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Protein

Homeotic protein labial

Gene

lab

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for proper head development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi507 – 56660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • enhancer binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • brain development Source: FlyBase
  • brain segmentation Source: FlyBase
  • cell differentiation Source: FlyBase
  • cell fate determination Source: FlyBase
  • head morphogenesis Source: FlyBase
  • midgut development Source: FlyBase
  • positive regulation of decapentaplegic signaling pathway Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein labial
Alternative name(s):
F24
F90-2
Gene namesi
Name:lab
ORF Names:CG1264
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002522. lab.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Homeotic protein labialPRO_0000200262Add
BLAST

Proteomic databases

PaxDbiP10105.

Expressioni

Tissue specificityi

During embryogenesis, expressed in mandibular lobe, hypopharyngeal organ, neural and epidermal cells of procephalic lobe, sensory cells of clypeolabrum, posterior midgut, thoracic and abdominal segments.2 Publications

Developmental stagei

Expressed both maternally and zygotically. High expression in embryos and third instar larvae, lower expression in pupae.1 Publication

Gene expression databases

BgeeiP10105.
GenevisibleiP10105. DM.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi66015. 7 interactions.
DIPiDIP-59868N.
STRINGi7227.FBpp0081194.

Structurei

3D structure databases

ProteinModelPortaliP10105.
SMRiP10105. Positions 511-568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 188His-rich
Compositional biasi42 – 6423Gln-richAdd
BLAST
Compositional biasi96 – 11116Gln-richAdd
BLAST
Compositional biasi129 – 1346Ser/Thr-rich
Compositional biasi191 – 1966Gln-rich
Compositional biasi306 – 33934Gln/His-richAdd
BLAST
Compositional biasi361 – 37010Ser/Thr-rich

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000263879.
InParanoidiP10105.
KOiK09301.
OMAiSSHQVVQ.
OrthoDBiEOG7PK91P.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P10105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDVSSMYGN HPHHHHPHAN AYDGYSTTTA SAANASSYFA PQQHQPHLQL
60 70 80 90 100
QQQQQHQHLQ QPQQHLTYNG YESSSPGNYY PQQQAQLTPP PTSSHQVVQQ
110 120 130 140 150
HQQQQQAQQQ QLYPHSHLFS PSAAEYGITT STTTGNPGTP LHPSSHSPAD
160 170 180 190 200
SYYESDSVHS YYATAAVATV APPSNSSPIT AANASATSNT QQQQQQAAII
210 220 230 240 250
SSENGMMYTN LDCMYPTAQA QAPVHGYAGQ IEEKYAAVLH ASYAPGMVLE
260 270 280 290 300
DQDPMMQQAT QSQMWHHQQH LAGSYALDAM DSLGMHAHMH HGLPHGHLGN
310 320 330 340 350
LANNPHQQQP QVQQQQQQPH QQPQHPQNQS PAAHQQHHQN SVSPNGGMNR
360 370 380 390 400
QQRGGVISPG SSTSSSTSAS NGAHPASTQS KSPNHSSSIP TYKWMQLKRN
410 420 430 440 450
VPKPQAPSYL PAPKLPASGI ASMHDYQMNG QLDMCRGGGG GGSGVGNGPV
460 470 480 490 500
GVGGNGSPGI GGVLSVQNSL IMANSAAAAG SAHPNGMGVG LGSGSGLSSC
510 520 530 540 550
SLSSNTNNSG RTNFTNKQLT ELEKEFHFNR YLTRARRIEI ANTLQLNETQ
560 570 580 590 600
VKIWFQNRRM KQKKRVKEGL IPADILTQHS TSVISEKPPQ QQQPQPPELQ
610 620 630
LKSQGSDLGG NELATGAPST PTTAMTLTAP TSKQS
Length:635
Mass (Da):68,154
Last modified:November 28, 2002 - v2
Checksum:iB39A58813F4D5778
GO
Isoform Short (identifier: P10105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-411: Missing.

Show »
Length:629
Mass (Da):67,525
Checksum:i8B50E02C60EBD322
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311S → A (PubMed:2566560).Curated
Sequence conflicti46 – 461P → H (PubMed:2566560).Curated
Sequence conflicti139 – 1391T → K in CAB57786 (PubMed:2461299).Curated
Sequence conflicti139 – 1391T → K in CAB57787 (PubMed:2461299).Curated
Sequence conflicti444 – 4441G → D in CAA31495 (PubMed:2461299).Curated
Sequence conflicti444 – 4441G → D in CAB57786 (PubMed:2461299).Curated
Sequence conflicti444 – 4441G → D in CAB57787 (PubMed:2461299).Curated
Sequence conflicti447 – 4471N → S (PubMed:2461299).Curated
Sequence conflicti447 – 4471N → S (PubMed:2566560).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei406 – 4116Missing in isoform Short. 1 PublicationVSP_002397

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13103 mRNA. Translation: CAA31495.1.
X13104, X13105, X13106 Genomic DNA. Translation: CAB57786.1.
X13104, X13105, X13106 Genomic DNA. Translation: CAB57787.1.
AE001572 Genomic DNA. Translation: AAD19811.1.
AE014297 Genomic DNA. Translation: AAF54098.1.
AY095089 mRNA. Translation: AAM11417.1.
M13570 Genomic DNA. Translation: AAA28610.1.
PIRiA30168.
S01164.
RefSeqiNP_476613.1. NM_057265.4. [P10105-2]
UniGeneiDm.4752.

Genome annotation databases

GeneIDi40817.
KEGGidme:Dmel_CG1264.
UCSCiCG1264-RA. d. melanogaster. [P10105-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13103 mRNA. Translation: CAA31495.1.
X13104, X13105, X13106 Genomic DNA. Translation: CAB57786.1.
X13104, X13105, X13106 Genomic DNA. Translation: CAB57787.1.
AE001572 Genomic DNA. Translation: AAD19811.1.
AE014297 Genomic DNA. Translation: AAF54098.1.
AY095089 mRNA. Translation: AAM11417.1.
M13570 Genomic DNA. Translation: AAA28610.1.
PIRiA30168.
S01164.
RefSeqiNP_476613.1. NM_057265.4. [P10105-2]
UniGeneiDm.4752.

3D structure databases

ProteinModelPortaliP10105.
SMRiP10105. Positions 511-568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66015. 7 interactions.
DIPiDIP-59868N.
STRINGi7227.FBpp0081194.

Proteomic databases

PaxDbiP10105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi40817.
KEGGidme:Dmel_CG1264.
UCSCiCG1264-RA. d. melanogaster. [P10105-1]

Organism-specific databases

CTDi40817.
FlyBaseiFBgn0002522. lab.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000263879.
InParanoidiP10105.
KOiK09301.
OMAiSSHQVVQ.
OrthoDBiEOG7PK91P.

Miscellaneous databases

GenomeRNAii40817.
PROiP10105.

Gene expression databases

BgeeiP10105.
GenevisibleiP10105. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex."
    Mlodzik M., Fjose A., Gehring W.J.
    EMBO J. 7:2569-2578(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Oregon-R.
    Tissue: Embryo.
  2. "Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development."
    Diederich R.J., Merrill V.K.L., Pultz M.A., Kaufman T.C.
    Genes Dev. 3:399-414(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM SHORT), CHARACTERIZATION.
    Strain: Canton-S and Oregon-R.
    Tissue: Embryo.
  3. "Complete sequence of the Antennapedia complex of Drosophila."
    Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A., Palazzolo M.J.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
    Strain: Berkeley.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM SHORT).
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Strain: Berkeley.
    Tissue: Embryo.
  7. "Homeo box gene expression in anterior and posterior regions of the Drosophila embryo."
    Hoey T., Doyle H.J., Harding K., Wedeen C., Levine M.
    Proc. Natl. Acad. Sci. U.S.A. 83:4809-4813(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-567, TISSUE SPECIFICITY.
    Strain: Canton-S.

Entry informationi

Entry nameiLAB_DROME
AccessioniPrimary (citable) accession number: P10105
Secondary accession number(s): O97065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 28, 2002
Last modified: June 8, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-2 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.