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P10107

- ANXA1_MOUSE

UniProt

P10107 - ANXA1_MOUSE

Protein

Annexin A1

Gene

Anxa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phospholipase A2 inhibitor activity Source: UniProtKB-KW
    4. protein binding Source: MGI
    5. structural molecule activity Source: Ensembl

    GO - Biological processi

    1. alpha-beta T cell differentiation Source: BHF-UCL
    2. arachidonic acid secretion Source: MGI
    3. cell surface receptor signaling pathway Source: Ensembl
    4. cellular response to glucocorticoid stimulus Source: Ensembl
    5. cellular response to hydrogen peroxide Source: Ensembl
    6. endocrine pancreas development Source: Ensembl
    7. estrous cycle phase Source: Ensembl
    8. gliogenesis Source: Ensembl
    9. hepatocyte differentiation Source: Ensembl
    10. insulin secretion Source: Ensembl
    11. keratinocyte differentiation Source: Ensembl
    12. negative regulation of acute inflammatory response Source: Ensembl
    13. negative regulation of apoptotic process Source: Ensembl
    14. negative regulation of protein secretion Source: Ensembl
    15. neutrophil clearance Source: Ensembl
    16. neutrophil homeostasis Source: BHF-UCL
    17. peptide cross-linking Source: Ensembl
    18. positive regulation of G1/S transition of mitotic cell cycle Source: MGI
    19. positive regulation of neutrophil apoptotic process Source: BHF-UCL
    20. positive regulation of prostaglandin biosynthetic process Source: Ensembl
    21. positive regulation of vesicle fusion Source: Ensembl
    22. regulation of cell proliferation Source: MGI
    23. response to drug Source: Ensembl
    24. response to estradiol Source: Ensembl
    25. response to interleukin-1 Source: Ensembl
    26. response to peptide hormone Source: Ensembl
    27. response to X-ray Source: Ensembl
    28. signal transduction Source: MGI

    Keywords - Molecular functioni

    Phospholipase A2 inhibitor

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A1
    Alternative name(s):
    Annexin I
    Annexin-1
    Calpactin II
    Calpactin-2
    Chromobindin-9
    Lipocortin I
    Phospholipase A2 inhibitory protein
    p35
    Gene namesi
    Name:Anxa1
    Synonyms:Anx1, Lpc-1, Lpc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:96819. Anxa1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity. Basolateral cell membrane By similarity
    Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. cilium Source: UniProtKB-SubCell
    3. cornified envelope Source: Ensembl
    4. extracellular space Source: Ensembl
    5. extracellular vesicular exosome Source: Ensembl
    6. mitochondrial membrane Source: Ensembl
    7. nucleus Source: UniProtKB-SubCell
    8. protein complex Source: Ensembl
    9. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 346345Annexin A1PRO_0000067461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei5 – 51Phosphoserine; by TRPM7By similarity
    Cross-linki19 – 19Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)By similarity
    Modified residuei21 – 211Phosphotyrosine1 Publication
    Modified residuei27 – 271Phosphoserine; by PKCBy similarity
    Modified residuei37 – 371PhosphoserineBy similarity
    Modified residuei58 – 581N6-acetyllysine1 Publication
    Modified residuei312 – 3121N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity By similarity.By similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein

    Proteomic databases

    MaxQBiP10107.
    PaxDbiP10107.
    PRIDEiP10107.

    2D gel databases

    COMPLUYEAST-2DPAGEP10107.

    PTM databases

    PhosphoSiteiP10107.

    Expressioni

    Gene expression databases

    ArrayExpressiP10107.
    BgeeiP10107.
    CleanExiMM_ANXA1.
    GenevestigatoriP10107.

    Interactioni

    Subunit structurei

    Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF.1 Publication

    Protein-protein interaction databases

    BioGridi201194. 4 interactions.
    IntActiP10107. 6 interactions.
    MINTiMINT-274958.

    Structurei

    3D structure databases

    ProteinModelPortaliP10107.
    SMRiP10107. Positions 2-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati51 – 11161Annexin 1Add
    BLAST
    Repeati123 – 18361Annexin 2Add
    BLAST
    Repeati207 – 26761Annexin 3Add
    BLAST
    Repeati282 – 34261Annexin 4Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG282829.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    KOiK17091.
    OMAiGTRHKTL.
    OrthoDBiEOG74XS72.
    PhylomeDBiP10107.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002388. AnnexinI.
    [Graphical view]
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00197. ANNEXINI.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10107-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMVSEFLKQ ARFLENQEQE YVQAVKSYKG GPGSAVSPYP SFNVSSDVAA    50
    LHKAIMVKGV DEATIIDILT KRTNAQRQQI KAAYLQENGK PLDEVLRKAL 100
    TGHLEEVVLA MLKTPAQFDA DELRGAMKGL GTDEDTLIEI LTTRSNEQIR 150
    EINRVYREEL KRDLAKDITS DTSGDFRKAL LALAKGDRCQ DLSVNQDLAD 200
    TDARALYEAG ERRKGTDVNV FTTILTSRSF PHLRRVFQNY GKYSQHDMNK 250
    ALDLELKGDI EKCLTTIVKC ATSTPAFFAE KLYEAMKGAG TRHKALIRIM 300
    VSRSEIDMNE IKVFYQKKYG ISLCQAILDE TKGDYEKILV ALCGGN 346
    Length:346
    Mass (Da):38,734
    Last modified:January 23, 2007 - v2
    Checksum:i9393A11B24191D3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 792QQ → PR in AAA39420. (PubMed:2522299)Curated
    Sequence conflicti212 – 2121R → I in AAA39437. (PubMed:1676980)Curated
    Sequence conflicti222 – 2221T → H in AAA39420. (PubMed:2522299)Curated
    Sequence conflicti274 – 2741T → H in AAA39420. (PubMed:2522299)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07486 mRNA. Translation: CAA30371.1.
    M69260
    , M69250, M69251, M69252, M69253, M69254, M69255, M69256, M69257, M69258, M69259 Genomic DNA. Translation: AAA39437.1.
    BC002289 mRNA. Translation: AAH02289.1.
    BC004594 mRNA. Translation: AAH04594.1.
    M24554 mRNA. Translation: AAA39420.1.
    CCDSiCCDS29692.1.
    PIRiS02181. LUMS1.
    RefSeqiNP_034860.2. NM_010730.2.
    UniGeneiMm.248360.

    Genome annotation databases

    EnsembliENSMUST00000025561; ENSMUSP00000025561; ENSMUSG00000024659.
    GeneIDi16952.
    KEGGimmu:16952.
    UCSCiuc008gyi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07486 mRNA. Translation: CAA30371.1 .
    M69260
    , M69250 , M69251 , M69252 , M69253 , M69254 , M69255 , M69256 , M69257 , M69258 , M69259 Genomic DNA. Translation: AAA39437.1 .
    BC002289 mRNA. Translation: AAH02289.1 .
    BC004594 mRNA. Translation: AAH04594.1 .
    M24554 mRNA. Translation: AAA39420.1 .
    CCDSi CCDS29692.1.
    PIRi S02181. LUMS1.
    RefSeqi NP_034860.2. NM_010730.2.
    UniGenei Mm.248360.

    3D structure databases

    ProteinModelPortali P10107.
    SMRi P10107. Positions 2-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201194. 4 interactions.
    IntActi P10107. 6 interactions.
    MINTi MINT-274958.

    PTM databases

    PhosphoSitei P10107.

    2D gel databases

    COMPLUYEAST-2DPAGE P10107.

    Proteomic databases

    MaxQBi P10107.
    PaxDbi P10107.
    PRIDEi P10107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025561 ; ENSMUSP00000025561 ; ENSMUSG00000024659 .
    GeneIDi 16952.
    KEGGi mmu:16952.
    UCSCi uc008gyi.1. mouse.

    Organism-specific databases

    CTDi 301.
    MGIi MGI:96819. Anxa1.

    Phylogenomic databases

    eggNOGi NOG282829.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    KOi K17091.
    OMAi GTRHKTL.
    OrthoDBi EOG74XS72.
    PhylomeDBi P10107.
    TreeFami TF105452.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi ANXA1. mouse.
    NextBioi 291004.
    PROi P10107.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10107.
    Bgeei P10107.
    CleanExi MM_ANXA1.
    Genevestigatori P10107.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002388. AnnexinI.
    [Graphical view ]
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00197. ANNEXINI.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse lipocortin I gene structure and chromosomal assignment: gene duplication and the origins of a gene family."
      Horlick K.R., Cheng I.C., Wong W.T., Wakeland E.K., Nick H.S.
      Genomics 10:365-374(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    4. "cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I."
      Philipps C., Rose-John S., Rincke G., Fuerstenberger G., Marks F.
      Biochem. Biophys. Res. Commun. 159:155-162(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-346.
    5. "Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing."
      Lennon N.J., Kho A., Bacskai B.J., Perlmutter S.L., Hyman B.T., Brown R.H. Jr.
      J. Biol. Chem. 278:50466-50473(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYSF.
    6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-58 AND LYS-312, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiANXA1_MOUSE
    AccessioniPrimary (citable) accession number: P10107
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3