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P10092

- CALCB_HUMAN

UniProt

P10092 - CALCB_HUMAN

Protein

Calcitonin gene-related peptide 2

Gene

CALCB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: ProtInc

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_18290. Calcitonin-like ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin gene-related peptide 2
    Alternative name(s):
    Beta-type CGRP
    Short name:
    Beta-CGRP
    Calcitonin gene-related peptide II
    Short name:
    CGRP-II
    Gene namesi
    Name:CALCB
    Synonyms:CALC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1438. CALCB.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 7954PRO_0000004086Add
    BLAST
    Peptidei82 – 11837Calcitonin gene-related peptide 2PRO_0000004087Add
    BLAST
    Propeptidei124 – 1274PRO_0000004088

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 881 Publication
    Modified residuei118 – 1181Phenylalanine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP10092.
    PRIDEiP10092.

    PTM databases

    PhosphoSiteiP10092.

    Miscellaneous databases

    PMAP-CutDBP10092.

    Expressioni

    Gene expression databases

    ArrayExpressiP10092.
    BgeeiP10092.
    CleanExiHS_CALCB.
    GenevestigatoriP10092.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000346017.

    Structurei

    3D structure databases

    ProteinModelPortaliP10092.
    SMRiP10092. Positions 82-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcitonin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47567.
    HOGENOMiHOG000038203.
    HOVERGENiHBG031362.
    InParanoidiP10092.
    PhylomeDBiP10092.
    TreeFamiTF333069.

    Family and domain databases

    InterProiIPR018360. Calcitonin_CS.
    IPR015476. Calcitonin_gene-rel_peptide.
    IPR001693. Calcitonin_peptide-like.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view]
    PANTHERiPTHR10505. PTHR10505. 1 hit.
    PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view]
    PRINTSiPR00817. CALCITONINB.
    SMARTiSM00113. CALCITONIN. 1 hit.
    [Graphical view]
    PROSITEiPS00258. CALCITONIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10092-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL    50
    AALVQDYVQM KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS 100
    GGMVKSNFVP TNVGSKAFGR RRRDLQA 127
    Length:127
    Mass (Da):13,706
    Last modified:July 1, 1989 - v1
    Checksum:iB0A71A063CD5ACE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731G → S in CAA26249. (PubMed:2985435)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04855, X04857, X04861 Genomic DNA. Translation: CAC05295.1.
    AK291188 mRNA. Translation: BAF83877.1.
    CH471064 Genomic DNA. Translation: EAW68466.1.
    CH471064 Genomic DNA. Translation: EAW68467.1.
    BC092468 mRNA. Translation: AAH92468.1.
    X02404 mRNA. Translation: CAA26249.1.
    CCDSiCCDS7820.1.
    PIRiA25864.
    I37232.
    RefSeqiNP_000719.1. NM_000728.3.
    XP_005253192.1. XM_005253135.1.
    UniGeneiHs.534305.

    Genome annotation databases

    EnsembliENST00000324229; ENSP00000346017; ENSG00000175868.
    ENST00000533448; ENSP00000433490; ENSG00000175868.
    GeneIDi797.
    KEGGihsa:797.
    UCSCiuc001mlx.1. human.

    Polymorphism databases

    DMDMi115487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04855 , X04857 , X04861 Genomic DNA. Translation: CAC05295.1 .
    AK291188 mRNA. Translation: BAF83877.1 .
    CH471064 Genomic DNA. Translation: EAW68466.1 .
    CH471064 Genomic DNA. Translation: EAW68467.1 .
    BC092468 mRNA. Translation: AAH92468.1 .
    X02404 mRNA. Translation: CAA26249.1 .
    CCDSi CCDS7820.1.
    PIRi A25864.
    I37232.
    RefSeqi NP_000719.1. NM_000728.3.
    XP_005253192.1. XM_005253135.1.
    UniGenei Hs.534305.

    3D structure databases

    ProteinModelPortali P10092.
    SMRi P10092. Positions 82-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000346017.

    PTM databases

    PhosphoSitei P10092.

    Polymorphism databases

    DMDMi 115487.

    Proteomic databases

    PaxDbi P10092.
    PRIDEi P10092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324229 ; ENSP00000346017 ; ENSG00000175868 .
    ENST00000533448 ; ENSP00000433490 ; ENSG00000175868 .
    GeneIDi 797.
    KEGGi hsa:797.
    UCSCi uc001mlx.1. human.

    Organism-specific databases

    CTDi 797.
    GeneCardsi GC11P014926.
    HGNCi HGNC:1438. CALCB.
    MIMi 114160. gene.
    neXtProti NX_P10092.
    PharmGKBi PA26030.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47567.
    HOGENOMi HOG000038203.
    HOVERGENi HBG031362.
    InParanoidi P10092.
    PhylomeDBi P10092.
    TreeFami TF333069.

    Enzyme and pathway databases

    Reactomei REACT_18290. Calcitonin-like ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GenomeRNAii 797.
    NextBioi 3242.
    PMAP-CutDB P10092.
    PROi P10092.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10092.
    Bgeei P10092.
    CleanExi HS_CALCB.
    Genevestigatori P10092.

    Family and domain databases

    InterProi IPR018360. Calcitonin_CS.
    IPR015476. Calcitonin_gene-rel_peptide.
    IPR001693. Calcitonin_peptide-like.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view ]
    PANTHERi PTHR10505. PTHR10505. 1 hit.
    Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view ]
    PRINTSi PR00817. CALCITONINB.
    SMARTi SM00113. CALCITONIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00258. CALCITONIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-127.
    6. "Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord."
      Petermann J.B., Born W., Chang J.Y., Fischer J.A.
      J. Biol. Chem. 262:542-545(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 82-108.
    7. "Isolation, purification and characterization of beta-hCGRP from human spinal cord."
      Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M., McIntyre I.
      Biochem. Biophys. Res. Commun. 167:993-1000(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, DISULFIDE BOND.
      Tissue: Spinal cord.
    8. "Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma."
      Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.
      Biochem. Biophys. Res. Commun. 185:134-141(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 82-104.
      Tissue: Pheochromocytoma.

    Entry informationi

    Entry nameiCALCB_HUMAN
    AccessioniPrimary (citable) accession number: P10092
    Secondary accession number(s): A8K573
    , D3DQX4, Q569I0, Q9UCN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3