P10092 (CALCB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcitonin gene-related peptide 2

Alternative name(s):
Beta-type CGRP
Short name=Beta-CGRP
Calcitonin gene-related peptide II
Short name=CGRP-II

Gene names

Name:	CALCB
Synonyms:	CALC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
Subcellular location	Secreted.
Sequence similarities	Belongs to the calcitonin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Traceable author statement Ref.5. Source: ProtInc signal transduction Traceable author statement Ref.5. Source: ProtInc vasodilation Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Molecular_function	neuropeptide hormone activity Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 79	54			PRO_0000004086
	Peptide	82 – 118	37	Calcitonin gene-related peptide 2		PRO_0000004087
	Propeptide	124 – 127	4			PRO_0000004088
Amino acid modifications
	Modified residue	118	1	Phenylalanine amide Ref.7
	Disulfide bond	83 ↔ 88		Ref.7
Experimental info
	Sequence conflict	73	1	G → S in CAA26249. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P10092 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: B0A71A063CD5ACE7	FASTA	127	13,706
	10 20 30 40 50 60 MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM 70 80 90 100 110 120 KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR RRRDLQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the human calcitonin/CGRP genes." Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Visser A., Lips C.J.M., Jansz H.S. FEBS Lett. 209:97-103(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"A second human calcitonin/CGRP gene." Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Lips C.J.M., Jansz H.S. FEBS Lett. 183:403-407(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-127.
[6]	"Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord." Petermann J.B., Born W., Chang J.Y., Fischer J.A. J. Biol. Chem. 262:542-545(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 82-108.
[7]	"Isolation, purification and characterization of beta-hCGRP from human spinal cord." Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M., McIntyre I. Biochem. Biophys. Res. Commun. 167:993-1000(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, DISULFIDE BOND. Tissue: Spinal cord.
[8]	"Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma." Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T. Biochem. Biophys. Res. Commun. 185:134-141(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 82-104. Tissue: Pheochromocytoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04855, X04857, X04861 Genomic DNA. Translation: CAC05295.1. AK291188 mRNA. Translation: BAF83877.1. CH471064 Genomic DNA. Translation: EAW68466.1. CH471064 Genomic DNA. Translation: EAW68467.1. BC092468 mRNA. Translation: AAH92468.1. X02404 mRNA. Translation: CAA26249.1.
IPI	IPI00018941.
PIR	A25864. I37232.
RefSeq	NP_000719.1. NM_000728.3.
UniGene	Hs.534305.
3D structure databases
ProteinModelPortal	P10092.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000346017.
PTM databases
PhosphoSite	P10092.
Polymorphism databases
DMDM	115487.
Proteomic databases
PaxDb	P10092.
PRIDE	P10092.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000324229; ENSP00000346017; ENSG00000175868. ENST00000533448; ENSP00000433490; ENSG00000175868.
GeneID	797.
KEGG	hsa:797.
UCSC	uc001mlx.1. human.
Organism-specific databases
CTD	797.
GeneCards	GC11P014926.
HGNC	HGNC:1438. CALCB.
MIM	114160. gene.
neXtProt	NX_P10092.
PharmGKB	PA26030.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47567.
HOGENOM	HOG000038203.
HOVERGEN	HBG031362.
InParanoid	P10092.
OrthoDB	EOG43N7F5.
PhylomeDB	P10092.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P10092.
Bgee	P10092.
CleanEx	HS_CALCB.
Genevestigator	P10092.
GermOnline	ENSG00000175868. Homo sapiens.
Family and domain databases
InterPro	IPR018360. Calcitonin_CS. IPR001693. Calcitonin_peptide-like. IPR021117. Procalcitonin-like. IPR021116. Procalcitonin/adrenomedullin. IPR015476. Procalcitonin_gene-rel_peptide. [Graphical view]
PANTHER	PTHR10505. PTHR10505. 1 hit. PTHR10505:SF2. PTHR10505:SF2. 1 hit.
Pfam	PF00214. Calc_CGRP_IAPP. 1 hit. [Graphical view]
PRINTS	PR00817. CALCITONINB.
SMART	SM00113. CALCITONIN. 1 hit. [Graphical view]
PROSITE	PS00258. CALCITONIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	797.
NextBio	3242.
PMAP-CutDB	P10092.
SOURCE	Search...

Entry information

Entry name

CALCB_HUMAN

Accession

Primary (citable) accession number: P10092
Secondary accession number(s): A8K573 , D3DQX4, Q569I0, Q9UCN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.