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Protein

Zinc finger and BTB domain-containing protein 48

Gene

ZBTB48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and regulates the J and/or S elements in MHC II promoter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri291 – 31323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40124C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45924C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 48
Alternative name(s):
Krueppel-related zinc finger protein 3
Protein HKR3
Zinc finger protein 855
Gene namesi
Name:ZBTB48
Synonyms:HKR3, ZNF855
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4930. ZBTB48.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409481.

Polymorphism and mutation databases

BioMutaiZBTB48.
DMDMi1708212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688Zinc finger and BTB domain-containing protein 48PRO_0000047272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei171 – 1711PhosphoserineCombined sources
Modified residuei179 – 1791PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP10074.
MaxQBiP10074.
PaxDbiP10074.
PRIDEiP10074.

PTM databases

iPTMnetiP10074.
PhosphoSiteiP10074.

Expressioni

Tissue specificityi

Detected in adrenal gland and neuroblastoma.1 Publication

Gene expression databases

BgeeiP10074.
CleanExiHS_ZBTB48.
ExpressionAtlasiP10074. baseline and differential.
GenevisibleiP10074. HS.

Organism-specific databases

HPAiHPA030417.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GPATCH2LQ9NWQ43EBI-744864,EBI-5666657
KRTAP10-5P603703EBI-744864,EBI-10172150
NME7Q9Y5B83EBI-744864,EBI-744782
ZBTB8AQ96BR94EBI-744864,EBI-742740

Protein-protein interaction databases

BioGridi109349. 95 interactions.
IntActiP10074. 17 interactions.
MINTiMINT-8247379.
STRINGi9606.ENSP00000366902.

Structurei

Secondary structure

1
688
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2218Combined sources
Beta strandi28 – 325Combined sources
Beta strandi35 – 395Combined sources
Helixi41 – 477Combined sources
Helixi49 – 557Combined sources
Turni56 – 594Combined sources
Beta strandi63 – 653Combined sources
Helixi67 – 693Combined sources
Helixi70 – 8213Combined sources
Turni89 – 913Combined sources
Helixi92 – 10110Combined sources
Helixi105 – 1139Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B84X-ray1.74A4-120[»]
ProteinModelPortaliP10074.
SMRiP10074. Positions 4-115, 291-607.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10074.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8964BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri291 – 31323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40124C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 43024C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45924C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129819.
HOGENOMiHOG000049146.
HOVERGENiHBG000087.
InParanoidiP10074.
KOiK10519.
OMAiNVIRKPC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP10074.
TreeFamiTF331310.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF
60 70 80 90 100
FQSLYGDGSG GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR
110 120 130 140 150
ELRVPEAVEL CQSFKPKTSV GQAAGGQSGL GPPASQNVNS HVKEPAGLEE
160 170 180 190 200
EEVSRTLGLV PRDQEPRGSH SPQRPQLHSP AQSEGPSSLC GKLKQALKPC
210 220 230 240 250
PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD GDGDYMSEPE
260 270 280 290 300
AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AENRKGTAVP VECPTCHKKF
310 320 330 340 350
LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF
360 370 380 390 400
TCSVCQETFR RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL
410 420 430 440 450
HGAPKPHACP TCAKCFLSRT ELQLHEAFKH RGEKLFVCEE CGHRASSRNG
460 470 480 490 500
LQMHIKAKHR NERPHVCEFC SHAFTQKANL NMHLRTHTGE KPFQCHLCGK
510 520 530 540 550
TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV ASRHQEGRPH
560 570 580 590 600
FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH
610 620 630 640 650
DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG
660 670 680
LASQLPGQRL CAEESFTGPG VLEPSLIITA AVPEDCDT
Length:688
Mass (Da):77,054
Last modified:October 1, 1996 - v2
Checksum:iEBECCE3D6CBBD524
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011P → S in AAA65124 (PubMed:7969177).Curated
Sequence conflicti244 – 2441D → S in AAA65124 (PubMed:7969177).Curated
Sequence conflicti350 – 3512FT → LP in AAA65124 (PubMed:7969177).Curated
Sequence conflicti607 – 6071N → K in AAA65124 (PubMed:7969177).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti675 – 6751S → A.
Corresponds to variant rs2229330 [ dbSNP | Ensembl ].
VAR_052925

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16896 mRNA. Translation: AAA65124.1.
U45325, U45324 Genomic DNA. Translation: AAB08973.1.
AL591866 Genomic DNA. Translation: CAI16079.1.
BC013573 mRNA. Translation: AAH13573.1.
M20677 Genomic DNA. Translation: AAA35989.1.
CCDSiCCDS84.1.
PIRiA56360.
RefSeqiNP_001265576.1. NM_001278647.1.
NP_001265577.1. NM_001278648.1.
NP_005332.1. NM_005341.3.
UniGeneiHs.502330.

Genome annotation databases

EnsembliENST00000377674; ENSP00000366902; ENSG00000204859.
GeneIDi3104.
KEGGihsa:3104.
UCSCiuc001anx.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16896 mRNA. Translation: AAA65124.1.
U45325, U45324 Genomic DNA. Translation: AAB08973.1.
AL591866 Genomic DNA. Translation: CAI16079.1.
BC013573 mRNA. Translation: AAH13573.1.
M20677 Genomic DNA. Translation: AAA35989.1.
CCDSiCCDS84.1.
PIRiA56360.
RefSeqiNP_001265576.1. NM_001278647.1.
NP_001265577.1. NM_001278648.1.
NP_005332.1. NM_005341.3.
UniGeneiHs.502330.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B84X-ray1.74A4-120[»]
ProteinModelPortaliP10074.
SMRiP10074. Positions 4-115, 291-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109349. 95 interactions.
IntActiP10074. 17 interactions.
MINTiMINT-8247379.
STRINGi9606.ENSP00000366902.

PTM databases

iPTMnetiP10074.
PhosphoSiteiP10074.

Polymorphism and mutation databases

BioMutaiZBTB48.
DMDMi1708212.

Proteomic databases

EPDiP10074.
MaxQBiP10074.
PaxDbiP10074.
PRIDEiP10074.

Protocols and materials databases

DNASUi3104.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377674; ENSP00000366902; ENSG00000204859.
GeneIDi3104.
KEGGihsa:3104.
UCSCiuc001anx.5. human.

Organism-specific databases

CTDi3104.
GeneCardsiZBTB48.
HGNCiHGNC:4930. ZBTB48.
HPAiHPA030417.
MIMi165270. gene.
neXtProtiNX_P10074.
PharmGKBiPA162409481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129819.
HOGENOMiHOG000049146.
HOVERGENiHBG000087.
InParanoidiP10074.
KOiK10519.
OMAiNVIRKPC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP10074.
TreeFamiTF331310.

Miscellaneous databases

ChiTaRSiZBTB48. human.
EvolutionaryTraceiP10074.
GenomeRNAii3104.
NextBioi12315.
PROiP10074.
SOURCEiSearch...

Gene expression databases

BgeeiP10074.
CleanExiHS_ZBTB48.
ExpressionAtlasiP10074. baseline and differential.
GenevisibleiP10074. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein."
    Sugawara M., Scholl T., Ponath P.D., Strominger J.L.
    Mol. Cell. Biol. 14:8438-8450(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DNA-BINDING, FUNCTION.
  2. "Human Kruppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?"
    Maris J.M., Jensen J., Sulman E.P., Beltinger C.P., Allen C., Biegel J.A., Brodeur G.M., White P.S.
    Eur. J. Cancer 33:1991-1996(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "The GLI-Kruppel family of human genes."
    Ruppert J.M., Kinzler K.W., Wong A.J., Bigner S.H., Kao F.T., Law M.L., Seuanez H.N., O'Brien S.J., Vogelstein B.
    Mol. Cell. Biol. 8:3104-3113(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 461-488.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-171 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Crystal structure of the human BTB domain of the krueppel-related zinc finger protein 3 (hKR3)."
    Structural genomics consortium (SGC)
    Submitted (NOV-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 2-120.

Entry informationi

Entry nameiZBT48_HUMAN
AccessioniPrimary (citable) accession number: P10074
Secondary accession number(s): Q5SY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.