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P10082

- PYY_HUMAN

UniProt

P10082 - PYY_HUMAN

Protein

Peptide YY

Gene

PYY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. cellular component movement Source: ProtInc
    4. cytoskeleton organization Source: ProtInc
    5. digestion Source: ProtInc
    6. eating behavior Source: Ensembl
    7. feeding behavior Source: ProtInc
    8. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide YY
    Short name:
    PYY
    Alternative name(s):
    PYY-I
    Peptide tyrosine tyrosine
    Cleaved into the following chain:
    Alternative name(s):
    PYY-II
    Gene namesi
    Name:PYY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:9748. PYY.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28282 PublicationsAdd
    BLAST
    Peptidei29 – 6436Peptide YYPRO_0000025384Add
    BLAST
    Peptidei31 – 6434Peptide YY(3-36)PRO_0000025385Add
    BLAST
    Propeptidei68 – 9730PRO_0000025386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411PhosphoserineBy similarity
    Modified residuei64 – 641Tyrosine amide2 Publications

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Phosphoprotein

    Proteomic databases

    PRIDEiP10082.

    Expressioni

    Gene expression databases

    BgeeiP10082.
    CleanExiHS_PYY.
    GenevestigatoriP10082.

    Organism-specific databases

    HPAiCAB016734.
    HPA010973.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NPY1RP259292EBI-6655667,EBI-372227
    NPY2RP491462EBI-6655667,EBI-6655721

    Protein-protein interaction databases

    BioGridi111670. 1 interaction.
    IntActiP10082. 4 interactions.
    MINTiMINT-8090682.
    STRINGi9606.ENSP00000353198.

    Structurei

    Secondary structure

    1
    97
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi31 – 333
    Helixi41 – 5919
    Turni60 – 623

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DEZNMR-A29-64[»]
    2DF0NMR-A31-64[»]
    2L60NMR-A41-64[»]
    ProteinModelPortaliP10082.
    SMRiP10082. Positions 29-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10082.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NPY family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43897.
    HOGENOMiHOG000252942.
    HOVERGENiHBG006485.
    KOiK05233.
    OMAiYTSLRHY.
    OrthoDBiEOG7WDN4S.
    PhylomeDBiP10082.
    TreeFamiTF332778.

    Family and domain databases

    InterProiIPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view]
    PANTHERiPTHR10533. PTHR10533. 1 hit.
    PfamiPF00159. Hormone_3. 1 hit.
    [Graphical view]
    PRINTSiPR00278. PANCHORMONE.
    ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00309. PAH. 1 hit.
    [Graphical view]
    PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA   50
    SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW 97
    Length:97
    Mass (Da):11,145
    Last modified:January 11, 2011 - v3
    Checksum:iC166B73412E356B1
    GO
    Isoform 2 (identifier: P10082-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         91-97: Missing.

    Show »
    Length:90
    Mass (Da):10,360
    Checksum:iA1C48F08021136B4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371R → G.6 Publications
    Corresponds to variant rs229969 [ dbSNP | Ensembl ].
    VAR_047407
    Natural varianti72 – 721T → R.3 Publications
    Corresponds to variant rs1058046 [ dbSNP | Ensembl ].
    VAR_006382
    Natural varianti95 – 951D → H.
    Corresponds to variant rs465407 [ dbSNP | Ensembl ].
    VAR_047408

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei91 – 977Missing in isoform 2. 2 PublicationsVSP_005081

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13897 Genomic DNA. Translation: BAA02997.1.
    D13897 Genomic DNA. Translation: BAA02998.1.
    D13899 mRNA. Translation: BAA03000.1.
    D13902 mRNA. Translation: BAA03002.1.
    L25648 Genomic DNA. Translation: AAA36433.1.
    CR542129 mRNA. Translation: CAG46926.1.
    AC007993 Genomic DNA. No translation available.
    BC041057 mRNA. Translation: AAH41057.1.
    CCDSiCCDS32662.1. [P10082-1]
    PIRiA31358.
    S33795.
    S34568.
    S34569.
    RefSeqiNP_004151.3. NM_004160.4.
    UniGeneiHs.169249.

    Genome annotation databases

    EnsembliENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
    ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
    GeneIDi5697.
    KEGGihsa:5697.
    UCSCiuc002ieq.3. human. [P10082-1]

    Polymorphism databases

    DMDMi317373516.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13897 Genomic DNA. Translation: BAA02997.1 .
    D13897 Genomic DNA. Translation: BAA02998.1 .
    D13899 mRNA. Translation: BAA03000.1 .
    D13902 mRNA. Translation: BAA03002.1 .
    L25648 Genomic DNA. Translation: AAA36433.1 .
    CR542129 mRNA. Translation: CAG46926.1 .
    AC007993 Genomic DNA. No translation available.
    BC041057 mRNA. Translation: AAH41057.1 .
    CCDSi CCDS32662.1. [P10082-1 ]
    PIRi A31358.
    S33795.
    S34568.
    S34569.
    RefSeqi NP_004151.3. NM_004160.4.
    UniGenei Hs.169249.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DEZ NMR - A 29-64 [» ]
    2DF0 NMR - A 31-64 [» ]
    2L60 NMR - A 41-64 [» ]
    ProteinModelPortali P10082.
    SMRi P10082. Positions 29-64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111670. 1 interaction.
    IntActi P10082. 4 interactions.
    MINTi MINT-8090682.
    STRINGi 9606.ENSP00000353198.

    Polymorphism databases

    DMDMi 317373516.

    Proteomic databases

    PRIDEi P10082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360085 ; ENSP00000353198 ; ENSG00000131096 . [P10082-1 ]
    ENST00000592796 ; ENSP00000467310 ; ENSG00000131096 . [P10082-2 ]
    GeneIDi 5697.
    KEGGi hsa:5697.
    UCSCi uc002ieq.3. human. [P10082-1 ]

    Organism-specific databases

    CTDi 5697.
    GeneCardsi GC17M042040.
    HGNCi HGNC:9748. PYY.
    HPAi CAB016734.
    HPA010973.
    MIMi 600781. gene.
    neXtProti NX_P10082.
    PharmGKBi PA34090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43897.
    HOGENOMi HOG000252942.
    HOVERGENi HBG006485.
    KOi K05233.
    OMAi YTSLRHY.
    OrthoDBi EOG7WDN4S.
    PhylomeDBi P10082.
    TreeFami TF332778.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P10082.
    GeneWikii Peptide_YY.
    GenomeRNAii 5697.
    NextBioi 22132.
    PROi P10082.
    SOURCEi Search...

    Gene expression databases

    Bgeei P10082.
    CleanExi HS_PYY.
    Genevestigatori P10082.

    Family and domain databases

    InterProi IPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view ]
    PANTHERi PTHR10533. PTHR10533. 1 hit.
    Pfami PF00159. Hormone_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00278. PANCHORMONE.
    ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00309. PAH. 1 hit.
    [Graphical view ]
    PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and structural determination of human peptide YY cDNA and gene."
      Kohri K., Nata K., Yonekura H., Nagai A., Konno K., Okamoto H.
      Biochim. Biophys. Acta 1173:345-349(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS GLY-37 AND ARG-72.
      Tissue: Colon mucosa.
    2. "Genomic organisation and localisation of the gene for the human peptide YY."
      Herzog H.
      Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-37.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-37 AND ARG-72.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-37 AND ARG-72.
      Tissue: Brain.
    6. Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, SYNTHESIS OF 29-64, VARIANT GLY-37.
    7. "A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36)."
      Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., Reeve J.R. Jr.
      Peptides 10:797-803(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, VARIANT GLY-37.
    8. "The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR."
      Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M.
      Biochemistry 45:8350-8357(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 29-64.

    Entry informationi

    Entry nameiPYY_HUMAN
    AccessioniPrimary (citable) accession number: P10082
    Secondary accession number(s): Q5U5Q6, Q6FGH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3