P10099 (LYS8_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysis protein for colicin E8

Gene names

Name:

lys

Encoded on

Plasmid ColE8

Organism

Escherichia coli

Taxonomic identifier

562 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	47 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Function	Lysis proteins are required for both colicin release and partial cell lysis.
Subcellular location	Cell outer membrane; Lipid-anchor Potential.

Ontologies

Keywords
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 47	28	Lysis protein for colicin E8		PRO_0000005688
Amino acid modifications
	Lipidation	20	1	N-palmitoyl cysteine Potential
	Lipidation	20	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	P10099 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 691E149A8A056B38	FASTA	47	4,844
	10 20 30 40 MKKITGIILL LLAVIILAAC QANYIRDVQG GTVSPSSTAE VTGLATQ

References

[1]	"Nucleotide sequences from the colicin E8 operon: homology with plasmid ColE2-P9." Uchimura T., Lau P.C.K. Mol. Gen. Genet. 209:489-493(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Colicin E8, a DNase which indicates an evolutionary relationship between colicins E2 and E3." Toba M., Masaki H., Ohta T. J. Bacteriol. 170:3237-3242(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M21404 Genomic DNA. Translation: AAA23075.1. X06119 Genomic DNA. Translation: CAA29493.1.
PIR	ZHECE8. C28184.
RefSeq	YP_002993421.1. NC_012882.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8094684.
Phylogenomic databases
ProtClustDB	CLSK2480606.
Family and domain databases
InterPro	IPR003059. Lysis_col. [Graphical view]
Pfam	PF02402. Lysis_col. 1 hit. [Graphical view]
PRINTS	PR01297. LYSISCOLICIN.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYS8_ECOLX

Accession

Primary (citable) accession number: P10099

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program