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P10052

- KITH_FOWPN

UniProt

P10052 - KITH_FOWPN

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Protein

Thymidine kinase

Gene
TK, FPV086
Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor Reviewed prediction
Binding sitei119 – 1191Substrate; via amide nitrogen By similarity
Metal bindingi144 – 1441Zinc By similarity
Metal bindingi147 – 1471Zinc By similarity
Metal bindingi176 – 1761Zinc By similarity
Metal bindingi179 – 1791Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Ordered Locus Names:FPV086
OrganismiFowlpox virus (strain NVSL) (FPV)
Taxonomic identifieri928301 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostiVertebrata [TaxID: 7742]
ProteomesiUP000008597: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Thymidine kinasePRO_0000174930Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10052.
SMRiP10052. Positions 3-181.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1675Substrate binding By similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10052-1 [UniParc]FASTAAdd to Basket

« Hide

MSSGSIHVIT GPMFSGKTSE LVRRIKRFML SNFKCIIIKH CGDNRYNEDD    50
INKVYTHDLL FMEATASSNL SVLVPTLLND GVQVIGIDEA QFFLDIVEFS 100
ESMANLGKTV IVAALNGDFK RELFGNVYKL LSLAETVSSL TAICVKCYCD 150
ASFSKRVTEN KEVMDIGGKD KYIAVCRKCF FSN 183
Length:183
Mass (Da):20,381
Last modified:July 1, 1989 - v1
Checksum:iFA60C5629F2DF276
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16617 Genomic DNA. Translation: AAA43822.1.
D00321 Genomic DNA. Translation: BAA00233.1.
AJ223385 Genomic DNA. Translation: CAA11295.1.
X52860 Genomic DNA. Translation: CAA37041.1.
AF198100 Genomic DNA. Translation: AAF44430.1.
AF396867 Genomic DNA. Translation: AAK77606.1.
PIRiA27532. KIVZFP.
RefSeqiNP_039049.1. NC_002188.1.

Genome annotation databases

GeneIDi1486634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16617 Genomic DNA. Translation: AAA43822.1 .
D00321 Genomic DNA. Translation: BAA00233.1 .
AJ223385 Genomic DNA. Translation: CAA11295.1 .
X52860 Genomic DNA. Translation: CAA37041.1 .
AF198100 Genomic DNA. Translation: AAF44430.1 .
AF396867 Genomic DNA. Translation: AAK77606.1 .
PIRi A27532. KIVZFP.
RefSeqi NP_039049.1. NC_002188.1.

3D structure databases

ProteinModelPortali P10052.
SMRi P10052. Positions 3-181.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1486634.

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases."
    Boyle D.B., Coupar B.E.H., Gibbs A.J., Seigman L.J., Both G.W.
    Virology 156:355-365(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene."
    Binns M.M., Tomley F.M., Campbell J., Boursnell M.E.G.
    J. Gen. Virol. 69:1275-1283(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FP-9 / Isolate HP-440.
  3. "Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene."
    Binns M.M., Boursnell M.E.G., Skinner M.A.
    Virus Res. 24:161-172(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FP-9 / Isolate HP-440.
  4. Beisel C.E., Nazerian K.
    Submitted (APR-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Vaccine.
  5. "Sequence of thymidine kinase gene of Indian isolate of fowlpox virus."
    Senthilvelan A., Purushothaman V., Palaniswami K.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_FOWPN
AccessioniPrimary (citable) accession number: P10052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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