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Protein

Zinc finger protein GLI4

Gene

GLI4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 205C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLI4
Alternative name(s):
Krueppel-related zinc finger protein 4
Protein HKR4
Gene namesi
Name:GLI4
Synonyms:HKR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4320. GLI4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000250571.
PharmGKBiPA28723.

Polymorphism and mutation databases

BioMutaiGLI4.
DMDMi33302619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472671 – 376Zinc finger protein GLI4Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP10075.
PaxDbiP10075.
PeptideAtlasiP10075.
PRIDEiP10075.

PTM databases

iPTMnetiP10075.
PhosphoSitePlusiP10075.

Expressioni

Gene expression databases

BgeeiENSG00000250571.
CleanExiHS_GLI4.
ExpressionAtlasiP10075. baseline and differential.
GenevisibleiP10075. HS.

Organism-specific databases

HPAiHPA023131.

Interactioni

Protein-protein interaction databases

BioGridi109000. 2 interactors.
STRINGi9606.ENSP00000345024.

Structurei

3D structure databases

ProteinModelPortaliP10075.
SMRiP10075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 205C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133693.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP10075.
OMAiTCWPDSE.
OrthoDBiEOG091G02KC.
PhylomeDBiP10075.
TreeFamiTF337438.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV
60 70 80 90 100
LSQPSDLDLQ DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL
110 120 130 140 150
RSLLRSLPRR ARCSAGFGPE SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ
160 170 180 190 200
AAAGPEGAPE RAAELGVNFG RSRQGSARGA KPHRCEACGK SFKYNSLLLK
210 220 230 240 250
HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE CGQCGRAFSH
260 270 280 290 300
SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC
310 320 330 340 350
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP
360 370
FACGACGKAF GQSSQLIQHQ RVHYRE
Length:376
Mass (Da):41,145
Last modified:July 25, 2003 - v2
Checksum:i68B1A638CC0758BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 146RVT → ARD in AAA35990 (PubMed:2850480).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052734180A → T.1 PublicationCorresponds to variant rs1056148dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014165 mRNA. Translation: AAH14165.1.
M20678 Genomic DNA. Translation: AAA35990.1.
M20679 Genomic DNA. No translation available.
CCDSiCCDS6398.1.
PIRiF31201.
RefSeqiNP_612474.1. NM_138465.3.
UniGeneiHs.400533.

Genome annotation databases

EnsembliENST00000340042; ENSP00000345024; ENSG00000250571.
ENST00000523522; ENSP00000430987; ENSG00000250571.
GeneIDi2738.
KEGGihsa:2738.
UCSCiuc003yxx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014165 mRNA. Translation: AAH14165.1.
M20678 Genomic DNA. Translation: AAA35990.1.
M20679 Genomic DNA. No translation available.
CCDSiCCDS6398.1.
PIRiF31201.
RefSeqiNP_612474.1. NM_138465.3.
UniGeneiHs.400533.

3D structure databases

ProteinModelPortaliP10075.
SMRiP10075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109000. 2 interactors.
STRINGi9606.ENSP00000345024.

PTM databases

iPTMnetiP10075.
PhosphoSitePlusiP10075.

Polymorphism and mutation databases

BioMutaiGLI4.
DMDMi33302619.

Proteomic databases

MaxQBiP10075.
PaxDbiP10075.
PeptideAtlasiP10075.
PRIDEiP10075.

Protocols and materials databases

DNASUi2738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340042; ENSP00000345024; ENSG00000250571.
ENST00000523522; ENSP00000430987; ENSG00000250571.
GeneIDi2738.
KEGGihsa:2738.
UCSCiuc003yxx.4. human.

Organism-specific databases

CTDi2738.
GeneCardsiGLI4.
HGNCiHGNC:4320. GLI4.
HPAiHPA023131.
MIMi165280. gene.
neXtProtiNX_P10075.
OpenTargetsiENSG00000250571.
PharmGKBiPA28723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133693.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP10075.
OMAiTCWPDSE.
OrthoDBiEOG091G02KC.
PhylomeDBiP10075.
TreeFamiTF337438.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181638-MONOMER.

Miscellaneous databases

GenomeRNAii2738.
PROiP10075.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000250571.
CleanExiHS_GLI4.
ExpressionAtlasiP10075. baseline and differential.
GenevisibleiP10075. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLI4_HUMAN
AccessioniPrimary (citable) accession number: P10075
Secondary accession number(s): Q96CK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 25, 2003
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.