| PROSITE | PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00648. Mitotane. |
| LinkHub | P10109. |
| NextBio | 9031. |
| SOURCE | Search... |
Entry information
| Entry name | ADX_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P10109 Secondary accession number(s): Q53YD6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


