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Protein

Protein white

Gene

w

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi130 – 137ATPIEP:8

GO - Molecular functioni

GO - Biological processi

  • aminergic neurotransmitter loading into synaptic vesicle Source: FlyBase
  • cellular biogenic amine biosynthetic process Source: FlyBase
  • cGMP transport Source: FlyBase
  • compound eye pigmentation Source: FlyBase
  • eye pigment metabolic process Source: FlyBase
  • eye pigment precursor transport Source: FlyBase
  • gravitaxis Source: FlyBase
  • histamine uptake Source: FlyBase
  • male courtship behavior Source: FlyBase
  • memory Source: FlyBase
  • ommochrome biosynthetic process Source: FlyBase
  • transmembrane transport Source: FlyBase

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

TCDBi3.A.1.204.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein white
Gene namesi
Name:w
ORF Names:CG2759
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003996. w.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei435 – 453HelicalIEP:Add BLAST19
Transmembranei465 – 485HelicalIEP:Add BLAST21
Transmembranei515 – 533HelicalIEP:Add BLAST19
Transmembranei542 – 563HelicalIEP:Add BLAST22
Transmembranei576 – 594HelicalIEP:Add BLAST19
Transmembranei659 – 678HelicalIEP:Add BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933821 – 687Protein whiteAdd BLAST687

Proteomic databases

PaxDbiP10090.
PRIDEiP10090.

Expressioni

Gene expression databases

BgeeiFBgn0003996.
ExpressionAtlasiP10090. differential.
GenevisibleiP10090. DM.

Interactioni

Subunit structurei

Heterodimer of white with either brown or scarlet.

Protein-protein interaction databases

BioGridi57802. 81 interactors.
DIPiDIP-388N.
IntActiP10090. 1 interactor.
MINTiMINT-878173.
STRINGi7227.FBpp0070468.

Structurei

3D structure databases

ProteinModelPortaliP10090.
SMRiP10090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 341ABC transporterIEP:Add BLAST249

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
InParanoidiP10090.
KOiK21396.
OrthoDBiEOG091G05L3.
PhylomeDBiP10090.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
PfamiView protein in Pfam
PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P10090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQEDQELLI RGGSKHPSAE HLNNGDSGAA SQSCINQGFG QAKNYGTLLP
60 70 80 90 100
PSPPEDSGSG SGQLAENLTY AWHNMDIFGA VNQPGSGWRQ LVNRTRGLFC
110 120 130 140 150
NERHIPAPRK HLLKNVCGVA YPGELLAVMG SSGAGKTTLL NALAFRSPQG
160 170 180 190 200
IQVSPSGMRL LNGQPVDAKE MQARCAYVQQ DDLFIGSLTA REHLIFQAMV
210 220 230 240 250
RMPRHLTYRQ RVARVDQVIQ ELSLSKCQHT IIGVPGRVKG LSGGERKRLA
260 270 280 290 300
FASEALTDPP LLICDEPTSG LDSFTAHSVV QVLKKLSQKG KTVILTIHQP
310 320 330 340 350
SSELFELFDK ILLMAEGRVA FLGTPSEAVD FFSYVGAQCP TNYNPADFYV
360 370 380 390 400
QVLAVVPGRE IESRDRIAKI CDNFAISKVA RDMEQLLATK NLEKPLEQPE
410 420 430 440 450
NGYTYKATWF MQFRAVLWRS WLSVLKEPLL VKVRLIQTTM VAILIGLIFL
460 470 480 490 500
GQQLTQVGVM NINGAIFLFL TNMTFQNVFA TINVFTSELP VFMREARSRL
510 520 530 540 550
YRCDTYFLGK TIAELPLFLT VPLVFTAIAY PMIGLRAGVL HFFNCLALVT
560 570 580 590 600
LVANVSTSFG YLISCASSST SMALSVGPPV IIPFLLFGGF FLNSGSVPVY
610 620 630 640 650
LKWLSYLSWF RYANEGLLIN QWADVEPGEI SCTSSNTTCP SSGKVILETL
660 670 680
NFSAADLPLD YVGLAILIVS FRVLAYLALR LRARRKE
Length:687
Mass (Da):75,673
Last modified:November 1, 1991 - v2
Checksum:i24AFAD799DE0D396
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 29GDSGA → LIFEIPYHCRVTAD in BAA78210 (PubMed:11156992).IKR:5
Sequence conflicti49L → R in AAF45826 (PubMed:10731132).IKR:1
Sequence conflicti49L → R in CAB65847 (PubMed:10731137).IKR:1
Sequence conflicti335 – 371VGAQC…IAKIC → ITLHLNSYPAWVPSVLPTTI RRTFTYRCWPLCPDGRSSPV IGSPRYG in BAA78210 (PubMed:11156992).IKR:Add BLAST37
Sequence conflicti616G → A in CAA26716 (PubMed:6084717).IKR:1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51749 mRNA. Translation: CAA36038.1.
X02974 Genomic DNA. Translation: CAA26716.2.
AB028139 Genomic DNA. Translation: BAA78210.1.
AE014298 Genomic DNA. Translation: AAF45826.1.
AL133506 Genomic DNA. Translation: CAB65847.1.
X76202 Genomic DNA. Translation: CAA53795.1.
PIRiS08635. FYFFW.
RefSeqiNP_476787.1. NM_057439.2.
UniGeneiDm.19661.

Genome annotation databases

GeneIDi31271.
KEGGidme:Dmel_CG2759.

Similar proteinsi

Entry informationi

Entry nameiWHITE_DROME
AccessioniPrimary (citable) accession number: P10090
Secondary accession number(s): Q9V3A2, Q9XY33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: October 25, 2017
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families