P10082 (PYY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide YY
Short name=PYY

Alternative name(s):
PYY-I
Peptide tyrosine tyrosine

Cleaved into the following chain:

1. Peptide YY(3-36)
   Alternative name(s):
   PYY-II

Gene names

Name:

PYY

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Subcellular location	Secreted.
Sequence similarities	Belongs to the NPY family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement PubMed 7592911. Source: ProtInc cell proliferation Traceable author statement PubMed 10488139. Source: ProtInc cell-cell signaling Traceable author statement PubMed 7493937. Source: ProtInc cellular component movement Traceable author statement PubMed 10488139. Source: ProtInc cytoskeleton organization Traceable author statement PubMed 7493937. Source: ProtInc digestion Traceable author statement PubMed 7493937. Source: ProtInc eating behavior Inferred from electronic annotation. Source: Compara feeding behavior Traceable author statement PubMed 10698177. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	hormone activity Traceable author statement PubMed 10698177. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P10082-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P10082-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Ref.6 Ref.7

Peptide

29 – 64

36

Peptide YY Ref.6 Ref.7

PRO_0000025384

Peptide

31 – 64

34

Peptide YY(3-36)

PRO_0000025385

Propeptide

68 – 97

30

PRO_0000025386

Amino acid modifications

Modified residue

41

1

Phosphoserine By similarity

Modified residue

64

1

Tyrosine amide Ref.6 Ref.7

Natural variations

Alternative sequence

91 – 97

7

Missing in isoform 2.

VSP_005081

Natural variant

37

1

R → G. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs229969 [ dbSNP | Ensembl ].

VAR_047407

Natural variant

72

1

T → R. Ref.1 Ref.3 Ref.5
Corresponds to variant rs1058046 [ dbSNP | Ensembl ].

VAR_006382

Natural variant

95

1

D → H.
Corresponds to variant rs465407 [ dbSNP | Ensembl ].

VAR_047408

Secondary structure

1

.

.

.

.

.

.

97

Helix Strand Turn

Details...

Beta strand

31 – 33

3

Helix

41 – 59

19

Turn

60 – 62

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified January 11, 2011. Version 3. Checksum: C166B73412E356B1	FASTA	97	11,145
	10 20 30 40 50 60 MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA SLRHYLNLVT 70 80 90 RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
	Isoform 2 (Short) [UniParc]. Checksum: A1C48F08021136B4	FASTA	90	10,360
	10 20 30 40 50 60 MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA SLRHYLNLVT 70 80 90 RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and structural determination of human peptide YY cDNA and gene." Kohri K., Nata K., Yonekura H., Nagai A., Konno K., Okamoto H. Biochim. Biophys. Acta 1173:345-349(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS GLY-37 AND ARG-72. Tissue: Colon mucosa.
[2]	"Genomic organisation and localisation of the gene for the human peptide YY." Herzog H. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-37.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-37 AND ARG-72.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-37 AND ARG-72. Tissue: Brain.
[6]	"Isolation and primary structure of human peptide YY." Tatemoto K., Nakano I., Makk G., Angwin P., Mann M., Schilling J., Go V.L.W. Biochem. Biophys. Res. Commun. 157:713-717(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, SYNTHESIS OF 29-64, VARIANT GLY-37.
[7]	"A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36)." Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., Reeve J.R. Jr. Peptides 10:797-803(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, VARIANT GLY-37.
[8]	"The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR." Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M. Biochemistry 45:8350-8357(2006) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 29-64.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.

IPI

IPI00219199.
IPI00298252.

PIR

A31358.
S33795.
S34568.
S34569.

RefSeq

NP_004151.3. NM_004160.4.

UniGene

Hs.169249.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DEZ	NMR	-	A	29-64	[»]
2DF0	NMR	-	A	31-64	[»]
2L60	NMR	-	A	41-64	[»]

ProteinModelPortal

P10082.

SMR

P10082. Positions 29-64.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000353198.

Polymorphism databases

DMDM

1172796.

Proteomic databases

PRIDE

P10082.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000360085; ENSP00000353198; ENSG00000131096.
ENST00000592796; ENSP00000467310; ENSG00000131096.

GeneID

5697.

KEGG

hsa:5697.

UCSC

uc002ieq.3. human.

Organism-specific databases

CTD

5697.

GeneCards

GC17M042040.

HGNC

HGNC:9748. PYY.

HPA

CAB016734.
HPA010973.

MIM

600781. gene.

neXtProt

NX_P10082.

PharmGKB

PA34090.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG43897.

HOGENOM

HOG000252942.

HOVERGEN

HBG006485.

KO

K05233.

OMA

SKLLFPD.

PhylomeDB

P10082.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

P10082.

CleanEx

HS_PYY.

Genevestigator

P10082.

Family and domain databases

InterPro

IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]

PANTHER

PTHR10533. PTHR10533. 1 hit.

Pfam

PF00159. Hormone_3. 1 hit.
[Graphical view]

PRINTS

PR00278. PANCHORMONE.

ProDom

PD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00309. PAH. 1 hit.
[Graphical view]

PROSITE

PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P10082.

GenomeRNAi

5697.

NextBio

22132.

SOURCE

Search...

Entry information

Entry name

PYY_HUMAN

Accession

Primary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 121 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.