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Protein

Gamma-crystallin B

Gene

Crygb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

  • lens development in camera-type eye Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin B
Alternative name(s):
Gamma-B-crystallin
Gamma-crystallin 1-2
Gene namesi
Name:Crygb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1584991. Crygb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 175174Gamma-crystallin BPRO_0000057590Add
BLAST

PTM databases

PhosphoSiteiP10066.

Structurei

3D structure databases

ProteinModelPortaliP10066.
SMRiP10066. Positions 2-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 12941Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 17243Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 885Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP10066.
PhylomeDBiP10066.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFFEDR GFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GDYPDYQQWM GFSDSIRSCR LIPQHSGTYR MRIYERDDFR
110 120 130 140 150
GQMSEITDDC LSLQDRFHLS EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG
160 170
EYRRYLDWGA ANAKVGSFRR VMDFY
Length:175
Mass (Da):21,089
Last modified:January 23, 2007 - v3
Checksum:i85DB9E0813C9523C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161C → S no nucleotide entry (PubMed:3783678).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19359 Genomic DNA. Translation: AAA40982.1.
PIRiB24060.
RefSeqiNP_001103345.1. NM_001109875.1.
UniGeneiRn.202960.

Genome annotation databases

GeneIDi301468.
KEGGirno:301468.
UCSCiRGD:1584991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19359 Genomic DNA. Translation: AAA40982.1.
PIRiB24060.
RefSeqiNP_001103345.1. NM_001109875.1.
UniGeneiRn.202960.

3D structure databases

ProteinModelPortaliP10066.
SMRiP10066. Positions 2-175.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP10066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301468.
KEGGirno:301468.
UCSCiRGD:1584991. rat.

Organism-specific databases

CTDi1419.
RGDi1584991. Crygb.

Phylogenomic databases

HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP10066.
PhylomeDBiP10066.

Miscellaneous databases

PROiP10066.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRGB_RAT
AccessioniPrimary (citable) accession number: P10066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are six different gamma crystallins identified in rat lens.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.