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Protein

Peptide YY

Gene

PYY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei30 – 312Cleavage; by FAP1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: GO_Central
  2. hormone activity Source: ProtInc
  3. neuropeptide hormone activity Source: GO_Central

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell proliferation Source: ProtInc
  3. cellular component movement Source: ProtInc
  4. cytoskeleton organization Source: ProtInc
  5. digestion Source: ProtInc
  6. eating behavior Source: Ensembl
  7. feeding behavior Source: ProtInc
  8. G-protein coupled receptor signaling pathway Source: ProtInc
  9. neuropeptide signaling pathway Source: GO_Central
  10. regulation of appetite Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
PYY-IBy similarity
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)1 Publication
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:PYY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:9748. PYY.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28282 PublicationsAdd
BLAST
Peptidei29 – 6436Peptide YYPRO_0000025384Add
BLAST
Peptidei31 – 6434Peptide YY(3-36)PRO_0000025385Add
BLAST
Propeptidei68 – 9730PRO_0000025386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei64 – 641Tyrosine amide2 Publications

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PRIDEiP10082.

Expressioni

Gene expression databases

BgeeiP10082.
CleanExiHS_PYY.
GenevestigatoriP10082.

Organism-specific databases

HPAiCAB016734.
HPA010973.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NPY1RP259292EBI-6655667,EBI-372227
NPY2RP491462EBI-6655667,EBI-6655721

Protein-protein interaction databases

BioGridi111670. 1 interaction.
IntActiP10082. 4 interactions.
MINTiMINT-8090682.
STRINGi9606.ENSP00000353198.

Structurei

Secondary structure

1
97
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 333Combined sources
Helixi41 – 5919Combined sources
Turni60 – 623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
ProteinModelPortaliP10082.
SMRiP10082. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10082.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43897.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10082.
KOiK05233.
OMAiVDAYPAK.
OrthoDBiEOG7WDN4S.
PhylomeDBiP10082.
TreeFamiTF332778.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
Length:97
Mass (Da):11,145
Last modified:January 11, 2011 - v3
Checksum:iC166B73412E356B1
GO
Isoform 2 (identifier: P10082-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Show »
Length:90
Mass (Da):10,360
Checksum:iA1C48F08021136B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371R → G.6 Publications
Corresponds to variant rs229969 [ dbSNP | Ensembl ].
VAR_047407
Natural varianti72 – 721T → R.3 Publications
Corresponds to variant rs1058046 [ dbSNP | Ensembl ].
VAR_006382
Natural varianti95 – 951D → H.
Corresponds to variant rs465407 [ dbSNP | Ensembl ].
VAR_047408

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 977Missing in isoform 2. 2 PublicationsVSP_005081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.
CCDSiCCDS32662.1. [P10082-1]
PIRiA31358.
S33795.
S34568.
S34569.
RefSeqiNP_004151.3. NM_004160.4.
UniGeneiHs.169249.

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
GeneIDi5697.
KEGGihsa:5697.
UCSCiuc002ieq.3. human. [P10082-1]

Polymorphism databases

DMDMi317373516.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.
CCDSiCCDS32662.1. [P10082-1]
PIRiA31358.
S33795.
S34568.
S34569.
RefSeqiNP_004151.3. NM_004160.4.
UniGeneiHs.169249.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
ProteinModelPortaliP10082.
SMRiP10082. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111670. 1 interaction.
IntActiP10082. 4 interactions.
MINTiMINT-8090682.
STRINGi9606.ENSP00000353198.

Polymorphism databases

DMDMi317373516.

Proteomic databases

PRIDEiP10082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
GeneIDi5697.
KEGGihsa:5697.
UCSCiuc002ieq.3. human. [P10082-1]

Organism-specific databases

CTDi5697.
GeneCardsiGC17M042040.
HGNCiHGNC:9748. PYY.
HPAiCAB016734.
HPA010973.
MIMi600781. gene.
neXtProtiNX_P10082.
PharmGKBiPA34090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43897.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10082.
KOiK05233.
OMAiVDAYPAK.
OrthoDBiEOG7WDN4S.
PhylomeDBiP10082.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiP10082.
GeneWikiiPeptide_YY.
GenomeRNAii5697.
NextBioi22132.
PROiP10082.
SOURCEiSearch...

Gene expression databases

BgeeiP10082.
CleanExiHS_PYY.
GenevestigatoriP10082.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and structural determination of human peptide YY cDNA and gene."
    Kohri K., Nata K., Yonekura H., Nagai A., Konno K., Okamoto H.
    Biochim. Biophys. Acta 1173:345-349(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS GLY-37 AND ARG-72.
    Tissue: Colon mucosa.
  2. "Genomic organisation and localisation of the gene for the human peptide YY."
    Herzog H.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-37.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-37 AND ARG-72.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-37 AND ARG-72.
    Tissue: Brain.
  6. Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, SYNTHESIS OF 29-64, VARIANT GLY-37.
  7. "A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36)."
    Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., Reeve J.R. Jr.
    Peptides 10:797-803(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, VARIANT GLY-37.
  8. "Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
    Keane F.M., Nadvi N.A., Yao T.W., Gorrell M.D.
    FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY FAP, CLEAVAGE SITE.
  9. "The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR."
    Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M.
    Biochemistry 45:8350-8357(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 29-64.

Entry informationi

Entry nameiPYY_HUMAN
AccessioniPrimary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: February 4, 2015
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.