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Protein

Gamma-crystallin B

Gene

Crygb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

Miscellaneous

There are six different gamma crystallins identified in rat lens.

GO - Molecular functioni

GO - Biological processi

  • lens development in camera-type eye Source: RGD

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin B
Alternative name(s):
Gamma-B-crystallin
Gamma-crystallin 1-2
Gene namesi
Name:Crygb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1584991. Crygb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575901 – 175Gamma-crystallin BAdd BLAST175

PTM databases

PhosphoSitePlusiP10066.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043562.

Structurei

3D structure databases

ProteinModelPortaliP10066.
SMRiP10066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini89 – 129Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini130 – 172Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 88Connecting peptide5

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP10066.
PhylomeDBiP10066.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
PfamiView protein in Pfam
PF00030. Crystall. 2 hits.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00247. XTALbg. 2 hits.
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.

Sequencei

Sequence statusi: Complete.

P10066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFFEDR GFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GDYPDYQQWM GFSDSIRSCR LIPQHSGTYR MRIYERDDFR
110 120 130 140 150
GQMSEITDDC LSLQDRFHLS EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG
160 170
EYRRYLDWGA ANAKVGSFRR VMDFY
Length:175
Mass (Da):21,089
Last modified:January 23, 2007 - v3
Checksum:i85DB9E0813C9523C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16C → S no nucleotide entry (PubMed:3783678).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19359 Genomic DNA. Translation: AAA40982.1.
PIRiB24060.
RefSeqiNP_001103345.1. NM_001109875.1.
UniGeneiRn.202960.

Genome annotation databases

GeneIDi301468.
KEGGirno:301468.
UCSCiRGD:1584991. rat.

Similar proteinsi

Entry informationi

Entry nameiCRGB_RAT
AccessioniPrimary (citable) accession number: P10066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families