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Protein

Achaete-scute complex protein T5

Gene

ac

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • central nervous system development Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • epithelial cell proliferation involved in Malpighian tubule morphogenesis Source: FlyBase
  • Malpighian tubule tip cell differentiation Source: FlyBase
  • nervous system development Source: FlyBase
  • neuroblast fate determination Source: FlyBase
  • oogenesis Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: FlyBase
  • regulation of antimicrobial peptide biosynthetic process Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of mitotic cell cycle Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • sensory organ development Source: FlyBase
  • ventral cord development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP10083.

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute complex protein T5
Alternative name(s):
Protein achaete
Gene namesi
Name:ac
Synonyms:T5
ORF Names:CG3796
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000022. ac.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
  • transcription factor complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Achaete-scute complex protein T5PRO_0000127137Add
BLAST

Proteomic databases

PaxDbiP10083.
PRIDEiP10083.

Expressioni

Tissue specificityi

L1SC, SC and AC strongly label the presumptive stomatogastric nervous system, while ASE is more prominent in the presumptive procephalic lobe.

Gene expression databases

BgeeiP10083.
GenevisibleiP10083. DM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi57554. 10 interactions.
DIPiDIP-187N.
IntActiP10083. 4 interactions.
MINTiMINT-842893.
STRINGi7227.FBpp0070071.

Structurei

3D structure databases

ProteinModelPortaliP10083.
SMRiP10083. Positions 33-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9067bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISUZ. Eukaryota.
ENOG410Y0IE. LUCA.
GeneTreeiENSGT00530000063321.
InParanoidiP10083.
KOiK09067.
OMAiQHFYAWQ.
OrthoDBiEOG7B5WZK.
PhylomeDBiP10083.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. Achaete-scute-rel.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGSENHSV FNDDEESSSA FNGPSVIRRN ARERNRVKQV NNGFSQLRQH
60 70 80 90 100
IPAAVIADLS NGRRGIGPGA NKKLSKVSTL KMAVEYIRRL QKVLHENDQQ
110 120 130 140 150
KQKQLHLQQQ HLHFQQQQQH QHLYAWHQEL QLQSPTGSTS SCNSISSYCK
160 170 180 190 200
PATSTIPGAT PPNNFHTKLE ASFEDYRNNS CSSGTEDEDI LDYISLWQDD

L
Length:201
Mass (Da):22,753
Last modified:July 1, 1989 - v1
Checksum:iAAA906600CA764C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17120 Genomic DNA. Translation: AAA28312.1.
AE014298 Genomic DNA. Translation: AAF45498.1.
AL023873 Genomic DNA. Translation: CAA19641.1.
BT022154 mRNA. Translation: AAY51549.1.
PIRiA43731.
RefSeqiNP_476824.1. NM_057476.3.
UniGeneiDm.25370.

Genome annotation databases

EnsemblMetazoaiFBtr0070072; FBpp0070071; FBgn0000022.
GeneIDi30981.
KEGGidme:Dmel_CG3796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17120 Genomic DNA. Translation: AAA28312.1.
AE014298 Genomic DNA. Translation: AAF45498.1.
AL023873 Genomic DNA. Translation: CAA19641.1.
BT022154 mRNA. Translation: AAY51549.1.
PIRiA43731.
RefSeqiNP_476824.1. NM_057476.3.
UniGeneiDm.25370.

3D structure databases

ProteinModelPortaliP10083.
SMRiP10083. Positions 33-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57554. 10 interactions.
DIPiDIP-187N.
IntActiP10083. 4 interactions.
MINTiMINT-842893.
STRINGi7227.FBpp0070071.

Proteomic databases

PaxDbiP10083.
PRIDEiP10083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070072; FBpp0070071; FBgn0000022.
GeneIDi30981.
KEGGidme:Dmel_CG3796.

Organism-specific databases

CTDi11358.
FlyBaseiFBgn0000022. ac.

Phylogenomic databases

eggNOGiENOG410ISUZ. Eukaryota.
ENOG410Y0IE. LUCA.
GeneTreeiENSGT00530000063321.
InParanoidiP10083.
KOiK09067.
OMAiQHFYAWQ.
OrthoDBiEOG7B5WZK.
PhylomeDBiP10083.

Enzyme and pathway databases

SignaLinkiP10083.

Miscellaneous databases

GenomeRNAii30981.
NextBioi771306.
PROiP10083.

Gene expression databases

BgeeiP10083.
GenevisibleiP10083. DM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. Achaete-scute-rel.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc."
    Villares R., Cabrera C.V.
    Cell 50:415-424(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oregon-R.
  5. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.W., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.

Entry informationi

Entry nameiAST5_DROME
AccessioniPrimary (citable) accession number: P10083
Secondary accession number(s): Q4V702, Q9W5G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.