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P10082 (PYY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide YY

Short name=PYY
Alternative name(s):
PYY-I
Peptide tyrosine tyrosine

Cleaved into the following chain:

  1. Peptide YY(3-36)
    Alternative name(s):
    PYY-II
Gene names
Name:PYY
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Subcellular location

Secreted.

Sequence similarities

Belongs to the NPY family.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P10082-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P10082-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.6 Ref.7
Peptide29 – 6436Peptide YY Ref.6 Ref.7
PRO_0000025384
Peptide31 – 6434Peptide YY(3-36)
PRO_0000025385
Propeptide68 – 9730
PRO_0000025386

Amino acid modifications

Modified residue411Phosphoserine By similarity
Modified residue641Tyrosine amide Ref.6 Ref.7

Natural variations

Alternative sequence91 – 977Missing in isoform 2.
VSP_005081
Natural variant371R → G. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs229969 [ dbSNP | Ensembl ].
VAR_047407
Natural variant721T → R. Ref.1 Ref.3 Ref.5
Corresponds to variant rs1058046 [ dbSNP | Ensembl ].
VAR_006382
Natural variant951D → H.
Corresponds to variant rs465407 [ dbSNP | Ensembl ].
VAR_047408

Secondary structure

...... 97
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: C166B73412E356B1

FASTA9711,145
        10         20         30         40         50         60 
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA SLRHYLNLVT 

        70         80         90 
RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: A1C48F08021136B4
Show »

FASTA9010,360

References

« Hide 'large scale' references
[1]"Cloning and structural determination of human peptide YY cDNA and gene."
Kohri K., Nata K., Yonekura H., Nagai A., Konno K., Okamoto H.
Biochim. Biophys. Acta 1173:345-349(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS GLY-37 AND ARG-72.
Tissue: Colon mucosa.
[2]"Genomic organisation and localisation of the gene for the human peptide YY."
Herzog H.
Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-37.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-37 AND ARG-72.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-37 AND ARG-72.
Tissue: Brain.
[6]"Isolation and primary structure of human peptide YY."
Tatemoto K., Nakano I., Makk G., Angwin P., Mann M., Schilling J., Go V.L.W.
Biochem. Biophys. Res. Commun. 157:713-717(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, SYNTHESIS OF 29-64, VARIANT GLY-37.
[7]"A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36)."
Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., Reeve J.R. Jr.
Peptides 10:797-803(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-64, AMIDATION AT TYR-64, VARIANT GLY-37.
[8]"The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR."
Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M.
Biochemistry 45:8350-8357(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 29-64.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.
PIRA31358.
S33795.
S34568.
S34569.
RefSeqNP_004151.3. NM_004160.4.
UniGeneHs.169249.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
ProteinModelPortalP10082.
SMRP10082. Positions 29-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111670. 1 interaction.
IntActP10082. 4 interactions.
MINTMINT-8090682.
STRING9606.ENSP00000353198.

Polymorphism databases

DMDM317373516.

Proteomic databases

PRIDEP10082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
GeneID5697.
KEGGhsa:5697.
UCSCuc002ieq.3. human. [P10082-1]

Organism-specific databases

CTD5697.
GeneCardsGC17M042040.
HGNCHGNC:9748. PYY.
HPACAB016734.
HPA010973.
MIM600781. gene.
neXtProtNX_P10082.
PharmGKBPA34090.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43897.
HOGENOMHOG000252942.
HOVERGENHBG006485.
KOK05233.
OMAVDAYPAK.
OrthoDBEOG7WDN4S.
PhylomeDBP10082.
TreeFamTF332778.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP10082.
CleanExHS_PYY.
GenevestigatorP10082.

Family and domain databases

InterProIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERPTHR10533. PTHR10533. 1 hit.
PfamPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSPR00278. PANCHORMONE.
ProDomPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00309. PAH. 1 hit.
[Graphical view]
PROSITEPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP10082.
GeneWikiPeptide_YY.
GenomeRNAi5697.
NextBio22132.
PROP10082.
SOURCESearch...

Entry information

Entry namePYY_HUMAN
AccessionPrimary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM