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P10092 (CALCB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcitonin gene-related peptide 2
Alternative name(s):
Beta-type CGRP
Short name=Beta-CGRP
Calcitonin gene-related peptide II
Short name=CGRP-II
Gene names
Name:CALCB
Synonyms:CALC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Subcellular location

Secreted.

Sequence similarities

Belongs to the calcitonin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular calcium ion homeostasis

Traceable author statement Ref.5. Source: ProtInc

signal transduction

Traceable author statement Ref.5. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

   Molecular_functionneuropeptide hormone activity

Traceable author statement Ref.5. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 7954
PRO_0000004086
Peptide82 – 11837Calcitonin gene-related peptide 2
PRO_0000004087
Propeptide124 – 1274
PRO_0000004088

Amino acid modifications

Modified residue1181Phenylalanine amide Ref.7
Disulfide bond83 ↔ 88 Ref.7

Experimental info

Sequence conflict731G → S in CAA26249. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P10092 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: B0A71A063CD5ACE7

FASTA12713,706
        10         20         30         40         50         60 
MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM 

        70         80         90        100        110        120 
KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR 


RRRDLQA 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the human calcitonin/CGRP genes."
Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Visser A., Lips C.J.M., Jansz H.S.
FEBS Lett. 209:97-103(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"A second human calcitonin/CGRP gene."
Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Lips C.J.M., Jansz H.S.
FEBS Lett. 183:403-407(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-127.
[6]"Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord."
Petermann J.B., Born W., Chang J.Y., Fischer J.A.
J. Biol. Chem. 262:542-545(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 82-108.
[7]"Isolation, purification and characterization of beta-hCGRP from human spinal cord."
Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M., McIntyre I.
Biochem. Biophys. Res. Commun. 167:993-1000(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, DISULFIDE BOND.
Tissue: Spinal cord.
[8]"Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma."
Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.
Biochem. Biophys. Res. Commun. 185:134-141(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 82-104.
Tissue: Pheochromocytoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04855, X04857, X04861 Genomic DNA. Translation: CAC05295.1.
AK291188 mRNA. Translation: BAF83877.1.
CH471064 Genomic DNA. Translation: EAW68466.1.
CH471064 Genomic DNA. Translation: EAW68467.1.
BC092468 mRNA. Translation: AAH92468.1.
X02404 mRNA. Translation: CAA26249.1.
CCDSCCDS7820.1.
PIRA25864.
I37232.
RefSeqNP_000719.1. NM_000728.3.
XP_005253192.1. XM_005253135.1.
UniGeneHs.534305.

3D structure databases

ProteinModelPortalP10092.
SMRP10092. Positions 82-118.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000346017.

PTM databases

PhosphoSiteP10092.

Polymorphism databases

DMDM115487.

Proteomic databases

PaxDbP10092.
PRIDEP10092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324229; ENSP00000346017; ENSG00000175868.
ENST00000533448; ENSP00000433490; ENSG00000175868.
GeneID797.
KEGGhsa:797.
UCSCuc001mlx.1. human.

Organism-specific databases

CTD797.
GeneCardsGC11P014926.
HGNCHGNC:1438. CALCB.
MIM114160. gene.
neXtProtNX_P10092.
PharmGKBPA26030.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47567.
HOGENOMHOG000038203.
HOVERGENHBG031362.
InParanoidP10092.
PhylomeDBP10092.
TreeFamTF333069.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP10092.
BgeeP10092.
CleanExHS_CALCB.
GenevestigatorP10092.

Family and domain databases

InterProIPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERPTHR10505. PTHR10505. 1 hit.
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00817. CALCITONINB.
SMARTSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi797.
NextBio3242.
PMAP-CutDBP10092.
PROP10092.
SOURCESearch...

Entry information

Entry nameCALCB_HUMAN
AccessionPrimary (citable) accession number: P10092
Secondary accession number(s): A8K573 expand/collapse secondary AC list , D3DQX4, Q569I0, Q9UCN9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM