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Protein

Calcitonin gene-related peptide 2

Gene

CALCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

GO - Molecular functioni

  • neuropeptide hormone activity Source: ProtInc

GO - Biological processi

  • cellular calcium ion homeostasis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 2
Alternative name(s):
Beta-type CGRP
Short name:
Beta-CGRP
Calcitonin gene-related peptide II
Short name:
CGRP-II
Gene namesi
Name:CALCB
Synonyms:CALC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175868.13
HGNCiHGNC:1438 CALCB
MIMi114160 gene
neXtProtiNX_P10092

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi797
OpenTargetsiENSG00000175868
PharmGKBiPA26030

Chemistry databases

ChEMBLiCHEMBL3832947
DrugBankiDB05760 MK-0974

Polymorphism and mutation databases

BioMutaiCALCB
DMDMi115487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000408626 – 79Add BLAST54
PeptideiPRO_000000408782 – 118Calcitonin gene-related peptide 2Add BLAST37
PropeptideiPRO_0000004088124 – 1274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 881 Publication
Modified residuei118Phenylalanine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP10092
PeptideAtlasiP10092
PRIDEiP10092
ProteomicsDBi52565

PTM databases

iPTMnetiP10092
PhosphoSitePlusiP10092

Miscellaneous databases

PMAP-CutDBiP10092

Expressioni

Gene expression databases

BgeeiENSG00000175868
CleanExiHS_CALCB
ExpressionAtlasiP10092 baseline and differential
GenevisibleiP10092 HS

Organism-specific databases

HPAiHPA059886

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: ProtInc

Protein-protein interaction databases

BioGridi107248, 3 interactors
IntActiP10092, 1 interactor
STRINGi9606.ENSP00000346017

Structurei

3D structure databases

ProteinModelPortaliP10092
SMRiP10092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZP Eukaryota
ENOG410YIU3 LUCA
GeneTreeiENSGT00390000010511
HOGENOMiHOG000038203
HOVERGENiHBG031362
InParanoidiP10092
PhylomeDBiP10092
TreeFamiTF333069

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR015476 Calcitonin_gene-rel_peptide
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00817 CALCITONINB
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL
60 70 80 90 100
AALVQDYVQM KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS
110 120
GGMVKSNFVP TNVGSKAFGR RRRDLQA
Length:127
Mass (Da):13,706
Last modified:July 1, 1989 - v1
Checksum:iB0A71A063CD5ACE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73G → S in CAA26249 (PubMed:2985435).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04855, X04857, X04861 Genomic DNA Translation: CAC05295.1
AK291188 mRNA Translation: BAF83877.1
CH471064 Genomic DNA Translation: EAW68466.1
CH471064 Genomic DNA Translation: EAW68467.1
BC092468 mRNA Translation: AAH92468.1
X02404 mRNA Translation: CAA26249.1
CCDSiCCDS7820.1
PIRiA25864
I37232
RefSeqiNP_000719.1, NM_000728.3
UniGeneiHs.534305

Genome annotation databases

EnsembliENST00000324229; ENSP00000346017; ENSG00000175868
ENST00000533448; ENSP00000433490; ENSG00000175868
GeneIDi797
KEGGihsa:797
UCSCiuc001mlx.2 human

Similar proteinsi

Entry informationi

Entry nameiCALCB_HUMAN
AccessioniPrimary (citable) accession number: P10092
Secondary accession number(s): A8K573
, D3DQX4, Q569I0, Q9UCN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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