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P10090

- WHITE_DROME

UniProt

P10090 - WHITE_DROME

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Protein

Protein white

Gene

w

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi130 – 1378ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. pigment binding Source: UniProtKB-KW
  4. transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  1. cellular biogenic amine biosynthetic process Source: FlyBase
  2. cGMP transport Source: FlyBase
  3. compound eye pigmentation Source: FlyBase
  4. eye pigment metabolic process Source: FlyBase
  5. eye pigment precursor transport Source: FlyBase
  6. gravitaxis Source: FlyBase
  7. male courtship behavior Source: FlyBase
  8. memory Source: FlyBase
  9. ommochrome biosynthetic process Source: FlyBase
  10. signal transduction Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

TCDBi3.A.1.204.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein white
Gene namesi
Name:w
ORF Names:CG2759
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003996. w.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic granule membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Pigment granules within pigment cells and retinula cells of the compound eye (when complexed with st).

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei435 – 45319HelicalSequence AnalysisAdd
BLAST
Transmembranei465 – 48521HelicalSequence AnalysisAdd
BLAST
Transmembranei515 – 53319HelicalSequence AnalysisAdd
BLAST
Transmembranei542 – 56322HelicalSequence AnalysisAdd
BLAST
Transmembranei576 – 59419HelicalSequence AnalysisAdd
BLAST
Transmembranei659 – 67820HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: FlyBase
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 687687Protein whitePRO_0000093382Add
BLAST

Expressioni

Gene expression databases

BgeeiP10090.
ExpressionAtlasiP10090. differential.

Interactioni

Subunit structurei

Heterodimer of white with either brown or scarlet.

Protein-protein interaction databases

BioGridi57802. 45 interactions.
DIPiDIP-388N.
IntActiP10090. 1 interaction.
MINTiMINT-878173.

Structurei

3D structure databases

ProteinModelPortaliP10090.
SMRiP10090. Positions 84-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 341249ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
InParanoidiP10090.
OrthoDBiEOG71K62F.
PhylomeDBiP10090.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10090-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQEDQELLI RGGSKHPSAE HLNNGDSGAA SQSCINQGFG QAKNYGTLLP
60 70 80 90 100
PSPPEDSGSG SGQLAENLTY AWHNMDIFGA VNQPGSGWRQ LVNRTRGLFC
110 120 130 140 150
NERHIPAPRK HLLKNVCGVA YPGELLAVMG SSGAGKTTLL NALAFRSPQG
160 170 180 190 200
IQVSPSGMRL LNGQPVDAKE MQARCAYVQQ DDLFIGSLTA REHLIFQAMV
210 220 230 240 250
RMPRHLTYRQ RVARVDQVIQ ELSLSKCQHT IIGVPGRVKG LSGGERKRLA
260 270 280 290 300
FASEALTDPP LLICDEPTSG LDSFTAHSVV QVLKKLSQKG KTVILTIHQP
310 320 330 340 350
SSELFELFDK ILLMAEGRVA FLGTPSEAVD FFSYVGAQCP TNYNPADFYV
360 370 380 390 400
QVLAVVPGRE IESRDRIAKI CDNFAISKVA RDMEQLLATK NLEKPLEQPE
410 420 430 440 450
NGYTYKATWF MQFRAVLWRS WLSVLKEPLL VKVRLIQTTM VAILIGLIFL
460 470 480 490 500
GQQLTQVGVM NINGAIFLFL TNMTFQNVFA TINVFTSELP VFMREARSRL
510 520 530 540 550
YRCDTYFLGK TIAELPLFLT VPLVFTAIAY PMIGLRAGVL HFFNCLALVT
560 570 580 590 600
LVANVSTSFG YLISCASSST SMALSVGPPV IIPFLLFGGF FLNSGSVPVY
610 620 630 640 650
LKWLSYLSWF RYANEGLLIN QWADVEPGEI SCTSSNTTCP SSGKVILETL
660 670 680
NFSAADLPLD YVGLAILIVS FRVLAYLALR LRARRKE
Length:687
Mass (Da):75,673
Last modified:November 1, 1991 - v2
Checksum:i24AFAD799DE0D396
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 295GDSGA → LIFEIPYHCRVTAD in BAA78210. (PubMed:11156992)Curated
Sequence conflicti49 – 491L → R in AAF45826. (PubMed:10731132)Curated
Sequence conflicti49 – 491L → R in CAB65847. (PubMed:10731137)Curated
Sequence conflicti335 – 37137VGAQC…IAKIC → ITLHLNSYPAWVPSVLPTTI RRTFTYRCWPLCPDGRSSPV IGSPRYG in BAA78210. (PubMed:11156992)CuratedAdd
BLAST
Sequence conflicti616 – 6161G → A in CAA26716. (PubMed:6084717)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51749 mRNA. Translation: CAA36038.1.
X02974 Genomic DNA. Translation: CAA26716.2.
AB028139 Genomic DNA. Translation: BAA78210.1.
AE014298 Genomic DNA. Translation: AAF45826.1.
AL133506 Genomic DNA. Translation: CAB65847.1.
X76202 Genomic DNA. Translation: CAA53795.1.
PIRiS08635. FYFFW.
RefSeqiNP_476787.1. NM_057439.2.
UniGeneiDm.19661.

Genome annotation databases

GeneIDi31271.
KEGGidme:Dmel_CG2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51749 mRNA. Translation: CAA36038.1 .
X02974 Genomic DNA. Translation: CAA26716.2 .
AB028139 Genomic DNA. Translation: BAA78210.1 .
AE014298 Genomic DNA. Translation: AAF45826.1 .
AL133506 Genomic DNA. Translation: CAB65847.1 .
X76202 Genomic DNA. Translation: CAA53795.1 .
PIRi S08635. FYFFW.
RefSeqi NP_476787.1. NM_057439.2.
UniGenei Dm.19661.

3D structure databases

ProteinModelPortali P10090.
SMRi P10090. Positions 84-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 57802. 45 interactions.
DIPi DIP-388N.
IntActi P10090. 1 interaction.
MINTi MINT-878173.

Protein family/group databases

TCDBi 3.A.1.204.1. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 31271.
KEGGi dme:Dmel_CG2759.

Organism-specific databases

CTDi 31271.
FlyBasei FBgn0003996. w.

Phylogenomic databases

eggNOGi COG1131.
InParanoidi P10090.
OrthoDBi EOG71K62F.
PhylomeDBi P10090.

Miscellaneous databases

ChiTaRSi W. fly.
GenomeRNAii 31271.
NextBioi 772783.

Gene expression databases

Bgeei P10090.
ExpressionAtlasi P10090. differential.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view ]
Pfami PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00955. 3a01204. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a cDNA from the Drosophila melanogaster white gene."
    Pepling M., Mount S.M.
    Nucleic Acids Res. 18:1633-1633(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head.
  2. "DNA sequence of the white locus of Drosophila melanogaster."
    O'Hare K., Murphy C., Levis R., Rubin G.M.
    J. Mol. Biol. 180:437-455(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. O'Hare K.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 25-29 AND 616.
  4. "Dual-tagging gene trap of novel genes in Drosophila melanogaster."
    Lukacsovich T., Asztalos Z., Awano W., Baba K., Kondo S., Niwa S., Yamamoto D.
    Genetics 157:727-742(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oregon-R.
  8. "Cloning and characterization of the scarlet gene of Drosophila melanogaster."
    Tearle R.G., Belote J.M., McKeown M., Baker B.S., Howells A.J.
    Genetics 122:595-606(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 224-331.
  9. "Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster."
    Mackenzie S.M., Howells A.J., Cox G.B., Ewart G.D.
    Genetica 108:239-252(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiWHITE_DROME
AccessioniPrimary (citable) accession number: P10090
Secondary accession number(s): Q9V3A2, Q9XY33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: November 26, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3