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Protein

Lysis protein for colicin E8

Gene

lys

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Lysis proteins are required for both colicin release and partial cell lysis.

GO - Biological processi

  1. cytolysis Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysis protein for colicin E8
Gene namesi
Name:lys
Encoded oniPlasmid ColE80 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

Cell outer membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919PROSITE-ProRule annotationAdd
BLAST
Chaini20 – 4728Lysis protein for colicin E8PRO_0000005688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR003059. Lysis_col.
[Graphical view]
PfamiPF02402. Lysis_col. 1 hit.
[Graphical view]
PRINTSiPR01297. LYSISCOLICIN.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MKKITGIILL LLAVIILAAC QANYIRDVQG GTVSPSSTAE VTGLATQ
Length:47
Mass (Da):4,844
Last modified:July 1, 1989 - v1
Checksum:i691E149A8A056B38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21404 Genomic DNA. Translation: AAA23075.1.
X06119 Genomic DNA. Translation: CAA29493.1.
PIRiC28184. ZHECE8.
RefSeqiYP_002993421.1. NC_012882.1.
YP_009077592.1. NG_035658.1.

Genome annotation databases

GeneIDi8094684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21404 Genomic DNA. Translation: AAA23075.1.
X06119 Genomic DNA. Translation: CAA29493.1.
PIRiC28184. ZHECE8.
RefSeqiYP_002993421.1. NC_012882.1.
YP_009077592.1. NG_035658.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8094684.

Family and domain databases

InterProiIPR003059. Lysis_col.
[Graphical view]
PfamiPF02402. Lysis_col. 1 hit.
[Graphical view]
PRINTSiPR01297. LYSISCOLICIN.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequences from the colicin E8 operon: homology with plasmid ColE2-P9."
    Uchimura T., Lau P.C.K.
    Mol. Gen. Genet. 209:489-493(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Colicin E8, a DNase which indicates an evolutionary relationship between colicins E2 and E3."
    Toba M., Masaki H., Ohta T.
    J. Bacteriol. 170:3237-3242(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLYS8_ECOLX
AccessioniPrimary (citable) accession number: P10099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.