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Protein

Zinc finger and SCAN domain-containing protein 22

Gene

ZSCAN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 290C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 22
Alternative name(s):
Krueppel-related zinc finger protein 2
Protein HKR2
Zinc finger protein 50
Gene namesi
Name:ZSCAN22
Synonyms:HKR2, ZNF50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182318.5
HGNCiHGNC:4929 ZSCAN22
MIMi165260 gene
neXtProtiNX_P10073

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi342945
OpenTargetsiENSG00000182318
PharmGKBiPA29307

Polymorphism and mutation databases

BioMutaiZSCAN22
DMDMi134047986

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472711 – 491Zinc finger and SCAN domain-containing protein 22Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Cross-linki443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP10073
MaxQBiP10073
PaxDbiP10073
PeptideAtlasiP10073
PRIDEiP10073

PTM databases

iPTMnetiP10073
PhosphoSitePlusiP10073

Expressioni

Gene expression databases

BgeeiENSG00000182318
CleanExiHS_ZSCAN22
GenevisibleiP10073 HS

Organism-specific databases

HPAiHPA006471

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131214, 8 interactors
IntActiP10073, 22 interactors
STRINGi9606.ENSP00000332433

Structurei

3D structure databases

ProteinModelPortaliP10073
SMRiP10073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 131SCAN boxPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 28Poly-Glu5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 290C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiP10073
KOiK09230
OMAiVPWEEDS
OrthoDBiEOG091G02KC
PhylomeDBiP10073
TreeFamiTF337913

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

P10073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPKHSLSP VPWEEDSFLQ VKVEEEEEAS LSQGGESSHD HIAHSEAARL
60 70 80 90 100
RFRHFRYEEA SGPHEALAHL RALCCQWLQP EAHSKEQILE LLVLEQFLGA
110 120 130 140 150
LPPEIQAWVG AQSPKSGEEA AVLVEDLTQV LDKRGWDPGA EPTEASCKQS
160 170 180 190 200
DLGESEPSNV TETLMGGVSL GPAFVKACEP EGSSERSGLS GEIWTKSVTQ
210 220 230 240 250
QIHFKKTSGP YKDVPTDQRG RESGASRNSS SAWPNLTSQE KPPSEDKFDL
260 270 280 290 300
VDAYGTEPPY TYSGKRSSKC RECRKMFQSA SALEAHQKTH SRKTPYACSE
310 320 330 340 350
CGKAFSRSTH LAQHQVVHTG AKPHECKECG KAFSRVTHLT QHQRIHTGEK
360 370 380 390 400
PYKCGECGKT FSRSTHLTQH QRVHTGERPY ECDACGKAFS QSTHLTQHQR
410 420 430 440 450
IHTGEKPYKC DACGRAFSDC SALIRHLRIH SGEKPYQCKV CPKAFAQSSS
460 470 480 490
LIEHQRIHTG EKPYKCSDCG KAFSRSSALM VHLRIHITVL Q
Length:491
Mass (Da):54,561
Last modified:March 20, 2007 - v2
Checksum:i4FD4BF55E1D00C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128716 mRNA Translation: BAC87588.1
BX537741 mRNA Translation: CAD97822.1
BC101630 mRNA Translation: AAI01631.1
BC112277 mRNA Translation: AAI12278.1
M88360 Genomic DNA Translation: AAA61318.1
CCDSiCCDS12975.1
PIRiD31201
D43284
RefSeqiNP_001308045.1, NM_001321116.1
NP_001308046.1, NM_001321117.1
NP_862829.1, NM_181846.2
XP_006723255.1, XM_006723192.3
XP_011525219.1, XM_011526917.2
UniGeneiHs.388162

Genome annotation databases

EnsembliENST00000329665; ENSP00000332433; ENSG00000182318
GeneIDi342945
KEGGihsa:342945
UCSCiuc002qsc.3 human

Similar proteinsi

Entry informationi

Entry nameiZSC22_HUMAN
AccessioniPrimary (citable) accession number: P10073
Secondary accession number(s): Q15922, Q7Z3L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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