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P10052 (KITH_FOWPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
Ordered Locus Names:FPV086
OrganismFowlpox virus (strain NVSL) (FPV) [Reference proteome]
Taxonomic identifier928301 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostVertebrata [TaxID: 7742]

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Thymidine kinase
PRO_0000174930

Regions

Nucleotide binding11 – 188ATP By similarity
Region163 – 1675Substrate binding By similarity

Sites

Active site891Proton acceptor Potential
Metal binding1441Zinc By similarity
Metal binding1471Zinc By similarity
Metal binding1761Zinc By similarity
Metal binding1791Zinc By similarity
Binding site1191Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P10052 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: FA60C5629F2DF276

FASTA18320,381
        10         20         30         40         50         60 
MSSGSIHVIT GPMFSGKTSE LVRRIKRFML SNFKCIIIKH CGDNRYNEDD INKVYTHDLL 

        70         80         90        100        110        120 
FMEATASSNL SVLVPTLLND GVQVIGIDEA QFFLDIVEFS ESMANLGKTV IVAALNGDFK 

       130        140        150        160        170        180 
RELFGNVYKL LSLAETVSSL TAICVKCYCD ASFSKRVTEN KEVMDIGGKD KYIAVCRKCF 


FSN 

« Hide

References

« Hide 'large scale' references
[1]"Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases."
Boyle D.B., Coupar B.E.H., Gibbs A.J., Seigman L.J., Both G.W.
Virology 156:355-365(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene."
Binns M.M., Tomley F.M., Campbell J., Boursnell M.E.G.
J. Gen. Virol. 69:1275-1283(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FP-9 / Isolate HP-440.
[3]"Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene."
Binns M.M., Boursnell M.E.G., Skinner M.A.
Virus Res. 24:161-172(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FP-9 / Isolate HP-440.
[4]Beisel C.E., Nazerian K.
Submitted (APR-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Vaccine.
[5]"Sequence of thymidine kinase gene of Indian isolate of fowlpox virus."
Senthilvelan A., Purushothaman V., Palaniswami K.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The genome of fowlpox virus."
Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.
J. Virol. 74:3815-3831(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16617 Genomic DNA. Translation: AAA43822.1.
D00321 Genomic DNA. Translation: BAA00233.1.
AJ223385 Genomic DNA. Translation: CAA11295.1.
X52860 Genomic DNA. Translation: CAA37041.1.
AF198100 Genomic DNA. Translation: AAF44430.1.
AF396867 Genomic DNA. Translation: AAK77606.1.
PIRKIVZFP. A27532.
RefSeqNP_039049.1. NC_002188.1.

3D structure databases

ProteinModelPortalP10052.
SMRP10052. Positions 3-181.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1486634.

Phylogenomic databases

ProtClustDBCLSP2509781.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_FOWPN
AccessionPrimary (citable) accession number: P10052
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families