Reviewed, UniProtKB/Swiss-Prot P10083 (AST5_DROME)

Names and origin

Protein names

Recommended name:
    Achaete-scute complex protein T5
      Short name=Achaete

Gene names

Name:	ac
Synonyms:	T5
ORF Names:	CG3796

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Tissue specificity	L1SC, SC and AC strongly label the presumptive stomatogastric nervous system, while ASE is more prominent in the presumptive procephalic lobe.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	bristle morphogenesis Inferred from mutant phenotype. Source: FlyBase neuroblast fate determination Traceable author statement. Source: FlyBase oogenesis Traceable author statement. Source: FlyBase peripheral nervous system development Inferred from mutant phenotype. Source: FlyBase positive regulation of transcription Traceable author statement. Source: FlyBase regulation of mitotic cell cycle Traceable author statement. Source: FlyBase regulation of transcription, DNA-dependent Non-traceable author statement. Source: FlyBase ventral cord development Non-traceable author statement. Source: FlyBase
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Traceable author statement. Source: FlyBase protein binding Inferred from physical interaction. Source: IntAct transcription activator activity Traceable author statement. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HLHm3	Q01068	2	EBI-152748,EBI-121622

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Achaete-scute complex protein T5		PRO_0000127137
Regions
	Domain	38 – 91	54	Helix-loop-helix motif
	DNA binding	27 – 37	11	Basic motif

Sequences

	Sequence		Length	Mass (Da)
	P10083-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: AAA906600CA764C0	FASTA	201	22,753
	10 20 30 40 50 60 MALGSENHSV FNDDEESSSA FNGPSVIRRN ARERNRVKQV NNGFSQLRQH IPAAVIADLS 70 80 90 100 110 120 NGRRGIGPGA NKKLSKVSTL KMAVEYIRRL QKVLHENDQQ KQKQLHLQQQ HLHFQQQQQH 130 140 150 160 170 180 QHLYAWHQEL QLQSPTGSTS SCNSISSYCK PATSTIPGAT PPNNFHTKLE ASFEDYRNNS 190 200 CSSGTEDEDI LDYISLWQDD L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc." Villares R., Cabrera C.V. Cell 50:415-424(1987) [PubMed: 3111716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[5]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.W., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M17120 Genomic DNA. Translation: AAA28312.1. AE014298 Genomic DNA. Translation: AAF45498.1. AL023873 Genomic DNA. Translation: CAA19641.1. BT022154 mRNA. Translation: AAY51549.1.
PIR	A43731.
RefSeq	NP_476824.1.
UniGene	Dm.25370
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:187N.
IntAct	P10083. 15 interactions.
Proteomic databases
PRIDE	P10083.
Genome annotation databases
Ensembl	FBgn0000022. Drosophila melanogaster. [Contig view]
GeneID	30981.
KEGG	dme:Dmel_CG3796.
NMPDR	fig|7227.3.peg.15887.
Organism-specific databases
FlyBase	FBgn0000022. ac.
Phylogenomic databases
HOGENOM	P10083.
OMA	P10083. CSSGTED.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-000018-MON.
Gene expression databases
ArrayExpress	P10083.
GermOnline	CG3796. Drosophila melanogaster.
Family and domain databases
InterPro	IPR015660. ASH. IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
PANTHER	PTHR13935. ASH. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	771306.

Entry information

Entry name

AST5_DROME

Accession

Primary (citable) accession number: P10083
Secondary accession number(s): Q4V702, Q9W5G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	June 16, 2009
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project