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P10104 (WAC_BPT4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibritin
Alternative name(s):
Collar protein
Whisker antigen control protein
Gene names
Name:wac
OrganismEnterobacteria phage T4 (Bacteriophage T4) [Reference proteome]
Taxonomic identifier10665 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chaperone responsible for attachment of long tail fibers to virus particle. Forms the fibrous structure on the neck of the virion called whiskers. During phage assembly, 6 fibritin molecules attach to each virion neck through their N-terminal domains, to form a collar with six fibers ('whiskers').

Subunit structure

Homotrimer.

Domain

The central domain consists of 12 alpha-helical domains (19-40 residues long) with coiled-coil structural patterns.

Ontologies

Keywords
   DomainCoiled coil
   Molecular functionChaperone
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentvirion

Inferred from direct assay PubMed 18524932. Source: CACAO

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host
Chain2 – 487486Fibritin
PRO_0000165075

Experimental info

Sequence conflict3581P → H in CAA31379. Ref.4
Sequence conflict4791F → L in CAA31379. Ref.4
Sequence conflict4811S → P Ref.1

Secondary structure

........................ 487
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P10104 [UniParc].

Last modified January 23, 2007. Version 5.
Checksum: 253A30F0F0ED13B5

FASTA48751,872
        10         20         30         40         50         60 
MTDIVLNDLP FVDGPPAEGQ SRISWIKNGE EILGADTQYG SEGSMNRPTV SVLRNVEVLD 

        70         80         90        100        110        120 
KNIGILKTSL ETANSDIKTI QGILDVSGDI EALAQIGINK KDISDLKTLT SEHTEILNGT 

       130        140        150        160        170        180 
NNTVDSILAD IGPFNAEANS VYRTIRNDLL WIKRELGQYT GQDINGLPVV GNPSSGMKHR 

       190        200        210        220        230        240 
IINNTDVITS QGIRLSELET KFIESDVGSL TIEVGNLREE LGPKPPSFSQ NVYSRLNEID 

       250        260        270        280        290        300 
TKQTTVESDI SAIKTSIGYP GNNSIITSVN TNTDNIASIN LELNQSGGIK QRLTVIETSI 

       310        320        330        340        350        360 
GSDDIPSSIK GQIKDNTTSI ESLNGIVGEN TSSGLRANVS WLNQIVGTDS SGGQPSPPGS 

       370        380        390        400        410        420 
LLNRVSTIET SVSGLNNAVQ NLQVEIGNNS AGIKGQVVAL NTLVNGTNPN GSTVEERGLT 

       430        440        450        460        470        480 
NSIKANETNI ASVTQEVNTA KGNISSLQGD VQALQEAGYI PEAPRDGQAY VRKDGEWVFL 


STFLSPA 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide and deduced amino acid sequence of bacteriophage T4 gene wac."
Prilipov A.G., Selivanov N.A., Nikolaeva L.I., Mesyanzhinov V.V.
Nucleic Acids Res. 16:10361-10361(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: D.
[2]"Fibritin encoded by bacteriophage T4 gene wac has a parallel triple-stranded alpha-helical coiled-coil structure."
Efimov V.P., Nepluev I.V., Sobolev B.N., Zurabishvili T.G., Schulthess T., Lustig A., Engel J., Haener M., Aebi U., Venyaminov S.Y., Potekhin S.A., Mesyanzhinov V.V.
J. Mol. Biol. 242:470-486(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: D.
[3]Mesyanzhinov V.V.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 358 AND 479.
Strain: D.
[4]"Bacteriophage T4 genome."
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.
Microbiol. Mol. Biol. Rev. 67:86-156(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Nucleotide sequences of bacteriophage T4 genes 13, 14 and 15."
Selivanov N.A., Prilipov A.G., Mesyanzhinov V.V.
Nucleic Acids Res. 17:3583-3583(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 480-487.
Strain: D.
[6]"Nucleotide and deduced amino acid sequence of bacteriophage T4 gene 12."
Selivanov N.A., Prilipov A.G., Mesyanzhinov V.V.
Nucleic Acids Res. 16:2334-2334(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
Strain: D.
[7]"The wac gene product of bacteriophage T4 contains coiled-coil structural patterns."
Sobolev B.N., Mesyanzhinov V.V.
J. Biomol. Struct. Dyn. 8:953-965(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY.
[8]"Structure of bacteriophage T4 fibritin: a segmented coiled coil and the role of the C-terminal domain."
Tao Y., Strelkov S.V., Mesyanzhinov V.V., Rossmann M.G.
Structure 5:789-798(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 369-487.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X12888 Genomic DNA. Translation: CAA31379.1.
AF158101 Genomic DNA. Translation: AAD42679.1.
X14868 Genomic DNA. Translation: CAA33006.1.
X06792 Genomic DNA. Translation: CAA29952.1.
PIRFIBPT4. S01917.
RefSeqNP_049771.1. NC_000866.4.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AA0X-ray2.20A372-484[»]
1AVYX-ray1.85A/B/C414-487[»]
1OX3X-ray2.00A3-484[»]
1RFONMR-A/B/C458-484[»]
1V1HX-ray1.90A/B/C/D/E/F458-483[»]
1V1IX-ray1.90A/B/C458-483[»]
2BSGelectron microscopy15.00A/B/C2-486[»]
2IBLX-ray1.32A2-80[»]
2KBLNMR-A458-484[»]
3A1MX-ray2.00A/B/C/D/E/F458-484[»]
3J2Oelectron microscopy25.00A/B/C/D/E/F2-487[»]
4MMQX-ray3.25B458-484[»]
4MMRX-ray3.10B458-484[»]
4MMSX-ray2.40B/D/F458-484[»]
4MMTX-ray3.05B458-484[»]
4MMUX-ray3.00B458-484[»]
4MMVX-ray2.81B458-484[»]
ProteinModelPortalP10104.
SMRP10104. Positions 3-81, 372-484.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1258630.

Phylogenomic databases

ProtClustDBPHA2607.

Family and domain databases

Gene3D1.20.5.320. 2 hits.
InterProIPR012284. Fibritin/6PGD_C-extension.
IPR012473. Fibritin_C.
[Graphical view]
PfamPF07921. Fibritin_C. 1 hit.
[Graphical view]
PRINTSPR01880. FIBRITIN.
ProtoNetSearch...

Other

EvolutionaryTraceP10104.

Entry information

Entry nameWAC_BPT4
AccessionPrimary (citable) accession number: P10104
Secondary accession number(s): O10628, Q9T0U8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 90 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references