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Protein

Calcitonin gene-related peptide 2

Gene

CALCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

GO - Molecular functioni

  1. neuropeptide hormone activity Source: ProtInc

GO - Biological processi

  1. cellular calcium ion homeostasis Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 2
Alternative name(s):
Beta-type CGRP
Short name:
Beta-CGRP
Calcitonin gene-related peptide II
Short name:
CGRP-II
Gene namesi
Name:CALCB
Synonyms:CALC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1438. CALCB.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 7954PRO_0000004086Add
BLAST
Peptidei82 – 11837Calcitonin gene-related peptide 2PRO_0000004087Add
BLAST
Propeptidei124 – 1274PRO_0000004088

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 881 Publication
Modified residuei118 – 1181Phenylalanine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP10092.
PRIDEiP10092.

PTM databases

PhosphoSiteiP10092.

Miscellaneous databases

PMAP-CutDBP10092.

Expressioni

Gene expression databases

BgeeiP10092.
CleanExiHS_CALCB.
ExpressionAtlasiP10092. baseline and differential.
GenevestigatoriP10092.

Interactioni

Protein-protein interaction databases

BioGridi107248. 1 interaction.
STRINGi9606.ENSP00000346017.

Structurei

3D structure databases

ProteinModelPortaliP10092.
SMRiP10092. Positions 82-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47567.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP10092.
PhylomeDBiP10092.
TreeFamiTF333069.

Family and domain databases

InterProiIPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL
60 70 80 90 100
AALVQDYVQM KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS
110 120
GGMVKSNFVP TNVGSKAFGR RRRDLQA
Length:127
Mass (Da):13,706
Last modified:June 30, 1989 - v1
Checksum:iB0A71A063CD5ACE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731G → S in CAA26249 (PubMed:2985435).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04855, X04857, X04861 Genomic DNA. Translation: CAC05295.1.
AK291188 mRNA. Translation: BAF83877.1.
CH471064 Genomic DNA. Translation: EAW68466.1.
CH471064 Genomic DNA. Translation: EAW68467.1.
BC092468 mRNA. Translation: AAH92468.1.
X02404 mRNA. Translation: CAA26249.1.
CCDSiCCDS7820.1.
PIRiA25864.
I37232.
RefSeqiNP_000719.1. NM_000728.3.
XP_005253192.1. XM_005253135.1.
UniGeneiHs.534305.

Genome annotation databases

EnsembliENST00000324229; ENSP00000346017; ENSG00000175868.
ENST00000533448; ENSP00000433490; ENSG00000175868.
GeneIDi797.
KEGGihsa:797.
UCSCiuc001mlx.1. human.

Polymorphism databases

DMDMi115487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04855, X04857, X04861 Genomic DNA. Translation: CAC05295.1.
AK291188 mRNA. Translation: BAF83877.1.
CH471064 Genomic DNA. Translation: EAW68466.1.
CH471064 Genomic DNA. Translation: EAW68467.1.
BC092468 mRNA. Translation: AAH92468.1.
X02404 mRNA. Translation: CAA26249.1.
CCDSiCCDS7820.1.
PIRiA25864.
I37232.
RefSeqiNP_000719.1. NM_000728.3.
XP_005253192.1. XM_005253135.1.
UniGeneiHs.534305.

3D structure databases

ProteinModelPortaliP10092.
SMRiP10092. Positions 82-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107248. 1 interaction.
STRINGi9606.ENSP00000346017.

PTM databases

PhosphoSiteiP10092.

Polymorphism databases

DMDMi115487.

Proteomic databases

PaxDbiP10092.
PRIDEiP10092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324229; ENSP00000346017; ENSG00000175868.
ENST00000533448; ENSP00000433490; ENSG00000175868.
GeneIDi797.
KEGGihsa:797.
UCSCiuc001mlx.1. human.

Organism-specific databases

CTDi797.
GeneCardsiGC11P014926.
HGNCiHGNC:1438. CALCB.
MIMi114160. gene.
neXtProtiNX_P10092.
PharmGKBiPA26030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47567.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP10092.
PhylomeDBiP10092.
TreeFamiTF333069.

Enzyme and pathway databases

ReactomeiREACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GenomeRNAii797.
NextBioi3242.
PMAP-CutDBP10092.
PROiP10092.
SOURCEiSearch...

Gene expression databases

BgeeiP10092.
CleanExiHS_CALCB.
ExpressionAtlasiP10092. baseline and differential.
GenevestigatoriP10092.

Family and domain databases

InterProiIPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-127.
  6. "Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord."
    Petermann J.B., Born W., Chang J.Y., Fischer J.A.
    J. Biol. Chem. 262:542-545(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 82-108.
  7. "Isolation, purification and characterization of beta-hCGRP from human spinal cord."
    Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M., McIntyre I.
    Biochem. Biophys. Res. Commun. 167:993-1000(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, DISULFIDE BOND.
    Tissue: Spinal cord.
  8. "Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma."
    Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.
    Biochem. Biophys. Res. Commun. 185:134-141(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 82-104.
    Tissue: Pheochromocytoma.

Entry informationi

Entry nameiCALCB_HUMAN
AccessioniPrimary (citable) accession number: P10092
Secondary accession number(s): A8K573
, D3DQX4, Q569I0, Q9UCN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1989
Last sequence update: June 30, 1989
Last modified: January 6, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.