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Protein

Thymidine kinase

Gene

TK

Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorSequence analysis1
Binding sitei119Substrate; via amide nitrogenBy similarity1
Metal bindingi144ZincBy similarity1
Metal bindingi147ZincBy similarity1
Metal bindingi176ZincBy similarity1
Metal bindingi179ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Ordered Locus Names:FPV086
OrganismiFowlpox virus (strain NVSL) (FPV)
Taxonomic identifieri928301 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostiVertebrata [TaxID: 7742]
Proteomesi
  • UP000008597 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749301 – 183Thymidine kinaseAdd BLAST183

Structurei

3D structure databases

ProteinModelPortaliP10052.
SMRiP10052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 167Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Phylogenomic databases

OrthoDBiVOG090000XT.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

P10052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGSIHVIT GPMFSGKTSE LVRRIKRFML SNFKCIIIKH CGDNRYNEDD
60 70 80 90 100
INKVYTHDLL FMEATASSNL SVLVPTLLND GVQVIGIDEA QFFLDIVEFS
110 120 130 140 150
ESMANLGKTV IVAALNGDFK RELFGNVYKL LSLAETVSSL TAICVKCYCD
160 170 180
ASFSKRVTEN KEVMDIGGKD KYIAVCRKCF FSN
Length:183
Mass (Da):20,381
Last modified:July 1, 1989 - v1
Checksum:iFA60C5629F2DF276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16617 Genomic DNA. Translation: AAA43822.1.
D00321 Genomic DNA. Translation: BAA00233.1.
AJ223385 Genomic DNA. Translation: CAA11295.1.
X52860 Genomic DNA. Translation: CAA37041.1.
AF198100 Genomic DNA. Translation: AAF44430.1.
AF396867 Genomic DNA. Translation: AAK77606.1.
PIRiA27532. KIVZFP.
RefSeqiNP_039049.1. NC_002188.1.

Genome annotation databases

GeneIDi1486634.
KEGGivg:1486634.

Similar proteinsi

Entry informationi

Entry nameiKITH_FOWPN
AccessioniPrimary (citable) accession number: P10052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families