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Protein

Zinc finger and SCAN domain-containing protein 22

Gene

ZSCAN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 29023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 22
Alternative name(s):
Krueppel-related zinc finger protein 2
Protein HKR2
Zinc finger protein 50
Gene namesi
Name:ZSCAN22
Synonyms:HKR2, ZNF50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4929. ZSCAN22.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29307.

Polymorphism and mutation databases

BioMutaiZSCAN22.
DMDMi134047986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Zinc finger and SCAN domain-containing protein 22PRO_0000047271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP10073.
MaxQBiP10073.
PaxDbiP10073.
PeptideAtlasiP10073.
PRIDEiP10073.

PTM databases

iPTMnetiP10073.
PhosphoSiteiP10073.

Expressioni

Gene expression databases

BgeeiP10073.
CleanExiHS_ZSCAN22.
GenevisibleiP10073. HS.

Organism-specific databases

HPAiHPA006471.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PGBD1Q96JS34EBI-10178224,EBI-10290053
ZNF446Q96AF53EBI-10178224,EBI-740232
ZNF483Q6P0883EBI-10178224,EBI-10196963
ZNF496Q96IT13EBI-10178224,EBI-743906
ZSCAN32I3L3J25EBI-10178224,EBI-10178206

Protein-protein interaction databases

BioGridi131214. 8 interactions.
IntActiP10073. 5 interactions.
MINTiMINT-4720089.
STRINGi9606.ENSP00000332433.

Structurei

3D structure databases

ProteinModelPortaliP10073.
SMRiP10073. Positions 46-127, 261-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 13183SCAN boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 285Poly-Glu

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 29023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP10073.
KOiK09230.
OMAiSSKCREC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP10073.
TreeFamiTF337913.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPKHSLSP VPWEEDSFLQ VKVEEEEEAS LSQGGESSHD HIAHSEAARL
60 70 80 90 100
RFRHFRYEEA SGPHEALAHL RALCCQWLQP EAHSKEQILE LLVLEQFLGA
110 120 130 140 150
LPPEIQAWVG AQSPKSGEEA AVLVEDLTQV LDKRGWDPGA EPTEASCKQS
160 170 180 190 200
DLGESEPSNV TETLMGGVSL GPAFVKACEP EGSSERSGLS GEIWTKSVTQ
210 220 230 240 250
QIHFKKTSGP YKDVPTDQRG RESGASRNSS SAWPNLTSQE KPPSEDKFDL
260 270 280 290 300
VDAYGTEPPY TYSGKRSSKC RECRKMFQSA SALEAHQKTH SRKTPYACSE
310 320 330 340 350
CGKAFSRSTH LAQHQVVHTG AKPHECKECG KAFSRVTHLT QHQRIHTGEK
360 370 380 390 400
PYKCGECGKT FSRSTHLTQH QRVHTGERPY ECDACGKAFS QSTHLTQHQR
410 420 430 440 450
IHTGEKPYKC DACGRAFSDC SALIRHLRIH SGEKPYQCKV CPKAFAQSSS
460 470 480 490
LIEHQRIHTG EKPYKCSDCG KAFSRSSALM VHLRIHITVL Q
Length:491
Mass (Da):54,561
Last modified:March 20, 2007 - v2
Checksum:i4FD4BF55E1D00C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128716 mRNA. Translation: BAC87588.1.
BX537741 mRNA. Translation: CAD97822.1.
BC101630 mRNA. Translation: AAI01631.1.
BC112277 mRNA. Translation: AAI12278.1.
M88360 Genomic DNA. Translation: AAA61318.1.
CCDSiCCDS12975.1.
PIRiD31201.
D43284.
RefSeqiNP_001308045.1. NM_001321116.1.
NP_001308046.1. NM_001321117.1.
NP_862829.1. NM_181846.2.
XP_006723254.1. XM_006723191.2.
XP_006723255.1. XM_006723192.2.
XP_011525219.1. XM_011526917.1.
UniGeneiHs.388162.

Genome annotation databases

EnsembliENST00000329665; ENSP00000332433; ENSG00000182318.
GeneIDi342945.
KEGGihsa:342945.
UCSCiuc002qsc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128716 mRNA. Translation: BAC87588.1.
BX537741 mRNA. Translation: CAD97822.1.
BC101630 mRNA. Translation: AAI01631.1.
BC112277 mRNA. Translation: AAI12278.1.
M88360 Genomic DNA. Translation: AAA61318.1.
CCDSiCCDS12975.1.
PIRiD31201.
D43284.
RefSeqiNP_001308045.1. NM_001321116.1.
NP_001308046.1. NM_001321117.1.
NP_862829.1. NM_181846.2.
XP_006723254.1. XM_006723191.2.
XP_006723255.1. XM_006723192.2.
XP_011525219.1. XM_011526917.1.
UniGeneiHs.388162.

3D structure databases

ProteinModelPortaliP10073.
SMRiP10073. Positions 46-127, 261-488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131214. 8 interactions.
IntActiP10073. 5 interactions.
MINTiMINT-4720089.
STRINGi9606.ENSP00000332433.

PTM databases

iPTMnetiP10073.
PhosphoSiteiP10073.

Polymorphism and mutation databases

BioMutaiZSCAN22.
DMDMi134047986.

Proteomic databases

EPDiP10073.
MaxQBiP10073.
PaxDbiP10073.
PeptideAtlasiP10073.
PRIDEiP10073.

Protocols and materials databases

DNASUi342945.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329665; ENSP00000332433; ENSG00000182318.
GeneIDi342945.
KEGGihsa:342945.
UCSCiuc002qsc.3. human.

Organism-specific databases

CTDi342945.
GeneCardsiZSCAN22.
HGNCiHGNC:4929. ZSCAN22.
HPAiHPA006471.
MIMi165260. gene.
neXtProtiNX_P10073.
PharmGKBiPA29307.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP10073.
KOiK09230.
OMAiSSKCREC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP10073.
TreeFamiTF337913.

Miscellaneous databases

GenomeRNAii342945.
PROiP10073.
SOURCEiSearch...

Gene expression databases

BgeeiP10073.
CleanExiHS_ZSCAN22.
GenevisibleiP10073. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes."
    Lichter P., Bray P., Ried T., Dawid I.B., Ward D.C.
    Genomics 13:999-1007(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-457.
    Tissue: Placenta.
  5. "The GLI-Kruppel family of human genes."
    Ruppert J.M., Kinzler K.W., Wong A.J., Bigner S.H., Kao F.T., Law M.L., Seuanez H.N., O'Brien S.J., Vogelstein B.
    Mol. Cell. Biol. 8:3104-3113(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiZSC22_HUMAN
AccessioniPrimary (citable) accession number: P10073
Secondary accession number(s): Q15922, Q7Z3L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.