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Reviewed, UniProtKB/Swiss-Prot P10074 (ZBT48_HUMAN)

Last modified November 25, 2008. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc finger and BTB domain-containing protein 48
Alternative name(s):
    Krueppel-related zinc finger protein 3
    Protein HKR3
Gene names
Name: ZBTB48
Synonyms: HKR3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length688 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds to and regulates the J and/or S elements in MHC II promoter.

Subcellular location

Nucleus.

Tissue specificity

Detected in adrenal gland and neuroblastoma.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 1 BTB (POZ) domain.

Contains 11 C2H2-type zinc fingers.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   Technical term3D-structure

Gene Ontology (GO)

   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity

Traceable author statement. Source: ProtInc

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 688688Zinc finger and BTB domain-containing protein 48
PRO_0000047272

Regions

Domain26 – 8964BTB
Zinc finger291 – 31323C2H2-type 1
Zinc finger319 – 34123C2H2-type 2; degenerate
Zinc finger350 – 37223C2H2-type 3
Zinc finger378 – 40124C2H2-type 4
Zinc finger407 – 43024C2H2-type 5
Zinc finger436 – 45924C2H2-type 6
Zinc finger465 – 48723C2H2-type 7
Zinc finger493 – 51523C2H2-type 8
Zinc finger521 – 54424C2H2-type 9
Zinc finger550 – 57223C2H2-type 10
Zinc finger578 – 60023C2H2-type 11

Experimental info

Sequence conflict2011P → S in AAA65124. Ref.1
Sequence conflict2441D → S in AAA65124. Ref.1
Sequence conflict350 – 3512FT → LP in AAA65124. Ref.1
Sequence conflict6071N → K in AAA65124. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P10074-1 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: EBECCE3D6CBBD524

FASTA68877,054
        10         20         30         40         50         60 
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG 

        70         80         90        100        110        120 
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV 

       130        140        150        160        170        180 
GQAAGGQSGL GPPASQNVNS HVKEPAGLEE EEVSRTLGLV PRDQEPRGSH SPQRPQLHSP 

       190        200        210        220        230        240 
AQSEGPSSLC GKLKQALKPC PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD 

       250        260        270        280        290        300 
GDGDYMSEPE AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AENRKGTAVP VECPTCHKKF 

       310        320        330        340        350        360 
LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF TCSVCQETFR 

       370        380        390        400        410        420 
RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL HGAPKPHACP TCAKCFLSRT 

       430        440        450        460        470        480 
ELQLHEAFKH RGEKLFVCEE CGHRASSRNG LQMHIKAKHR NERPHVCEFC SHAFTQKANL 

       490        500        510        520        530        540 
NMHLRTHTGE KPFQCHLCGK TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV 

       550        560        570        580        590        600 
ASRHQEGRPH FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH 

       610        620        630        640        650        660 
DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG LASQLPGQRL 

       670        680 
CAEESFTGPG VLEPSLIITA AVPEDCDT

« Hide

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References

« Hide 'large scale' references
[1]"A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein."
Sugawara M., Scholl T., Ponath P.D., Strominger J.L.
Mol. Cell. Biol. 14:8438-8450(1994) [PubMed: 7969177] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DNA BINDING, FUNCTION.
[2]"Human Kruppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?"
Maris J.M., Jensen J., Sulman E.P., Beltinger C.P., Allen C., Biegel J.A., Brodeur G.M., White P.S.
Eur. J. Cancer 33:1991-1996(1997) [PubMed: 9516840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"The GLI-Kruppel family of human genes."
Ruppert J.M., Kinzler K.W., Wong A.J., Bigner S.H., Kao F.T., Law M.L., Seuanez H.N., O'Brien S.J., Vogelstein B.
Mol. Cell. Biol. 8:3104-3113(1988) [PubMed: 2850480] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 461-488.

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Cross-references

Sequence databases

L16896 mRNA. Translation: AAA65124.1.
U45325, U45324 Genomic DNA. Translation: AAB08973.1.
AL591866 Genomic DNA. Translation: CAI16079.1.
BC013573 mRNA. Translation: AAH13573.1.
M20677 Genomic DNA. Translation: AAA35989.1.
PIRA56360.
RefSeqNP_005332.1.
UniGeneHs.502330

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3B84X-ray1.74A2-120[»]
SMRP10074. Positions 291-404.
ModBaseSearch...

Protein-protein interaction databases

IntActP10074.

Genome annotation databases

EnsemblENSG00000204859. Homo sapiens. [Contig view]
GeneID3104.
KEGGhsa:3104.

Organism-specific databases

HGNCHGNC:4930. ZBTB48.
MIM165270. gene.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP10074.

Gene expression databases

CleanExHS_ZBTB48.
GermOnlineENSG00000204859. Homo sapiens.

Family and domain databases

InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 10 hits.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio12315.
SOURCESearch...

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Entry information

Entry nameZBT48_HUMAN
AccessionPrimary (citable) accession number: P10074
Secondary accession number(s): Q5SY19
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents