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P10082

- PYY_HUMAN

UniProt

P10082 - PYY_HUMAN

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Protein

Peptide YY

Gene

PYY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei30 – 312Cleavage; by FAP1 Publication

GO - Molecular functioni

  1. hormone activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell proliferation Source: ProtInc
  3. cellular component movement Source: ProtInc
  4. cytoskeleton organization Source: ProtInc
  5. digestion Source: ProtInc
  6. eating behavior Source: Ensembl
  7. feeding behavior Source: ProtInc
  8. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
PYY-IBy similarity
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)1 Publication
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:PYY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:9748. PYY.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28282 PublicationsAdd
BLAST
Peptidei29 – 6436Peptide YYPRO_0000025384Add
BLAST
Peptidei31 – 6434Peptide YY(3-36)PRO_0000025385Add
BLAST
Propeptidei68 – 9730PRO_0000025386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei64 – 641Tyrosine amide2 Publications

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PRIDEiP10082.

Expressioni

Gene expression databases

BgeeiP10082.
CleanExiHS_PYY.
GenevestigatoriP10082.

Organism-specific databases

HPAiCAB016734.
HPA010973.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NPY1RP259292EBI-6655667,EBI-372227
NPY2RP491462EBI-6655667,EBI-6655721

Protein-protein interaction databases

BioGridi111670. 1 interaction.
IntActiP10082. 4 interactions.
MINTiMINT-8090682.
STRINGi9606.ENSP00000353198.

Structurei

Secondary structure

1
97
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 333Combined sources
Helixi41 – 5919Combined sources
Turni60 – 623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
ProteinModelPortaliP10082.
SMRiP10082. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10082.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43897.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10082.
KOiK05233.
OMAiYTSLRHY.
OrthoDBiEOG7WDN4S.
PhylomeDBiP10082.
TreeFamiTF332778.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
Length:97
Mass (Da):11,145
Last modified:January 11, 2011 - v3
Checksum:iC166B73412E356B1
GO
Isoform 2 (identifier: P10082-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Show »
Length:90
Mass (Da):10,360
Checksum:iA1C48F08021136B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371R → G.6 Publications
Corresponds to variant rs229969 [ dbSNP | Ensembl ].
VAR_047407
Natural varianti72 – 721T → R.3 Publications
Corresponds to variant rs1058046 [ dbSNP | Ensembl ].
VAR_006382
Natural varianti95 – 951D → H.
Corresponds to variant rs465407 [ dbSNP | Ensembl ].
VAR_047408

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 977Missing in isoform 2. 2 PublicationsVSP_005081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.
CCDSiCCDS32662.1. [P10082-1]
PIRiA31358.
S33795.
S34568.
S34569.
RefSeqiNP_004151.3. NM_004160.4.
UniGeneiHs.169249.

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
GeneIDi5697.
KEGGihsa:5697.
UCSCiuc002ieq.3. human. [P10082-1]

Polymorphism databases

DMDMi317373516.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA. Translation: BAA02997.1 .
D13897 Genomic DNA. Translation: BAA02998.1 .
D13899 mRNA. Translation: BAA03000.1 .
D13902 mRNA. Translation: BAA03002.1 .
L25648 Genomic DNA. Translation: AAA36433.1 .
CR542129 mRNA. Translation: CAG46926.1 .
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1 .
CCDSi CCDS32662.1. [P10082-1 ]
PIRi A31358.
S33795.
S34568.
S34569.
RefSeqi NP_004151.3. NM_004160.4.
UniGenei Hs.169249.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DEZ NMR - A 29-64 [» ]
2DF0 NMR - A 31-64 [» ]
2L60 NMR - A 41-64 [» ]
ProteinModelPortali P10082.
SMRi P10082. Positions 29-64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111670. 1 interaction.
IntActi P10082. 4 interactions.
MINTi MINT-8090682.
STRINGi 9606.ENSP00000353198.

Polymorphism databases

DMDMi 317373516.

Proteomic databases

PRIDEi P10082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360085 ; ENSP00000353198 ; ENSG00000131096 . [P10082-1 ]
ENST00000592796 ; ENSP00000467310 ; ENSG00000131096 . [P10082-2 ]
GeneIDi 5697.
KEGGi hsa:5697.
UCSCi uc002ieq.3. human. [P10082-1 ]

Organism-specific databases

CTDi 5697.
GeneCardsi GC17M042040.
HGNCi HGNC:9748. PYY.
HPAi CAB016734.
HPA010973.
MIMi 600781. gene.
neXtProti NX_P10082.
PharmGKBi PA34090.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43897.
GeneTreei ENSGT00390000010775.
HOGENOMi HOG000252942.
HOVERGENi HBG006485.
InParanoidi P10082.
KOi K05233.
OMAi YTSLRHY.
OrthoDBi EOG7WDN4S.
PhylomeDBi P10082.
TreeFami TF332778.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P10082.
GeneWikii Peptide_YY.
GenomeRNAii 5697.
NextBioi 22132.
PROi P10082.
SOURCEi Search...

Gene expression databases

Bgeei P10082.
CleanExi HS_PYY.
Genevestigatori P10082.

Family and domain databases

InterProi IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view ]
PANTHERi PTHR10533. PTHR10533. 1 hit.
Pfami PF00159. Hormone_3. 1 hit.
[Graphical view ]
PRINTSi PR00278. PANCHORMONE.
ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00309. PAH. 1 hit.
[Graphical view ]
PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and structural determination of human peptide YY cDNA and gene."
    Kohri K., Nata K., Yonekura H., Nagai A., Konno K., Okamoto H.
    Biochim. Biophys. Acta 1173:345-349(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS GLY-37 AND ARG-72.
    Tissue: Colon mucosa.
  2. "Genomic organisation and localisation of the gene for the human peptide YY."
    Herzog H.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-37.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-37 AND ARG-72.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-37 AND ARG-72.
    Tissue: Brain.
  6. Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, SYNTHESIS OF 29-64, VARIANT GLY-37.
  7. "A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36)."
    Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., Reeve J.R. Jr.
    Peptides 10:797-803(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, VARIANT GLY-37.
  8. "Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
    Keane F.M., Nadvi N.A., Yao T.W., Gorrell M.D.
    FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY FAP, CLEAVAGE SITE.
  9. "The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR."
    Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M.
    Biochemistry 45:8350-8357(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 29-64.

Entry informationi

Entry nameiPYY_HUMAN
AccessioniPrimary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3