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P10052

- KITH_FOWPN

UniProt

P10052 - KITH_FOWPN

Protein

Thymidine kinase

Gene

TK

Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorSequence Analysis
    Binding sitei119 – 1191Substrate; via amide nitrogenBy similarity
    Metal bindingi144 – 1441ZincBy similarity
    Metal bindingi147 – 1471ZincBy similarity
    Metal bindingi176 – 1761ZincBy similarity
    Metal bindingi179 – 1791ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Ordered Locus Names:FPV086
    OrganismiFowlpox virus (strain NVSL) (FPV)
    Taxonomic identifieri928301 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
    Virus hostiVertebrata [TaxID: 7742]
    ProteomesiUP000008597: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Thymidine kinasePRO_0000174930Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP10052.
    SMRiP10052. Positions 3-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni163 – 1675Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10052-1 [UniParc]FASTAAdd to Basket

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    MSSGSIHVIT GPMFSGKTSE LVRRIKRFML SNFKCIIIKH CGDNRYNEDD    50
    INKVYTHDLL FMEATASSNL SVLVPTLLND GVQVIGIDEA QFFLDIVEFS 100
    ESMANLGKTV IVAALNGDFK RELFGNVYKL LSLAETVSSL TAICVKCYCD 150
    ASFSKRVTEN KEVMDIGGKD KYIAVCRKCF FSN 183
    Length:183
    Mass (Da):20,381
    Last modified:July 1, 1989 - v1
    Checksum:iFA60C5629F2DF276
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16617 Genomic DNA. Translation: AAA43822.1.
    D00321 Genomic DNA. Translation: BAA00233.1.
    AJ223385 Genomic DNA. Translation: CAA11295.1.
    X52860 Genomic DNA. Translation: CAA37041.1.
    AF198100 Genomic DNA. Translation: AAF44430.1.
    AF396867 Genomic DNA. Translation: AAK77606.1.
    PIRiA27532. KIVZFP.
    RefSeqiNP_039049.1. NC_002188.1.

    Genome annotation databases

    GeneIDi1486634.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16617 Genomic DNA. Translation: AAA43822.1 .
    D00321 Genomic DNA. Translation: BAA00233.1 .
    AJ223385 Genomic DNA. Translation: CAA11295.1 .
    X52860 Genomic DNA. Translation: CAA37041.1 .
    AF198100 Genomic DNA. Translation: AAF44430.1 .
    AF396867 Genomic DNA. Translation: AAK77606.1 .
    PIRi A27532. KIVZFP.
    RefSeqi NP_039049.1. NC_002188.1.

    3D structure databases

    ProteinModelPortali P10052.
    SMRi P10052. Positions 3-181.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1486634.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases."
      Boyle D.B., Coupar B.E.H., Gibbs A.J., Seigman L.J., Both G.W.
      Virology 156:355-365(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene."
      Binns M.M., Tomley F.M., Campbell J., Boursnell M.E.G.
      J. Gen. Virol. 69:1275-1283(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FP-9 / Isolate HP-440.
    3. "Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene."
      Binns M.M., Boursnell M.E.G., Skinner M.A.
      Virus Res. 24:161-172(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FP-9 / Isolate HP-440.
    4. Beisel C.E., Nazerian K.
      Submitted (APR-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Vaccine.
    5. "Sequence of thymidine kinase gene of Indian isolate of fowlpox virus."
      Senthilvelan A., Purushothaman V., Palaniswami K.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_FOWPN
    AccessioniPrimary (citable) accession number: P10052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3