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Protein

Calcitonin gene-related peptide 2

Gene

Calcb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 2
Alternative name(s):
Beta-type CGRP
Calcitonin gene-related peptide II
Short name:
CGRP-II
Gene namesi
Name:Calcb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620997. Calcb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Propeptidei27 – 8660By similarityPRO_0000004092Add
BLAST
Peptidei89 – 12537Calcitonin gene-related peptide 2PRO_0000004093Add
BLAST
Propeptidei131 – 1344By similarityPRO_0000004094

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 95By similarity
Modified residuei125 – 1251Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP10093.

PTM databases

iPTMnetiP10093.
PhosphoSiteiP10093.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014764.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZP. Eukaryota.
ENOG410YIU3. LUCA.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP10093.
PhylomeDBiP10093.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFWKFFPFL ALSSMWVLCL ASSLQAAPFR SALESSLDLG TLSDQEKHLL
60 70 80 90 100
LAALIQDYEQ KARKLEQEEQ ETEGSRKGSS SSVISQKRSC NTATCVTHRL
110 120 130
AGLLRRSGGV VKDNFVPTNV GSKAFGRRRR DLRV
Length:134
Mass (Da):14,965
Last modified:July 1, 1989 - v1
Checksum:iBF6CAFB87A489B38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11596 mRNA. Translation: AAA40850.1.
PIRiA44173.
RefSeqiNP_612522.1. NM_138513.1.
UniGeneiRn.88080.

Genome annotation databases

GeneIDi171519.
KEGGirno:171519.
UCSCiRGD:620997. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11596 mRNA. Translation: AAA40850.1.
PIRiA44173.
RefSeqiNP_612522.1. NM_138513.1.
UniGeneiRn.88080.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014764.

PTM databases

iPTMnetiP10093.
PhosphoSiteiP10093.

Proteomic databases

PaxDbiP10093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171519.
KEGGirno:171519.
UCSCiRGD:620997. rat.

Organism-specific databases

CTDi797.
RGDi620997. Calcb.

Phylogenomic databases

eggNOGiENOG410IYZP. Eukaryota.
ENOG410YIU3. LUCA.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP10093.
PhylomeDBiP10093.

Miscellaneous databases

PROiP10093.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide."
    Amara S.G., Arriza J.L., Leff S.E., Swanson L.W., Evans R.M., Rosenfeld M.G.
    Science 229:1094-1097(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCALCB_RAT
AccessioniPrimary (citable) accession number: P10093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.