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P10090

- WHITE_DROME

UniProt

P10090 - WHITE_DROME

Protein

Protein white

Gene

w

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi130 – 1378ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. pigment binding Source: UniProtKB-KW
    4. transmembrane signaling receptor activity Source: FlyBase

    GO - Biological processi

    1. cellular biogenic amine biosynthetic process Source: FlyBase
    2. cGMP transport Source: FlyBase
    3. compound eye pigmentation Source: FlyBase
    4. eye pigment metabolic process Source: FlyBase
    5. eye pigment precursor transport Source: FlyBase
    6. gravitaxis Source: FlyBase
    7. male courtship behavior Source: FlyBase
    8. memory Source: FlyBase
    9. ommochrome biosynthetic process Source: FlyBase
    10. signal transduction Source: GOC

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Pigment

    Protein family/group databases

    TCDBi3.A.1.204.1. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein white
    Gene namesi
    Name:w
    ORF Names:CG2759
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0003996. w.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic granule membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Pigment granules within pigment cells and retinula cells of the compound eye (when complexed with st).

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: FlyBase
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 687687Protein whitePRO_0000093382Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiP10090.

    Interactioni

    Subunit structurei

    Heterodimer of white with either brown or scarlet.

    Protein-protein interaction databases

    BioGridi57802. 45 interactions.
    DIPiDIP-388N.
    IntActiP10090. 1 interaction.
    MINTiMINT-878173.

    Structurei

    3D structure databases

    ProteinModelPortaliP10090.
    SMRiP10090. Positions 59-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei435 – 45319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei515 – 53319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei542 – 56322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei576 – 59419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei659 – 67820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 341249ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    InParanoidiP10090.
    OrthoDBiEOG71K62F.
    PhylomeDBiP10090.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    IPR005284. Pigment_permease.
    [Graphical view]
    PfamiPF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00955. 3a01204. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQEDQELLI RGGSKHPSAE HLNNGDSGAA SQSCINQGFG QAKNYGTLLP    50
    PSPPEDSGSG SGQLAENLTY AWHNMDIFGA VNQPGSGWRQ LVNRTRGLFC 100
    NERHIPAPRK HLLKNVCGVA YPGELLAVMG SSGAGKTTLL NALAFRSPQG 150
    IQVSPSGMRL LNGQPVDAKE MQARCAYVQQ DDLFIGSLTA REHLIFQAMV 200
    RMPRHLTYRQ RVARVDQVIQ ELSLSKCQHT IIGVPGRVKG LSGGERKRLA 250
    FASEALTDPP LLICDEPTSG LDSFTAHSVV QVLKKLSQKG KTVILTIHQP 300
    SSELFELFDK ILLMAEGRVA FLGTPSEAVD FFSYVGAQCP TNYNPADFYV 350
    QVLAVVPGRE IESRDRIAKI CDNFAISKVA RDMEQLLATK NLEKPLEQPE 400
    NGYTYKATWF MQFRAVLWRS WLSVLKEPLL VKVRLIQTTM VAILIGLIFL 450
    GQQLTQVGVM NINGAIFLFL TNMTFQNVFA TINVFTSELP VFMREARSRL 500
    YRCDTYFLGK TIAELPLFLT VPLVFTAIAY PMIGLRAGVL HFFNCLALVT 550
    LVANVSTSFG YLISCASSST SMALSVGPPV IIPFLLFGGF FLNSGSVPVY 600
    LKWLSYLSWF RYANEGLLIN QWADVEPGEI SCTSSNTTCP SSGKVILETL 650
    NFSAADLPLD YVGLAILIVS FRVLAYLALR LRARRKE 687
    Length:687
    Mass (Da):75,673
    Last modified:November 1, 1991 - v2
    Checksum:i24AFAD799DE0D396
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 295GDSGA → LIFEIPYHCRVTAD in BAA78210. (PubMed:11156992)Curated
    Sequence conflicti49 – 491L → R in AAF45826. (PubMed:10731132)Curated
    Sequence conflicti49 – 491L → R in CAB65847. (PubMed:10731137)Curated
    Sequence conflicti335 – 37137VGAQC…IAKIC → ITLHLNSYPAWVPSVLPTTI RRTFTYRCWPLCPDGRSSPV IGSPRYG in BAA78210. (PubMed:11156992)CuratedAdd
    BLAST
    Sequence conflicti616 – 6161G → A in CAA26716. (PubMed:6084717)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51749 mRNA. Translation: CAA36038.1.
    X02974 Genomic DNA. Translation: CAA26716.2.
    AB028139 Genomic DNA. Translation: BAA78210.1.
    AE014298 Genomic DNA. Translation: AAF45826.1.
    AL133506 Genomic DNA. Translation: CAB65847.1.
    X76202 Genomic DNA. Translation: CAA53795.1.
    PIRiS08635. FYFFW.
    RefSeqiNP_476787.1. NM_057439.2.
    UniGeneiDm.19661.

    Genome annotation databases

    GeneIDi31271.
    KEGGidme:Dmel_CG2759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51749 mRNA. Translation: CAA36038.1 .
    X02974 Genomic DNA. Translation: CAA26716.2 .
    AB028139 Genomic DNA. Translation: BAA78210.1 .
    AE014298 Genomic DNA. Translation: AAF45826.1 .
    AL133506 Genomic DNA. Translation: CAB65847.1 .
    X76202 Genomic DNA. Translation: CAA53795.1 .
    PIRi S08635. FYFFW.
    RefSeqi NP_476787.1. NM_057439.2.
    UniGenei Dm.19661.

    3D structure databases

    ProteinModelPortali P10090.
    SMRi P10090. Positions 59-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 57802. 45 interactions.
    DIPi DIP-388N.
    IntActi P10090. 1 interaction.
    MINTi MINT-878173.

    Protein family/group databases

    TCDBi 3.A.1.204.1. the atp-binding cassette (abc) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 31271.
    KEGGi dme:Dmel_CG2759.

    Organism-specific databases

    CTDi 31271.
    FlyBasei FBgn0003996. w.

    Phylogenomic databases

    eggNOGi COG1131.
    InParanoidi P10090.
    OrthoDBi EOG71K62F.
    PhylomeDBi P10090.

    Miscellaneous databases

    ChiTaRSi W. drosophila.
    GenomeRNAii 31271.
    NextBioi 772783.

    Gene expression databases

    Bgeei P10090.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    IPR005284. Pigment_permease.
    [Graphical view ]
    Pfami PF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00955. 3a01204. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a cDNA from the Drosophila melanogaster white gene."
      Pepling M., Mount S.M.
      Nucleic Acids Res. 18:1633-1633(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Head.
    2. "DNA sequence of the white locus of Drosophila melanogaster."
      O'Hare K., Murphy C., Levis R., Rubin G.M.
      J. Mol. Biol. 180:437-455(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. O'Hare K.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 25-29 AND 616.
    4. "Dual-tagging gene trap of novel genes in Drosophila melanogaster."
      Lukacsovich T., Asztalos Z., Awano W., Baba K., Kondo S., Niwa S., Yamamoto D.
      Genetics 157:727-742(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    6. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Oregon-R.
    8. "Cloning and characterization of the scarlet gene of Drosophila melanogaster."
      Tearle R.G., Belote J.M., McKeown M., Baker B.S., Howells A.J.
      Genetics 122:595-606(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 224-331.
    9. "Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster."
      Mackenzie S.M., Howells A.J., Cox G.B., Ewart G.D.
      Genetica 108:239-252(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiWHITE_DROME
    AccessioniPrimary (citable) accession number: P10090
    Secondary accession number(s): Q9V3A2, Q9XY33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3