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Protein

Krueppel-related zinc finger protein 1

Gene

HKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri301 – 32323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri635 – 65723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-related zinc finger protein 1
Alternative name(s):
Protein HKR1
Zinc finger protein 875
Gene namesi
Name:HKR1
Synonyms:ZNF875
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4928. HKR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29306.

Polymorphism and mutation databases

BioMutaiHKR1.
DMDMi215274257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Krueppel-related zinc finger protein 1PRO_0000047270Add
BLAST

Proteomic databases

PaxDbiP10072.
PRIDEiP10072.

PTM databases

PhosphoSiteiP10072.

Expressioni

Gene expression databases

BgeeiP10072.
CleanExiHS_HKR1.
ExpressionAtlasiP10072. baseline and differential.
GenevisibleiP10072. HS.

Organism-specific databases

HPAiHPA036126.
HPA044855.

Interactioni

Protein-protein interaction databases

BioGridi129883. 1 interaction.
IntActiP10072. 1 interaction.
STRINGi9606.ENSP00000315505.

Structurei

3D structure databases

ProteinModelPortaliP10072.
SMRiP10072. Positions 228-659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri301 – 32323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri635 – 65723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP10072.
KOiK09228.
OMAiQQQDPFC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP10072.
TreeFamiTF338096.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10072-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVNHTVSTM LPTCMVHRQT MSCSGAGGIT AFVAFRDVAV YFTQEEWRLL
60 70 80 90 100
SPAQRTLHRE VMLETYNHLV SLEIPSSKPK LIAQLERGEA PWREERKCPL
110 120 130 140 150
DLCPESKPEI QLSPSCPLIF SSQQALSQHV WLSHLSQLFS SLWAGNPLHL
160 170 180 190 200
GKHYPEDQKQ QQDPFCFSGK AEWIQEGEDS RLLFGRVSKN GTSKALSSPP
210 220 230 240 250
EEQQPAQSKE DNTVVDIGSS PERRADLEET DKVLHGLEVS GFGEIKYEEF
260 270 280 290 300
GPGFIKESNL LSLQKTQTGE TPYMYTEWGD SFGSMSVLIK NPRTHSGGKP
310 320 330 340 350
YVCRECGRGF TWKSNLITHQ RTHSGEKPYV CKDCGRGFTW KSNLFTHQRT
360 370 380 390 400
HSGLKPYVCK ECGQSFSLKS NLITHQRAHT GEKPYVCREC GRGFRQHSHL
410 420 430 440 450
VRHKRTHSGE KPYICRECEQ GFSQKSHLIR HLRTHTGEKP YVCTECGRHF
460 470 480 490 500
SWKSNLKTHQ RTHSGVKPYV CLECGQCFSL KSNLNKHQRS HTGEKPFVCT
510 520 530 540 550
ECGRGFTRKS TLSTHQRTHS GEKPFVCAEC GRGFNDKSTL ISHQRTHSGE
560 570 580 590 600
KPFMCRECGR RFRQKPNLFR HKRAHSGAFV CRECGQGFCA KLTLIKHQRA
610 620 630 640 650
HAGGKPHVCR ECGQGFSRQS HLIRHQRTHS GEKPYICRKC GRGFSRKSNL

IRHQRTHSG
Length:659
Mass (Da):75,128
Last modified:November 25, 2008 - v4
Checksum:i36D48F8EA3A6D80A
GO
Isoform 2 (identifier: P10072-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MRVNHTVSTMLPTCMVHRQTMSCSGAGGIT → MATGLLRAKKE

Show »
Length:640
Mass (Da):73,138
Checksum:i8A3779E239A360B4
GO

Sequence cautioni

The sequence BAA86058.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti448 – 4481R → H.
Corresponds to variant rs2921563 [ dbSNP | Ensembl ].
VAR_047404
Natural varianti513 – 5131S → I.2 Publications
Corresponds to variant rs3745765 [ dbSNP | Ensembl ].
VAR_047405
Natural varianti628 – 6281T → I.
Corresponds to variant rs3745764 [ dbSNP | Ensembl ].
VAR_047406

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3030MRVNH…AGGIT → MATGLLRAKKE in isoform 2. CuratedVSP_035755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013897 mRNA. Translation: BAA86058.1. Different initiation.
AC016590 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56722.1.
BC004513 mRNA. Translation: AAH04513.2.
BC017256 mRNA. Translation: AAH17256.1.
M20675 Genomic DNA. No translation available.
CCDSiCCDS12502.1. [P10072-1]
PIRiC31201.
RefSeqiNP_861451.1. NM_181786.2. [P10072-1]
UniGeneiHs.657027.
Hs.729090.

Genome annotation databases

EnsembliENST00000324411; ENSP00000315505; ENSG00000181666. [P10072-1]
ENST00000392153; ENSP00000375994; ENSG00000181666. [P10072-2]
GeneIDi284459.
KEGGihsa:284459.
UCSCiuc002ogb.5. human. [P10072-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013897 mRNA. Translation: BAA86058.1. Different initiation.
AC016590 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56722.1.
BC004513 mRNA. Translation: AAH04513.2.
BC017256 mRNA. Translation: AAH17256.1.
M20675 Genomic DNA. No translation available.
CCDSiCCDS12502.1. [P10072-1]
PIRiC31201.
RefSeqiNP_861451.1. NM_181786.2. [P10072-1]
UniGeneiHs.657027.
Hs.729090.

3D structure databases

ProteinModelPortaliP10072.
SMRiP10072. Positions 228-659.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129883. 1 interaction.
IntActiP10072. 1 interaction.
STRINGi9606.ENSP00000315505.

PTM databases

PhosphoSiteiP10072.

Polymorphism and mutation databases

BioMutaiHKR1.
DMDMi215274257.

Proteomic databases

PaxDbiP10072.
PRIDEiP10072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324411; ENSP00000315505; ENSG00000181666. [P10072-1]
ENST00000392153; ENSP00000375994; ENSG00000181666. [P10072-2]
GeneIDi284459.
KEGGihsa:284459.
UCSCiuc002ogb.5. human. [P10072-1]

Organism-specific databases

CTDi284459.
GeneCardsiHKR1.
HGNCiHGNC:4928. HKR1.
HPAiHPA036126.
HPA044855.
MIMi165250. gene.
neXtProtiNX_P10072.
PharmGKBiPA29306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP10072.
KOiK09228.
OMAiQQQDPFC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP10072.
TreeFamiTF338096.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiHKR1. human.
GeneWikiiHKR1.
GenomeRNAii284459.
NextBioi94910.
PROiP10072.
SOURCEiSearch...

Gene expression databases

BgeeiP10072.
CleanExiHS_HKR1.
ExpressionAtlasiP10072. baseline and differential.
GenevisibleiP10072. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Kruppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs."
    Oguri T., Katoh O., Takahashi T., Isobe T., Kuramoto K., Hirata S., Yamakido M., Watanabe H.
    Gene 222:61-67(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-513.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-513.
    Tissue: Ovary.
  5. "The GLI-Kruppel family of human genes."
    Ruppert J.M., Kinzler K.W., Wong A.J., Bigner S.H., Kao F.T., Law M.L., Seuanez H.N., O'Brien S.J., Vogelstein B.
    Mol. Cell. Biol. 8:3104-3113(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 276-499.

Entry informationi

Entry nameiHKR1_HUMAN
AccessioniPrimary (citable) accession number: P10072
Secondary accession number(s): A8MRS7
, Q6PJD0, Q9BSW9, Q9UM09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: May 11, 2016
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.