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P10104

- WAC_BPT4

UniProt

P10104 - WAC_BPT4

Protein

Fibritin

Gene

wac

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 5 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Chaperone responsible for attachment of long tail fibers to virus particle. Forms the fibrous structure on the neck of the virion called whiskers. During phage assembly, 6 fibritin molecules attach to each virion neck through their N-terminal domains, to form a collar with six fibers ('whiskers').

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibritin
    Alternative name(s):
    Collar protein
    Whisker antigen control protein
    Gene namesi
    Name:wac
    OrganismiEnterobacteria phage T4 (Bacteriophage T4)
    Taxonomic identifieri10665 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
    Virus hostiEscherichia coli [TaxID: 562]
    ProteomesiUP000009087: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. virion Source: CACAO

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; by host
    Chaini2 – 487486FibritinPRO_0000165075Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.

    Structurei

    Secondary structure

    1
    487
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 156
    Beta strandi36 – 394
    Turni44 – 463
    Helixi47 – 8135
    Helixi373 – 38614
    Beta strandi389 – 3924
    Helixi393 – 40513
    Helixi414 – 4174
    Helixi422 – 45635
    Beta strandi465 – 4673
    Beta strandi470 – 4734
    Beta strandi476 – 4794
    Helixi480 – 4834

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AA0X-ray2.20A372-484[»]
    1AVYX-ray1.85A/B/C414-487[»]
    1OX3X-ray2.00A2-81[»]
    1RFONMR-A/B/C458-484[»]
    1V1HX-ray1.90A/B/C/D/E/F456-484[»]
    1V1IX-ray1.90A/B/C456-484[»]
    2BSGelectron microscopy15.00A/B/C1-487[»]
    2IBLX-ray1.32A2-81[»]
    2KBLNMR-A458-484[»]
    3A1MX-ray2.00A/B/C/D/E/F458-484[»]
    3J2Oelectron microscopy25.00A/B/C/D/E/F2-487[»]
    4MMQX-ray3.25B458-484[»]
    4MMRX-ray3.10B458-484[»]
    4MMSX-ray2.40B/D/F458-484[»]
    4MMTX-ray3.05B458-484[»]
    4MMUX-ray3.00B458-484[»]
    4MMVX-ray2.81B458-484[»]
    4NCUX-ray1.11A458-484[»]
    4NCVX-ray1.20A/B/C458-484[»]
    4NCWX-ray1.30A/B/C458-484[»]
    ProteinModelPortaliP10104.
    SMRiP10104. Positions 3-81, 372-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10104.

    Family & Domainsi

    Domaini

    The central domain consists of 12 alpha-helical domains (19-40 residues long) with coiled-coil structural patterns.

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    Gene3Di1.20.5.320. 2 hits.
    InterProiIPR012284. Fibritin/6PGD_C-extension.
    IPR012473. Fibritin_C.
    [Graphical view]
    PfamiPF07921. Fibritin_C. 1 hit.
    [Graphical view]
    PRINTSiPR01880. FIBRITIN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDIVLNDLP FVDGPPAEGQ SRISWIKNGE EILGADTQYG SEGSMNRPTV    50
    SVLRNVEVLD KNIGILKTSL ETANSDIKTI QGILDVSGDI EALAQIGINK 100
    KDISDLKTLT SEHTEILNGT NNTVDSILAD IGPFNAEANS VYRTIRNDLL 150
    WIKRELGQYT GQDINGLPVV GNPSSGMKHR IINNTDVITS QGIRLSELET 200
    KFIESDVGSL TIEVGNLREE LGPKPPSFSQ NVYSRLNEID TKQTTVESDI 250
    SAIKTSIGYP GNNSIITSVN TNTDNIASIN LELNQSGGIK QRLTVIETSI 300
    GSDDIPSSIK GQIKDNTTSI ESLNGIVGEN TSSGLRANVS WLNQIVGTDS 350
    SGGQPSPPGS LLNRVSTIET SVSGLNNAVQ NLQVEIGNNS AGIKGQVVAL 400
    NTLVNGTNPN GSTVEERGLT NSIKANETNI ASVTQEVNTA KGNISSLQGD 450
    VQALQEAGYI PEAPRDGQAY VRKDGEWVFL STFLSPA 487
    Length:487
    Mass (Da):51,872
    Last modified:January 23, 2007 - v5
    Checksum:i253A30F0F0ED13B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti358 – 3581P → H in CAA31379. (PubMed:12626685)Curated
    Sequence conflicti479 – 4791F → L in CAA31379. (PubMed:12626685)Curated
    Sequence conflicti481 – 4811S → P(PubMed:3194206)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12888 Genomic DNA. Translation: CAA31379.1.
    AF158101 Genomic DNA. Translation: AAD42679.1.
    X14868 Genomic DNA. Translation: CAA33006.1.
    X06792 Genomic DNA. Translation: CAA29952.1.
    PIRiS01917. FIBPT4.
    RefSeqiNP_049771.1. NC_000866.4.

    Genome annotation databases

    GeneIDi1258630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12888 Genomic DNA. Translation: CAA31379.1 .
    AF158101 Genomic DNA. Translation: AAD42679.1 .
    X14868 Genomic DNA. Translation: CAA33006.1 .
    X06792 Genomic DNA. Translation: CAA29952.1 .
    PIRi S01917. FIBPT4.
    RefSeqi NP_049771.1. NC_000866.4.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AA0 X-ray 2.20 A 372-484 [» ]
    1AVY X-ray 1.85 A/B/C 414-487 [» ]
    1OX3 X-ray 2.00 A 2-81 [» ]
    1RFO NMR - A/B/C 458-484 [» ]
    1V1H X-ray 1.90 A/B/C/D/E/F 456-484 [» ]
    1V1I X-ray 1.90 A/B/C 456-484 [» ]
    2BSG electron microscopy 15.00 A/B/C 1-487 [» ]
    2IBL X-ray 1.32 A 2-81 [» ]
    2KBL NMR - A 458-484 [» ]
    3A1M X-ray 2.00 A/B/C/D/E/F 458-484 [» ]
    3J2O electron microscopy 25.00 A/B/C/D/E/F 2-487 [» ]
    4MMQ X-ray 3.25 B 458-484 [» ]
    4MMR X-ray 3.10 B 458-484 [» ]
    4MMS X-ray 2.40 B/D/F 458-484 [» ]
    4MMT X-ray 3.05 B 458-484 [» ]
    4MMU X-ray 3.00 B 458-484 [» ]
    4MMV X-ray 2.81 B 458-484 [» ]
    4NCU X-ray 1.11 A 458-484 [» ]
    4NCV X-ray 1.20 A/B/C 458-484 [» ]
    4NCW X-ray 1.30 A/B/C 458-484 [» ]
    ProteinModelPortali P10104.
    SMRi P10104. Positions 3-81, 372-484.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1258630.

    Miscellaneous databases

    EvolutionaryTracei P10104.

    Family and domain databases

    Gene3Di 1.20.5.320. 2 hits.
    InterProi IPR012284. Fibritin/6PGD_C-extension.
    IPR012473. Fibritin_C.
    [Graphical view ]
    Pfami PF07921. Fibritin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01880. FIBRITIN.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide and deduced amino acid sequence of bacteriophage T4 gene wac."
      Prilipov A.G., Selivanov N.A., Nikolaeva L.I., Mesyanzhinov V.V.
      Nucleic Acids Res. 16:10361-10361(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: D.
    2. "Fibritin encoded by bacteriophage T4 gene wac has a parallel triple-stranded alpha-helical coiled-coil structure."
      Efimov V.P., Nepluev I.V., Sobolev B.N., Zurabishvili T.G., Schulthess T., Lustig A., Engel J., Haener M., Aebi U., Venyaminov S.Y., Potekhin S.A., Mesyanzhinov V.V.
      J. Mol. Biol. 242:470-486(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: D.
    3. Mesyanzhinov V.V.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 358 AND 479.
      Strain: D.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Nucleotide sequences of bacteriophage T4 genes 13, 14 and 15."
      Selivanov N.A., Prilipov A.G., Mesyanzhinov V.V.
      Nucleic Acids Res. 17:3583-3583(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 480-487.
      Strain: D.
    6. "Nucleotide and deduced amino acid sequence of bacteriophage T4 gene 12."
      Selivanov N.A., Prilipov A.G., Mesyanzhinov V.V.
      Nucleic Acids Res. 16:2334-2334(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
      Strain: D.
    7. "The wac gene product of bacteriophage T4 contains coiled-coil structural patterns."
      Sobolev B.N., Mesyanzhinov V.V.
      J. Biomol. Struct. Dyn. 8:953-965(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
    8. "Structure of bacteriophage T4 fibritin: a segmented coiled coil and the role of the C-terminal domain."
      Tao Y., Strelkov S.V., Mesyanzhinov V.V., Rossmann M.G.
      Structure 5:789-798(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 369-487.

    Entry informationi

    Entry nameiWAC_BPT4
    AccessioniPrimary (citable) accession number: P10104
    Secondary accession number(s): O10628, Q9T0U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3