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Protein

Protein white

Gene

w

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi130 – 137ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cellular biogenic amine biosynthetic process Source: FlyBase
  • cGMP transport Source: FlyBase
  • compound eye pigmentation Source: FlyBase
  • eye pigment metabolic process Source: FlyBase
  • eye pigment precursor transport Source: FlyBase
  • gravitaxis Source: FlyBase
  • male courtship behavior Source: FlyBase
  • memory Source: FlyBase
  • ommochrome biosynthetic process Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

TCDBi3.A.1.204.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein white
Gene namesi
Name:w
ORF Names:CG2759
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003996. w.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei435 – 453HelicalSequence analysisAdd BLAST19
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei515 – 533HelicalSequence analysisAdd BLAST19
Transmembranei542 – 563HelicalSequence analysisAdd BLAST22
Transmembranei576 – 594HelicalSequence analysisAdd BLAST19
Transmembranei659 – 678HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • cytoplasmic vesicle Source: FlyBase
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933821 – 687Protein whiteAdd BLAST687

Proteomic databases

PaxDbiP10090.
PRIDEiP10090.

Expressioni

Gene expression databases

BgeeiFBgn0003996.
ExpressionAtlasiP10090. baseline.
GenevisibleiP10090. DM.

Interactioni

Subunit structurei

Heterodimer of white with either brown or scarlet.

Protein-protein interaction databases

BioGridi57802. 45 interactors.
DIPiDIP-388N.
IntActiP10090. 1 interactor.
MINTiMINT-878173.
STRINGi7227.FBpp0070468.

Structurei

3D structure databases

ProteinModelPortaliP10090.
SMRiP10090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 341ABC transporterPROSITE-ProRule annotationAdd BLAST249

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
InParanoidiP10090.
OrthoDBiEOG091G05L3.
PhylomeDBiP10090.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQEDQELLI RGGSKHPSAE HLNNGDSGAA SQSCINQGFG QAKNYGTLLP
60 70 80 90 100
PSPPEDSGSG SGQLAENLTY AWHNMDIFGA VNQPGSGWRQ LVNRTRGLFC
110 120 130 140 150
NERHIPAPRK HLLKNVCGVA YPGELLAVMG SSGAGKTTLL NALAFRSPQG
160 170 180 190 200
IQVSPSGMRL LNGQPVDAKE MQARCAYVQQ DDLFIGSLTA REHLIFQAMV
210 220 230 240 250
RMPRHLTYRQ RVARVDQVIQ ELSLSKCQHT IIGVPGRVKG LSGGERKRLA
260 270 280 290 300
FASEALTDPP LLICDEPTSG LDSFTAHSVV QVLKKLSQKG KTVILTIHQP
310 320 330 340 350
SSELFELFDK ILLMAEGRVA FLGTPSEAVD FFSYVGAQCP TNYNPADFYV
360 370 380 390 400
QVLAVVPGRE IESRDRIAKI CDNFAISKVA RDMEQLLATK NLEKPLEQPE
410 420 430 440 450
NGYTYKATWF MQFRAVLWRS WLSVLKEPLL VKVRLIQTTM VAILIGLIFL
460 470 480 490 500
GQQLTQVGVM NINGAIFLFL TNMTFQNVFA TINVFTSELP VFMREARSRL
510 520 530 540 550
YRCDTYFLGK TIAELPLFLT VPLVFTAIAY PMIGLRAGVL HFFNCLALVT
560 570 580 590 600
LVANVSTSFG YLISCASSST SMALSVGPPV IIPFLLFGGF FLNSGSVPVY
610 620 630 640 650
LKWLSYLSWF RYANEGLLIN QWADVEPGEI SCTSSNTTCP SSGKVILETL
660 670 680
NFSAADLPLD YVGLAILIVS FRVLAYLALR LRARRKE
Length:687
Mass (Da):75,673
Last modified:November 1, 1991 - v2
Checksum:i24AFAD799DE0D396
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 29GDSGA → LIFEIPYHCRVTAD in BAA78210 (PubMed:11156992).Curated5
Sequence conflicti49L → R in AAF45826 (PubMed:10731132).Curated1
Sequence conflicti49L → R in CAB65847 (PubMed:10731137).Curated1
Sequence conflicti335 – 371VGAQC…IAKIC → ITLHLNSYPAWVPSVLPTTI RRTFTYRCWPLCPDGRSSPV IGSPRYG in BAA78210 (PubMed:11156992).CuratedAdd BLAST37
Sequence conflicti616G → A in CAA26716 (PubMed:6084717).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51749 mRNA. Translation: CAA36038.1.
X02974 Genomic DNA. Translation: CAA26716.2.
AB028139 Genomic DNA. Translation: BAA78210.1.
AE014298 Genomic DNA. Translation: AAF45826.1.
AL133506 Genomic DNA. Translation: CAB65847.1.
X76202 Genomic DNA. Translation: CAA53795.1.
PIRiS08635. FYFFW.
RefSeqiNP_476787.1. NM_057439.2.
UniGeneiDm.19661.

Genome annotation databases

GeneIDi31271.
KEGGidme:Dmel_CG2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51749 mRNA. Translation: CAA36038.1.
X02974 Genomic DNA. Translation: CAA26716.2.
AB028139 Genomic DNA. Translation: BAA78210.1.
AE014298 Genomic DNA. Translation: AAF45826.1.
AL133506 Genomic DNA. Translation: CAB65847.1.
X76202 Genomic DNA. Translation: CAA53795.1.
PIRiS08635. FYFFW.
RefSeqiNP_476787.1. NM_057439.2.
UniGeneiDm.19661.

3D structure databases

ProteinModelPortaliP10090.
SMRiP10090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57802. 45 interactors.
DIPiDIP-388N.
IntActiP10090. 1 interactor.
MINTiMINT-878173.
STRINGi7227.FBpp0070468.

Protein family/group databases

TCDBi3.A.1.204.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP10090.
PRIDEiP10090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31271.
KEGGidme:Dmel_CG2759.

Organism-specific databases

CTDi31271.
FlyBaseiFBgn0003996. w.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
InParanoidiP10090.
OrthoDBiEOG091G05L3.
PhylomeDBiP10090.

Miscellaneous databases

ChiTaRSiW. fly.
GenomeRNAii31271.
PROiP10090.

Gene expression databases

BgeeiFBgn0003996.
ExpressionAtlasiP10090. baseline.
GenevisibleiP10090. DM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWHITE_DROME
AccessioniPrimary (citable) accession number: P10090
Secondary accession number(s): Q9V3A2, Q9XY33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.