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Protein

Zinc finger protein GLI4

Gene

GLI4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri183 – 20523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri239 – 26123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLI4
Alternative name(s):
Krueppel-related zinc finger protein 4
Protein HKR4
Gene namesi
Name:GLI4
Synonyms:HKR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4320. GLI4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28723.

Polymorphism and mutation databases

BioMutaiGLI4.
DMDMi33302619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Zinc finger protein GLI4PRO_0000047267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10075.
PeptideAtlasiP10075.
PRIDEiP10075.

PTM databases

iPTMnetiP10075.
PhosphoSiteiP10075.

Expressioni

Gene expression databases

BgeeiP10075.
CleanExiHS_GLI4.
ExpressionAtlasiP10075. baseline and differential.
GenevisibleiP10075. HS.

Organism-specific databases

HPAiHPA023131.

Interactioni

Protein-protein interaction databases

BioGridi109000. 2 interactions.
STRINGi9606.ENSP00000345024.

Structurei

3D structure databases

ProteinModelPortaliP10075.
SMRiP10075. Positions 151-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri183 – 20523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri239 – 26123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127140.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP10075.
OMAiTCWPDSE.
PhylomeDBiP10075.
TreeFamiTF337438.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV
60 70 80 90 100
LSQPSDLDLQ DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL
110 120 130 140 150
RSLLRSLPRR ARCSAGFGPE SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ
160 170 180 190 200
AAAGPEGAPE RAAELGVNFG RSRQGSARGA KPHRCEACGK SFKYNSLLLK
210 220 230 240 250
HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE CGQCGRAFSH
260 270 280 290 300
SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC
310 320 330 340 350
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP
360 370
FACGACGKAF GQSSQLIQHQ RVHYRE
Length:376
Mass (Da):41,145
Last modified:July 25, 2003 - v2
Checksum:i68B1A638CC0758BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1463RVT → ARD in AAA35990 (PubMed:2850480).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti180 – 1801A → T.1 Publication
Corresponds to variant rs1056148 [ dbSNP | Ensembl ].
VAR_052734

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014165 mRNA. Translation: AAH14165.1.
M20678 Genomic DNA. Translation: AAA35990.1.
M20679 Genomic DNA. No translation available.
CCDSiCCDS6398.1.
PIRiF31201.
RefSeqiNP_612474.1. NM_138465.3.
UniGeneiHs.400533.

Genome annotation databases

EnsembliENST00000340042; ENSP00000345024; ENSG00000250571.
ENST00000523522; ENSP00000430987; ENSG00000250571.
GeneIDi2738.
KEGGihsa:2738.
UCSCiuc003yxx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014165 mRNA. Translation: AAH14165.1.
M20678 Genomic DNA. Translation: AAA35990.1.
M20679 Genomic DNA. No translation available.
CCDSiCCDS6398.1.
PIRiF31201.
RefSeqiNP_612474.1. NM_138465.3.
UniGeneiHs.400533.

3D structure databases

ProteinModelPortaliP10075.
SMRiP10075. Positions 151-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109000. 2 interactions.
STRINGi9606.ENSP00000345024.

PTM databases

iPTMnetiP10075.
PhosphoSiteiP10075.

Polymorphism and mutation databases

BioMutaiGLI4.
DMDMi33302619.

Proteomic databases

PaxDbiP10075.
PeptideAtlasiP10075.
PRIDEiP10075.

Protocols and materials databases

DNASUi2738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340042; ENSP00000345024; ENSG00000250571.
ENST00000523522; ENSP00000430987; ENSG00000250571.
GeneIDi2738.
KEGGihsa:2738.
UCSCiuc003yxx.4. human.

Organism-specific databases

CTDi2738.
GeneCardsiGLI4.
HGNCiHGNC:4320. GLI4.
HPAiHPA023131.
MIMi165280. gene.
neXtProtiNX_P10075.
PharmGKBiPA28723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127140.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP10075.
OMAiTCWPDSE.
PhylomeDBiP10075.
TreeFamiTF337438.

Miscellaneous databases

GenomeRNAii2738.
PROiP10075.
SOURCEiSearch...

Gene expression databases

BgeeiP10075.
CleanExiHS_GLI4.
ExpressionAtlasiP10075. baseline and differential.
GenevisibleiP10075. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "The GLI-Kruppel family of human genes."
    Ruppert J.M., Kinzler K.W., Wong A.J., Bigner S.H., Kao F.T., Law M.L., Seuanez H.N., O'Brien S.J., Vogelstein B.
    Mol. Cell. Biol. 8:3104-3113(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-272 AND 283-376, VARIANT THR-180.
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiGLI4_HUMAN
AccessioniPrimary (citable) accession number: P10075
Secondary accession number(s): Q96CK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 25, 2003
Last modified: July 6, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.