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Protein

Peptide YY

Gene

PYY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: GO_Central

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • cytoskeleton organization Source: ProtInc
  • digestion Source: ProtInc
  • eating behavior Source: Ensembl
  • feeding behavior Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • movement of cell or subcellular component Source: ProtInc
  • neuropeptide signaling pathway Source: GO_Central
  • regulation of appetite Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131096-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP10082.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
PYY-IBy similarity
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)1 Publication
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:PYY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:9748. PYY.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5697.
MalaCardsiPYY.
OpenTargetsiENSG00000131096.
PharmGKBiPA34090.

Polymorphism and mutation databases

BioMutaiPYY.
DMDMi317373516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
PeptideiPRO_000002538429 – 64Peptide YYAdd BLAST36
PeptideiPRO_000002538531 – 64Peptide YY(3-36)Add BLAST34
PropeptideiPRO_000002538668 – 97Add BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei64Tyrosine amide2 Publications1

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP10082.
PeptideAtlasiP10082.
PRIDEiP10082.

Expressioni

Gene expression databases

BgeeiENSG00000131096.
CleanExiHS_PYY.
GenevisibleiP10082. HS.

Organism-specific databases

HPAiCAB016734.
HPA010973.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NPY1RP259292EBI-6655667,EBI-372227
NPY2RP491462EBI-6655667,EBI-6655721

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: GO_Central

Protein-protein interaction databases

BioGridi111670. 1 interactor.
IntActiP10082. 4 interactors.
MINTiMINT-8090682.
STRINGi9606.ENSP00000353198.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi41 – 59Combined sources19
Turni60 – 62Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
2NA5NMR-A31-63[»]
ProteinModelPortaliP10082.
SMRiP10082.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10082.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10082.
KOiK05233.
OMAiPEGAYLW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP10082.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
Length:97
Mass (Da):11,145
Last modified:January 11, 2011 - v3
Checksum:iC166B73412E356B1
GO
Isoform 2 (identifier: P10082-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Show »
Length:90
Mass (Da):10,360
Checksum:iA1C48F08021136B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04740737R → G.6 PublicationsCorresponds to variant rs229969dbSNPEnsembl.1
Natural variantiVAR_00638272T → R.3 PublicationsCorresponds to variant rs1058046dbSNPEnsembl.1
Natural variantiVAR_04740895D → H.Corresponds to variant rs465407dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00508191 – 97Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.
CCDSiCCDS32662.1. [P10082-1]
PIRiA31358.
S33795.
S34568.
S34569.
RefSeqiNP_004151.3. NM_004160.5.
XP_011523337.1. XM_011525035.1. [P10082-1]
UniGeneiHs.169249.

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
GeneIDi5697.
KEGGihsa:5697.
UCSCiuc002ieq.4. human. [P10082-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA. Translation: BAA02997.1.
D13897 Genomic DNA. Translation: BAA02998.1.
D13899 mRNA. Translation: BAA03000.1.
D13902 mRNA. Translation: BAA03002.1.
L25648 Genomic DNA. Translation: AAA36433.1.
CR542129 mRNA. Translation: CAG46926.1.
AC007993 Genomic DNA. No translation available.
BC041057 mRNA. Translation: AAH41057.1.
CCDSiCCDS32662.1. [P10082-1]
PIRiA31358.
S33795.
S34568.
S34569.
RefSeqiNP_004151.3. NM_004160.5.
XP_011523337.1. XM_011525035.1. [P10082-1]
UniGeneiHs.169249.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
2NA5NMR-A31-63[»]
ProteinModelPortaliP10082.
SMRiP10082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111670. 1 interactor.
IntActiP10082. 4 interactors.
MINTiMINT-8090682.
STRINGi9606.ENSP00000353198.

Polymorphism and mutation databases

BioMutaiPYY.
DMDMi317373516.

Proteomic databases

PaxDbiP10082.
PeptideAtlasiP10082.
PRIDEiP10082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096. [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096. [P10082-2]
GeneIDi5697.
KEGGihsa:5697.
UCSCiuc002ieq.4. human. [P10082-1]

Organism-specific databases

CTDi5697.
DisGeNETi5697.
GeneCardsiPYY.
HGNCiHGNC:9748. PYY.
HPAiCAB016734.
HPA010973.
MalaCardsiPYY.
MIMi600781. gene.
neXtProtiNX_P10082.
OpenTargetsiENSG00000131096.
PharmGKBiPA34090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10082.
KOiK05233.
OMAiPEGAYLW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP10082.
TreeFamiTF332778.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131096-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP10082.

Miscellaneous databases

EvolutionaryTraceiP10082.
GeneWikiiPeptide_YY.
GenomeRNAii5697.
PROiP10082.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131096.
CleanExiHS_PYY.
GenevisibleiP10082. HS.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYY_HUMAN
AccessioniPrimary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.